The nervous heart

Progress in Biophysics and Molecular Biology - Tập 120 - Trang 199-209 - 2016
Crystal M. Ripplinger1, Sami F. Noujaim2, Dominik Linz3
1Department of Pharmacology, University of California Davis, 451 Health Sciences Drive, Davis, CA 95616, USA
2Molecular Pharmacology and Physiology, University of South Florida, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
3Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes, 66421 Homburg, Saar, Germany

Tài liệu tham khảo

Ajijola, 2013, Functional differences between junctional and extrajunctional adrenergic receptor activation in mammalian ventricle, AJP Heart Circ. Physiol., 304, H579, 10.1152/ajpheart.00754.2012 Ajijola, 2013, Focal myocardial infarction induces global remodeling of cardiac sympathetic innervation: neural remodeling in a spatial context, AJP Heart Circ. Physiol., 305, H1031, 10.1152/ajpheart.00434.2013 Ardell, 2014, Chronic spinal cord stimulation modifies intrinsic cardiac synaptic efficacy in the suppression of atrial fibrillation, Auton. Neurosci., 186, 38, 10.1016/j.autneu.2014.09.017 Armaganijan, 2015, 6-Month outcomes in patients with implantable cardioverter-defibrillators undergoing renal sympathetic denervation for the treatment of refractory ventricular arrhythmias, JACC Cardiovasc. Interv., 8, 984, 10.1016/j.jcin.2015.03.012 Armour, 1997, Gross and microscopic anatomy of the human intrinsic cardiac nervous system, Anat. Rec., 247, 289, 10.1002/(SICI)1097-0185(199702)247:2<289::AID-AR15>3.0.CO;2-L Arruda, 2008, Ablation of permanent AF: adjunctive strategies to pulmonary veins isolation: targeting AF NEST in sinus rhythm and CFAE in AF, J. Interv. Card. Electrophysiol., 23, 51, 10.1007/s10840-008-9252-z Bauer, 2006, Effects of circumferential or segmental pulmonary vein ablation for paroxysmal atrial fibrillation on cardiac autonomic function, Heart Rhythm, 3, 1428, 10.1016/j.hrthm.2006.08.025 Beaumont, 2013, Network interactions within the canine intrinsic cardiac nervous system: implications for reflex control of regional cardiac function, J. Physiol., 591, 4515, 10.1113/jphysiol.2013.259382 Bernstein, 2012, Spinal cord stimulation protects against atrial fibrillation induced by tachypacing, Heart Rhythm, 9, 10.1016/j.hrthm.2012.04.038 Bers, 2002, Cardiac excitation-contraction coupling, Nature, 415, 198, 10.1038/415198a Bhatt, 2014, A controlled trial of renal denervation for resistant hypertension, N. Engl. J. Med., 370, 1393, 10.1056/NEJMoa1402670 Bohm, 2013, Renal sympathetic denervation: applications in hypertension and beyond, Nat. Rev. Cardiol., 10, 465, 10.1038/nrcardio.2013.89 Boogers, 2010, Cardiac sympathetic denervation assessed with 123-iodine metaiodobenzylguanidine imaging predicts ventricular arrhythmias in implantable cardioverter-defibrillator patients, J. Am. Coll. Cardiol., 55, 2769, 10.1016/j.jacc.2009.12.066 Bourke, 2010, Neuraxial modulation for refractory ventricular arrhythmias: value of thoracic epidural anesthesia and surgical left cardiac sympathetic denervation, Circulation, 121, 2255, 10.1161/CIRCULATIONAHA.109.929703 Bucchi, 2007, Modulation of rate by autonomic agonists in SAN cells involves changes in diastolic depolarization and the pacemaker current, J. Mol. Cell. Cardiol., 43, 39, 10.1016/j.yjmcc.2007.04.017 Cao, 2000, Nerve sprouting and sudden cardiac death, Circ. Res., 86, 816, 10.1161/01.RES.86.7.816 Cao, 2000, Relationship between regional cardiac hyperinnervation and ventricular arrhythmia, Circulation, 101, 1960, 10.1161/01.CIR.101.16.1960 Choi, 2010, Intrinsic cardiac nerve activity and paroxysmal atrial tachyarrhythmia in ambulatory dogs, Circulation, 121, 2615, 10.1161/CIRCULATIONAHA.109.919829 Coumel, 1978, [The atrial arrhythmia syndrome of vagal origin], Arch. Mal. Coeur Vaiss., 71, 645 Doppalapudi, 2008, Intracoronary infusion of catecholamines causes focal arrhythmias in pigs, J. Cardiovasc. Electrophysiol., 19, 963, 10.1111/j.1540-8167.2008.01199.x Fallavollita, 2014, Regional myocardial sympathetic denervation predicts the risk of sudden cardiac arrest in ischemic cardiomyopathy, J. Am. Coll. Cardiol., 63, 141, 10.1016/j.jacc.2013.07.096 Gallego, 2014, Adrenergic regulation of cardiac ionic channels: role of membrane microdomains in the regulation of kv4 channels, Biochim. Biophys. Acta, 1838, 692, 10.1016/j.bbamem.2013.06.025 Gardner, 2013, Infarct-derived chondroitin sulfate proteoglycans prevent sympathetic reinnervation after cardiac ischemia-reperfusion injury, J. Neurosci., 33, 7175, 10.1523/JNEUROSCI.5866-12.2013 Gardner, 2015, Targeting protein tyrosine phosphatase σ after myocardial infarction restores cardiac sympathetic innervation and prevents arrhythmias, Nat. Commun., 6, 6235, 10.1038/ncomms7235 George, 2016, Cardiac conduction in isolated hearts of genetically modified mice - connexin43 and salts, Prog. Biophys. Mol. Biol., 120, 189, 10.1016/j.pbiomolbio.2015.11.004 Glukhov, 2010, Functional anatomy of the murine sinus node: high-resolution optical mapping of ankyrin-B heterozygous mice, Am. J. Physiol. Heart Circ. Physiol., 299, H482, 10.1152/ajpheart.00756.2009 Haissaguerre, 1998, Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins, N. Engl. J. Med., 339, 659, 10.1056/NEJM199809033391003 Han, 2012, Electroanatomic remodeling of the left stellate ganglion after myocardial infarction, J. Am. Coll. Cardiol., 59, 954, 10.1016/j.jacc.2011.11.030 Hartzell, 1988, Regulation of cardiac ion channels by catecholamines, acetylcholine and second messenger systems, Prog. Biophys. Mol. Biol., 52, 165, 10.1016/0079-6107(88)90014-4 Hasan, 2006, Sympathetic hyperinnervation and inflammatory cell NGF synthesis following myocardial infarction in rats, Brain Res., 1124, 142, 10.1016/j.brainres.2006.09.054 Hasking, 1986, Norepinephrine spillover to plasma in patients with congestive heart failure: evidence of increased overall and cardiorenal sympathetic nervous activity, Circulation, 73, 615, 10.1161/01.CIR.73.4.615 He, 2013, Effects of ganglionated plexi ablation on ventricular electrophysiological properties in normal hearts and after acute myocardial ischemia, Int. J. Cardiol., 168, 86, 10.1016/j.ijcard.2012.09.067 Hering, 2013, Substantial reduction in single sympathetic nerve firing after renal denervation in patients with resistant hypertension, Hypertension, 61, 457, 10.1161/HYPERTENSIONAHA.111.00194 Hou, 2007, Ganglionated plexi modulate extrinsic cardiac autonomic nerve input: effects on sinus rate, atrioventricular conduction, refractoriness, and inducibility of atrial fibrillation, J. Am. Coll. Cardiol., 50, 61, 10.1016/j.jacc.2007.02.066 Hou, 2007, Interactive atrial neural network: determining the connections between ganglionated plexi, Heart Rhythm, 4, 56, 10.1016/j.hrthm.2006.09.020 Issa, 2005, Thoracic spinal cord stimulation reduces the risk of ischemic ventricular arrhythmias in a postinfarction heart failure canine model, Circulation, 111, 3217, 10.1161/CIRCULATIONAHA.104.507897 Jacobson, 2010, Myocardial iodine-123 meta-iodobenzylguanidine imaging and cardiac events in heart failure. Results of the prospective ADMIRE-HF (AdreView myocardial imaging for risk evaluation in heart Failure) study, J. Am. Coll. Cardiol., 55, 2212, 10.1016/j.jacc.2010.01.014 Kagan, 2002, 14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity, EMBO J., 21, 1889, 10.1093/emboj/21.8.1889 Kanazawa, 2010, Heart failure causes cholinergic transdifferentiation of cardiac sympathetic nerves via gp130-signaling cytokines in rodents, J. Clin. Invest., 120, 408, 10.1172/JCI39778 Katritsis, 2008, Anatomic approach for ganglionic plexi ablation in patients with paroxysmal atrial fibrillation, Am. J. Cardiol., 102, 330, 10.1016/j.amjcard.2008.03.062 Katritsis, 2009, Complex fractionated atrial electrograms at anatomic sites of ganglionated plexi in atrial fibrillation, Europace, 11, 308, 10.1093/europace/eup036 Katritsis, 2011, Rapid pulmonary vein isolation combined with autonomic ganglia modification: a randomized study, Heart Rhythm, 8, 672, 10.1016/j.hrthm.2010.12.047 Kimura, 2010, Norepinephrine-induced nerve growth factor depletion causes cardiac sympathetic denervation in severe heart failure, Aut. Neurosci. Basic Clin., 156, 27, 10.1016/j.autneu.2010.02.005 Krum, 2009, Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study, Lancet, 373, 1275, 10.1016/S0140-6736(09)60566-3 Kumar, 1996, Experimental model for an ectopic focus coupled to ventricular cells, Circulation, 94, 833, 10.1161/01.CIR.94.4.833 Lemery, 2006, Feasibility study of endocardial mapping of ganglionated plexuses during catheter ablation of atrial fibrillation, Heart Rhythm, 3, 387, 10.1016/j.hrthm.2006.01.009 Lemola, 2008, Pulmonary vein region ablation in experimental vagal atrial fibrillation: role of pulmonary veins versus autonomic ganglia, Circulation, 117, 470, 10.1161/CIRCULATIONAHA.107.737023 Li, 2004, Vagal nerve stimulation markedly improves long-term survival after chronic heart failure in rats, Circulation, 109, 120, 10.1161/01.CIR.0000105721.71640.DA Li, 2009, Low-level vagosympathetic stimulation: a paradox and potential new modality for the treatment of focal atrial fibrillation, Circ. Arrhythm. Electrophysiol., 2, 645, 10.1161/CIRCEP.109.868331 Li, 2004, Infarction alters both the distribution and noradrenergic properties of cardiac sympathetic neurons, Am. J. Physiol. Heart Circ. Physiol., 286, H2229, 10.1152/ajpheart.00768.2003 Liao, 2015, Low-level baroreceptor stimulation suppresses atrial fibrillation by inhibiting ganglionated plexus activity, Can. J. Cardiol., 31, 767, 10.1016/j.cjca.2015.01.007 Lin, 2008, Inducibility of atrial and ventricular arrhythmias along the ligament of marshall: role of autonomic factors, J. Cardiovasc. Electrophysiol., 19, 955, 10.1111/j.1540-8167.2008.01159.x Lin, 2007, Autonomic mechanism to explain complex fractionated atrial electrograms (CFAE), J. Cardiovasc. Electrophysiol., 18, 1197, 10.1111/j.1540-8167.2007.00976.x Linz, 2013, Effect of renal denervation on neurohumoral activation triggering atrial fibrillation in obstructive sleep apnea, Hypertension, 62, 767, 10.1161/HYPERTENSIONAHA.113.01728 Linz, 2013, Renal sympathetic denervation provides ventricular rate control but does not prevent atrial electrical remodeling during atrial fibrillation, Hypertension, 61, 225, 10.1161/HYPERTENSIONAHA.111.00182 Linz, 2013, Effects of electrical stimulation of carotid baroreflex and renal denervation on atrial electrophysiology, J. Cardiovasc. Electrophysiol., 24, 1028, 10.1111/jce.12171 Linz, 2014, Atrial autonomic innervation: a target for interventional antiarrhythmic therapy?, J. Am. Coll. Cardiol., 63, 215, 10.1016/j.jacc.2013.09.020 Linz, 2015, Catheter-based renal denervation reduces atrial nerve sprouting and complexity of atrial fibrillation in goats, Circ. Arrhythm. Electrophysiol., 8, 466, 10.1161/CIRCEP.114.002453 Linz, 2013, Renal denervation suppresses ventricular arrhythmias during acute ventricular ischemia in pigs, Heart Rhythm, 10, 1525, 10.1016/j.hrthm.2013.07.015 Liu, 2003, Sympathetic nerve sprouting, electrical remodeling, and increased vulnerability to ventricular fibrillation in hypercholesterolemic rabbits, Circ. Res., 92, 1145, 10.1161/01.RES.0000072999.51484.92 Lopshire, 2009, Spinal cord stimulation improves ventricular function and reduces ventricular arrhythmias in a canine postinfarction heart failure model, Circulation, 120, 286, 10.1161/CIRCULATIONAHA.108.812412 Lu, 2008, Atrial fibrillation begets atrial fibrillation: autonomic mechanism for atrial electrical remodeling induced by short-term rapid atrial pacing, Circ. Arrhythm. Electrophysiol., 1, 184, 10.1161/CIRCEP.108.784272 Mackaay, 1980, Interaction of adrenaline and acetylcholine on cardiac pacemaker function. Functional inhomogeneity of the rabbit sinus node, J. Pharmacol. Exp. Ther., 214, 417 Male, 2014, Role of neural modulation in the pathophysiology of atrial fibrillation, Indian J. Med. Res., 139, 512 Mannheimer, 1993, Effects of spinal cord stimulation in angina pectoris induced by pacing and possible mechanisms of action, BMJ, 307, 477, 10.1136/bmj.307.6902.477 Mantravadi, 2007, Autonomic nerve stimulation reverses ventricular repolarization sequence in rabbit hearts, Circ. Res., 100, e72, 10.1161/01.RES.0000264101.06417.33 Marx, 2002, Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel, Science (New York, NY), 295, 496, 10.1126/science.1066843 Marx, 2000, PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts, Cell, 101, 365, 10.1016/S0092-8674(00)80847-8 Moghtadaei, 2016, Electrophysiological effects of natriuretic peptides in the heart are mediated by multiple receptor subtypes, Prog. Biophys. Mol. Biol., 120, 37, 10.1016/j.pbiomolbio.2015.12.001 Moss, 1996, Improved survival with an implanted defibrillator in patients with coronary disease at high risk for ventricular arrhythmia. Multicenter automatic defibrillator implantation trial Investigators, N. Engl. J. Med., 335, 1933, 10.1056/NEJM199612263352601 Myles, 2015, Decreased inward rectifying K+ current and increased ryanodine receptor sensitivity synergistically contribute to sustained focal arrhythmia in the intact rabbit heart, J. Physiol., 593, 1479, 10.1113/jphysiol.2014.279638 Myles, 2012, Local β-adrenergic stimulation overcomes source-sink mismatch to generate focal arrhythmia, Circ. Res., 110, 1454, 10.1161/CIRCRESAHA.111.262345 Nash, 2001, Ventricular activation during sympathetic imbalance and its computational reconstruction, J. Appl. Physiol., 90, 287, 10.1152/jappl.2001.90.1.287 Nykjaer, 2004, Sortilin is essential for proNGF-induced neuronal cell death, Nature, 427, 843, 10.1038/nature02319 Odenstedt, 2011, Spinal cord stimulation effects on myocardial ischemia, infarct size, ventricular arrhythmia, and noninvasive electrophysiology in a porcine ischemia-reperfusion model, Heart Rhythm, 8, 892, 10.1016/j.hrthm.2011.01.029 Olivas, 2016, Myocardial infarction causes transient cholinergic transdifferentiation of cardiac sympathetic nerves via gp130, J. Neurosci., 36, 479, 10.1523/JNEUROSCI.3556-15.2016 Osman, 2010, Ganglionic plexus ablation during pulmonary vein isolation–predisposing to ventricular arrhythmias?, Indian Pacing Electrophysiol. J., 10, 104 Pappone, 2004, Pulmonary vein denervation enhances long-term benefit after circumferential ablation for paroxysmal atrial fibrillation, Circulation, 109, 327, 10.1161/01.CIR.0000112641.16340.C7 Patterson, 2005, Triggered firing in pulmonary veins initiated by in vitro autonomic nerve stimulation, Heart Rhythm, 2, 624, 10.1016/j.hrthm.2005.02.012 Pauza, 2002, Comparative quantitative study of the intrinsic cardiac ganglia and neurons in the rat, guinea pig, dog and human as revealed by histochemical staining for acetylcholinesterase, Ann. Anat., 184, 125, 10.1016/S0940-9602(02)80005-X Pauza, 2002, Morphology of the intrinsic cardiac nervous system in the dog: a whole-mount study employing histochemical staining with acetylcholinesterase, Cells Tissues Organs, 172, 297, 10.1159/000067198 Pieroni, 2007, Myocardial production of chromogranin A in human heart: a new regulatory peptide of cardiac function, Eur. Heart J., 28, 1117, 10.1093/eurheartj/ehm022 Pogwizd, 2004, Cellular basis of triggered arrhythmias in heart failure, Trends Cardiovasc. Med., 14, 61, 10.1016/j.tcm.2003.12.002 Pogwizd, 2001, Arrhythmogenesis and contractile dysfunction in heart failure: roles of sodium-calcium exchange, inward rectifier potassium current, and residual beta-adrenergic responsiveness, Circ. Res., 88, 1159, 10.1161/hh1101.091193 Pokushalov, 2012, A randomized comparison of pulmonary vein isolation with versus without concomitant renal artery denervation in patients with refractory symptomatic atrial fibrillation and resistant hypertension, J. Am. Coll. Cardiol., 60, 1163, 10.1016/j.jacc.2012.05.036 Pokushalov, 2009, Selective ganglionated plexi ablation for paroxysmal atrial fibrillation, Heart Rhythm, 6, 1257, 10.1016/j.hrthm.2009.05.018 Porter, 2008, Prospective study of atrial fibrillation termination during ablation guided by automated detection of fractionated electrograms, J. Cardiovasc. Electrophysiol., 19, 613, 10.1111/j.1540-8167.2008.01189.x Puodziukynas, 2012, Radiofrequency catheter ablation of pulmonary vein roots results in axonal degeneration of distal epicardial nerves, Auton. Neurosci., 167, 61, 10.1016/j.autneu.2012.01.001 Raake, 2012, Cardiac G-protein-coupled receptor kinase 2 ablation induces a novel Ca2+ handling phenotype resistant to adverse alterations and remodeling after myocardial infarction, Circulation, 125, 2108, 10.1161/CIRCULATIONAHA.111.044255 Randall, 2003, Interactions within the intrinsic cardiac nervous system contribute to chronotropic regulation, Am. J. Physiol. Regul. Integr. Comp. Physiol., 285, R1066, 10.1152/ajpregu.00167.2003 Remo, 2014, Safety and efficacy of renal denervation as a novel treatment of ventricular tachycardia storm in patients with cardiomyopathy, Heart Rhythm, 11, 541, 10.1016/j.hrthm.2013.12.038 Rysevaite, 2011, Morphologic pattern of the intrinsic ganglionated nerve plexus in mouse heart, Heart Rhythm, 8, 448, 10.1016/j.hrthm.2010.11.019 Rysevaite, 2011, Immunohistochemical characterization of the intrinsic cardiac neural plexus in whole-mount mouse heart preparations, Heart Rhythm, 8, 731, 10.1016/j.hrthm.2011.01.013 Sampaio, 2003, Differential chronotropic and dromotropic responses to focal stimulation of cardiac vagal ganglia in the rat, Exp. Physiol., 88, 315, 10.1113/eph8802525 Scanavacca, 2006, Selective atrial vagal denervation guided by evoked vagal reflex to treat patients with paroxysmal atrial fibrillation, Circulation, 114, 876, 10.1161/CIRCULATIONAHA.106.633560 Scherlag, 2005, Electrical stimulation to identify neural elements on the heart: their role in atrial fibrillation, J. Interv. Card. Electrophysiol., 13, 37, 10.1007/s10840-005-2492-2 Schotten, 2011, Pathophysiological mechanisms of atrial fibrillation: a translational appraisal, Physiol. Rev., 91, 265, 10.1152/physrev.00031.2009 Schwartz, 2004, Left cardiac sympathetic denervation in the management of high-risk patients affected by the long-QT syndrome, Circulation, 109, 1826, 10.1161/01.CIR.0000125523.14403.1E Shannon, 2000, Potentiation of fractional sarcoplasmic reticulum calcium release by total and free intra-sarcoplasmic reticulum calcium concentration, Biophys. J., 78, 334, 10.1016/S0006-3495(00)76596-9 Sheng, 2011, Prevention and reversal of atrial fibrillation inducibility and autonomic remodeling by low-level vagosympathetic nerve stimulation, J. Am. Coll. Cardiol., 57, 563, 10.1016/j.jacc.2010.09.034 Shibata, 2001, Pacemaker shift in the rabbit sinoatrial node in response to vagal nerve stimulation, Exp. Physiol., 86, 177, 10.1113/eph8602100 Siao, 2012, ProNGF, a cytokine induced after myocardial infarction in humans, targets pericytes to promote microvascular damage and activation, J. Exp. Med., 209, 2291, 10.1084/jem.20111749 Singh, 1996, Topography of cardiac ganglia in the adult human heart, J. Thorac. Cardiovasc. Surg., 112, 943, 10.1016/S0022-5223(96)70094-6 Song, 2001, beta-Adrenergic stimulation synchronizes intracellular Ca(2+) release during excitation-contraction coupling in cardiac myocytes, Circ. Res., 88, 794, 10.1161/hh0801.090461 Sperelakis, 1994, Regulation of calcium slow channels of heart by cyclic nucleotides and effects of ischemia, Adv. Pharmacol. (San Diego, Calif.), 31, 1 Stavrakis, 2012, Antiarrhythmic effects of vasostatin-1 in a canine model of atrial fibrillation, J. Cardiovasc. Electrophysiol., 23, 771, 10.1111/j.1540-8167.2012.02317.x Ukena, 2012, Renal sympathetic denervation for treatment of electrical storm: first-in-man experience, Clin. Res. Cardiol., 101, 63, 10.1007/s00392-011-0365-5 Vaitkevicius, 2009, Nerve supply of the human pulmonary veins: an anatomical study, Heart Rhythm, 6, 221, 10.1016/j.hrthm.2008.10.027 Valdivia, 1995, Rapid adaptation of cardiac ryanodine receptors: modulation by Mg2+ and phosphorylation, Science (New York, NY), 267, 1997, 10.1126/science.7701323 Vanoli, 1991, Vagal stimulation and prevention of sudden death in conscious dogs with a healed myocardial infarction, Circ. Res., 68, 1471, 10.1161/01.RES.68.5.1471 Vaseghi, 2014, Cardiac sympathetic denervation in patients with refractory ventricular arrhythmias or electrical storm: intermediate and long-term follow-up, Heart Rhythm, 11, 360, 10.1016/j.hrthm.2013.11.028 Vaseghi, 2012, Sympathetic stimulation increases dispersion of repolarization in humans with myocardial infarction, AJP Heart Circ. Physiol., 302, H1838, 10.1152/ajpheart.01106.2011 Vatner, 1985, Mechanisms of supersensitivity to sympathomimetic amines in the chronically denervated heart of the conscious dog, Circ. Res., 57, 55, 10.1161/01.RES.57.1.55 Verma, 2008, A prospective, multicenter evaluation of ablating complex fractionated electrograms (CFEs) during atrial fibrillation (AF) identified by an automated mapping algorithm: acute effects on AF and efficacy as an adjuvant strategy, Heart Rhythm, 5, 198, 10.1016/j.hrthm.2007.09.027 Viatchenko-Karpinski, 2001, Modulation of the Ca(2+)-induced Ca(2+) release cascade by beta-adrenergic stimulation in rat ventricular myocytes, J. Physiol., 533, 837, 10.1111/j.1469-7793.2001.t01-1-00837.x Vinogradova, 2006, High basal protein kinase A-dependent phosphorylation drives rhythmic internal Ca2+ store oscillations and spontaneous beating of cardiac pacemaker cells, Circ. Res., 98, 505, 10.1161/01.RES.0000204575.94040.d1 Vollmann, 2013, Renal artery ablation instead of pulmonary vein ablation in a hypertensive patient with symptomatic, drug-resistant, persistent atrial fibrillation, Clin. Res. Cardiol., 102, 315, 10.1007/s00392-012-0529-y Wang, 2016, Spinal cord stimulation suppresses atrial fibrillation by inhibiting autonomic remodeling, Heart Rhythm, 13, 274, 10.1016/j.hrthm.2015.08.018 Weerasooriya, 2011, Catheter ablation for atrial fibrillation: are results maintained at 5 years of follow-up?, J. Am. Coll. Cardiol., 57, 160, 10.1016/j.jacc.2010.05.061 Wickramasinghe, 2013, Local innervation and atrial fibrillation, Circulation, 128, 1566, 10.1161/CIRCULATIONAHA.113.001596 Wilde, 2008, Left cardiac sympathetic denervation for catecholaminergic polymorphic ventricular tachycardia, N. Engl. J. Med., 358, 2024, 10.1056/NEJMoa0708006 Xie, 2010, So little source, so much sink: requirements for afterdepolarizations to propagate in tissue, Biophys. J., 99, 1408, 10.1016/j.bpj.2010.06.042 Yagishita, 2015, Sympathetic nerve stimulation, not circulating norepinephrine, modulates T-peak to T-end interval by increasing global dispersion of repolarization, Circ. Arrhythmia Electrophysiol., 8, 174, 10.1161/CIRCEP.114.002195 Yang, 2011, Effects of high thoracic epidural anesthesia on atrial electrophysiological characteristics and sympathetic nerve sprouting in a canine model of atrial fibrillation, Basic Res. Cardiol., 106, 495, 10.1007/s00395-011-0154-3 Yatani, 2006, Down regulation of the L-type Ca2+ channel, GRK2, and phosphorylated phospholamban: protective mechanisms for the denervated failing heart, J. Mol. Cell. Cardiol., 40, 619, 10.1016/j.yjmcc.2006.02.002 Yu, 2014, Spinal cord stimulation suppresses focal rapid firing-induced atrial fibrillation by inhibiting atrial ganglionated plexus activity, J. Cardiovasc. Pharmacol., 64, 554, 10.1097/FJC.0000000000000154 Yu, 2013, Low-level transcutaneous electrical stimulation of the auricular branch of the vagus nerve: a noninvasive approach to treat the initial phase of atrial fibrillation, Heart Rhythm, 10, 428, 10.1016/j.hrthm.2012.11.019 Yu, 2011, Low-level vagosympathetic nerve stimulation inhibits atrial fibrillation inducibility: direct evidence by neural recordings from intrinsic cardiac ganglia, J. Cardiovasc. Electrophysiol., 22, 455, 10.1111/j.1540-8167.2010.01908.x Yuan, 1993, Differential cardiac responses induced by nicotine sensitive canine atrial and ventricular neurones, Cardiovasc. Res., 27, 760, 10.1093/cvr/27.5.760 Zarzoso, 2013, Nerves projecting from the intrinsic cardiac ganglia of the pulmonary veins modulate sinoatrial node pacemaker function, Cardiovasc. Res., 99, 566, 10.1093/cvr/cvt081 Zhang, 2009, Chronic vagus nerve stimulation improves autonomic control and attenuates systemic inflammation and heart failure progression in a canine high-rate pacing model, Circ. Heart Fail., 2, 692, 10.1161/CIRCHEARTFAILURE.109.873968 Zhao, 2013, Vagal stimulation triggers peripheral vascular protection through the cholinergic anti-inflammatory pathway in a rat model of myocardial ischemia/reperfusion, Basic Res. Cardiol., 108, 345, 10.1007/s00395-013-0345-1 Zipes, 2006, Eur. Heart J., 27, 2099, 10.1093/eurheartj/ehl199