Effect of chronic hypoxia on acetaminophen metabolism in the rat

Biochemical Pharmacology - Tập 42 - Trang 1029-1038 - 1991
Tak Yee Aw1, Xiaoqin Shan1, Alberto H. Sillau1, Dean P. Jones1
1Department of Biochemistry and Winship Cancer Center, Emory University School of Medicine, Atlanta, GA 30322, U.S.A.

Tài liệu tham khảo

Jones, 1988, New concepts of the molecular pathogenesis arising from hypoxia, 127 Jones, 1989, Drug metabolism and toxicity during hypoxia, Drug Metab Rev, 20, 247, 10.3109/03602538909103540 Jones, 1981, Hypoxia and drug metabolism, Biochem Pharmacol, 30, 1019, 10.1016/0006-2952(81)90436-6 Angus, 1988, Synergistic effects of hypoxia and fasting on harmol elimination in the isolated perfused rat liver, Biochem Pharmacol, 37, 1207, 10.1016/0006-2952(88)90772-1 Angus, 1987, Hypoxia impairs conjugation and elimination of harmol in the isolated perfused rat liver, J Pharmacol Exp Ther, 240, 931 Aw, 1982, Secondary bioenergetic hypoxia. Inhibition of sulfation and glucuronidation reactions in isolated hepatocytes at low O2 concentration, J Biol Chem, 257, 8997, 10.1016/S0021-9258(18)34232-7 Juarbe, 1988, Muscle capillarity in rats with increased blood oxygen affinity, Respir Physiol, 72, 83, 10.1016/0034-5687(88)90081-3 Moldeus, 1978, Isolation and use of hepatocytes, Methods Enzymol, 51, 60 Ernster, 1962, Enzyme-structure relationships in the endoplasmic reticulum of rat liver. A morphological and biochemical study, J Cell Biol, 15, 541, 10.1083/jcb.15.3.541 Howie, 1977, Paracetamol metabolism following overdosage: Application of high performance liquid chromatography, J Pharm Pharmacol, 29, 235, 10.1111/j.2042-7158.1977.tb11295.x Moldeus, 1978, Paracetamol metabolism and toxicity in isolated hepatocytes from rat and mouse, Biochem Pharmacol, 27, 2859, 10.1016/0006-2952(78)90201-0 Smith, 1985, Measurement of protein using bicinchoninic acid, Anal Biochem, 150, 76, 10.1016/0003-2697(85)90442-7 Gibaldi, 1991 Galinsky, 1981, Dose- and time-dependent elimination of acetaminophen in rats: Pharmacokinetic implications of cosubstrate depletion, J Pharmacol Exp Ther, 219, 14 Dutton, 1980 Thurman, 1986, Biotransformation and zonal toxicity, 321 Aw, 1984, Control of glucuronidation during hypoxia. Limitation by UDP-glucose pyrophosphorylase, Biochem J, 219, 707, 10.1042/bj2190707 Reinke, 1981, Conjugation of p-nitrophenol in the perfused rat liver: The effect of substrate concentration and carbohydrate reserves, J Pharmacol Exp Ther, 217, 863 Jones, 1978, Gradients of O2 concentration in hepatocytes, J Biol Chem, 253, 4874, 10.1016/S0021-9258(17)34627-6 Sillau, 1988, O2 dependence of cytochrome c oxidation in hepatocytes from hypoxic rats, Physiologist, 34, A146 Hagen, 1987, Transepithelial transport of glutathione in vascularly perfused small intestine of rat, Am J Physiol, 252, G607 Van Liere, 1963 Gazzard, 1973, The binding of paracetamol to plasma proteins of man and pig, J Pharm Pharmacol, 25, 964, 10.1111/j.2042-7158.1973.tb09987.x Costa, 1988, Liver and heart mitochondria in rats submitted to chronic hypobaric hypoxia, Am J Physiol, 255, C123, 10.1152/ajpcell.1988.255.1.C123 Jones, 1984, Effect of mitochondrial clustering on O2 supply in hepatocytes, Am J Physiol, 250, C83, 10.1152/ajpcell.1984.247.1.C83 Jones, 1991, Regulation of mitochondrial distribution: An adaptive response to changes in oxygen supply, 25 Kaplan, 1983, O2 dependence of acetaminophen metabolism, Clin Res, 31, 418a Pang, 1983, Normal and retrograde perfusion to probe the zonal distribution of sulfation and glucuronidation activities of harmol in the perfused rat liver preparation, J Pharmacol Exp Ther, 224, 647 Boyd, 1966, Liver necrosis from paracetamol, Br J Pharmacol, 26, 606