The Prevalence of Autistic Spectrum Disorder in Children Surveyed in a Tertiary Care Epilepsy Clinic

Epilepsia - Tập 46 Số 12 - Trang 1970-1977 - 2005
Dave Clarke1, Wendy Roberts2, Mina Daraksan2, Annie Dupuis2, Jane McCabe2, Halyey Wood2, O. Carter Snead2, Shelly K. Weiss2
1Department of Pediatrics, Division of Neurology, Le Bonheur, University of Tennessee Health Science Center Comprehensive Epilepsy Program, Memphis, Tennessee, U.S.A
2University of Toronto

Tóm tắt

Summary:  It is well documented that children with autistic spectrum disorder (ASD) have an increased prevalence of seizures; however, studies have not been done to evaluate the prevalence of ASD in children with epilepsy. This comorbidity is important to define as early diagnosis and intervention in some children with ASD has been shown to improve outcome. Method: Children with epilepsy seen in a tertiary care epilepsy clinic were evaluated using validated autism screening questionnaires (ASQ). In addition, questions about sleep‐related disorders, behavior, seizure characteristics, antiepileptic agents, and body mass index (BMI) were requested. An attempt was then made to determine if there was a correlation between the factors identified and ASD. Results: Of the 107 questionnaires returned, 97 ASQ's were properly completed and used in this study. Approximately 32% of children fit the ASQ criteria for having ASD. Most children had not been previously diagnosed. Worst behavior and daytime sleepiness was seen in those at greater risk (p < 0.01). Seizures also occurred earlier (approximately 2 years) in children at risk of having ASD. Conclusion: Though confirmatory diagnostic evaluations are needed, this questionnaire‐based study suggests that children with epilepsy are at greater risk of having ASD, and illustrates the need for more clinical vigilance. Behavioral difficulties and daytime sleepiness identified in these children could potentially affect their ability to learn. It is of interest that the age of seizure onset identified in those at greater risk corresponds with the approximate age of regression identified in some children with ASD.

Từ khóa


Tài liệu tham khảo

10.1002/ana.410150203

Caplan R, Epilepsy: a comprehensive textbook, 2125

10.1023/A:1021943802493

10.1056/NEJMp020062

10.1016/S0733-8619(03)00011-2

10.1038/sj.mp.4001162

10.1001/jama.289.1.49

10.1001/jama.285.24.3093

10.1001/archpsyc.60.5.524

10.1001/archneur.1988.00520300086024

10.1097/00004583-199001000-00020

10.1016/S0887-8994(00)00266-6

10.1016/S0002-7138(09)60447-7

10.1111/j.1469-7610.1992.tb00894.x

10.1542/peds.99.4.560

10.1016/S1474-4422(02)00160-6

10.1023/A:1022247903401

10.1093/brain/122.3.561

10.1016/S0887-8994(99)00029-6

Griesemer DA, 2001, Medlink neurology

10.1111/j.1469-7610.1989.tb00286.x

10.1016/S0887-8994(96)00251-2

10.1177/088307389901400208

10.1542/peds.107.5.1221

10.1542/peds.102.3.616

DahlRE.The impact of inadequate sleep on children's daytime cognitive function.1996;3:44–50.

10.1111/j.1528-1157.1999.tb02040.x

10.1016/j.yebeh.2004.06.004

10.1007/BF01980456

Hoshino Y, 1984, An investigation on the sleep disturbance of autistic children, Folia Psychiatr Neurol Jpn, 38, 45

10.1046/j.1440-1754.1998.00291.x

Dawson G, 1997, The effectiveness of early intervention, 307

McEachin JJ, 1993, Long term outcome for children with autism who received early intensive behavioral treatment, Am J Ment Retard, 97, 359

10.1192/bjp.175.5.444

10.1016/S1389-9457(99)00009-X

10.1017/S1092852900005708

10.1542/peds.104.3.405

10.1001/archneur.1996.00550090114017

10.1016/0887-8994(95)00185-I

10.1111/j.1469-8749.2003.tb00881.x

10.1002/mrdd.20021

10.1111/j.1469-8749.2001.tb00147.x

D'Amelio M, 2002, Epilepsy and developmental disabilities, 3

10.1016/S0387-7604(99)00119-9

10.1023/A:1023092627223

10.1023/A:1005407622050

10.1007/BF01377349

10.1076/1380-3395(200010)22:5;1-9;FT554

Thông tin
Thông tin xuất bản

Epilepsia

Tập 46 Số 12

1970-1977

Thông tin tác giả