Efficacy of telemedical interventional management in patients with heart failure (TIM-HF2): a randomised, controlled, parallel-group, unmasked trial

Cowie, 2016, e-Health: a position statement of the European Society of Cardiology, Eur Heart J, 37, 63, 10.1093/eurheartj/ehv416 Cowie, 2014, Improving care for patients with acute heart failure: before, during and after hospitalization, ESC Heart Fail, 1, 110, 10.1002/ehf2.12021 van Riet, 2016, Epidemiology of heart failure: the prevalence of heart failure and ventricular dysfunction in older adults over time. A systematic review, Eur J Heart Fail, 18, 242, 10.1002/ejhf.483 Chioncel, 2017, Epidemiology and one-year outcomes in patients with chronic heart failure and preserved, mid-range and reduced ejection fraction: an analysis of the ESC Heart Failure Long-Term Registry, Eur J Heart Fail, 19, 1574, 10.1002/ejhf.813 Ponikowski, 2016, Eur J Heart Fail, 18, 891, 10.1002/ejhf.592 Cleland, 2005, Noninvasive home telemonitoring for patients with heart failure at high risk of recurrent admission and death: the Trans-European Network-Home-Care Management System (TEN-HMS) study, J Am Coll Cardiol, 45, 1654, 10.1016/j.jacc.2005.01.050 van Veldhuisen, 2011, Intrathoracic impedance monitoring, audible patient alerts, and outcome in patients with heart failure, Circulation, 124, 1719, 10.1161/CIRCULATIONAHA.111.043042 Ong, 2016, Effectiveness of remote patient monitoring after discharge of hospitalised patients with heart failure: the Better Effectiveness After Transition–Heart Failure (BEAT-HF) randomized clinical trial, JAMA Intern Med, 76, 310, 10.1001/jamainternmed.2015.7712 Chaudhry, 2010, Telemonitoring in patients with heart failure, N Engl J Med, 363, 2301, 10.1056/NEJMoa1010029 Koehler, 2011, Impact of remote telemedical management on mortality and hospitalisations in ambulatory patients with chronic heart failure: the telemedical interventional monitoring in heart failure study, Circulation, 123, 1873, 10.1161/CIRCULATIONAHA.111.018473 Morgan, 2017, Remote management of heart failure using implantable electronic devices, Eur Heart J, 38, 2352, 10.1093/eurheartj/ehx227 Bohm, 2016, Fluid status telemedicine alerts for heart failure: a randomized controlled trial, Eur Heart J, 37, 3154, 10.1093/eurheartj/ehw099 Hindricks, 2014, Implant-based multiparameter telemonitoring of patients with heart failure (IN-TIME): a randomised controlled trial, Lancet, 384, 583, 10.1016/S0140-6736(14)61176-4 Abraham, 2011, Wireless pulmonary artery haemodynamic monitoring in chronic heart failure: a randomised controlled trial, Lancet, 377, 658, 10.1016/S0140-6736(11)60101-3 Inglis, 2015, Structured telephone support or non-invasive telemonitoring for patients with heart failure, Cochrane Database Syst Rev, 10 Dierckx, 2017, Telemedicine in heart failure: new insights from the Cochrane meta analyses, Eur J Heart Fail, 19, 304, 10.1002/ejhf.759 Anker, 2011, Telemedicine and remote management of patients with heart failure, Lancet, 378, 731, 10.1016/S0140-6736(11)61229-4 Koehler, 2012, Telemedicine in heart failure: pre-specified and exploratory subgroup analyses from the TIM-HF trial, Int J Cardiol, 161, 143, 10.1016/j.ijcard.2011.09.007 Koehler F, Koehler K, Deckwart O, et al. Telemedical Interventional Management in Heart Failure II (TIM-HF 2), a randomised, controlled trial investigating the impact of telemedicine on unplanned cardiovascular hospitalisations and mortality in HF patients: study design and description of the intervention. Eur J Heart Fail (in press). Pocock, 1975, Sequential treatment assignment with balancing for prognostic factors in the controlled clinical trial, Biometrics, 31, 103, 10.2307/2529712 Garthwaite, 1996, Confidence intervals from randomization tests, Biometrics, 52, 1387, 10.2307/2532852