Expression and Characterization of Hypoxia-Inducible Factor (HIF)-3α in Human Kidney: Suppression of HIF-Mediated Gene Expression by HIF-3α

Semenza, 1999, Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1, Annu. Rev. Cell Dev. Biol., 15, 551, 10.1146/annurev.cellbio.15.1.551 Semenza, 2000, HIF-1: Mediator of physiological and pathophysiological responses to hypoxia, J. Appl. Physiol., 88, 1474, 10.1152/jappl.2000.88.4.1474 Gu, 2000, The PAS superfamily: Sensors of environmental and developmental signals, Annu. Rev. Pharmacol. Toxicol., 40, 519, 10.1146/annurev.pharmtox.40.1.519 Wang, 1995, Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension, Proc. Natl. Acad. Sci. USA, 92, 5510, 10.1073/pnas.92.12.5510 Salceda, 1997, Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions: Its stabilization by hypoxia depends on redox-induced changes, J. Biol. Chem., 272, 22642, 10.1074/jbc.272.36.22642 Huang, 1998, Regulation of hypoxia-inducible factor 1α is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway, Proc. Natl. Acad. Sci. USA, 95, 7987, 10.1073/pnas.95.14.7987 Maxwell, 1999, The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis, Nature, 399, 271, 10.1038/20459 Kallio, 1998, Signal transcription in hypoxic cells: Inducible nuclear translocation and recruitment of the CBP/p300 coativator by the hypoxia-inducible factor-1α, EMBO J., 17, 6573, 10.1093/emboj/17.22.6573 Ema, 1999, Molecular mechanisms of transcription activation by HLF and HIF1α in response to hypoxia: Their stabilization and redox signal-induced interaction with CBP/p300, EMBO J., 18, 1905, 10.1093/emboj/18.7.1905 Wenger, 1997, Oxygen(es) and the hypoxia-inducible factor-1, Biol. Chem., 378, 609 Tian, 1997, Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells, Genes Dev., 11, 72, 10.1101/gad.11.1.72 Ema, 1997, A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the VEGF expression and is potentially involved in lung and vascular development, Proc. Natl. Acad. Sci. USA, 94, 4273, 10.1073/pnas.94.9.4273 Flamme, 1997, HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1α and developmentally expressed in blood vessels, Mech. Dev., 63, 51, 10.1016/S0925-4773(97)00674-6 Hogenesch, 1997, Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway, J. Biol. Chem., 272, 8581, 10.1074/jbc.272.13.8581 Hara, 1999, Molecular cloning of cDNAs encoding hypoxia-inducible factor (HIF)-1α and -2α of bovine arterial endothelial cells, Biochim. Biophys. Acta, 1445, 237, 10.1016/S0167-4781(99)00048-2 Hara, 1999, Nuclear localization of hypoxia-inducible factor-2α in bovine arterial endothelial cells, Mol. Cell Biol. Res. Commun., 2, 119, 10.1006/mcbr.1999.0160 Wiesener, 1998, Induction of endothelial PAS domain protein-1 by hypoxia: Characterization and comparison with hypoxia-inducible factor-1α, Blood, 92, 2260, 10.1182/blood.V92.7.2260 Gu, 1998, Molecular characterization and chromosomal localization of a third α-class hypoxia inducible factor subunit, HIF3α, Gene Expression, 7, 205 Pugh, 1997, Activation of hypoxia-inducible factor-1: Definition of regulatory domains with a subunit, J. Biol. Chem., 272, 11205, 10.1074/jbc.272.17.11205 Jiang, 1997, Transactivation and inhibitory domains of hypoxia-inducible factor 1α: Modulation of transcriptional activity by oxygen tension, J. Biol. Chem., 272, 19253, 10.1074/jbc.272.31.19253 O'Rourke, 1999, Oxygen-regulated and transactivating domains in endothelial PAS protein 1: Comparison with hypoxia-inducible factor-1α, J. Biol. Chem., 274, 2060, 10.1074/jbc.274.4.2060 Maxwell, 1998, Regulation of expression of the erythropoietin gene, Curr. Opin. Hematol., 5, 166, 10.1097/00062752-199805000-00003 Chomczynski, 1987, Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction, Anal. Biochem., 162, 156, 10.1016/0003-2697(87)90021-2 Wenger, 1996, Nucleotide sequence, chromosomal assignment and mRNA expression of mouse hypoxia-inducible factor-1α, Biochem. Biophys. Res. Commun., 223, 54, 10.1006/bbrc.1996.0845 Ladoux, 1997, Cardiac expression of HIF-1α and HLF/EPAS, two basic loop helix/PAS domain transcription factors involved in adaptative responses to hypoxic stresses, Biochem. Biophys. Res. Commun., 240, 552, 10.1006/bbrc.1997.7708 Kubota, 1991, Xenobiotic responsive element in the 5′-upstream region of the human P-450c gene, J. Biochem., 110, 232, 10.1093/oxfordjournals.jbchem.a123562 Srinivas, 1999, Characterization of an oxygen/redox-dependent degradation domain of hypoxia-inducible factor α (HIF-α) proteins, Biochem. Biophys. Res. Commun., 260, 557, 10.1006/bbrc.1999.0878 Hogenesch, 1998, The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors, Proc. Natl. Acad. Sci. USA, 95, 5474, 10.1073/pnas.95.10.5474 Takahata, 1998, Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1α, HLF, and Clock, Biochem. Biophys. Res. Commun., 248, 789, 10.1006/bbrc.1998.9012 Maemura, 2000, CLIF, a novel Cycle-like factor, regulates the circadian oscillation of plasminogen activator inhibitor-1 gene expression, J. Biol. Chem., 275, 36847, 10.1074/jbc.C000629200 Mimura, 2000, Identification of a novel mechanism of regulation of Ah (dioxin) receptor function, J. Biol. Chem., 275, 36847