Autoantibody-Negative Type 1 Diabetes: A Neglected Subtype

Trends in Endocrinology & Metabolism - Tập 32 - Trang 295-305 - 2021
Shivani K. Patel1,2,3, Cindy S. Ma3,4, Spiros Fourlanos5, Jerry R. Greenfield1,2,3
1Diabetes and Metabolism, Garvan Institute of Medical Research, Sydney, NSW, Australia
2Department of Diabetes and Endocrinology, St. Vincent’s Hospital, Sydney, NSW, Australia
3St. Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia
4Human Immune Disorders, Garvan Institute of Medical Research, Sydney, NSW, Australia
5Department of Diabetes and Endocrinology, Royal Melbourne Hospital, Melbourne, VIC, Australia

Tài liệu tham khảo

American Diabetes Association, 2020, Classification and diagnosis of diabetes: standards of medical care in diabetes—2020, Diabetes Care, 43, S14, 10.2337/dc20-S002 World Health Organization, 1999 Harrison, 2011, Persistently autoantibody-negative type 1 diabetes: rich pickings or much ado about nothing?, Pediatr. Diabetes, 12, 139, 10.1111/j.1399-5448.2011.00786.x Ahmed, 2019, Standardizing T-cell biomarkers in type 1 diabetes: challenges and recent advances, Diabetes, 68, 1366, 10.2337/db19-0119 Imagawa, 2000, A Novel Subtype of Type 1 Diabetes mellitus characterized by a rapid onset and an absence of diabetes-related antibodies, N. Engl. J. Med., 342, 301, 10.1056/NEJM200002033420501 American Diabetes Association, 2014, Diagnosis and classification of diabetes Mellitus, Diabetes Care, 37, S81, 10.2337/dc14-S081 Bravis, 2018, Relationship between islet autoantibody status and the clinical characteristics of children and adults with incident type 1 diabetes in a UK cohort, BMJ Open, 8, 10.1136/bmjopen-2017-020904 World Health Organization, 2019 Mannering, 2016, The case for an autoimmune aetiology of type 1 diabetes, Clin. Exp. Immunol., 183, 8, 10.1111/cei.12699 Wilkin, 2001, The accelerator hypothesis: weight gain as the missing link between Type I and Type II diabetes, Diabetologia, 44, 914, 10.1007/s001250100548 Fourlanos, 2008, The accelerator hypothesis and increasing incidence of type 1, Diabetes, 15, 321 Cedillo, 2015, Obesity, islet cell autoimmunity, and cardiovascular risk factors in youth at onset of type 1 autoimmune diabetes, J. Clin. Endocrinol. Metab., 100, E82, 10.1210/jc.2014-2340 Wilkin, 2009, The accelerator hypothesis: a review of the evidence for insulin resistance as the basis for type I as well as type II diabetes, Int. J. Obes., 33, 716, 10.1038/ijo.2009.97 Carlsson, 2020, Absence of islet autoantibodies and modestly raised glucose values at diabetes diagnosis should lead to testing for MODY: lessons from a 5-year pediatric Swedish National Cohort Study, Diabetes Care, 43, 82, 10.2337/dc19-0747 Thomas, 2019, Type 1 diabetes defined by severe insulin deficiency occurs after 30 years of age and is commonly treated as type 2 diabetes, Diabetologia, 62, 1167, 10.1007/s00125-019-4863-8 Noble, 2011, Genetics of the HLA region in the prediction of type 1 diabetes, Curr. Diabetes Rep., 11, 533, 10.1007/s11892-011-0223-x Van Lummel, 2012, Type 1 diabetes-associated HLA-DQ8 transdimer accommodates a unique peptide repertoire, J. Biol. Chem., 287, 9514, 10.1074/jbc.M111.313940 Aguilera, 2004, Adult-onset atypical (type 1) diabetes: additional insights and differences with type 1a diabetes in a European Mediterranean population, Diabetes Care, 27, 1108, 10.2337/diacare.27.5.1108 Hameed, 2011, Persistently autoantibody negative (PAN) type 1 diabetes mellitus in children, Pediatr. Diabetes, 12, 142, 10.1111/j.1399-5448.2010.00681.x Tiberti, 2000, Autoantibody negative new onset Type 1 diabetic patients lacking high risk HLA alleles in a Caucasian population: are these Type 1b diabetes cases?, Diabetes Metab. Res. Rev., 16, 8, 10.1002/(SICI)1520-7560(200001/02)16:1<8::AID-DMRR77>3.0.CO;2-T Willcox, 2009, Analysis of islet inflammation in human type 1 diabetes, Clin. Exp. Immunol., 155, 173, 10.1111/j.1365-2249.2008.03860.x Dimeglio, 2018, Type 1 diabetes, Lancet, 391, 2449, 10.1016/S0140-6736(18)31320-5 Pugliese, 2017, Autoreactive T cells in type 1 diabetes, J. Clin. Investig., 127, 2881, 10.1172/JCI94549 Fousteri, 2017, Beta-cell specific autoantibodies: are they just an indicator of type 1 diabetes?, Curr. Diabetes Rev., 13, 322, 10.2174/1573399812666160427104157 Arif, 2014, Blood and islet phenotypes indicate immunological heterogeneity in type 1 diabetes, Diabetes, 63, 3835, 10.2337/db14-0365 Leete, 2016, Differential insulitic profiles determine the extent of β-cell destruction and the age at onset of type 1 diabetes, Diabetes, 65, 1362, 10.2337/db15-1615 Davis, 2015, Prevalence of detectable C-peptide according to age at diagnosis and duration of Type 1 diabetes, Diabetes Care, 38, 476, 10.2337/dc14-1952 Leete, 2020, Studies of insulin and proinsulin in pancreas and serum support the existence of aetiopathological endotypes of type 1 diabetes associated with age at diagnosis, Diabetologia, 63, 1258, 10.1007/s00125-020-05115-6 Menart-Houtermans, 2014, Leukocyte profiles differ between type 1 and type 2 diabetes and are associated with metabolic phenotypes: results from the German Diabetes Study (GDS), Diabetes Care, 37, 2326, 10.2337/dc14-0316 Viisanen, 2017, Circulating CXCR5+PD-1+ICOS+ follicular t helper cells are increased close to the diagnosis of type 1 diabetes in children with multiple autoantibodies, Diabetes, 66, 437, 10.2337/db16-0714 Oras, 2019, A study of 51 subtypes of peripheral blood immune cells in newly diagnosed young type 1 diabetes patients, Clin. Exp. Immunol., 198, 57, 10.1111/cei.13332 Pescovitz, 2014, B-Lymphocyte depletion with rituximab and -cell function: two-year results, Diabetes Care, 37, 453, 10.2337/dc13-0626 Milota, 2015, Negativity for specific autoantibodies in patients with type 1 diabetes that developed on a background of common variable immunodeficiency, Int. Arch. Allergy Immunol., 168, 197, 10.1159/000441723 Battaglia, 2014, Experiments by nature: lessons on type 1, Diabetes, 83, 1 Kumar, 2002, Celiac disease and immunoglobulin a deficiency: how effective are the serological methods of diagnosis?, Clin. Diagn. Lab. Immunol., 9, 1295 Kenefeck, 2015, Follicular helper T cell signature in type 1 diabetes, J. Clin. Investig., 125, 292, 10.1172/JCI76238 Xu, 2013, Inhibition of increased circulating Tfh cell by anti-CD20 monoclonal antibody in patients with type 1 diabetes, PLoS ONE, 8 Yang, 2015, Natural variation in interleukin-2 sensitivity influences regulatory t-cell frequency and function in individuals with long-standing type 1 diabetes, Diabetes, 64, 3891, 10.2337/db15-0516 Battaglia, 2020, Introducing the endotype concept to address the challenge of disease heterogeneity in type 1 diabetes, Diabetes Care, 43, 5, 10.2337/dc19-0880 Greenbaum, 2019, Disease-modifying therapies in type 1 diabetes: a look into the future of diabetes practice, Drugs, 79, 43, 10.1007/s40265-018-1035-y Herold, 2019, An Anti-CD3 antibody, teplizumab, in relatives at risk for type 1 diabetes, N. Engl. J. Med., 381, 603, 10.1056/NEJMoa1902226 Sprangers, 2011, Otelixizumab in the treatment of type 1 diabetes mellitus, Immunotherapy, 3, 1303, 10.2217/imt.11.123 Stamatouli, 2018, Collateral damage: insulin-dependent diabetes induced with checkpoint inhibitors, Diabetes, 67, 1471, 10.2337/dbi18-0002 Akturk, 2019, Immune checkpoint inhibitor-induced Type 1 diabetes: a systematic review and meta-analysis, Diabet. Med., 36, 1075, 10.1111/dme.14050 De Filette, 2019, Immune checkpoint inhibitors and type 1 diabetes mellitus: a case report and systematic review, Eur. J. Endocrinol., 181, 363, 10.1530/EJE-19-0291 Wang, 2007, Prevalence of autoantibody-negative diabetes is not rare at all ages and increases with older age and obesity, J. Clin. Endocrinol. Metab., 92, 88, 10.1210/jc.2006-1494 Burkart, 2018, Inverse association of insulin antibody levels with insulin sensitivity in adults with Type 1 diabetes, Diabet. Med., 35, 595, 10.1111/dme.13608 Perchard, 2015, Islet autoantibody status in a multi-ethnic UK clinic cohort of children presenting with diabetes, Arch. Dis. Child., 100, 348, 10.1136/archdischild-2014-306542 Niechciał, 2018, Autoantibodies against zinc transporter 8 are related to age and metabolic state in patients with newly diagnosed autoimmune diabetes, Acta Diabetol., 55, 287, 10.1007/s00592-017-1091-x Cousminer, 2018, First genome-wide association study of latent autoimmune diabetes in adults reveals novel insights linking immune and metabolic diabetes, Diabetes Care, 41, 2396, 10.2337/dc18-1032 Wherrett, 2015, Defining pathways for development of disease-modifying therapies in children with type 1 diabetes: a consensus report, Diabetes Care, 38, 1975, 10.2337/dc15-1429 Park, 2017, Clinical heterogeneity of type 1 diabetes (T1D) found in Asia, Diabetes Metab. Res. Rev., 33, 10.1002/dmrr.2907 Orban, 2009, Pancreatic islet autoantibodies as predictors of type 1 diabetes in the Diabetes Prevention Trial-Type 1, Diabetes Care, 32, 2269, 10.2337/dc09-0934 Eisenbarth, 1986, Type I diabetes mellitus, N. Engl. J. Med., 314, 1360, 10.1056/NEJM198605223142106 Kallionpää, 2019, Early detection of peripheral blood cell signature in children developing β-cell autoimmunity at a young age, Diabetes, 68, 2024, 10.2337/db19-0287 So, 2020, Autoantibody reversion: changing risk categories in multiple-autoantibody-positive individuals, Diabetes Care, 43, 10.2337/dc19-1731 Nokoff, 2012, The interplay of autoimmunity and insulin resistance in type 1 diabetes, Discov. Med., 13, 115 Richardson, 2013, High frequency of autoantibodies in patients with long duration type 1 diabetes, Diabetologia, 56, 2538, 10.1007/s00125-013-3017-7 Williams, 2016, Beta cell function and ongoing autoimmunity in long-standing, childhood onset type 1 diabetes, Diabetologia, 59, 2722, 10.1007/s00125-016-4087-0 Yu, 2019, Residual β cell function and monogenic variants in long-duration type 1 diabetes patients, J. Clin. Invest., 129, 3252, 10.1172/JCI127397 Gerard-Gonzalez, 2013, Comparison of autoantibody-positive and autoantibody-negative pediatric participants enrolled in the T1D Exchange clinic registry, J. Diabetes, 5, 216, 10.1111/1753-0407.12031 Xu, 2007, Role of insulin resistance in predicting progression to type 1 diabetes, Diabetes Care, 30, 2314, 10.2337/dc06-2389 Greenfield, 2002, Insulin Resistance, intra-abdominal fat, cardiovascular risk factors, and androgens in healthy young women with type 1 diabetes mellitus, J. Clin. Endocrinol. Metab., 87, 1036, 10.1210/jcem.87.3.8324 Redondo, 2019, Single Islet autoantibody at diagnosis of clinical type 1 diabetes is associated with older age and insulin resistance, J. Clin. Endocrinol. Metab., 105, 1629, 10.1210/clinem/dgz296 Redondo, 2019, The Influence of type 2 diabetes-associated factors on type 1 diabetes, Diabetes Care, 42, 1357, 10.2337/dc19-0102 Insel, 2015, Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association, Diabetes Care, 38, 1964, 10.2337/dc15-1419 Pescovitz, 2009, Rituximab, B-lymphocyte depletion, and preservation of beta-cell function, N. Engl. J. Med., 361, 2143, 10.1056/NEJMoa0904452 Orban, 2011, Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial, Lancet, 378, 412, 10.1016/S0140-6736(11)60886-6 Herold, 2002, Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus, N. Engl. J. Med., 346, 1692, 10.1056/NEJMoa012864 Turton, 2018, Low-carbohydrate diets for type 1 diabetes mellitus: a systematic review, PLoS ONE, 13, 10.1371/journal.pone.0194987 Rother, 2009, Effects of exenatide alone and in combination with daclizumab on beta-cell function in long-standing type 1 diabetes, Diabetes Care, 32, 2251, 10.2337/dc09-0773 Maldonado, 2003, Ketosis-prone diabetes: dissection of a heterogeneous syndrome using an immunogenetic and β-cell functional classification, prospective analysis, and clinical outcomes, J. Clin. Endocrinol. Metab., 88, 5090, 10.1210/jc.2003-030180 Dabelea, 2011, Etiological approach to characterization of diabetes type: The SEARCH for Diabetes in Youth Study, Diabetes Care, 34, 1628, 10.2337/dc10-2324 Chung, 2020, Precision Medicine in Diabetes: a Consensus Report from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD), Diabetes Care, 43, 1617, 10.2337/dci20-0022 Balasubramanyam, 2008, Syndromes of ketosis-prone diabetes mellitus, Endocr. Rev., 29, 292, 10.1210/er.2007-0026 Sobngwi, 2002, Adult-onset idiopathic type I or ketosis-prone type II diabetes: evidence to revisit diabetes classification, Diabetologia, 45, 283, 10.1007/s00125-001-0739-8