Low natural killer cell cytotoxic activity in autism: The role of glutathione, IL-2 and IL-15

Journal of Neuroimmunology - Tập 205 - Trang 148-154 - 2008
Aristo Vojdani1, Elizabeth Mumper2, Doreen Granpeesheh3, Lynne Mielke4, David Traver5, Kenneth Bock6, Karima Hirani7, James Neubrander8, Kurt N. Woeller9, Nancy O'Hara10, Anju Usman11, Cindy Schneider12, Frank Hebroni1, Joshua Berookhim1, Jaquelyn McCandless13
1Immunosciences Lab., Inc., 10350 Santa Monica Blvd., Ste. 205, Los Angeles, CA 90025, United States
2Rimland Center, 2919 Confederate Avenue, Lynchburg, VA, 24501, United States
3The Center for Autism and Related Disorders, 19019 Ventura Blvd., 3rd Flr., Tarzana, CA 91356, United States
4Developmental Spectrums, 4463 Stoneridge Drive, Suite A, Pleasanton, CA 94588, United States
51261 East Hilldale Boulevard, Foster City, CA, 94404, United States
6Rhinebeck Health Center, 108 Montgomery Street, Rhinebeck, NY, 12572, United States
7Hirani Wellness Center, 9736 Venice Boulevard, Culver City, 90232, United States
8100 Menlo Park, Suite 410, Edison, NJ, 08337, United States
9Stillpoint Center for Integrative Medicine, 32605 Temecula Parkway, Suite 201, Temecula, CA 92592, United States
10152 Danbury Road, Wilton, CT 06897, United States
11603 East Diehl Road, Suite 135, Naperville, IL, 60563, United States
12Center for Autism Research and Education, 300 East Osborn Road, Suite 200, Phoenix, AZ, 85012, United States
137031 Jordan Avenue, #18, Canoga Park, CA 91303, United States

Tài liệu tham khảo

Ashwood, 2006, Immune activation of peripheral blood and mucosal CD3+ lymphocyte cytokine profiles in children with autism and gastrointestinal symptoms, J. Neuroimmunol., 173, 126, 10.1016/j.jneuroim.2005.12.007 Ashwood, 2004, Spontaneous mucosal lymphocyte cytokine profiles in children with autism and gastrointestinal symptoms: mucosal immune activation and reduced counter regulatory interleukin-10, J. Clin. Immunol., 24, 664, 10.1007/s10875-004-6241-6 Ashwood, 2006, The immune response in autism: a new frontier for autism research, J. Leukoc. Biol., 80, 1, 10.1189/jlb.1205707 Baird, 2003, Diagnosis of autism, Br. Med. J., 327, 488, 10.1136/bmj.327.7413.488 Biron, 1999, Natural killer cells in antiviral defense: function and regulation by innate cytokines, Annu. Rev. Immunol., 17, 189, 10.1146/annurev.immunol.17.1.189 Bryceson, 2006, Activation, coactivation and costimulation of resting human natural killer cells, Immunol. Rev., 214, 73, 10.1111/j.1600-065X.2006.00457.x Carson, 1997, A potential role for interleukin-15 in the regulation of human natural killer cell survival, J. Clin. Invest., 99, 937, 10.1172/JCI119258 Cohen, 2005, Specific genetic disorders and autism: clinical contribution towards their identification, J. Autism Dev. Disord., 35, 103, 10.1007/s10803-004-1038-2 Colucci, 2003, What does it take to make a natural killer?, Nature Rev. Immunology, 3, 413, 10.1038/nri1088 Cooper, 2001, The biology of human natural killer-cell subsets, Trends Immunol., 22, 633, 10.1016/S1471-4906(01)02060-9 Deniz, 2008, Regulatory NK cells suppress antigen-specific T cell responses, J. Immunol., 180, 850, 10.4049/jimmunol.180.2.850 Droge, 1986, Glutathione augments the activation of cytotoxic T lymphocytes in vivo, Immunobiology, 17, 151, 10.1016/S0171-2985(86)80061-4 Droge, 1994, Functions of glutathione and glutathione disulfide in immunology and immunopathology, FASEB J., 8, 1131, 10.1096/fasebj.8.14.7958618 Edelson, 2000, The neurotoxic etiology of the autistic spectrum disorder: a replicative study, Toxicol. Ind. Health, 16, 239, 10.1177/074823370001600604 Farag, 2006, Human natural killer cell development and biology, Blood Rev., 20, 123, 10.1016/j.blre.2005.10.001 Fatemi, 2002, Prenatal viral infection leads to pyramidal cell atrophy and macrocephaly in adulthood: implications for genesis of autism and schizophrenia, Cell. Mol. Neurobiol., 22, 25, 10.1023/A:1015337611258 Fatemi, 2005, Reelin signaling is impaired in autism, Biol. Psychiatry, 57, 777, 10.1016/j.biopsych.2004.12.018 Fehniger, 2002, Interleukin-2 and interleukin-15: immunotherapy for cancer, Cytokine Growth Factor Rev., 13, 169, 10.1016/S1359-6101(01)00021-1 Fortier, 2006, NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase, J. Immunol., 176, 6454, 10.4049/jimmunol.176.11.6454 Freitag, 2007, The genetics of autistic disorders and its clinical relevance: a review of the literature, Mol. Psychiatry, 12, 2, 10.1038/sj.mp.4001896 Galter, 1994, Distinct effects of glutathione disulfide on the transcription factors NFκN and AP-1, Eur. J. Biochem., 221, 639, 10.1111/j.1432-1033.1994.tb18776.x Gmunder, 1991, Differential effects of glutathione depletion on T cell subsets, Cell. Immunol., 138, 229, 10.1016/0008-8749(91)90147-4 Gosselin, 1999, Interleukin-15 as an activator of natural killer cell-mediated antiviral response, Blood, 94, 4210, 10.1182/blood.V94.12.4210 Hallett, 2008, Sensitization of tumor cells to NK cell-mediated killing by proteasome inhibition, J. Immunol., 180, 163, 10.4049/jimmunol.180.1.163 Hamilos, 1985, The role of glutathione in lymphocyte activation. I. Comparison of inhibitory effects of buthionine sulfoximine and 2-cyclohexene-1-one by nuclear size transformation, J. Immunol., 135, 2740, 10.4049/jimmunol.135.4.2740 Hargrove, 1993, Regulation by glutathione of the activation and differentiation of IL-4-dependent activated killer cells, Cell. Immunol., 149, 433, 10.1006/cimm.1993.1168 Hayakawa, 2006, Innate immune recognition and suppression of tumors, Adv. Cancer Res., 95, 293, 10.1016/S0065-230X(06)95008-8 Herberman, 1975, Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic acid allogeneic tumors. I. Distribution of reactivity and specificity, Int. J. Cancer., 16, 216, 10.1002/ijc.2910160204 Huang, 2006, A novel NF-κB binding site controls human granzyme B gene transcription, J. Immmunol., 176, 4173, 10.4049/jimmunol.176.7.4173 Jyonouchi, 2001, Proinflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autism spectrum disorders and developmental regression, J. Neuroimmunol., 120, 170, 10.1016/S0165-5728(01)00421-0 Johansson, 2005, NK cells: elusive players in autoimmunity, Trend Immunol., 26, 613, 10.1016/j.it.2005.08.008 Kiessling, 1975, ‘Natural’ killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotype, Eur. J. Immunol., 5, 112, 10.1002/eji.1830050208 Kim, 2008, Disruption of neurexin 1 (NRXN1) associated with autism spectrum disorder, Am. J. Hum. Genet., 82, 199, 10.1016/j.ajhg.2007.09.011 Kinscherf, 1994, Effect of glutathione depletion and oral N-acetyl-cysteine treatment on CD4+ and CD8+ cells, FASEB J, 8, 448, 10.1096/fasebj.8.6.7909525 Kozlowski, 1999, NK lytic associated molecule: a novel gene selectively expressed in cells with cytolytic function, J. Immunol., 163, 1775, 10.4049/jimmunol.163.4.1775 Lehmann, 2001, Activation of natural killer cells with interleukin-2 (IL-2) and IL-12 increases perforin binding and subsequent lysis of tumour cells, Br. J. Haematol., 114, 660, 10.1046/j.1365-2141.2001.02995.x Liang, 1989, Glutathione regulates interleukin-2 activity on cytotoxic T-cells, J. Biol. Chem., 264, 13519, 10.1016/S0021-9258(18)80027-8 Ljunggren, 2007, Prospects for the use of NK cells in immunotherapy of human cancer, Nat. Rev. Immunol., 7, 329, 10.1038/nri2073 Molloy, 2006, Elevated cytokine levels in children with autism spectrum disorder, J. Neuroimmunol., 172, 198, 10.1016/j.jneuroim.2005.11.007 Mueller, 2008, IL-15 treatment during acute simian immunodeficiency virus (SIV) infection increases viral set point and accelerated disease progression despite the induction of stronger SIV-specific CD8+ T cell responses, J. Immunol., 180, 350, 10.4049/jimmunol.180.1.350 Nguyen, 2002, Coordinated and distinct roles for IFN-αβ, IL-12, and IL-15 regulation of NK cell response to viral infection, J. Immunol., 169, 4279, 10.4049/jimmunol.169.8.4279 Orange, 2006, Natural killer cells in human health and disease, Clin. Immunol., 118, 1, 10.1016/j.clim.2005.10.011 Pandey, 2007, NKp30 ligation induces rapid activation of the canonical NF-κB pathway in NK cells, J. Immunol., 179, 7385, 10.4049/jimmunol.179.11.7385 Raulet, 2004, Interplay of natural killer cells and their receptors with the adaptive immune response, Nature Immunol., 5, 996, 10.1038/ni1114 Rose, 1995, Analysis of water-soluble anti-oxidants by high-pressure chromatography, Biochem. J., 306, 101, 10.1042/bj3060101 Rutter, 2000, Genetic studies of autism: from the 1970s into the millennium, J. Abnorm. Child Psychol., 28, 3, 10.1023/A:1005113900068 Sebat, 2007, Strong association of de novo copy number mutations with autism, Science, 316, 445, 10.1126/science.1138659 Segal, 2007, The role of natural killer cells in curbing neuroinflammation, J. Neuroimmunol., 191, 2, 10.1016/j.jneuroim.2007.09.006 Shi, 2003, Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring, J. Neurosci., 23, 297, 10.1523/JNEUROSCI.23-01-00297.2003 Smyth, 1999, Glutathione modulates activation-dependent proliferation of human peripheral blood lymphocyte populations without regulating their activated function, J. Immunol., 146, 1921, 10.4049/jimmunol.146.6.1921 Stubbs, 1977, Depressed lymphocyte responsiveness in autistic children, J. Autism Child. Schizophr., 7, 49, 10.1007/BF01531114 Suthanthiran, 1990, Glutathione regulates activation-dependent DNA synthesis in highly purified normal human T lymphocytes stimulated via the CD2 and CD3 antigens, Proc. Natl. Acad. Sci. U. S. A., 87, 3343, 10.1073/pnas.87.9.3343 Valle Blazquez, 1997, Cellular redox status influences both cytotoxic and NF-κB activation in natural killer cells, Immunology, 90, 455, 10.1111/j.1365-2567.1997.00455.x Heuser, 1997, Enhancement of natural killer cell activity and T and B cell function by buffered vitamin C in patients exposed to toxic chemicals: the role of protein kinase-C, Immunopharmacol. Immunotoxicol., 19, 291, 10.3109/08923979709046977 Vojdani, 2002, Antibodies to neuron-specific antigens in children with autism: possible cross-reaction with encephalitogenic proteins from milk, Chlamydia pneumoniae and Streptococcus Group A, J. Neuroimmunol., 129, 168, 10.1016/S0165-5728(02)00180-7 Vojdani, 2003, Infections, toxic chemicals and dietary peptides binding to lymphocyte receptors and tissue enzymes are major instigators of autoimmunity in autism, Int. J. Immunopathol. Pharmacol., 16, 189, 10.1177/039463200301600302 Vojdani, 2004, Heat shock protein and gliadin peptide promote development of peptidase antibodies in children with autism and patients with autoimmune disease, Clin. Diag. Lab. Immunol., 11, 515, 10.1128/CDLI.11.3.515-524.2004 Warren, 1986, Immune abnormalities in patients with autism, J. Autism Dev. Disord., 16, 189, 10.1007/BF01531729 Warren, 1987, Reduced natural killer cell activity in autism, J. Am. Acad. Child Adolesc. Psych., 26, 333, 10.1097/00004583-198705000-00008 Weiss, 2008, Association between microdeletion and microduplication at 16p11.2 and autism, N. Engl. J. Med., 358, 1, 10.1056/NEJMoa075974 Whiteside, 1990, Natural killer cell cytotoxicity in the diagnosis of immune dysfunction: criteria for a reproducible assay, J. Clin. Lab. Anal., 4, 102, 10.1002/jcla.1860040207 Wiznitzer, 2004, Autism and tuberous sclerosis, J. Child Neurol., 19, 675, 10.1177/08830738040190090701 Wu, 2001, Natural killer cells and cancer, Adv. Cancer Res., 90, 127, 10.1016/S0065-230X(03)90004-2 Yamamura, 2007, Understanding the behavior of invariant NKT cells in autoimmune diseases, J. Neuroimmunol., 191, 8, 10.1016/j.jneuroim.2007.09.014 Zhou, 2002, A role for NF-κB activation in perforin expression of NK cells upon IL-2 receptor signaling, J. Immunol., 169, 1319, 10.4049/jimmunol.169.3.1319