The Role and Regulation of Adenosine in the Central Nervous System

Annual Review of Neuroscience - Tập 24 Số 1 - Trang 31-55 - 2001
Thomas V. Dunwiddie1,2, Susan A. Masino1,2
1Denver Veterans Administration Medical Center, Denver, Colorado, 80220
2Department of Pharmacology and Program in Neuroscience, University of Colorado Health Sciences Center, Denver, Colorado 80262;

Tóm tắt

▪ Abstract  Adenosine is a modulator that has a pervasive and generally inhibitory effect on neuronal activity. Tonic activation of adenosine receptors by adenosine that is normally present in the extracellular space in brain tissue leads to inhibitory effects that appear to be mediated by both adenosine A1and A2Areceptors. Relief from this tonic inhibition by receptor antagonists such as caffeine accounts for the excitatory actions of these agents. Characterization of the effects of adenosine receptor agonists and antagonists has led to numerous hypotheses concerning the role of this nucleoside. Previous work has established a role for adenosine in a diverse array of neural phenomena, which include regulation of sleep and the level of arousal, neuroprotection, regulation of seizure susceptibility, locomotor effects, analgesia, mediation of the effects of ethanol, and chronic drug use.

Từ khóa


Tài liệu tham khảo

10.1073/pnas.90.1.312

10.1016/0304-3940(89)90273-5

Andresen BT, 1999, J. Pharmacol. Exp. Ther., 291, 76

10.1111/j.1476-5381.1989.tb16886.x

10.1016/0006-8993(87)90428-8

10.1111/j.1748-1716.1991.tb09133.x

Barankiewicz J, 1997, J. Pharmacol. Exp. Ther., 283, 1230

10.1016/0304-3940(84)90118-6

10.1161/01.RES.35.2.262

10.1006/exnr.1999.7209

10.1016/S0896-6273(00)80082-3

10.1073/pnas.80.10.2829

10.1016/S0028-3908(97)00102-0

10.1523/JNEUROSCI.16-18-05603.1996

10.1097/00001756-199809140-00016

10.1016/0014-2999(95)00775-X

10.1523/JNEUROSCI.17-12-04509.1997

Carmichael FJ, 1991, J. Pharmacol. Exp. Ther., 259, 403

10.1139/bcb-76-5-761

10.1523/JNEUROSCI.19-21-09192.1999

10.1111/j.1476-5381.1992.tb14387.x

10.1111/j.1469-7793.1998.507bn.x

10.1111/j.1471-4159.1993.tb03256.x

10.1046/j.1471-4159.1994.63010207.x

10.1523/JNEUROSCI.18-06-01987.1998

Deckert J, 1994, J. Neural Transm. Suppl., 43, 23

10.1161/01.RES.81.2.154

10.1016/0165-0270(95)00119-0

Delaney SM, 1998, J. Pharmacol. Exp. Ther., 285, 561

Delle Donne KT, 1994, J. Pharmacol. Exp. Ther., 271, 1320

10.1016/S0014-2999(99)00132-6

10.1111/j.1749-6632.1991.tb33878.x

Dirnagl U, 1994, Am. J. Physiol., 267, H296

10.1111/j.1476-5381.1996.tb15561.x

10.1016/S0197-0186(96)00055-1

10.1016/0301-0082(88)90028-7

10.1111/j.1528-1157.1980.tb04305.x

10.1007/978-1-4615-4739-6_9

Dunwiddie TV. 1999b.Adenosine and suppression of seizures.InJasper's Basic Mechanisms of the Epilepsies, ed. A Delgado-Escueta, WA Wilson, RW Olsen, RJ Porter, pp. 1001–10. Philadelphia: Lippincott Williams & Wilkins

Dunwiddie TV, 1994, J. Pharmacol. Exp. Ther., 268, 537

10.1523/JNEUROSCI.17-02-00607.1997

10.1523/JNEUROSCI.17-20-07673.1997

10.1111/j.1476-5381.1980.tb10883.x

10.1523/JNEUROSCI.12-02-00506.1992

Dunwiddie TV, 1982, J. Pharmacol. Exp. Ther., 220, 70

10.1038/sj.bjp.0702881

10.1002/ana.410320504

10.1016/S0079-6123(08)63561-X

10.1038/sj.bjp.0703170

Feoktistov I, 1997, Pharm. Rev., 49, 381

10.1046/j.1365-2869.1997.00030.x

10.1152/jn.2000.83.3.1307

10.1016/0006-8993(89)90258-8

10.1007/BF00168775

10.1016/0304-3940(93)90648-5

10.1016/0304-3940(95)11920-R

10.1016/0024-3205(75)90299-4

10.1016/S0074-7742(08)60723-0

Fredholm BB, 1999, Pharm. Rev., 51, 83

10.1016/0165-6147(88)90194-0

10.1016/0014-2999(82)90629-X

10.1111/j.1748-1716.1978.tb06308.x

10.1016/S0304-3940(98)00121-9

10.1016/S0165-0173(97)00049-0

10.1016/S0306-4522(98)00011-6

10.1016/0896-6273(94)90319-0

10.1016/0006-8993(95)01313-X

10.1152/jn.1992.68.2.620

10.1016/0006-8993(90)90648-U

10.1016/0304-3940(93)90166-I

10.1016/S0006-8993(97)00364-8

10.1146/annurev.pa.35.040195.002545

10.1085/jgp.114.4.525

10.1006/jmcc.1998.0672

10.1016/0014-2999(89)90301-4

10.1073/pnas.92.10.4666

Ho IK, 1973, J. Pharmacol. Exp. Ther., 185, 336

10.1111/j.1471-4159.1990.tb13309.x

10.1096/fasebj.4.9.2161371

10.1016/0304-3940(94)90756-0

10.1016/0306-4522(96)00021-8

10.1038/jcbfm.1994.110

10.1016/S0014-2999(96)00905-3

Ko KR, 1990, Am. J. Physiol., 259, H1703

10.1073/pnas.81.20.6531

10.1517/13543784.9.3.551

Krauss SW, 1993, Mol. Pharmacol., 44, 1021

10.1161/01.RES.73.5.846

10.1038/sj.bjp.0702591

10.1016/0306-3623(96)00044-4

10.1038/41771

10.1111/j.1528-1157.1981.tb04129.x

10.1073/pnas.95.12.6995

Liang BT, 1999, Curr. Pharm. Design, 5, 1029, 10.2174/1381612805666230112212126

10.1002/(SICI)1520-6394(1997)5:1<21::AID-DA4>3.3.CO;2-A

10.1016/S0024-3205(98)00100-3

10.1016/0197-0186(94)00144-J

10.1016/0197-0186(93)90095-M

10.1523/JNEUROSCI.19-11-04238.1999

10.1113/jphysiol.1986.sp015923

10.1523/JNEUROSCI.18-16-06138.1998

10.1126/science.7916485

Marston HM, 1998, J. Pharmacol. Exp. Ther., 285, 1023

10.1097/00001756-199904060-00039

10.1523/JNEUROSCI.19-06-01932.1999

10.1016/S0304-3940(99)00693-X

10.1073/pnas.94.12.6541

10.1016/S0006-8993(99)02204-0

10.1097/00006123-199505000-00017

10.1523/JNEUROSCI.13-08-03439.1993

10.1046/j.1440-1681.1999.03003.x

Murray TF, 1992, Epilepsy Res. Suppl., 8, 255

10.1097/00001756-199911260-00014

10.1146/annurev.pa.35.040195.003053

10.1002/(SICI)1098-2299(199710)42:2<63::AID-DDR2>3.3.CO;2-O

10.1016/0028-3908(94)90142-2

10.1210/jcem-28-4-472

10.1111/j.1471-4159.1993.tb03566.x

10.1007/BF00169463

Phillis JW, 1989, Cerebrovasc. Brain Metab. Rev., 1, 26

10.1038/jcbfm.1987.122

10.1097/00004647-199912000-00002

10.3109/07853899908998788

10.1126/science.276.5316.1265

10.1016/S0306-4522(96)00640-9

10.1152/ajpcell.1996.270.2.C538

10.1042/bj1300975

Rabin RA, 1981, J. Pharmacol. Exp. Ther., 216, 129

10.1126/science.8303279

Ralevic V, 1998, Pharmacol. Rev., 50, 413

10.1097/00004647-199703000-00002

10.1016/0006-8993(95)00668-G

10.1046/j.1460-9568.1999.00569.x

10.1016/S0014-2999(97)01605-1

10.1016/0165-6147(89)90235-6

10.1016/0896-6273(92)90244-8

10.1007/BF00580977

10.1111/j.1749-6632.1997.tb48409.x

10.1097/00001573-199907000-00010

10.1523/JNEUROSCI.19-06-02347.1999

10.1161/01.CIR.98.7.711

10.1016/S0028-3908(99)00083-0

10.1523/JNEUROSCI.18-20-08153.1998

Sosnowski M, 1989, J. Pharmacol. Exp. Ther., 250, 915

10.1152/ajpheart.1997.273.1.H501

10.1002/ajmg.1320200116

10.1111/j.1476-5381.1981.tb16817.x

10.1016/0165-6147(89)90064-3

10.1016/0006-8993(90)90194-G

Sweeney MI, 1991, J. Pharmacol. Exp. Ther., 259, 1013

10.1016/0006-8993(93)91048-W

10.1016/0091-3057(91)90317-U

10.1073/pnas.82.14.4857

Wahl M, 1993, Acta Neurochir. Suppl., 59, 3

10.1046/j.1471-4159.1999.0720652.x

10.1038/267067a0

10.1038/jcbfm.1981.29

10.1161/01.RES.47.4.568

10.1016/S0166-2236(96)01015-6

10.1038/365256a0

10.1016/0304-3940(82)90338-X

10.1016/0304-3940(90)90588-Z

10.1016/0014-2999(94)90104-X

10.1016/S0925-4439(99)00111-8

10.1016/0306-4522(94)90545-2

10.1016/S0079-6123(08)63570-0

Thông tin
Thông tin xuất bản

Annual Review of Neuroscience

Tập 24 Số 1

31-55

Thông tin tác giả