Aberrant Schwann Cell Lipid Metabolism Linked to Mitochondrial Deficits Leads to Axon Degeneration and Neuropathy

Neuron - Tập 77 - Trang 886-898 - 2013
Andreu Viader1, Yo Sasaki1, Sungsu Kim1, Amy Strickland1, Cayce S. Workman1, Kui Yang2, Richard W. Gross2, Jeffrey Milbrandt1,3
1Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA
2Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
3Hope Center for Neurological Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA

Tài liệu tham khảo

Atkinson, 1968, The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers, Biochemistry, 7, 4030, 10.1021/bi00851a033 Baloh, 2008, Mitochondrial dynamics and peripheral neuropathy, Neuroscientist, 14, 12, 10.1177/1073858407307354 Barber, 2005, Structure and regulation of acetyl-CoA carboxylase genes of metazoa, Biochim. Biophys. Acta, 1733, 1, 10.1016/j.bbalip.2004.12.001 Barres, 2008, The mystery and magic of glia: a perspective on their roles in health and disease, Neuron, 60, 430, 10.1016/j.neuron.2008.10.013 Benarroch, 2005, Neuron-astrocyte interactions: partnership for normal function and disease in the central nervous system, Mayo Clin. Proc., 80, 1326, 10.4065/80.10.1326 Chrast, 2011, Lipid metabolism in myelinating glial cells: lessons from human inherited disorders and mouse models, J. Lipid Res., 52, 419, 10.1194/jlr.R009761 Dalton, 2012, Phosphoproteins in stress-induced disease, Prog. Mol. Biol. Transl. Sci., 106, 189, 10.1016/B978-0-12-396456-4.00003-1 Dupree, 1998, Myelin abnormalities in mice deficient in galactocerebroside and sulfatide, J. Neurocytol., 27, 649, 10.1023/A:1006908013972 Ekstrand, 2004, Mitochondrial transcription factor A regulates mtDNA copy number in mammals, Hum. Mol. Genet., 13, 935, 10.1093/hmg/ddh109 Feltri, 1999, P0-Cre transgenic mice for inactivation of adhesion molecules in Schwann cells, Ann. N Y Acad. Sci., 883, 116, 10.1111/j.1749-6632.1999.tb08574.x Fernyhough, 2010, Mitochondrial stress and the pathogenesis of diabetic neuropathy, Expert Rev. Endocrinol. Metab., 5, 39, 10.1586/eem.09.55 Fünfschilling, 2012, Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity, Nature, 485, 517, 10.1038/nature11007 Garbay, 2000, Myelin synthesis in the peripheral nervous system, Prog. Neurobiol., 61, 267, 10.1016/S0301-0082(99)00049-0 Gately, 1996, Cisplatin and taxol activate different signal pathways regulating cellular injury-induced expression of GADD153, Br. J. Cancer, 73, 18, 10.1038/bjc.1996.4 George, 1995, Axotomy-induced axonal degeneration is mediated by calcium influx through ion-specific channels, J. Neurosci., 15, 6445, 10.1523/JNEUROSCI.15-10-06445.1995 Han, 2008, Rapid Commun. Mass Spectrom., 22, 2115, 10.1002/rcm.3595 Hardie, 2012, AMPK: a nutrient and energy sensor that maintains energy homeostasis, Nat. Rev. Mol. Cell Biol., 13, 251, 10.1038/nrm3311 Harding, 2005, Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression, Cell Metab., 2, 361, 10.1016/j.cmet.2005.11.005 Hoshi, 2007, Nodal protrusions, increased Schmidt-Lanterman incisures, and paranodal disorganization are characteristic features of sulfatide-deficient peripheral nerves, Glia, 55, 584, 10.1002/glia.20487 Houten, 2010, A general introduction to the biochemistry of mitochondrial fatty acid β-oxidation, J. Inherit. Metab. Dis., 33, 469, 10.1007/s10545-010-9061-2 Hunter, 2007, Binary imaging analysis for comprehensive quantitative histomorphometry of peripheral nerve, J. Neurosci. Methods, 166, 116, 10.1016/j.jneumeth.2007.06.018 Ilieva, 2009, Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond, J. Cell Biol., 187, 761, 10.1083/jcb.200908164 Kalichman, 1998, Reactive, degenerative, and proliferative Schwann cell responses in experimental galactose and human diabetic neuropathy, Acta Neuropathol., 95, 47, 10.1007/s004010050764 Kennedy, 1996, Quantitation of epidermal nerves in diabetic neuropathy, Neurology, 47, 1042, 10.1212/WNL.47.4.1042 Larsson, 1998, Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice, Nat. Genet., 18, 231, 10.1038/ng0398-231 Lin, 2009, Endoplasmic reticulum stress in disorders of myelinating cells, Nat. Neurosci., 12, 379, 10.1038/nn.2273 Marbach, 1967, Rapid enzymatic measurement of blood lactate and pyruvate. Use and significance of metaphosphoric acid as a common precipitant, Clin. Chem., 13, 314, 10.1093/clinchem/13.4.314 Nagarajan, 2001, EGR2 mutations in inherited neuropathies dominant-negatively inhibit myelin gene expression, Neuron, 30, 355, 10.1016/S0896-6273(01)00282-3 Nave, 2008, Axon-glial signaling and the glial support of axon function, Annu. Rev. Neurosci., 31, 535, 10.1146/annurev.neuro.30.051606.094309 Niemann, 2006, Pathomechanisms of mutant proteins in Charcot-Marie-Tooth disease, Neuromolecular Med., 8, 217, 10.1385/NMM:8:1-2:217 Oyadomari, 2008, Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice, Cell Metab., 7, 520, 10.1016/j.cmet.2008.04.011 Pennuto, 2008, Ablation of the UPR-mediator CHOP restores motor function and reduces demyelination in Charcot-Marie-Tooth 1B mice, Neuron, 57, 393, 10.1016/j.neuron.2007.12.021 Qi, 2006, TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism, Science, 312, 1763, 10.1126/science.1123374 Schaefer, 1996, Trifunctional enzyme deficiency: adult presentation of a usually fatal beta-oxidation defect, Ann. Neurol., 40, 597, 10.1002/ana.410400409 Schröder, 1993, Neuropathy associated with mitochondrial disorders, Brain Pathol., 3, 177, 10.1111/j.1750-3639.1993.tb00742.x Silva, 2000, Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes, Nat. Genet., 26, 336, 10.1038/81649 Su, 2005, Accumulation of long-chain acylcarnitine and 3-hydroxy acylcarnitine molecular species in diabetic myocardium: identification of alterations in mitochondrial fatty acid processing in diabetic myocardium by shotgun lipidomics, Biochemistry, 44, 5234, 10.1021/bi047773a Tyni, 1999, Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency, Acta Paediatr., 88, 237, 10.1111/j.1651-2227.1999.tb01089.x Viader, 2011, Schwann cell mitochondrial metabolism supports long-term axonal survival and peripheral nerve function, J. Neurosci., 31, 10128, 10.1523/JNEUROSCI.0884-11.2011 Walter, 2011, The unfolded protein response: from stress pathway to homeostatic regulation, Science, 334, 1081, 10.1126/science.1209038 Yamada, 2000, Long-chain acylcarnitine induces Ca2+ efflux from the sarcoplasmic reticulum, J. Cardiovasc. Pharmacol., 36, 14, 10.1097/00005344-200007000-00002 Yang, 2009, Automated lipid identification and quantification by multidimensional mass spectrometry-based shotgun lipidomics, Anal. Chem., 81, 4356, 10.1021/ac900241u