Inhibition of inducible nitric oxide synthase reduces renal ischemia/reperfusion injury

Thadhani, 1996, Acute renal failure, N Engl J Med, 334, 1448, 10.1056/NEJM199605303342207 Star, 1998, Treatment of acute renal failure, Kidney Int, 54, 1817, 10.1046/j.1523-1755.1998.00210.x Spiegel, 1991, Determinants of survival and recovery in acute renal failure patients dialyzed in intensive-care units, Am J Nephrol, 11, 44, 10.1159/000168271 Novis, 1994, Association of preoperative risk factors with postoperative acute renal failure, Anesth Analg, 778, 143 Zanardo, 1994, Acute renal failure in the patient undergoing cardiac operation, J Thorac Cardiovasc Surg, 107, 1489, 10.1016/S0022-5223(94)70429-5 Maher, 1989, Prognosis of critically-ill patients with acute renal failure: APACHE II score and other predictive factors, Q J Med, 72, 857 McCarthy, 1996, Prognosis of patients with acute renal failure in the intensive care unit: A tail of two eras, Mayo Clin Proc, 71, 117, 10.4065/71.2.117 Lieberthal, 1996, Mechanisms of apoptosis and its potential role in renal tubular epithelial cell injury, Am J Physiol, 271, F477 Weight, 1996, Renal ischaemia-reperfusion injury, Br J Surg, 83, 162, 10.1002/bjs.1800830206 Venkatachalam, 1978, Ischemic damage and repair in the rat proximal tubule. Differences among the S1, S2 and S3 segments, Kidney Int, 14, 31, 10.1038/ki.1978.87 Nath, 2000, Reactive oxygen species and acute renal failure, Am J Med, 109, 655, 10.1016/S0002-9343(00)00612-4 Shoskes, 1996, Delayed graft function in renal transplantation: Etiology, management and long-term significance, J Urol, 155, 1837, 10.1016/S0022-5347(01)66023-3 Kone, 1997, Biosynthesis and homeostatic roles of nitric oxide in the normal kidney, Am J Physiol, 272, F561 Kone, 1997, Nitric oxide in renal health and disease, Am J Kidney Dis, 30, 311, 10.1016/S0272-6386(97)90275-4 Hill-Kapturczak, 1995, Nitric oxide and nitric oxide synthase in the kidney: Potential roles in normal renal function and in renal dysfunction, Endothelium, 3, 253, 10.3109/10623329509024671 Chatterjee, 1999, Cytokine-stimulated nitric oxide production in human renal proximal tubule and its modulation by natriuretic peptides: A novel immunomodulatory mechanism?, Exp Nephrol, 7, 438, 10.1159/000020623 Weight, 1998, Nitric oxide generation is increased in experimental renal warm ischaemia-reperfusion injury, Br J Surg, 85, 1663, 10.1046/j.1365-2168.1998.00960.x Lieberthal, 1998, Biology of ischemic and toxic renal tubular injury: Role of nitric oxide and the inflammatory response, Curr Opin Nephrol Hypertens, 7, 289, 10.1097/00041552-199805000-00009 Noiri, 1996, In vivo targeting of inducible NO synthase with oligodeoxynucleotides protects rat kidney against ischemia, J Clin Invest, 97, 2377, 10.1172/JCI118681 Ling, 1998, Effect of hypoxia on proximal tubules isolated from nitric oxide synthase knockout mice, Kidney Int, 53, 1642, 10.1046/j.1523-1755.1998.00913.x Ling, 1999, Attenuation of renal ischemia-reperfusion injury in inducible nitric oxide synthase knockout mice, Am J Physiol, 277, F383 Chatterjee, 2001, Calpain inhibitor-1 reduces renal ischemia/reperfusion injury in the rat, Kidney Int, 59, 2073, 10.1046/j.1523-1755.2001.00722.x Yokozawa, 1999, Involvement of superoxide and/or nitric oxide in renal tissue injury, Exp Toxicol Pathol, 51, 517, 10.1016/S0940-2993(99)80129-8 Kadkhodaee, 1998, DNA fragmentation reduced by antioxidants following ischaemia-reperfusion in the isolated perfused rat kidney, Nephrol, 4, 163, 10.1046/j.1440-1797.1998.d01-25.x Chatterjee, 1999, Inhibitors of poly (ADP-ribose) synthetase protect rat proximal tubular cells against oxidant stress, Kidney Int, 56, 973, 10.1046/j.1523-1755.1999.00644.x Chatterjee, 2000, Inhibitors of poly (ADP-ribose) synthetase reduce ischemia-reperfusion injury in the anesthetised rat in vivo, FASEB J, 14, 641, 10.1096/fasebj.14.5.641 Chatterjee, 2000, Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat, Kidney Int, 58, 658, 10.1046/j.1523-1755.2000.00212.x Radi, 2001, Unraveling peroxynitrite formation in biological systems, Free Rad Biol Med, 30, 463, 10.1016/S0891-5849(00)00373-7 Beckman, 1996, Oxidative damage and tyrosine nitration from peroxynitrite, Chem Res Toxicol, 9, 836, 10.1021/tx9501445 Paller, 1998, Nitric-oxide-mediated renal epithelial cell injury during hypoxia and reoxygenation, Ren Fail, 20, 459, 10.3109/08860229809045135 Walker, 2000, Evidence for peroxynitrite formation in renal ischemia-reperfusion injury: studies with the inducible nitric oxide synthase inhibitor L-N6-(1-Iminoethyl)lysine, J Pharmacol Exp Ther, 295, 417 Moore, 1994, L-N6-(1-Iminoethyl)lysine: A selective inhibitor of inducible nitric oxide synthase, J Med Chem, 37, 3886, 10.1021/jm00049a007 Garvey, 1994, Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas, J Biol Chem, 269, 26669, 10.1016/S0021-9258(18)47071-8 Alderton, 2001, Nitric oxide synthases: structure, function and inhibition, Biochem J, 357, 593, 10.1042/bj3570593 Millar, 1997, Intrarenal haemodynamics and renal dysfunction in endotoxaemia: Effects of nitric oxide synthase inhibition, Br J Pharmacol, 121, 1824, 10.1038/sj.bjp.0701335 Paller, 1994, Pathophysiologic mechanisms of acute renal failure,, 3 Bosomworth, 1999, Urine N-acetyl-β-D-glucosaminidase—A marker of tubular damage?, Nephrol Dial Transplant, 14, 620, 10.1093/ndt/14.3.620 Stogdale, 1981, Correlation of changes in blood chemistry with pathological changes in the animal's body. II. Electrolytes, kidney function tests, serum enzymes, and liver function tests, J South Afr Vet Assoc, 52, 155 Thiemermann, 1995, The multiple organ dysfunction syndrome caused by endotoxin in the rat: attenuation of liver dysfunction by inhibitors of nitric oxide synthase, Br J Pharmacol, 116, 2845, 10.1111/j.1476-5381.1995.tb15935.x McDonald, 2001, Calpain inhibitor I reduces the activation of nuclear factor-κB and organ injury/dysfunction in hemorrhagic shock, FASEB J, 15, 171, 10.1096/fj.99-0645com Markewitz, 1993, Cytokine-induced expression of a nitric oxide synthase in rat renal tubule cells, J Clin Invest, 91, 2138, 10.1172/JCI116439 Morrisey, 1994, Location of an inducible nitric oxide synthase mRNA in the normal kidney, Kidney Int, 45, 998, 10.1038/ki.1994.135 Mayeux, 1995, Effect of lipopolysaccharide on nitric oxide synthase activity in the rat proximal tubule, Biochem Pharmacol, 49, 115, 10.1016/0006-2952(94)00449-V Tojo, 1994, Immunocytochemical localisation of distinct isoforms of nitric oxide synthase in the juxtaglomerular apparatus of normal rat kidney, J Am Soc Nephrol, 4, 1438, 10.1681/ASN.V471438 Walder, 1991, The involvement of endothelium relaxing factor on the regulation of renal cortical blood flow in the rat, Br J Pharmacol, 102, 967, 10.1111/j.1476-5381.1991.tb12285.x Chintala, 1993, Inhibition of endothelial derived relaxing factor (EDRF) aggravates ischemic acute renal failure in anaesthetised rats, Naunyn-Schmiedeberg's Arch Pharmacol, 348, 305, 10.1007/BF00169160 Shultz, 1992, Endogenously synthesised nitric oxide prevents endotoxin-induced glomerular thrombosis, J Clin Invest, 90, 1718, 10.1172/JCI116045 Spain, 1994, Nitric oxide synthase inhibition exacerbates sepsis-induced renal hypoperfusion, Surgery, 116, 322 Thiemermann, 1994, The role of L-arginine: Nitric oxide pathway in circulatory shock, Adv Pharmacol, 28, 45, 10.1016/S1054-3589(08)60493-7 Faraci, 1996, 2-Amino-4-methylpyridine as a potent inhibitor of inducible NO synthase activity in vitro and in vivo, Br J Pharmacol, 119, 1101, 10.1111/j.1476-5381.1996.tb16010.x Southan, 1995, Isothioureas: Potent inhibitors of nitric oxide synthase with variable isoform selectivity, Br J Pharmacol, 114, 510, 10.1111/j.1476-5381.1995.tb13256.x Thiemermann, 1995, The multiple organ dysfunction syndrome caused by endotoxin in the rat: Attenuation of liver dysfunction by inhibitors of nitric oxide synthase, Br J Pharmacol, 116, 2845, 10.1111/j.1476-5381.1995.tb15935.x Thiemermann, 2001, Aminoethyl-isothiourea in gram-positive shock: An inhibitor of inducible nitric oxide synthase or a jack-of-all-trades?, Shock, 15, 453, 10.1097/00024382-200115060-00007 Saetre, 2001, Aminoethyl-isothiourea inhibits leukocyte production of reactive oxygen species and proinflammatory cytokines induced by streptococcal cell wall components in human whole blood, Shock, 15, 455, 10.1097/00024382-200115060-00008 Wangsiripaisan, 1999, Effect of nitric oxide donors on renal tubular epithelial cell-matrix adhesion, Kidney Int, 55, 2281, 10.1046/j.1523-1755.1999.00484.x