Genome-wide association study identifies novel breast cancer susceptibility loci

Nature - Tập 447 Số 7148 - Trang 1087-1093 - 2007
Douglas F. Easton1, Karen A. Pooley2, Alison M. Dunning2, Paul D.P. Pharoah2, Deborah J. Thompson1, Dennis G. Ballinger3, Jeffery P. Struewing4, Jonathan J. Morrison2, Helen I. Field2, Robert Luben5, Nicholas J. Wareham5, Shahana Ahmed2, Catherine S. Healey2, Adam Naguib6, Craig Luccarini2, Don Conroy2, Mitul Shah2, Hannah Munday2, Clare Jordan2, Barbara Perkins2, Judy West2, Karen Redman2, Kristy Driver2, Kerstin B. Meyer7, Graham J. Mann8, Laurence Kolonel9, Brian E. Henderson8, Loı̈c Le Marchand9, Paul Brennan10, Suleeporn Sangrajrang11, Valérie Gaborieau10, Fabrice Odefrey10, Chen‐Yang Shen12, Pei‐Ei Wu12, Hui‐Chun Wang12, Rosalind A. Eeles13, D. Gareth Evans14, Julian Peto15, Olivia Fletcher16, Nichola Johnson16, Cecilia M. Lindgren17, Michael R. Stratton18, Nazneen Rahman17, Georgia Chenevix‐Trench19, Stig E. Bojesen20, Børge G. Nordestgaard20, C. K. Axelsson21, Montserrat García‐Closas22, Louise A. Brinton22, Stephen J. Chanock23, Jolanta Lissowska24, Beata Pepłońska25, Heli Nevanlinna26, Rainer Fagerholm26, Hannaleena Eerola27, Daehee Kang28, Dong‐Young Noh28, Sei Hyun Ahn29, David Wyld30, Susan E. Hankinson30, David G. Cox31, Per Hall32, Sara Wedrén32, Jing Liu33, Yen-Ling Low33, Natalia Bogdanova34, Peter Schürmann35, Thilo Dörk35, Rob A.�E.�M. Tollenaar36, Catharina E. Jacobi37, Peter Devilee38, Jan G.M. Klijn39, Alice J. Sigurdson40, Michele M. Doody40, Bruce H. Alexander41, Jinghui Zhang4, Angela Cox42, Simon S. Cross42, Gordon R. Macpherson42, Malcolm Reed43, Fergus J. Couch44, Ellen L. Goode44, Janet E. Olson44, Hanne Meijers‐Heijboer45, Ans van den Ouweland45, André G. Uitterlinden46, Fernando Rivadeneira46, Roger L. Milne47, Glòria Ribas47, Anna González‐Neira47, Javier Benı́tez47, John L. Hopper48, Margaret McCredie49, Melissa C. Southey48, Graham G. Giles50, Chris Schroen51, Christina Justenhoven52, Hiltrud Brauch52, Ute Hamann53, Yon‐Dschun Ko54, Amanda B. Spurdle19, Jonathan Beesley19, Xiaohong Chen19, Morteza Aghmesheh55, David J. Amor56, Lesley Andrews57, Jeffrey N. Weitzel58, Jane E. Armes59, Shane Armitage60, Leanne Arnold60, Rosemary L. Balleine61, Glenn Begley62, Ian Bennett63, Barbara Bennett57, Geoffrey Berry64, Anneke C. Blackburn65, Meagan Brennan66, Melissa A. Brown67, Michael Buckley68, Jo Burke69, Phyllis Butow70, Keith Byron71, David F. Callen72, Ian Campbell73, Christine L. Clarke74, Alison Colley75, Daniel Cotton76, Jisheng Cui77, Bronwyn Culling78, Margaret C. Cummings79, Sarah‐Jane Dawson58, Joanne Dixon80, Alexander Dobrovic81, Tracy Dudding‐Byth82, Ted Edkins83, Maurice Eisenbruch84, Gelareh Farshid85, Susan Fawcett86, Michael Field87, F A Firgaira88, Jean S. Fleming89, John Forbes90, Michael Friedlander91, Clara Gaff92, Mary D. Gardner92, Mike Gattas93, Peter George94, Grantley Gill95, Jack Goldblatt96, Sian Greening97, G. B. D. Scott88, Eric Haan98, Thomas van Overeem Hansen99, Stewart Hart100, Nicholas K. Hayward101, Edward W. Humphrey69, Mark A. Jenkins102, Alison Jones60, Richard Kefford103, Sandrine M. Caputo104, James Kollias105, С. П. Коваленко106, Sunil R. Lakhani107, Jennifer Leary104, Jacqueline Lim108, Geoffrey J. Lindeman109, Lara Lipton110, Liz Lobb111, Mariette Maclurcan112, Deborah J. Marsh113, R. Michael L. McKay99, A. Bowcock114, Bettina Meiser57, Gillian Mitchell99, Beth Newman115, Imelda O’Loughlin116, Richard H. Osborne117, Lester J. Peters118, Kelly‐Anne Phillips58, Jeanne Reeve119, Tony Reeve120, Robert I. Richards121, Gina Rinehart122, Bridget A. Robinson123, Barney Rudzki124, Elizabeth Salisbury125, Joe Sambrook73, Christobel Saunders126, Clare L. Scott58, Elizabeth Scott127, Rodney J. Scott82, R. Seshadri88, Andrew N. Shelling128, Graeme Suthers98, Donna Taylor129, Christopher Tennant108, Heather Thorne73, Sharron Townshend96, Kathy Tucker57, Janet Tyler57, Deon J. Venter130, Jane E. Visvader131, Ian Walpole96, Robyn L. Ward132, Paul Waring81, Beverley Warner133, Graham Warren116, Elizabeth E. Watson116, Rachael Williams134, Ju Lee Oei135, Ingrid Winship119, Mary Ann Young99, David D.L. Bowtell136, Adèle C. Green101, Anna deFazio137, Dorota M. Gertig117, Penelope M. Webb101, Anne‐Lise Børresen‐Dale109, Veli‐Matti Kosma109, Vesa Kataja110, Jaana M. Hartikainen109, Nicholas Day58, David R. Cox56, Bruce A.J. Ponder60
1Department of Public Health and Primary Care and,, CR‐UK Genetic Epidemiology Unit,
2Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK
3Perlegen Sciences, Inc., 2021 Stierlin Court, Mountain View, California 94043, USA.,
4Laboratory of Population Genetics, US National Cancer Institute, Bethesda, Maryland 20892, USA.,
5Department of Public Health and Primary Care, EPIC, University of Cambridge, Cambridge CB1 8RN, UK.,
6MRC Dunn Clinical Nutrition Centre, Cambridge CB2 0XY, UK.,
7Cancer Research UK Cambridge Research Institute, Cambridge CB2 0RE, UK
8Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.,
9Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii 96813, USA.,
10International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon 69008, France
11National Cancer Institute, Bangkok 10400, Thailand
12Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan
13Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, SO16 5YA, UK
14Regional Genetic Service, St Mary’s Hospital, Manchester M13 0JH, UK.,
15London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK, and Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK.,
16Breakthrough Breast Cancer Research Centre, London SW3 6JB, UK.,
17Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK
18Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.,
19Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia
20Departments of Clinical Biochemistry and,
21Breast Surgery, Herlev and Bispebjerg University Hospitals, University of Copenhagen, DK‐2730 Herlev, Denmark.,
22Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA.,
23Advanced Technology Center, National Cancer Institute, Gaithersburg, Maryland 20877, USA.,
24Cancer Center and M. Sklodowska‐Curie Institute of Oncology, Warsaw 02781, Poland.,
25Nofer Institute of Occupational Medicine, Lodz 90950, Poland.,
26Departments of Obstetrics and Gynecology and
27Department of Oncology, Helsinki University Central Hospital, Helsinki 00029, Finland.,
28Seoul National University College of Medicine, Seoul 151‐742, Korea.,
29Ulsan University College of Medicine, Ulsan 680‐749, Korea.,
30Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, 181 Longwood Ave., Boston, Massachusetts 02115, USA.,
31Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, 677 Huntington Ave., Boston, Massachusetts 02115, USA.,
32Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm SE‐171 77, Sweden.,
33Population Genetics, Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672, Republic of Singapore.,
34Department of Radiation Oncology; and
35Department of Gynecology and Obstetrics, Hannover Medical School, D‐30625 Hannover, Germany.,
36Department of Surgery and
37Department of Medical Decision Making and,
38Departments of Human Genetics and Pathology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, the Netherlands.,
39Department of Medical Oncology, Family Cancer Clinic, Erasmus MC‐Daniel den Hoed Cancer Center, Groene Hilledijk 301, 3075 EA Rotterdam, the Netherlands.,
40Division of Cancer Epidemiology and Genetics, Radiation Epidemiology Branch, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20892, USA.,
41Environmental Health Sciences, University of Minnesota, Minneapolis, Minnesota 55455, USA.,
42Institute for Cancer Studies and,
43Academic Unit of Surgical Oncology, Sheffield University Medical School, Sheffield S10 2RX, UK.,
44Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.
45Department of Clinical Genetics and
46Internal Medicine, Erasmus University, Rotterdam NL‐3015‐GE, the Netherlands.,
47Spanish National Cancer Centre (CNIO), Madrid E‐28029, Spain.,
48Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, University of Melbourne, Carlton, Victoria 3053, Australia.,
49Department of Preventive and Social Medicine, University of Otago, Dunedin, 9001 New Zealand
50Cancer Epidemiology Centre, Cancer Council Victoria, Carlton, Victoria 3053, Australia.,
51Department of Pathology, Genetic Epidemiology Laboratory, University of Melbourne, Parkville, Victoria 3052, Australia.,
52Dr. Margarete Fischer‐Bosch‐Institute of Clinical Pharamcology, 70376 Stuttgart and University of Tuebingen, 72074 Tuebingen, Germany.,
53Deutsches Krebsforschungszentrum, Heidelberg 69120, Germany
54Evangelische Kliniken Bonn gGmbH Johanniter Krankenhaus, 53113 Bonn, Germany.,
55Oncology Research Centre, Prince of Wales Hospital, Randwick, New South Wales 2031, Australia.,
56Genetic Health Services Victoria, Royal Children’s Hospital, Melbourne, Victoria 3050, Australia.,
57Hereditary Cancer Clinic, Prince of Wales Hospital, Randwick, New South Wales 2031, Australia.,
58Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria, 3002, Australia
59Anatomical Pathology, Royal Women’s Hospital, Carlton, Victoria 3053, Australia.,
60Molecular Genetics Laboratory, Royal Brisbane and Women’s Hospital, Herston, Queensland 4029, Australia.,
61Departments of Translational and Medical Oncology, Westmead Hospital, Westmead, New South Wales 2145, Australia.,
62Cancer Biology Laboratory, TVW Institute for Child Health Research, Subiaco, Western Australia 6008, Australia.,
63Silverton Place, 101 Wickham Terrace, Brisbane, Queensland 4000, Australia.,
64Department of Public Health and Community Medicine, University of Sydney, Sydney, New South Wales, 2006, Australia
65John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra, Australian Capital Territory 2601, Australia.,
66NSW Breast Cancer Institute, PO Box 143, Westmead, New South Wales 2145, Australia.,
67Department of Biochemistry, University of Queensland, St. Lucia, Queensland 4072, USA.,
68Molecular and Cytogenetics Unit, Prince of Wales Hospital, Randwick, New South Wales 2031, Australia.,
69Royal Hobart Hospital, GPO Box 1061L, Hobart, Tasmania 7001, Australia.,
70Medical Psychology Unit, Royal Prince Alfred Hospital, Camperdown, New South Wales 2204, Australia.,
71Australian Genome Research Facility, Walter & Eliza Hall Medical Research Institute, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia.,
72Dame Roma Mitchell Cancer Research Laboratories, University of Adelaide/Hanson Institute, PO Box 14, Rundle Mall, South Australia 5000, Australia.,
73Peter MacCallum Cancer Centre, St Andrew’s Place, East Melbourne, Victoria 3002, Australia.,
74Westmead Institute for Cancer Research, University of Sydney, Westmead Hospital ,Westmead, New South Wales 2145, Australia.,
75Department of Clinical Genetics, Liverpool Health Service, PO Box 103, Liverpool, New South Wales 2170, Australia.,
76Mutation Research Centre, St Vincent’s Hospital, Victoria Parade, Fitzroy, Victoria 3065, Australia.,
77Centre for Genetic Epidemiology, The University of Melbourne, Level 2 723 Swanston Street, Carlton, Victoria 3053, Australia.,
78Molecular and Clinical Genetics, Level 1 Building 65, Royal Prince Alfred Hospital, Camperdown, New South Wales 2050, Australia.,
79Department of Pathology, University of Queensland Medical School, Herston, New South Wales 4006, Australia.,
80Central Regional Genetic Services, Wellington Hospital, Private bag 7902, Wellington South 6039, New Zealand.,
81Molecular Department of Pathology, Peter MacCallum Cancer Centre, St Andrew’s Place, East Melbourne, Victoria 3002, Australia.,
82Hunter Genetics, Hunter Area Health Service, Waratah, New South Wales 2310, Australia.,
83Clinical Chemistry, Princess Margret Hospital for Children, Box D184, Perth, Western Australia 6001, Australia.,
84Department of Multicultural Health, University of Sydney, New South Wales 2052, Australia.,
85Tissue Pathology, Institute of Medical & Veterinary Science, Adelaide, South Australia 5000, Australia.,
86Family Cancer Clinic, Monash Medical Centre, Clayton, Victoria 3168, Australia.,
87Faculty of Medicine, Royal North Shore Hospital, Vindin House, St Leonards, New South Wales 2065, Australia.,
88Department of Haematology, Flinders Medical Centre, Bedford Park, South Australia 5042, Australia
89Eskitis Institute of Cell & Molecular Therapies, School of Biomolecular and Biomedical Sciences, Griffith University, Nathan, Queensland 4111, Australia.,
90Surgical Oncology, University of Newcastle, Newcastle Mater Hospital, Waratah, New South Wales 2298, Australia.,
91Department of Medical Oncology, Prince of Wales Hospital, Randwick, New South Wales 2031, Australia.,
92Victorian Clinical Genetics Service, Royal Melbourne Hospital, Parkville, Victoria 3052, Australia.,
93Queensland Clinical Genetic Service, Royal Children’s Hospital, Bramston Terrace, Herston, Queensland 4020, Australia.,
94Clinical Biochemistry Unit, Canterbury Health Labs, PO Box 151, Christchurch 8140, New Zealand.,
95Department of Surgery, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia.,
96Genetic Services of WA, King Edward Memorial Hospital, 374 Bagot Road, Subiaco, Western Australia 6008, Australia.,
97Wollongong Hereditary Cancer Clinic, Wollongong Public Hospital, Private Mail Bag 8808, South Coast Mail Centre, New South Wales 2521, Australia.,
98Department of Medical Genetics, Women’s and Children’s Hospital, North Adelaide, South Australia 5006, Australia.,
99Familial Cancer Clinic, Peter MacCallum Cancer Centre, St Andrew’s Place, East Melbourne, Victoria 3002, Australia.,
100Breast and Ovarian Cancer Genetics, Monash Medical Centre, 871 Centre Road, Bentleigh East, Victoria 3165, Australia.,
101Queensland Institute of Medical Research, Herston, Queensland 4006 Australia
102School of Population Health, The University of Melbourne, 723 Swanston Street, Carlton, Victoria 3053, Australia.,
103Medical Oncology, Westmead Hospital, Westmead, New South Wales 2145, Australia.,
104Department of Medicine, Familial Cancer Service, Westmead Hospital, Westmead, New South Wales 2145, Australia.,
105Breast Endocrine and Surgical Unit, Royal Adelaide Hospital, North Terrace, South Australia 5000, Australia.,
106Molecular Pathology Department, Southern Cross Pathology, Monash Medical Centre, Clayton, Victoria 3168, Australia.,
107Molecular and Cellular Pathology, The University of Queensland, Herston, Queensland 4006, Australia.,
108Department of Psychological Medicine, Royal North Shore Hospital, St Leonards, New South Wales 2065, Australia.,
109Breast Cancer Laboratory, Walter and Eliza Hall Institute, PO Royal Melbourne Hospital, Parkville, Victoria 3050, Australia.,
110Medical Oncology and Clinical Haematology Unit, Western Hospital, Footscray, Victoria 3011, Australia.,
111WA Centre for Cancer, Edith Cowan University, Churchlands, Western Australia 6018, Australia.,
112Department of Psychological Medicine, University of Sydney, New South Wales 2006, Australia.,
113Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, New South Wales 2065, Australia.,
114Department of Oncology, St Vincent’s Hospital, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia.,
115School of Public Health, Queensland University of Technology, Victoria Park, Kelvin Grove, Queensland 4059, Australia.,
116St Vincent’s Breast Clinic, PO Box 4751, Toowoomba, Queensland 4350, Australia.,
117Centre for Molecular Environmental, Genetic & Analytic Epidemiology, University of Melbourne, Melbourne, Victoria 3010, Australia.,
118Radiation Oncology, Peter MacCallum Cancer Centre, St Andrew’s Place, East Melbourne, Victoria 3002, Australia.,
119Genetic Services, Auckland Hospital, Private Bag 92024, Auckland 1142, New Zealand.,
120Cancer Genetics Laboratory, University of Otago, PO Box 56, Dunedin 9054, New Zealand.,
121Department of Cytogenetics and Molecular Genetics, Women and Children’s Hospital, Adelaide, South Australia 5006, Australia.,
122Hancock Family Breast Cancer Foundation, PO Locked Bag 2, West Perth, Western Australia 6005, Australia.,
123Oncology Service, Christchurch Hospital, Private Bag 4710, Christchurch 8140, New Zealand.,
124Molecular Pathology Institute of Medical and Veterinary Science, Frome Road, Adelaide, South Australia 5000, Australia.,
125Section of Cytology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, New South Wales 2145, Australia.,
126School of Surgery and Pathology, QE11 Medical Centre, M block 2nd Floor, Nedlands, Western Australia 6907, Australia.,
127South View Clinic, Suite 13, Level 3 South Street, Kogarah, New South Wales 2217, Australia.,
128Department of Obstetrics and Gynaecology, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
129Department of Radiology, Royal Perth Hospital, Box X2213, Perth 6011, Western Australia, Australia.,
130Murdoch Institute, Royal Children’s Hospital, Parkville, Victoria 3050, Australia.,
131Molecular Genetics of Cancer Division, Walter & Eliza Hall Medical Research Institute, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia.,
132Department of Medical Oncology, St Vincents Hospital, Darlinghurst, New South Wales 2010, Australia.,
133Cabrini Hospital, 183 Wattletree Road, Malvern, Victoria 3144, Australia.,
134Family Cancer Clinic, St Vincent’s Hospital, Darlinghurst, New South Wales 2010, Australia.,
135Medical Psychology Research Unit, Royal North Shore Hospital, St Leonards, New South Wales 2065, Australia.,
136Cancer Genomics & Biochemistry Laboratory, Peter MacCallum Cancer Centre, St Andrew’s Place, East Melbourne, Victoria 3002, Australia.,
137Obstetrics & Gynaecology, Westmead Hospital, University of Sydney, New South Wales 2006, Australia.,

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Nature

Tập 447 Số 7148

1087-1093

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