Survival analysis of adjuvant chemotherapy with S-1 plus cisplatin for stage III gastric cancer

Daisuke Takahari1, Tetsuya Hamaguchi2, Kenichi Yoshimura3, Hitoshi Katai4, Seiji Ito5, Nozomu Fuse6, Masaru Konishi7, Hirofumi Yasui8, Masanori Terashima9, Masahiro Goto10, Nobuhiko Tanigawa11, Kuniaki Shirao12, Takeshi Sano13, Mitsuru Sasako14
1Department of Clinical Oncology, Aichi Cancer Center Hospital, Nagoya, Japan
2Gastrointestinal Oncology Division, National Cancer Center Hospital, Tokyo, Japan
3Translational Research Center, Graduate School of Medicine, Kyoto University Hospital, Kyoto, Japan
4Gastric Surgery Division, National Cancer Center Hospital, Kashiwa, Japan
5Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan
6Division of Gastrointestinal Oncology and Digestive Endoscopy, National Cancer Center Hospital East, Kashiwa, Japan
7Division of Surgical Oncology, National Cancer Center Hospital East, Kashiwa, Japan
8Division of Gastrointestinal Oncology, Shizuoka Cancer Center, Shizuoka, Japan
9Division of Gastric Surgery, Shizuoka Cancer Center, Shizuoka, Japan
10Cancer Chemotherapy Center, Osaka Medical College, Takatsuki, Japan
11General and Gastroenterological Surgery, Osaka Medical College, Takatsuki, Japan
12Department of Medical Oncology, Faculty of Medicine, Oita University, Yufu, Japan
13Department of Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan
14Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan

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Sasako M, Sakuramoto S, Katai H, Kinoshita T, Furukawa H, Yamaguchi T, et al. Five-year outcomes of a randomized phase III trial comparing adjuvant chemotherapy with S-1 versus surgery alone in stage II or III gastric cancer. J Clin Oncol. 2011;29:4387–93.

Koizumi W, Narahara H, Hara T, Takagane A, Akiya T, Takagi M, et al. S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial. Lancet Oncol. 2008;9:215–21.

Takahari D, Hamaguchi T, Yoshimura K, Katai H, Ito S, Fuse N, et al. Feasibility study of adjuvant chemotherapy with S-1 plus cisplatin for gastric cancer. Cancer Chemother Pharmacol. 2011;67:1423–8.

Japanese Gastric Cancer Association. Japanese Classification of Gastric Carcinoma—2nd English Edition. Gastric Cancer. 1998;1:10–24.

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