The relationship between serum cytokine levels and degree of psychosis in patients with schizophrenia

Abi-Dargham, 2014, Schizophrenia: the role of dopamine and glutamate, J. Clin. Psychiatry, 75, 274, 10.4088/JCP.13078co7c Agmon-Levin, 2009, Vaccines and autoimmunity, Nat. Rev. Rheumatol., 5, 648, 10.1038/nrrheum.2009.196 Akil, 1999, Lamina-specific alterations in the dopamine innervation of the prefrontal cortex in schizophrenic subjects, Am. J. Psychiatry, 156, 1580, 10.1176/ajp.156.10.1580 Anders, 2015, Abnormal immune system development and function in schizophrenia helps reconcile diverse findings and suggests new treatment and prevention strategies, Brain Res., 1617, 93, 10.1016/j.brainres.2015.02.043 Audemard-Verger, 2016, Is it relevant to screen young women hospitalized in psychiatric department for neuropsychiatric systemic lupus erythematosus (NPSLE)?: A prospective study of 100 psychiatric inpatients, Medicine (Baltimore), 95, e5288, 10.1097/MD.0000000000005288 Avgustin, 2005, Increased Th1 and Th2 immune reactivity with relative Th2 dominance in patients with acute exacerbation of schizophrenia, Croat. Med. J., 46, 268 Barak, 2006, The immune system and happiness, Autoimmun. Rev., 5, 523, 10.1016/j.autrev.2006.02.010 Bechter, 2010, Cerebrospinal fluid analysis in affective and schizophrenic spectrum disorders: identification of subgroups with immune responses and blood-CSF barrier dysfunction, J. Psychiatr. Res., 44, 321, 10.1016/j.jpsychires.2009.08.008 Beneke, 1992, “Clinical Global Impressions” (ECDEU): some critical comments, Pharmacopsychiatry, 25, 171, 10.1055/s-2007-1014401 Benros, 2011, Autoimmune diseases and severe infections as risk factors for schizophrenia: a 30-year population-based register study, Am. J. Psychiatry, 168, 1303, 10.1176/appi.ajp.2011.11030516 Brambilla, 2014, Increased M1/decreased M2 signature and signs of Th1/Th2 shift in chronic patients with bipolar disorder, but not in those with schizophrenia, Transl. Psychiatry, 4, e406, 10.1038/tp.2014.46 Bresee, 2009, Persistently increased serum soluble interleukin-2 receptors in continuously ill patients with schizophrenia, Int. J. Neuropsychopharmacol., 12, 861, 10.1017/S1461145709000315 Carpenter, 1974, The diagnosis and understanding of schizophrenia. Part I. Use of signs and symptoms for the identification of schizophrenic patients, Schizophr. Bull., 33, 508 Djeu, 1990, Functional activation of human neutrophils by recombinant monocyte-derived neutrophil chemotactic factor/IL-8, J. Immunol., 144, 2205, 10.4049/jimmunol.144.6.2205 Eaton, 2006, Association of schizophrenia and autoimmune diseases: linkage of Danish national registers, Am. J. Psychiatry, 163, 521, 10.1176/appi.ajp.163.3.521 Firer, 1994, Anticardiolipin antibodies are elevated in drug-free, multiply affected families with schizophrenia, J. Clin. Immunol., 14, 73, 10.1007/BF01541177 Freudenreich, 2010, Analysis of peripheral immune activation in schizophrenia using quantitative reverse-transcription polymerase chain reaction (RT-PCR), Psychiatry Res., 176, 99, 10.1016/j.psychres.2008.11.007 Ganguli, 1992, Antinuclear and gastric parietal cell autoantibodies in schizophrenic patients, Biol. Psychiatry, 32, 735, 10.1016/0006-3223(92)90306-K Ghazaryan, 2014, Chronic schizophrenia is associated with over-expression of the interleukin-2 receptor gamma gene, Psychiatry Res., 217, 158, 10.1016/j.psychres.2014.03.020 Girgis, 2018, A randomized, double-blind, placebo-controlled clinical trial of tocilizumab, an Interleukin-6 receptor antibody, for residual symptoms in schizophrenia, Neuropsychopharmacology, 43, 1317, 10.1038/npp.2017.258 2013, Regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the global burden of disease study, Lancet, 386, 743 Guidotti, 2000, Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study, Arch. Gen. Psychiatry, 57, 1061, 10.1001/archpsyc.57.11.1061 Henneberg, 1994, Increased prevalence of antibrain antibodies in the sera from schizophrenic patients, Schizophr. Res., 14, 15, 10.1016/0920-9964(94)90004-3 Hornig, 2002, Infectious and immune factors in neurodevelopmental damage, Mol. Psychiatry, 7, S34, 10.1038/sj.mp.4001182 Horvath, 2014, Immune system disturbances in schizophrenia, Biol. Psychiatry, 75, 316, 10.1016/j.biopsych.2013.06.010 Itzhaky, 2012, Low serum vitamin D concentrations in patients with schizophrenia, Isr. Med. Assoc. J., 14, 88 Ji, 2017, Association of inflammatory cytokines with the symptom cluster of pain, fatigue, depression, and sleep disturbance in Chinese patients with cancer, J. Pain Symptom Manag., 54, 843, 10.1016/j.jpainsymman.2017.05.003 Jones, 2005, Immune dysregulation and self-reactivity in schizophrenia: do some cases of schizophrenia have an autoimmune basis?, Immunol. Cell Biol., 83, 9, 10.1111/j.1440-1711.2005.01305.x Jones, 2014, Elevated levels of autoantibodies targeting the M1 muscarinic acetylcholine receptor and neurofilament medium in sera from subgroups of patients with schizophrenia, J. Neuroimmunol., 269, 68, 10.1016/j.jneuroim.2014.02.008 Khandaker, 2016, Is there a role for immune-to-brain communication in schizophrenia?, Psychopharmacology (Berl), 233, 1559, 10.1007/s00213-015-3975-1 Kishimoto, 2010, IL-6: from its discovery to clinical applications, Int. Immunol., 22, 347, 10.1093/intimm/dxq030 Kneeland, 2013, Viral infection, inflammation and schizophrenia, Prog. Neuropsychopharmacol. Biol. Psychiatry, 42, 35, 10.1016/j.pnpbp.2012.02.001 Lieberman, 1999, Is schizophrenia a neurodegenerative disorder? A clinical and neurobiological perspective, Biol. Psychiatry, 46, 729, 10.1016/S0006-3223(99)00147-X Lieberman, 1999, Is schizophrenia a neurodegenerative disorder? A clinical and neurobiological perspective, Biol. Psychiatry, 46, 729, 10.1016/S0006-3223(99)00147-X Liu, 2010, Tyrosine hydroxylase, interleukin-1beta and tumor necrosis factor-alpha are overexpressed in peripheral blood mononuclear cells from schizophrenia patients as determined by semi-quantitative analysis, Psychiatry Res., 176, 1, 10.1016/j.psychres.2008.10.024 Maes, 1994, Immune-inflammatory markers in schizophrenia: comparison to normal controls and effects of clozapine, Acta Psychiatr. Scand., 89, 346, 10.1111/j.1600-0447.1994.tb01527.x Margari, 2013, Anti-brain autoantibodies in the serum of schizophrenic patients: a case-control study, Psychiatry Res., 210, 800, 10.1016/j.psychres.2013.09.006 McAllister, 1995, Increases in CSF levels of interleukin-2 in schizophrenia: effects of recurrence of psychosis and medication status, Am. J. Psychiatry, 152, 1291, 10.1176/ajp.152.9.1291 McGrath, 2008, Schizophrenia: a concise overview of incidence, prevalence, and mortality, Epidemiol. Rev., 30, 67, 10.1093/epirev/mxn001 Metcalf, 2017, Serum C-reactive protein in adolescence and risk of schizophrenia in adulthood: a prospective birth cohort study, Brain Behav. Immun., 59, 253, 10.1016/j.bbi.2016.09.008 Miller, 2011, Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effects, Biol. Psychiatry, 70, 663, 10.1016/j.biopsych.2011.04.013 Miller, 2016, An open-label, pilot trial of adjunctive tocilizumab in schizophrenia, J. Clin. Psychiatry, 77, 275, 10.4088/JCP.15l09920 Miranda, 2017, Elevated serum levels of proinflammatory cytokines potentially correlate with depression and anxiety in colorectal cancer patients in different stages of the antitumor therapy, Cytokine, 104, 72, 10.1016/j.cyto.2017.09.030 Munn, 2000, Microglia dysfunction in schizophrenia: an integrative theory, Med. Hypotheses, 54, 198, 10.1054/mehy.1999.0018 Murray, 1997, Global mortality, disability, and the contribution of risk factors: global burden of disease study, Lancet, 349, 1436, 10.1016/S0140-6736(96)07495-8 Potvin, 2008, Inflammatory cytokine alterations in schizophrenia: a systematic quantitative review, Biol. Psychiatry, 63, 801, 10.1016/j.biopsych.2007.09.024 Rapaport, 1989, Elevated levels of soluble interleukin 2 receptors in schizophrenia, Arch. Gen. Psychiatry, 46, 291, 10.1001/archpsyc.1989.01810030097017 Rapaport, 1993, Increased serum soluble interleukin-2 receptors in schizophrenic monozygotic twins, Eur. Arch. Psychiatry Clin. Neurosci., 243, 7, 10.1007/BF02191517 Rapaport, 1994, Increased serum soluble interleukin-2 receptors in Caucasian and Korean schizophrenic patients, Biol. Psychiatry, 35, 767, 10.1016/0006-3223(94)91137-1 Sallusto, 2008, Chemokines and leukocyte traffic, Nat. Immunol., 9, 949, 10.1038/ni.f.214 Sasayama, 2013, Increased cerebrospinal fluid interleukin-6 levels in patients with schizophrenia and those with major depressive disorder, J. Psychiatr. Res., 47, 401, 10.1016/j.jpsychires.2012.12.001 Singh, 2009, Decreased serum levels of interleukin-2 and interleukin-6 in Indian Bengalee schizophrenic patients, Cytokine, 47, 1, 10.1016/j.cyto.2009.05.005 Sirota, 1993, Autoantibodies to DNA in multicase families with schizophrenia, Biol. Psychiatry, 33, 450, 10.1016/0006-3223(93)90173-B Smith, 1995, The macrophage-T-lymphocyte theory of schizophrenia: additional evidence, Med. Hypotheses, 45, 135, 10.1016/0306-9877(95)90062-4 Stojanovic, 2014, Increased serum interleukin-6 levels in early stages of psychosis: associations with at-risk mental states and the severity of psychotic symptoms, Psychoneuroendocrinology, 41, 23, 10.1016/j.psyneuen.2013.12.005 Tiosano, 2017, Schizophrenia among patients with systemic lupus erythematosus: population-based cross-sectional study, Epidemiol. Psychiatr. Sci., 26, 424, 10.1017/S2045796016000561 Villemain, 1988, Anti-histone antibodies in schizophrenia and affective disorders, Psychiatry Res., 24, 53, 10.1016/0165-1781(88)90139-4 Weidenhofer, 2006, Immunohistochemical localisation of the NK1 receptor in the human amygdala: preliminary investigation in schizophrenia, Prog. Neuropsychopharmacol. Biol. Psychiatry, 30, 1313, 10.1016/j.pnpbp.2006.05.008 Yang, 2017, The pro-inflammatory cytokines, salivary cortisol and alpha-amylase are associated with generalized anxiety disorder (GAD) in patients with asthma, Neurosci. Lett., 56, 15, 10.1016/j.neulet.2017.07.021 Yum, 2009, Clinical perspectives on autoimmune processes in schizophrenia, Psychiatr. Clin. North Am., 32, 795, 10.1016/j.psc.2009.09.003 Zhang, 2016, Duloxetine prevents the effects of prenatal stress on depressive-like and anxiety-like behavior and hippocampal expression of pro-inflammatory cytokines in adult male offspring rats, Int. J. Dev. Neurosci., 55, 41, 10.1016/j.ijdevneu.2016.09.005