Regulation of fibroblast-like synoviocyte transformation by transcription factors in arthritic diseases

Biochemical Pharmacology - Tập 165 - Trang 145-151 - 2019
Pallavi Bhattaram1,2, Kyle Jones1,2
1Department of Orthopaedics, Emory University School of Medicine, Atlanta, GA 30322, USA
2Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322 USA

Tài liệu tham khảo

Lelli, 2012, Disentangling the many layers of eukaryotic transcriptional regulation, Annu. Rev. Genet., 46, 43, 10.1146/annurev-genet-110711-155437 Lee, 2013, Transcriptional regulation and its misregulation in disease, Cell, 152, 1237, 10.1016/j.cell.2013.02.014 Hagenbuchner, 2016, Targeting transcription factors by small compounds – current strategies and future implications, Biochem. Pharmacol., 107, 1, 10.1016/j.bcp.2015.12.006 Lambert, 2018, Targeting transcription factors for cancer treatment, Molecules, 23, 10.3390/molecules23061479 Dowdy, 2017, Overcoming cellular barriers for RNA therapeutics, Nat. Biotechnol., 35, 222, 10.1038/nbt.3802 Tran, 2017, Cancer nanomedicine: a review of recent success in drug delivery, Clin. Transl. Med., 6, 44, 10.1186/s40169-017-0175-0 Adli, 2018, The CRISPR tool kit for genome editing and beyond, Nat. Commun., 9, 1911, 10.1038/s41467-018-04252-2 van Staalduinen, 2018, Epithelial-mesenchymal-transition-inducing transcription factors: new targets for tackling chemoresistance in cancer?, Oncogene, 10.1038/s41388-018-0378-x Bhattaram, 2017, The joint synovium: a critical determinant of articular cartilage fate in inflammatory joint diseases, Semin. Cell Dev. Biol., 62, 86, 10.1016/j.semcdb.2016.05.009 Furtado, 2016, Tissue fibroblasts: from bystanders to proactive modulators of homeostasis and disease, Differentiation, 92, 65, 10.1016/j.diff.2016.09.001 Ichim, 2018, Fibroblasts as a practical alternative to mesenchymal stem cells, J. Transl. Med., 16, 212, 10.1186/s12967-018-1536-1 Bottini, 2013, Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors, Nat. Rev. Rheumatol., 9, 24, 10.1038/nrrheum.2012.190 Chen, 2018, Turning foes to friends: targeting cancer-associated fibroblasts, Nat. Rev. Drug. Discov. Mathiessen, 2017, Synovitis in osteoarthritis: current understanding with therapeutic implications, Arthritis Res. Ther., 19, 18, 10.1186/s13075-017-1229-9 Bustamante, 2017, Fibroblast-like synoviocyte metabolism in the pathogenesis of rheumatoid arthritis, Arthritis Res. Ther., 19, 110, 10.1186/s13075-017-1303-3 Lefebvre, 2007, Control of cell fate and differentiation by Sry-related high-mobility-group box (Sox) transcription factors, Int. J. Biochem. Cell Biol., 39, 2195, 10.1016/j.biocel.2007.05.019 Julian, 2017, Direct reprogramming with SOX factors: masters of cell fate, Curr. Opin. Genet. Dev., 46, 24, 10.1016/j.gde.2017.06.005 Xu, 2017, SOX-mediated molecular crosstalk during the progression of tumorigenesis, Semin. Cell Dev. Biol., 63, 23, 10.1016/j.semcdb.2016.07.028 Lefebvre, 2010, The SoxD transcription factors–Sox5, Sox6, and Sox13–are key cell fate modulators, Int. J. Biochem. Cell Biol., 42, 429, 10.1016/j.biocel.2009.07.016 Lai, 2008, SOX5 controls the sequential generation of distinct corticofugal neuron subtypes, Neuron, 57, 232, 10.1016/j.neuron.2007.12.023 Kwan, 2008, SOX5 postmitotically regulates migration, postmigratory differentiation, and projections of subplate and deep-layer neocortical neurons, Proc. Natl. Acad. Sci. U.S.A., 105, 16021, 10.1073/pnas.0806791105 Liu, 2015, The transcription factors SOX9 and SOX5/SOX6 cooperate genome-wide through super-enhancers to drive chondrogenesis, Nucl. Acids Res., 43, 8183, 10.1093/nar/gkv688 Nesbitt, 2015, Exome sequencing expands the mechanism of SOX5-associated intellectual disability: a case presentation with review of sox-related disorders, Am. J. Med. Genet. A, 167A, 2548, 10.1002/ajmg.a.37221 Zou, 2018, SOX5 interacts with YAP1 to drive malignant potential of non-small cell lung cancer cells, Am. J. Cancer Res., 8, 866 Chen, 2018, SOX5 predicts poor prognosis in lung adenocarcinoma and promotes tumor metastasis through epithelial-mesenchymal transition, Oncotarget, 9, 10891, 10.18632/oncotarget.22443 Ma, 2009, DNA fingerprinting tags novel altered chromosomal regions and identifies the involvement of SOX5 in the progression of prostate cancer, Int. J. Cancer, 124, 2323, 10.1002/ijc.24243 Shi, 2018, Transcription factor SOX5 promotes the migration and invasion of fibroblast-like synoviocytes in part by regulating MMP-9 expression in collagen-induced arthritis, Front. Immunol., 9, 749, 10.3389/fimmu.2018.00749 Feng, 2016, Modulation of IL-6 induced RANKL expression in arthritic synovium by a transcription factor SOX5, Sci. Rep., 6, 32001, 10.1038/srep32001 Liu, 2018, miR-212-3p reduced proliferation, and promoted apoptosis of fibroblast-like synoviocytes via down-regulating SOX5 in rheumatoid arthritis, Eur. Rev. Med. Pharmacol. Sci., 22, 461 Bhattaram, 2014, SOXC proteins amplify canonical WNT signaling to secure nonchondrocytic fates in skeletogenesis, J. Cell Biol., 207, 657, 10.1083/jcb.201405098 Bhattaram, 2010, Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors, Nat. Commun., 1, 9, 10.1038/ncomms1008 Bhattaram, 2015, Progenitor cell fate, SOXC and WNT, Oncotarget, 6, 24596, 10.18632/oncotarget.5237 Bhattaram, 2018, Inflammatory cytokines stabilize SOXC transcription factors to mediate the transformation of fibroblast-like synoviocytes in arthritic disease, Arthritis Rheumatol., 70, 371, 10.1002/art.40386 Wuebben, 2017, The dark side of SOX2: cancer – a comprehensive overview, Oncotarget, 8, 44917, 10.18632/oncotarget.16570 Naka, 2010, Synovial sarcoma is a stem cell malignancy, Stem Cells, 28, 1119, 10.1002/stem.452 Mallo, 2018, Reassessing the role of Hox genes during vertebrate development and evolution, Trends Genet., 34, 209, 10.1016/j.tig.2017.11.007 Rux, 2017, Hox genes in the adult skeleton: novel functions beyond embryonic development, Dev. Dyn., 246, 310, 10.1002/dvdy.24482 Morgan, 2017, Targeting HOX/PBX dimers in cancer, Oncotarget, 8, 32322, 10.18632/oncotarget.15971 Pelttari, 2015, A potential role of homeobox transcription factors in osteoarthritis, Ann. Transl. Med., 3, 254 den Hollander, 2014, Knee and hip articular cartilage have distinct epigenomic landscapes: implications for future cartilage regeneration approaches, Ann. Rheum. Dis., 73, 2208, 10.1136/annrheumdis-2014-205980 Rux, 2016, Regionally restricted Hox function in adult bone marrow multipotent mesenchymal stem/stromal cells, Dev. Cell, 39, 653, 10.1016/j.devcel.2016.11.008 Frank-Bertoncelj, 2017, Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions, Nat. Commun., 8, 14852, 10.1038/ncomms14852 Barrallo-Gimeno, 2005, The snail genes as inducers of cell movement and survival: implications in development and cancer, Development, 132, 3151, 10.1242/dev.01907 Baulida, 2017, Epithelial-to-mesenchymal transition transcription factors in cancer-associated fibroblasts, Mol. Oncol., 11, 847, 10.1002/1878-0261.12080 Chen, 2015, Transcription factor snail regulates tumor necrosis factor alpha-mediated synovial fibroblast activation in the rheumatoid joint, Arthritis Rheumatol., 67, 39, 10.1002/art.38899 Lauzier, 2016, Snail is a critical mediator of invadosome formation and joint degradation in arthritis, Am. J. Pathol., 186, 359, 10.1016/j.ajpath.2015.10.021 Lauzier, 2011, Formation of invadopodia-like structures by synovial cells promotes cartilage breakdown in collagen-induced arthritis: involvement of the protein tyrosine kinase Src, Arthritis Rheumatol., 63, 1591, 10.1002/art.30305 Charbonneau, 2016, Platelet-derived growth factor receptor activation promotes the prodestructive invadosome-forming phenotype of synoviocytes from patients with rheumatoid arthritis, J. Immunol., 10.4049/jimmunol.1500502 Cha, 2010, Slug suppression induces apoptosis via Puma transactivation in rheumatoid arthritis fibroblast-like synoviocytes treated with hydrogen peroxide, Exp. Mol. Med., 42, 428, 10.3858/emm.2010.42.6.044 Chang, 2015, An evolutionarily conserved DNA architecture determines target specificity of the TWIST family bHLH transcription factors, Genes Dev., 29, 603, 10.1101/gad.242842.114 Howard, 1997, Mutations in TWIST, a basic helix-loop-helix transcription factor, in Saethre-Chotzen syndrome, Nat. Genet., 15, 36, 10.1038/ng0197-36 Zhao, 2017, Multiple biological functions of Twist1 in various cancers, Oncotarget, 8, 20380, 10.18632/oncotarget.14608 You, 2014, Identification of key regulators for the migration and invasion of rheumatoid synoviocytes through a systems approach, Proc. Natl. Acad. Sci. U.S.A., 111, 550, 10.1073/pnas.1311239111 Webb, 2014, FOXO transcription factors: key regulators of cellular quality control, Trends Biochem. Sci., 39, 159, 10.1016/j.tibs.2014.02.003 Paik, 2007, FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis, Cell, 128, 309, 10.1016/j.cell.2006.12.029 Ludikhuize, 2007, Inhibition of forkhead box class O family member transcription factors in rheumatoid synovial tissue, Arthritis Rheumatol., 56, 2180, 10.1002/art.22653 Grabiec, 2015, JNK-dependent downregulation of FoxO1 is required to promote the survival of fibroblast-like synoviocytes in rheumatoid arthritis, Ann. Rheum. Dis., 74, 1763, 10.1136/annrheumdis-2013-203610 Kok, 2013, Simvastatin inhibits cysteine-rich protein 61 expression in rheumatoid arthritis synovial fibroblasts through the regulation of sirtuin-1/FoxO3a signaling, Arthritis Rheumatol., 65, 639, 10.1002/art.37807 Hui, 2011, Gli proteins in development and disease, Annu. Rev. Cell Dev. Biol., 27, 513, 10.1146/annurev-cellbio-092910-154048 Rohatgi, 2007, Patched1 regulates hedgehog signaling at the primary cilium, Science, 317, 372, 10.1126/science.1139740 Skoda, 2018, The role of the Hedgehog signaling pathway in cancer: a comprehensive review, Bosn. J. Basic Med. Sci., 18, 8, 10.17305/bjbms.2018.2756 Wang, 2014, Sonic hedgehog signaling drives proliferation of synoviocytes in rheumatoid arthritis: a possible novel therapeutic target, J. Immunol. Res., 2014, 10.1155/2014/401903 Qin, 2018, GANT61 alleviates arthritic symptoms by targeting fibroblast-like synoviocytes in CIA rats, J. Orthop. Sci. Peng, 2017, Smoothened regulates migration of fibroblast-like synoviocytes in rheumatoid arthritis via activation of rho GTPase signaling, Front. Immunol., 8, 159, 10.3389/fimmu.2017.00159 Singh, 2017, DYRK1B blocks canonical and promotes non-canonical Hedgehog signaling through activation of the mTOR/AKT pathway, Oncotarget, 8, 833, 10.18632/oncotarget.13662 Sharma, 2015, PI3K/AKT/mTOR and sonic hedgehog pathways cooperate together to inhibit human pancreatic cancer stem cell characteristics and tumor growth, Oncotarget, 6, 32039, 10.18632/oncotarget.5055 Zhu, 2017, T-box family of transcription factor-TBX5, insights in development and disease, Am. J. Transl. Res., 9, 442 Mori, 2004, TBX5 mutations and congenital heart disease: Holt-Oram syndrome revealed, Curr. Opin. Cardiol., 19, 211, 10.1097/00001573-200405000-00004 Ma, 2017, Overexpression of T-box transcription factor 5 (TBX5) inhibits proliferation and invasion in non-small cell lung carcinoma cells, Oncol. Res., 25, 1495, 10.3727/096504017X14883287513729 Karouzakis, 2014, Epigenome analysis reveals TBX5 as a novel transcription factor involved in the activation of rheumatoid arthritis synovial fibroblasts, J. Immunol., 193, 4945, 10.4049/jimmunol.1400066 Briegel, 2001, Identification and characterization of Lbh, a novel conserved nuclear protein expressed during early limb and heart development, Dev. Biol., 233, 291, 10.1006/dbio.2001.0225 Conen, 2009, The transcriptional cofactor Lbh regulates angiogenesis and endochondral bone formation during fetal bone development, Dev. Biol., 333, 348, 10.1016/j.ydbio.2009.07.003 Briegel, 2005, Congenital heart disease reminiscent of partial trisomy 2p syndrome in mice transgenic for the transcription factor Lbh, Development, 132, 3305, 10.1242/dev.01887 Lurie, 1995, Trisomy 2p: analysis of unusual phenotypic findings, Am. J. Med. Genet., 55, 229, 10.1002/ajmg.1320550216 Hammaker, 2016, LBH gene transcription regulation by the interplay of an enhancer risk allele and DNA methylation in rheumatoid arthritis, Arthritis Rheumatol., 68, 2637, 10.1002/art.39746 Ekwall, 2015, The rheumatoid arthritis risk gene LBH regulates growth in fibroblast-like synoviocytes, Arthritis Rheumatol., 67, 1193, 10.1002/art.39060 Matsuda, 2017, Regulation of the cell cycle and inflammatory arthritis by the transcription cofactor LBH gene, J. Immunol., 199, 2316, 10.4049/jimmunol.1700719 Cavodeassi, 2001, The Iroquois family of genes: from body building to neural patterning, Development, 128, 2847, 10.1242/dev.128.15.2847 Becker, 2001, Irx1 and Irx2 expression in early lung development, Mech. Dev., 106, 155, 10.1016/S0925-4773(01)00412-9 Zulch, 2001, Expression pattern of Irx1 and Irx2 during mouse digit development, Mech. Dev., 106, 159, 10.1016/S0925-4773(01)00411-7 Houweling, 2001, Gene and cluster-specific expression of the Iroquois family members during mouse development, Mech. Dev., 107, 169, 10.1016/S0925-4773(01)00451-8 Yu, 2017, Irx1 regulates dental outer enamel epithelial and lung alveolar type II epithelial differentiation, Dev. Biol., 429, 44, 10.1016/j.ydbio.2017.07.011 Bennett, 2008, Frequently methylated tumor suppressor genes in head and neck squamous cell carcinoma, Cancer Res., 68, 4494, 10.1158/0008-5472.CAN-07-6509 Guo, 2010, Homeobox gene IRX1 is a tumor suppressor gene in gastric carcinoma, Oncogene, 29, 3908, 10.1038/onc.2010.143 Liu, 2018, Protein arginine methyltransferase 5-mediated epigenetic silencing of IRX1 contributes to tumorigenicity and metastasis of gastric cancer, Biochim. Biophys. Acta Mol. Basis Dis, 1864, 2835, 10.1016/j.bbadis.2018.05.015 Jiang, 2011, IRX1 influences peritoneal spreading and metastasis via inhibiting BDKRB2-dependent neovascularization on gastric cancer, Oncogene, 30, 4498, 10.1038/onc.2011.154 Selvarajah, 2007, Identification of cryptic microaberrations in osteosarcoma by high-definition oligonucleotide array comparative genomic hybridization, Cancer Genet. Cytogenet., 179, 52, 10.1016/j.cancergencyto.2007.08.003 Lu, 2015, IRX1 hypomethylation promotes osteosarcoma metastasis via induction of CXCL14/NF-kappaB signaling, J. Clin. Invest., 125, 1839, 10.1172/JCI78437 Julia, 2016, Identification of IRX1 as a risk locus for rheumatoid factor positivity in rheumatoid arthritis in a genome-wide association study, Arthritis Rheumatol., 68, 1384, 10.1002/art.39591 Park, 2013, Hypermethylation of EBF3 and IRX1 genes in synovial fibroblasts of patients with rheumatoid arthritis, Mol. Cells, 35, 298, 10.1007/s10059-013-2302-0 Leung, 2013, DNA-binding small molecules as inhibitors of transcription factors, Med. Res. Rev., 33, 823, 10.1002/med.21266 Sammak, 2015, Targeting protein-protein interactions (PPIs) of transcription factors: challenges of intrinsically disordered proteins (IDPs) and regions (IDRs), Prog. Biophys. Mol. Biol., 119, 41, 10.1016/j.pbiomolbio.2015.06.004 Fontaine, 2017, Small-molecule inhibitors of the SOX18 transcription factor, Cell Chem. Biol., 24, 346, 10.1016/j.chembiol.2017.01.003 Overman, 2017, Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice, Elife, 6, 10.7554/eLife.21221 Ladam, 2014, Hox regulation of transcription: more complex(es), Dev. Dyn., 243, 4, 10.1002/dvdy.23997 Alharbi, 2017, Inhibition of HOX/PBX dimer formation leads to necroptosis in acute myeloid leukemia cells, Oncotarget, 8, 89566, 10.18632/oncotarget.20023 Langlet, 2017, Selective inhibition of FOXO1 activator/repressor balance modulates hepatic glucose handling, Cell, 171, 10.1016/j.cell.2017.09.045 Agyeman, 2014, Mode and specificity of binding of the small molecule GANT61 to GLI determines inhibition of GLI-DNA binding, Oncotarget, 5, 4492, 10.18632/oncotarget.2046 Zhang, 2016, Targeting GLI by GANT61 involves mechanisms dependent on inhibition of both transcription and DNA licensing, Oncotarget, 7, 80190, 10.18632/oncotarget.13376 Srivastava, 2014, GLI inhibitor GANT-61 diminishes embryonal and alveolar rhabdomyosarcoma growth by inhibiting Shh/AKT-mTOR axis, Oncotarget, 5, 12151, 10.18632/oncotarget.2569 Lee, 2011, p53 activation by blocking Snail: a novel pharmacological strategy for cancer, Curr. Pharm. Des., 17, 610, 10.2174/138161211795222658 Harney, 2009, Targeted inhibition of Snail family zinc finger transcription factors by oligonucleotide-Co(III) Schiff base conjugate, Proc. Natl. Acad. Sci. U.S.A., 106, 13667, 10.1073/pnas.0906423106 Yochum, 2017, A first-in-class TWIST1 inhibitor with activity in oncogene-driven lung cancer, Mol. Cancer Res., 15, 1764, 10.1158/1541-7786.MCR-17-0298