Plant polyphenols in cancer and heart disease: implications as nutritional antioxidants

Nutrition Research Reviews - Tập 13 Số 1 - Trang 79-106 - 2000
Garry G. Duthie1, Susan J. Duthie1, Janet A. M. Kyle1
1Division of Cellular Integrity, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK

Tóm tắt

AbstractCertain dietary antioxidants such as vitamin E and vitamin C are important for maintaining optimum health. There is now much interest in polyphenolic products of the plant phenylpropanoid pathway as they have considerable antioxidant activityin vitroand are ubiquitous in our diet. Rich sources include tea, wine, fruits and vegetables although levels are affected by species, light, degree of ripeness, processing and storage. This confounds the formulation of databases for the estimation of dietary intakes. Most attention to date has focused on the flavonoids, a generic term which includes chalcones, flavones, flavanones, flavanols and anthocyanins. There is little convincing epidemiological evidence that intakes of polyphenols are inversely related to the incidence of cancer whereas a number of studies suggest that high intakes of flavonoids may be protective against CHD. In contrast, numerous cell culture and animal models indicate potent anticarcinogenic activity by certain polyphenols mediated through a range of mechanisms including antioxidant activity, enzyme modulation, gene expression, apoptosis, upregulation of gap junction communication and P-glycoprotein activation. Possible protective effects against heart disease may be due to the ability of some polyphenols to prevent the oxidation of LDL to an atherogenic form although anti-platelet aggregation activity and vasodilatory properties are also reported. However, some polyphenols are toxic in mammalian cells. Thus, until more is known about their bioavailability, metabolism and intracellular location, increasing intakes of polyphenols by supplements or food fortification may be unwise.

Từ khóa


Tài liệu tham khảo

10.1080/01635589609514482

10.1097/00006676-199801000-00003

10.1161/01.ATV.18.5.833

10.1016/0006-2952(94)90278-X

10.1172/JCI119735

10.3181/00379727-220-44377A

10.1097/00001813-199706000-00010

10.1007/978-1-4615-5335-9_17

10.1056/NEJM199708073370607

10.1093/ajcn/69.1.87

Chi, 1997, Effect of quercetin on the in vitro and in vivo growth of mouse hepatoma cells, Oncology Reports, 4, 1021

10.1021/jf970677e

10.1016/S0955-2863(96)00058-7

Siess, 1996, Time course of induction of rat hepatic drug-metabolizing enzyme activities following dietary administration of flavonoids, Journal of Toxicology and Environmental Health, 49, 481, 10.1080/009841096160709

10.1007/s11746-998-0036-5

10.1016/0140-6736(93)92876-U

10.2188/jea.8.168

Okushio, 1999, Identification of (–)-epicatechin metabolites and their metabolic fate in the rat, Drug Metabolism and Disposition, 27, 309

10.1016/S1360-1385(97)01018-2

10.1016/S0140-6736(79)92765-X

10.1093/mutage/9.3.193

10.1016/S0024-3205(99)00088-0

10.1016/0304-3835(81)90081-1

10.1097/00001813-199210000-00013

10.1016/0891-5849(92)90002-X

10.1021/jf00024a011

10.1016/S0278-6915(99)00079-4

10.1038/bjc.1995.518

10.1248/bpb.17.1567

10.1097/00041433-200002000-00007

10.1016/0006-2952(94)90040-X

10.1016/S0014-5793(99)00407-X

Ito, 1993, Effects of polyphenols, including flavonoids, on glutathione-S-transferase and glutathione-reductase, Bioscience, Biotechnology and Biochemistry, 57, 1678, 10.1271/bbb.57.1678

10.1016/0304-3835(94)90416-2

10.1016/S0271-5317(98)00183-3

10.7326/0003-4819-125-5-199609010-00005

Zhai, 1998, Comparative inhibition of human cytochromes P450 1a1 and 1a2 by flavonoids, Drug Metabolism and Disposition, 26, 989

Dewick, 1997, Medicinal Natural Products: A Biosynthetic Approach

10.1080/10715769800300281

10.1111/j.2042-7158.1997.tb06751.x

Kritz, 1997, Tea consumption, lipid metabolism and atherosclerosis, Weiner Klinische Wochenschrift, 109, 944

10.1093/carcin/17.11.2385

10.1021/jf960339y

10.3109/01902149809087391

10.1016/0031-6989(86)90159-1

10.1002/ptr.2650080711

10.1093/oxfordjournals.aje.a009738

10.1016/S0891-5849(99)00054-4

10.1021/jf00032a015

10.3109/10715769709065771

10.1093/ajcn/67.6.1210

10.1093/carcin/15.10.2325

10.1093/mutage/9.5.445

10.1080/01635589609514473

10.1016/S0304-3835(97)00311-X

10.1021/jf9809941

10.1007/BF01027170

10.1002/(SICI)1097-0010(19990315)79:4<561::AID-JSFA218>3.0.CO;2-X

10.1016/S0021-9150(97)00306-7

10.1021/jf00021a023

10.3181/00379727-220-44366

10.1016/S0378-4347(98)00509-X

10.1002/ijc.2910570214

10.1093/jn/128.6.1003

Nakayama, 1993, Suppression of active oxygen-induced cytotoxicity by flavonoids, Biochemical Pharmacology, 45, 265, 10.1016/0006-2952(93)90402-I

10.1016/0006-2952(93)90371-3

10.1007/BF00229567

10.1093/ajcn/61.3.549

10.1016/S0006-2952(97)00260-8

10.1007/978-3-642-46856-8_21

10.1039/a606499j

10.1159/000026224

10.1016/0304-3835(91)90122-X

10.1093/carcin/19.10.1771

10.1016/S0076-6879(99)99012-2

10.1016/0304-4165(69)90340-7

Verma, 1988, Inhibition of 7,12-dimethylbenz(a)anthracene-and N-nitrosomethylurea-induced rat mammary cancer by dietary flavonol quercetin, Cancer Research, 48, 5754

10.1016/S0002-8223(99)00051-6

10.1017/S000711459900080X

10.1093/jnci/89.24.1881

10.1096/fasebj.1.5.2824268

10.1042/bj1250024Pb

10.1016/S0165-1218(97)00010-4

10.1007/s11745-998-0258-y

10.1038/sj.ejcn.1600635

10.1002/jps.3030430613

10.1093/ajcn/66.5.1125

10.1016/0304-4165(65)90087-5

10.1016/S0306-9877(98)90273-0

10.1016/S0006-2952(97)00315-8

10.1016/S0021-9150(97)00305-5

10.1016/0887-2333(95)00060-L

10.1016/S0955-2863(98)00104-1

10.1016/S0891-5849(96)00383-8

10.1021/jf9809582

10.1016/0304-3835(94)90409-X

Whitehead, 1995, Effect of red wine ingestion on the antioxidant capacity of serum, Clinical Chemistry, 41, 32, 10.1093/clinchem/41.1.32

10.1007/BF01116239

10.1207/S15327914NC340112

Jackson, 1997, The assessment of bioavailability of micronutrients: Introduction, European Journal of Clinical Nutrition, 51, 51

10.1111/j.1753-4887.1998.tb01670.x

10.1021/jf981195l

Chesson, 1997, Polyphenols in Foods, 17

10.1016/S0021-9150(97)00139-1

Cao, 1999, Anthocyanins are detected in human plasma after oral administration of an elderberry extract, Clinical Chemistry, 45, 574, 10.1093/clinchem/45.4.574

10.1038/sj.ejcn.1600682

Chen, 1997, Absorption, distribution, elimination of tea polyphenols in rats, Drug Metabolism and Disposition, 25, 1045

10.1016/S0891-5849(99)00064-7

Combs, 1992, The Vitamins. Fundamental Aspects in Nutrition and Health

10.1016/0006-2952(94)90568-1

10.1111/j.1753-4887.1999.tb06951.x

10.1111/j.1749-6632.1998.tb09922.x

10.1007/978-3-642-67265-1_30

10.1093/ajcn/68.2.258

10.1016/S0024-3205(97)00230-0

10.1016/0300-483X(89)90116-9

10.1136/bmj.312.7029.478

10.1177/0748233793009001-216

10.1016/S0024-3205(99)00120-4

Dong, 1997, Quercetin induced apoptosis in human leukemia HL-60 cells, Acta Pharmacologica Sinica, 18, 280

10.1093/jn/129.9.1662

10.1016/S1383-5718(97)00107-1

10.1016/0304-3835(93)90077-M

10.1007/s003940050043

10.1093/mutage/12.4.289

10.1016/S0014-5793(97)01182-4

10.1111/j.1365-2621.1989.tb05143.x

10.1271/bbb.62.970

10.1016/0278-6915(95)00077-1

10.1016/0140-6736(93)90206-V

10.1007/s003940050056

10.1021/jf980755d

10.3164/jcbn.14.107

10.1001/archinte.159.18.2170

10.3109/00498259609046688

Graefe, 1999, Pharmacokinetics and bioavailability of the flavonol quercetin in humans, International Journal of Clinical Pharmacology and Therapeutics, 37, 219

10.1016/S0006-2952(97)00155-X

Harborne JB (1994) The Flavonoids: Advances in Research Since 1986. London: Chapman & Hall.

10.1161/01.ATV.17.11.2744

10.1080/01635589309514267

10.1080/01635589409514342

10.1001/archinte.1995.00430040053006

10.1093/ajcn/65.5.1489

10.1016/0024-3205(94)00641-5

10.1016/0304-3835(94)90312-3

10.1093/ajcn/62.6.1276

10.1016/S0753-3322(97)88045-6

10.1016/S0014-5793(97)01367-7

10.1016/S0304-3835(97)04644-2

10.1172/JCI117963

10.1093/ajcn/66.2.261

Katdare, 1998, Inhibition of aberrant proliferation and induction of apoptosis in pre-neoplastic human mammary epithelial cells by natural phytochemicals, Oncology Reports, 5, 311

10.1016/S0021-9150(98)00138-5

10.1093/jn/128.6.954

10.3181/00379727-220-44375

Blot, 1996, Tea and cancer: a review of the epidemiological evidence, European Journal of Cancer Prevention, 5, 425

10.1093/oxfordjournals.aje.a009257

10.1021/jf9810517

10.1007/BF01617836

10.3181/00379727-200-43429

Kuhnau, 1976, The flavonoids. A class of semi-essential food components: Their role in human nutrition, World Review of Nutrition and Dietetics, 24, 1117

10.1002/(SICI)1097-4644(1997)28/29+<39::AID-JCB5>3.0.CO;2-X

10.1017/S0029665199001330

10.1016/S0304-3835(96)04458-8

10.1016/S0014-5793(99)01160-6

10.1016/S0304-3835(97)00183-3

10.1016/S0304-3835(98)00108-6

Lagarrigue, 1995, Suppression of oncogene-induced transformation by quercetin and retinoic acid in rat liver epithelial cells, Cellular and Molecular Biology Research, 41, 551

10.1097/00041433-199902000-00005

10.1016/S0891-5849(96)00590-4

10.1007/BF01220800

10.3109/00498259509061876

10.1093/jn/125.7.1911

Melzig, 1997, Effect of flavonoids on daunomycin-induced toxicity in cultivated endothelial cells, Pharmazie, 52, 793

10.1248/bpb.21.93

10.1093/carcin/3.1.93

10.1016/S0378-4347(99)00520-4

10.1177/096032719701601202

10.1079/BJN19980106

10.1254/jjp.65.371

10.1007/BF02790104

Ngomuo, 1996, Genotoxicity studies of quercetin and shikimate in vivo in the bone marrow of mice and gastric mucosal cells of rats, Veterinary and Human Toxicology, 38, 176

10.1016/S0027-5107(97)00300-X

10.1016/S0304-3835(97)04655-7

10.1056/NEJM199605023341802

Parshad, 1998, Protective action of plant polyphenols on radiation-induced chromatid breaks in cultured human cells, Anticancer Research, 18, 3263

10.1093/ajcn/68.2.220

10.1016/S0271-5317(98)00169-9

Plaumann, 1996, Flavonoids activate wild-type p53, Oncogene, 13, 1605

10.1248/bpb.18.1

10.1023/A:1012197110917

10.1016/S0140-6736(97)01234-8

10.1016/0140-6736(92)91277-F

10.1002/(SICI)1097-0215(19971210)73:6<880::AID-IJC20>3.0.CO;2-7

10.1080/07315724.1999.10718841

10.1016/0304-3835(94)90269-0

10.1016/0304-3835(91)90026-E

10.1002/tcm.1770010209

10.1007/BF00685655

10.1093/carcin/15.8.1627

Serafini, 1996, In vivo antioxidant effect of green and black tea in man, European Journal of Clinical Nutrition, 50, 28

10.1016/S0891-5849(98)00040-9

10.1016/S0014-5793(98)01304-0

10.1042/bj2220001

10.1002/jsfa.2740261002

10.1074/jbc.272.34.20963

Uddin, 1995, Quercetin, a bioflavonoid, inhibits the DNA synthesis of human leukemia cells, Biochemistry amd Molecular Biology International, 36, 545

10.1093/carcin/18.12.2353

10.1007/s003940050061

10.1016/0021-9150(95)05763-3

Westhuyzen, 1997, The oxidation hypothesis of atherosclerosis: an update, Annals of Clinical and Laboratory Science, 27, 1

10.1177/000456329803500105

10.1016/S0940-2993(97)80096-6

10.1007/BF02435010

10.1165/ajrcmb.17.1.2728

10.1093/jn/128.9.1495

Thông tin
Thông tin xuất bản

Nutrition Research Reviews

Tập 13 Số 1

79-106

Thông tin tác giả