Modeling of polymer erosion in three dimensions: Rotationally symmetric devices

AICHE Journal - Tập 41 Số 10 - Trang 2292-2299 - 1995
Achim Göpferich1,2, R.M. Langer1
1Dept. of Chemical Engineering, Massachusetts Institute of Technology, Building E25, Room 342, Cambridge, MA 02139
2Dept. of Pharmaceutical Technology, University of Erlangen‐Nürnberg, Cauerstrasse 4, 91058 Erlangen, Germany

Tóm tắt

AbstractA three‐dimensional erosion model was developed to simulate the erosion of polymer cylinders. Erosion is regarded as a random event. After contact with the erosion medium small polymer parts are randomly assigned lifetimes from a first‐order Erlang distribution using a Monte Carlo sampling technique. The model takes into account the partially crystalline nature of polymers as well as the geometry of the devices. It allows investigation of the effect of slow or nonerodible coatings. It was found that by partially coating cylinders, erosion periods of polyanhydride polymers can be expanded substantially. This is very important for using polyanhydrides as drug carriers where the polymer erosion period controls drug release.

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AICHE Journal

Tập 41 Số 10

2292-2299

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