A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells

Cell - Tập 125 Số 2 - Trang 315-326 - 2006
B Bernstein1,2,3, Tarjei S. Mikkelsen1,4, Xiaohui Xie1, Michael Kamal1, Dana J. Huebert3, James Cuff1, Ben Fry1, Alex Meissner5, Marius Wernig5, Kathrin Plath5, Rudolf Jaenisch5, Alexandre Wagschal6, Robert Feil6, Stuart L. Schreiber1,7, Eric S. Lander1,5
1Broad Institute of Harvard and MIT, Cambridge, MA 02139, USA
2Department of Pathology, Harvard Medical School, Boston, MA 02115 USA
3Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA
4Division of Health Sciences and Technology, MIT, Cambridge, MA 02139, USA
5Whitehead Institute for Biomedical Research, MIT, Cambridge, MA 02139, USA
6Institute of Molecular Genetics, CNRS UMR-5535 and University of Montpellier-II, Montpellier, France
7Howard Hughes Medical Institute at the Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA

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