Angiotensin I-converting enzyme (ACE) inhibition and nitric oxide (NO)-mediated antihypertensive effect of octaphlorethol A isolated from Ishige sinicola: In vitro molecular mechanism and in vivo SHR model
Seok-Chun Ko1,2, Won-Kyo Jung1,2, Sung-Myung Kang3, Seung-Hong Lee4, Min Cheol Kang5, Soo-Jin Heo6, Kyong-Hwa Kang7, Yong-Tae Kim8, Sun-Joo Park9, Yoonhwa Jeong10, Misook Kim10, Hee-Guk Byun11, You-Jin Jeon12
1Marine-Integrated Bionics Research Center, Pukyong National University, Busan 608-737, Republic of Korea
2Department of Biomedical Engineering, Center for Marine-Integrated Biomedical Technology (BK21 Plus) Pukyong National University, Busan 608-737, Republic of Korea
3Department of Anatomy and Cell Biology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
4Division of Bioscience and Korea Nokyong Research Center, Konkuk University, Chungju 380-701, Republic of Korea
5Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA
6Global Bioresources Research Center, Korea Institute of Ocean Science and Technology, Ansan 426-744, Republic of Korea
7Department of Marine-bio Convergence Science and Marine Bioprocess Research Center, Pukyong National University, Busan 608-737, Republic of Korea
8Department of Food Science and Biotechnology, Kunsan National University, Kunsan 573-701, Republic of Korea
9Department of Chemistry, Pukyong National University, Busan 608-737, Republic of Korea
10Department of Food Science and Nutrition, Dankook University, Gyeonggi 448-701, Republic of Korea
11Department of Marine Biotechnology, Gangneung-Wonju National University 210-720, Republic of Korea
12Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Republic of Korea
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Journal of Functional Foods
Tập 18
289-299
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