Hepatic ischemia and reperfusion injury: Effects on the liver sinusoidal milieu

Journal of Hepatology - Tập 59 Số 5 - Trang 1094-1106 - 2013
Carmen Peralta1, Mónica B. Jiménez‐Castro1, Jordi Gracia‐Sancho2
1Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain
2Barcelona Hepatic Hemodynamic Laboratory, IDIBAPS, CIBEREHD, Barcelona, Spain

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Selzner, 2003, Protective strategies against ischemic injury of the liver, Gastroenterology, 125, 917, 10.1016/S0016-5085(03)01048-5

Montalvo-Jave, 2008, Factors in the pathophysiology of the liver ischemia-reperfusion injury, J Surg Res, 147, 153, 10.1016/j.jss.2007.06.015

Jaeschke, 2003, Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning, Am J Physiol Gastrointest Liver Physiol, 284, G15, 10.1152/ajpgi.00342.2002

Gracia-Sancho, 2010, Flow cessation triggers endothelial dysfunction during organ cold storage conditions: strategies for pharmacologic intervention, Transplantation, 90, 142, 10.1097/TP.0b013e3181e228db

Gasbarrini, 1992, Effect of anoxia on intracellular ATP, Na+i, Ca2+i, Mg2+i, and cytotoxicity in rat hepatocytes, J Biol Chem, 267, 6654, 10.1016/S0021-9258(19)50477-X

Peralta, 2000, Hepatic preconditioning preserves energy metabolism during sustained ischemia, Am J Physiol Gastrointest Liver Physiol, 279, G163, 10.1152/ajpgi.2000.279.1.G163

Caraceni, 2005, The reduced tolerance of rat fatty liver to ischemia reperfusion is associated with mitochondrial oxidative injury, J Surg Res, 124, 160, 10.1016/j.jss.2004.10.007

Wisse, 1972, An ultrastructural characterization of the endothelial cell in the rat liver sinusoid under normal and various experimental conditions, as a contribution to the distinction between endothelial and Kupffer cells, J Ultrastruct Res, 38, 528, 10.1016/0022-5320(72)90089-5

Caldwell-Kenkel, 1988, Selective loss of nonparenchymal cell viability after cold ischemic storage of rat livers, Transplantation, 45, 834, 10.1097/00007890-198804000-00041

Vollmar, 1994, Hepatic microcirculatory perfusion failure is a determinant of liver dysfunction in warm ischemia-reperfusion, Am J Pathol, 145, 1421

Serracino-Inglott, 2001, Hepatic ischemia-reperfusion injury, Am J Surg, 181, 160, 10.1016/S0002-9610(00)00573-0

Cywes, 1993, Role of platelets in hepatic allograft preservation injury in the rat, Hepatology, 18, 635, 10.1002/hep.1840180324

Clemens, 1999, Nitric oxide in liver injury, Hepatology, 30, 1, 10.1002/hep.510300148

Russo, 2012, Addition of simvastatin to cold storage solution prevents endothelial dysfunction in explanted rat livers, Hepatology, 55, 921, 10.1002/hep.24755

Huang, 2011, Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll-like receptor 9 in mice, Hepatology, 54, 999, 10.1002/hep.24501

Van Bossuyt, 1988, Structural changes produced in kupffer cells in the rat liver by injection of lipopolysaccharide, Cell Tissue Res, 251, 205, 10.1007/BF00215466

Bilzer, 2000, Preservation injury of the liver: mechanisms and novel therapeutic strategies, J Hepatol, 32, 508, 10.1016/S0168-8278(00)80404-3

Lentsch, 2000, Inflammatory mechanisms and therapeutic strategies for warm hepatic ischemia/reperfusion injury, Hepatology, 32, 169, 10.1053/jhep.2000.9323

Witthaut, 1994, Complement and tumor necrosis factor-alpha contribute to Mac-1 (CD11b/CD18) up-regulation and systemic neutrophil activation during endotoxemia in vivo, J Leukoc Biol, 55, 105, 10.1002/jlb.55.1.105

Perry, 2011, Tumor necrosis factor-α in liver ischemia/reperfusion injury, J Invest Surg, 24, 178, 10.3109/08941939.2011.568594

Peralta, 2001, Preconditioning protects against systemic disorders associated with hepatic ischemia-reperfusion through blockade of tumor necrosis factor-induced P-selectin up-regulation in the rat, Hepatology, 33, 100, 10.1053/jhep.2001.20529

Teoh, 2003, Hepatic ischemia reperfusion injury: pathogenic mechanisms and basis for hepatoprotection, J Gastroenterol Hepatol, 18, 891, 10.1046/j.1440-1746.2003.03056.x

Casillas-Ramírez, 2006, Past and future approaches to ischemia-reperfusion lesion associated with liver transplantation, Life Sci, 79, 1881, 10.1016/j.lfs.2006.06.024

Lesurtel, 2006, Platelet-derived serotonin mediates liver regeneration, Science, 312, 104, 10.1126/science.1123842

Sindram, 2000, Platelets induce sinusoidal endothelial cell apoptosis upon reperfusion of the cold ischemic rat liver, Gastroenterology, 118, 183, 10.1016/S0016-5085(00)70427-6

Rauen, 1997, Involvement of reactive oxygen species in the preservation injury to cultured liver endothelial cells, Free Radic Biol Med, 22, 17, 10.1016/S0891-5849(96)00273-0

Nishimura Y, Takei Y, Kawano S, Goto M, Nagai H, Ohmae A, et al. Expression of ICAM-1 is involved in the mechanism of liver injury after orthotopic liver transplantation. In: Wisse E, Knook DL, Wake K, editors. Cells of the hepatic sinusoid, vol. 5; 1994. p. 231–233.

Upadhya, 2003, Effect of cold preservation on intracellular calcium concentration and calpain activity in rat sinusoidal endothelial cells, Hepatology, 37, 313, 10.1053/jhep.2003.50069

Lasnier E, Blanc MC, Roch-Arveiller M, Housset C. Interaction between polymorphonuclear leukocytes and hepatic sinusoidal endothelial cells. Role of elastase. In: Wisse E, Knook DL, de Zanger R, Fraser R, editors. Cells of the hepatic sinusoid, vol. 7; 1998, p. 125–126.

Yuan, 2010, Machine perfusion or cold storage in organ transplantation: indication, mechanisms, and future perspectives, Transpl Int, 23, 561, 10.1111/j.1432-2277.2009.01047.x

Fondevila, 2011, Superior preservation of DCD livers with continuous normothermic perfusion, Ann Surg, 254, 1000, 10.1097/SLA.0b013e31822b8b2f

García-Valdecasas, 2010, In-vivo normothermic recirculation: an update, Curr Opin Organ Transplant, 15, 173, 10.1097/MOT.0b013e3283373488

Wanner, 1996, Liver ischemia and reperfusion induces a systemic inflammatory response through Kupffer cell activation, Shock, 5, 34, 10.1097/00024382-199601000-00008

Bradham, 1999, Activation of nuclear factor-kappaB during orthotopic liver transplantation in rats is protective and does not require Kupffer cells, Liver Transpl Surg, 5, 282, 10.1002/lt.500050401

Cutrin, 2002, Microvascular dysfunction induced by reperfusion injury and protective effect of ischemic preconditioning, Free Radic Biol Med, 33, 1200, 10.1016/S0891-5849(02)01017-1

Peralta, 2001, Preconditioning protects against systemic disorders associated with hepatic ischemia-reperfusion through blockade of tumor necrosis factor-induced P-selectin up-regulation in the rat, Hepatology, 33, 100, 10.1053/jhep.2001.20529

Jaeschke, 1996, Preservation injury: mechanisms, prevention and consequences, J Hepatol, 25, 774, 10.1016/S0168-8278(96)80253-4

Farhood, 1995, Intercellular adhesion molecule 1 (ICAM-1) expression and its role in neutrophil-induced ischemia-reperfusion injury in rat liver, J Leukoc Biol, 57, 368, 10.1002/jlb.57.3.368

Essani, 1998, Increased P-selectin gene expression in the liver vasculature and its role in the pathophysiology of neutrophil-induced liver injury in murine endotoxin shock, J Leukoc Biol, 63, 288, 10.1002/jlb.63.3.288

Amersi, 2001, A novel iron chelator in combination with a P-selectin antagonist prevents ischemia/reperfusion injury in a rat liver model, Transplantation, 71, 112, 10.1097/00007890-200101150-00018

Kubes, 2002, Molecular mechanisms of leukocyte recruitment in postischemic liver microcirculation, Am J Physiol Gastrointest Liver Physiol, 283, G139, 10.1152/ajpgi.00058.2002

Ikeda, 1992, Ischemic injury in liver transplantation: difference in injury sites between warm and cold ischemia in rats, Hepatology, 16, 454, 10.1002/hep.1840160226

Caldwell-Kenkel, 1989, Reperfusion injury to endothelial cells following cold ischemic storage of rat livers, Hepatology, 10, 292, 10.1002/hep.1840100307

Gonzalez-Flecha, 1993, Time course and mechanism of oxidative stress and tissue damage in rat liver subjected to in vivo ischemia-reperfusion, J Clin Invest, 91, 456, 10.1172/JCI116223

Pazo, 2002, Primary culture of rat hepatocytes after cold storage in the university of wisconsin solution: a tool to study the effects of hypothermic preservation, Cell Preservation Technol, 1, 189, 10.1089/153834402765035626

Fernández, 2002, Preconditioning protects liver and lung damage in rat liver transplantation: role of xanthine/xanthine oxidase, Hepatology, 36, 562, 10.1053/jhep.2002.34616

Reinders, 1996, Hyaluronic acid uptake in the assessment of sinusoidal endothelial cell damage after cold storage and normothermic reperfusion of rat livers, Transpl Int, 9, 446, 10.1111/j.1432-2277.1996.tb00987.x

Rauen, 1993, Energy-dependent injury to cultured sinusoidal endothelial cells of the rat liver in UW solution, Transplantation, 55, 469, 10.1097/00007890-199303000-00002

Kukan, 2001, Role of hepatocytes and bile duct cells in preservation-reperfusion injury of liver grafts, Liver Transpl, 7, 381, 10.1053/jlts.2001.23913

Vajdova, 2002, ATP-supplies in the cold-preserved liver: a long-neglected factor of organ viability, Hepatology, 36, 1543, 10.1002/hep.1840360633

Hasselgren, 1982, No beneficial affect of ATP-MgCl2 on impaired transmembrane potential and protein synthesis in liver ischemia, Acta Chir Scand, 148, 601

Clemens, 1985, Hepatic microcirculatory failure after ischemia and reperfusion: improvement with ATP-MgCl2 treatment, Am J Physiol, 248, H804

Anderson, 1984, Hepatic “no reflow” following transient ischemia, Circ Shock, 13, 103

Gao, 1998, Apoptosis of sinusoidal endothelial cells is a critical mechanism of preservation injury in rat liver transplantation, Hepatology, 27, 1652, 10.1002/hep.510270626

Kohli, 1999, Endothelial cell and hepatocyte deaths occur by apoptosis after ischemia-reperfusion injury in the rat liver, Transplantation, 67, 1099, 10.1097/00007890-199904270-00003

Theruvath, 2008, C-Jun N-terminal kinase 2 promotes graft injury via the mitochondrial permeability transition after mouse liver transplantation, Am J Transplant, 8, 1819, 10.1111/j.1600-6143.2008.02336.x

Rauen, 2003, Cold-induced apoptosis of hepatocytes: mitochondrial permeability transition triggered by nonmitochondrial chelatable iron, Free Radic Biol Med, 35, 1664, 10.1016/j.freeradbiomed.2003.09.018

Massip-Salcedo, 2007, The response of the hepatocyte to ischemia, Liver Int, 27, 6, 10.1111/j.1478-3231.2006.01390.x

Lemasters, 1999, V. Necrapoptosis and the mitochondrial permeability transition: shared pathways to necrosis and apoptosis, Am J Physiol, 276, G1

Grazi, 2001, A revised consideration on the use of very aged donors for liver transplantation, Am J Transplant, 1, 61, 10.1034/j.1600-6143.2001.010112.x

Fernandez, 2004, Is ischemic preconditioning a useful strategy in steatotic liver transplantation?, Am J Transplant, 4, 888, 10.1111/j.1600-6143.2004.00447.x

Zamboni, 2001, Effect of macrovescicular steatosis and other donor and recipient characteristics on the outcome of liver transplantation, Clin Transplant, 15, 53, 10.1034/j.1399-0012.2001.150109.x

Busuttil, 2003, The utility of marginal donors in liver transplantation, Liver transpl, 9, 651, 10.1053/jlts.2003.50105

Busquets, 2001, The impact of donor age on liver transplantation: influence of donor age on early liver function and on subsequent patient and graft survival, Transplantation, 71, 1765, 10.1097/00007890-200106270-00011

Stadler, 2005, Effect of nutritional status on oxidative stress in an ex vivo perfused rat liver, Anesthesiology, 103, 978, 10.1097/00000542-200511000-00012

Cywes, 1992, Effect of intraportal glucose infusion on hepatic glycogen content and degradation, and outcome of liver transplantation, Ann Surg, 216, 235, 10.1097/00000658-199209000-00003

Domenicali, 2005, Oxidative injury in rat fatty liver exposed to ischemia-reperfusion is modulated by nutritional status, Dig Liver Dis, 37, 689, 10.1016/j.dld.2005.04.015

Sankary, 1995, Inactivation of Kupffer cells after prolonged donor fasting improves viability of transplanted hepatic allografts, Hepatology, 22, 1236, 10.1002/hep.1840220432

Okaya, 2005, Age-dependent responses to hepatic ischemia/reperfusion injury, Shock, 24, 421, 10.1097/01.shk.0000181282.14050.11

Gasbarrini, 1998, Chemiluminescent real time imaging of post-ischemic oxygen free radicals formation in livers isolated from young and old rats, Free Radic Biol Med, 24, 211, 10.1016/S0891-5849(97)00056-7

Gracia-Sancho, 2013, Simvastatin maintains function and viability of steatotic rat livers procured for transplantation, J Hepatol, 58, 1140, 10.1016/j.jhep.2013.02.005

Ijaz, 2003, Impairment of hepatic microcirculation in fatty liver, Microcirculation, 10, 447, 10.1038/sj.mn.7800206

Selzner, 2000, Mechanisms of ischemic injury are different in the steatotic and normal rat liver, Hepatology, 32, 1280, 10.1053/jhep.2000.20528

Nardo, 2001, Increased generation of reactive oxygen species in isolated rat fatty liver during postischemic reoxygenation, Transplantation, 71, 1816, 10.1097/00007890-200106270-00018

Evans, 2012, Mitochondrial uncoupling protein-2 deficiency protects steatotic mouse hepatocytes from hypoxia/reoxygenation, Am J Physiol Gastrointest Liver Physiol, 302, G336, 10.1152/ajpgi.00049.2011

Carrasco-Chaumel, 2005, Adenosine monophosphate-activated protein kinase and nitric oxide in rat steatotic liver transplantation, J Hepatol, 43, 997, 10.1016/j.jhep.2005.05.021

Massip-Salcedo, 2006, Heat shock proteins and mitogen-activated protein kinases in steatotic livers undergoing ischemia-reperfusion: some answers, Am J Pathol, 168, 1474, 10.2353/ajpath.2006.050645

Ben Mosbah, 2010, Endoplasmic reticulum stress inhibition protects steatotic and non-steatotic livers in partial hepatectomy under ischemia-reperfusion, Cell Death Dis, 1, e52, 10.1038/cddis.2010.29

Alfany-Fernández, 2009, Therapeutic targets in liver transplantation: angiotensin II in nonsteatotic grafts and angiotensin-(1–7) in steatotic grafts, Am J Transplant, 9, 439, 10.1111/j.1600-6143.2008.02521.x

Casillas-Ramírez, 2011, Retinol-binding protein 4 and peroxisome proliferator-activated receptor-γ in steatotic liver transplantation, J Pharmacol Exp Ther, 338, 143, 10.1124/jpet.110.177691

Massip-Salcedo, 2008, Activation of peroxisome proliferator-activated receptor-alpha inhibits the injurious effects of adiponectin in rat steatotic liver undergoing ischemia-reperfusion, Hepatology, 47, 461, 10.1002/hep.21935

Serafin, 2004, Ischemic preconditioning affects interleukin release in fatty livers of rats undergoing ischemia/reperfusion, Hepatology, 39, 688, 10.1002/hep.20089

Gao, 1995, Primary nonfunction of fatty livers produced by alcohol is associated with a new, antioxidant-insensitive free radical species, Transplantation, 59, 674, 10.1097/00007890-199503150-00005

Yamada, 2000, Alcoholic fatty liver differentially induces a neutrophil-chemokine and hepatic necrosis after ischemia-reperfusion in rat, Hepatology, 32, 278, 10.1053/jhep.2000.9604

Jaeschke, 2012, Current strategies to minimize hepatic ischemia-reperfusion injury by targeting reactive oxygen species, Transplant Rev, 26, 103, 10.1016/j.trre.2011.10.006

Iñiguez, 2008, Novel pharmacologic strategies to protect the liver from ischemia-reperfusion injury, Recent Pat Cardiovasc Drug Discov, 3, 9, 10.2174/157489008783331643

Shi, 2012, Sphingosine kinase-2 inhibition improves mitochondrial function and survival after hepatic ischemia-reperfusion, J Hepatol, 56, 137, 10.1016/j.jhep.2011.05.025

Liu, 2008, Protective effects of apocynin and allopurinol on ischemia/reperfusion-induced liver injury in mice, World J Gastroenterol, 14, 2832, 10.3748/wjg.14.2832

Ramalho, 2009, Are angiotensin II receptor antagonists useful strategies in steatotic and nonsteatotic livers in conditions of partial hepatectomy under ischemia-reperfusion?, J Pharmacol Exp Ther, 329, 130, 10.1124/jpet.108.147835

Ichiki, 2008, Ascorbate inhibits apoptosis of Kupffer cells during warm ischemia/reperfusion injury, Hepatogastroenterology, 55, 338

Llacuna, 2011, Targeting colesterol at different levels in the mevalonate pathway protects fatty liver against ischemia-reperfusion injury, J Hepatol, 54, 1002, 10.1016/j.jhep.2010.08.031

Ajamieh, 2012, Atorvastatin protects obese mice against hepatic ischemia-reperfusion injury by Toll-like receptor-4 suppression and endothelial nitric oxide synthase activation, J Gastroenterol Hepatol, 27, 1353, 10.1111/j.1440-1746.2012.07123.x

Dal Ponte, 2011, Pharmacological postconditioning protects against hepatic ischemia/reperfusion injury, Liver Transpl, 17, 474, 10.1002/lt.22256

Casillas-Ramirez, 2008, Inhibition of angiotensin II action protects rat steatotic livers against ischemia-reperfusion injury, Crit Care Med, 36, 1256, 10.1097/CCM.0b013e31816a023c

Aguilar-Melero, 2013, Cardiotrophin-1 reduces ischemia/reperfusion injury during liver transplant, J Surg Res, 181, e83, 10.1016/j.jss.2012.07.046

Wei, 2010, Carbon monoxide-releasing molecule-2 (CORM-2) attenuates acute hepatic ischemia reperfusion injury in rats, BMC Gastroenterol, 10, 42, 10.1186/1471-230X-10-42

Casillas-Ramírez, 2009, Insulin-like growth factor and epidermal growth factor treatment: new approaches to protecting steatotic livers against ischemia-reperfusion injury, Endocrinology, 150, 3153, 10.1210/en.2008-1458

Hochhauser, 2008, Recombinant human erythropoietin attenuates hepatic injury induced by ischemia/reperfusion in an isolated mouse liver model, Apoptosis, 13, 77, 10.1007/s10495-007-0155-8

Yang, 2012, 17β-Estradiol protects the liver against cold ischemia/reperfusion injury through the Akt kinase pathway, J Surg Res, 178, 996, 10.1016/j.jss.2012.07.007

Kuroda, 2012, Rho inhibitor prevents ischemia-reperfusion injury in rat steatotic liver, J Hepatol, 56, 146, 10.1016/j.jhep.2011.04.029

Jiang, 2011, Allograft inflammatory factor-1 is up-regulated in warm and cold ischemia-reperfusion injury in rat liver and may be inhibited by FK506, J Surg Res, 165, 158, 10.1016/j.jss.2009.05.038

Lehne, 2013, Metabolic preconditioning with fructose prior to organ recovery attenuates ischemia-reperfusion injury in the isolated perfused rat liver, Scand J Gastroenterol, 48, 218, 10.3109/00365521.2012.741618

Xue, 2010, Protective effects of HGF-MSP chimer (metron factor-1) on liver ischemia-reperfusion injury in rat model, J Dig Dis, 11, 299, 10.1111/j.1751-2980.2010.00453.x

Jiménez-Castro, 2012, Tauroursodeoxycholic acid affects PPARã and TLR4 in steatotic liver transplantation, Am J Transplant, 12, 3257, 10.1111/j.1600-6143.2012.04261.x

Zúñiga, 2011, N-3 PUFA supplementation triggers PPAR-α activation and PPAR-α/NF-κB interaction: anti-inflammatory implications in liver ischemia-reperfusion injury, PLoS One, 6, e28502, 10.1371/journal.pone.0028502

Ocuin, 2012, Nilotinib protects the murine liver from ischemia/reperfusion injury, J Hepatol, 57, 766, 10.1016/j.jhep.2012.05.012

Li, 2013, Shock, 39, 197, 10.1097/SHK.0b013e3182814483

Elias-Miró, 2012, Retinol binding protein 4 and retinol in steatotic and nonsteatotic rat livers in the setting of partial hepatectomy under ischemia/reperfusion, Liver Transpl, 18, 1198, 10.1002/lt.23489

Schmeding, 2010, RHuEPo reduces ischemia-reperfusion injury and improves survival after transplantation of fatty livers in rats, Transplantation, 89, 161, 10.1097/TP.0b013e3181c425fd

Zhang, 2013, Targeting TIM-1 on CD4 T cells depresses macrophage activation and overcomes ischemia-reperfusion injury in mouse orthotopic liver transplantation, Am J Transplant, 13, 56, 10.1111/j.1600-6143.2012.04316.x

Hide, 2013, A novel recombinant form of the manganese superoxide dismutase protects rat liver grafts procured for transplantation, J Hepatol, 58, S231, 10.1016/S0168-8278(13)60565-6

Busuttil, 2011, RPSGL-Ig for improvement of early liver allograft function: a double-blind, placebo-controlled, single-center phase II study, Am J Transplant, 11, 786, 10.1111/j.1600-6143.2011.03441.x

Beck-Schimmer, 2012, Protection of pharmacological postconditioning in liver surgery: results of a prospective randomized controlled trial, Ann Surg, 256, 837, 10.1097/SLA.0b013e318272df7c

Liu, 2010, Sirolimus attenuates reduced-size liver ischemia-reperfusion injury but impairs liver regeneration in rats, Dig Dis Sci, 55, 2255, 10.1007/s10620-009-1002-2

Jiménez-Castro, 2011, Cyclic adenosine 3′,5′-monophosphate in rat steatotic liver transplantation, Liver transpl, 17, 1099

López-Neblina, 2008, Anti-ischemic effect of selectin blocker through modulation of tumor necrosis factor-alpha and interleukin-10, J Surg Res, 138, 275, 10.1016/j.jss.2006.04.012

Hassan-Khabbar, 2008, Postischemic treatment by trans-resveratrol in rat liver ischemia-reperfusion: a possible strategy in liver surgery, Liver Transpl, 14, 451, 10.1002/lt.21405

Cheng, 2008, Effects of tetrandrine on ischemia/reperfusion injury in mouse liver, Transplant Proc, 40, 2163, 10.1016/j.transproceed.2008.07.082

Xu, 2008, Effects of Wy-14,643 on hepatic ischemia reperfusion injury in rats, World J Gastroenterol, 14, 6936, 10.3748/wjg.14.6936

Teoh, 2010, Short-term therapy with peroxisome proliferation-activator receptor-alpha agonist Wy-14,643 protects murine fatty liver against ischemia-reperfusion injury, Hepatology, 51, 996

Kuriyama, 2010, The cytoprotective effects of addition of activated protein C into preservation solution on small-for-size grafts in rats, Liver Transpl, 16, 1, 10.1002/lt.21923

Ben Mosbah, 2010, Addition of carvedilol to University Wisconsin solution improves rat steatotic and nonsteatotic liver preservation, Liver Transpl, 16, 163, 10.1002/lt.21968

Zaouali, 2010, Improved rat steatotic and nonsteatotic liver preservation by the addition of epidermal growth factor and insulin-like growth factor-I to University of Wisconsin solution, Liver Transpl, 16, 1098, 10.1002/lt.22126

Bezinover, 2012, Use of a third-generation perfluorocarbon for preservation of rat DCD liver grafts, J Surg Res, 175, 131, 10.1016/j.jss.2011.02.046

Abbas, 2010, Polyethylene glycol modified-albumin enhances the cold preservation properties of University of Wisconsin solution in rat liver and a hepatocyte cell line, J Surg Res, 164, 95, 10.1016/j.jss.2009.03.030

Defamie, 2008, Matrix metalloproteinase inhibition protects rat livers from prolonged cold ischemia-warm reperfusion injury, Hepatology, 47, 177, 10.1002/hep.21929

Yue, 2010, Effect of fusion protein TAT and heme oxygenase-1 on liver sinusoidal endothelial cells apoptosis during preservation injury, Chin Med J (Engl), 123, 68

Anderson, 2011, Endoplasmic reticulum stress is a mediator of posttransplant injury in severly steatotic liver allografts, Liver Transplant, 17, 189, 10.1002/lt.22220

Saito, 2013, The protective effect of adipose-derived stem cells against liver injury by trophic molecules, J Surg Res, 180, 162, 10.1016/j.jss.2012.10.009

Sun, 2012, Systemic administration of autologous adipose-derived mesenchymal stem cells alleviates hepatic ischemia-reperfusion injury in rats, Crit Care Med, 40, 1279, 10.1097/CCM.0b013e31823dae23

Selzner, 2012, FGL2/fibroleukin mediates hepatic reperfusion injury by induction of sinusoidal endothelial cell and hepatocyte apoptosis in mice, J Hepatol, 56, 153, 10.1016/j.jhep.2011.05.033

Watanabe, 2012, Transfection of naked nuclear factor-κB decoy oligodeoxynucleotides into liver by rapid portal vein infusion in rats: its effect on ischemia-reperfusion injury of liver, Hum Gene Ther, 23, 428, 10.1089/hum.2011.151

Schneider, 2010, Loss or silencing of the PHD1 prolyl hydroxylase protects livers of mice against ischemia/reperfusion injury, Gastroenterology, 138, 1143, 10.1053/j.gastro.2009.09.057

Hui, 2009, Bone marrow and non-bone marrow TLR4 regulates hepatic ischemia/reperfusion injury, Biochem Biophys Res Commun, 389, 328, 10.1016/j.bbrc.2009.08.149

Ellett, 2009, Toll-like receptor 4 is a key mediator of murine steatotic liver warm ischemia/reperfusion injury, Liver Transpl, 15, 1101, 10.1002/lt.21782

Hong, 2012, Ischemic preconditioning decreased leukotriene C4 formation by depressing leukotriene C4 synthase expression and activity during hepatic I/R injury in rats, J Surg Res, 178, 1015, 10.1016/j.jss.2012.07.061

Jang, 2008, Ischemic preconditioning and intermittent clamping confer protection against ischemic injury in the cirrhotic mouse liver, Liver Transpl, 14, 980, 10.1002/lt.21467

Shimoda, 2008, Protective effect of ischemic preconditioning against liver injury after major hepatectomy using the intermittent Pringle maneuver in swine, Pathobiology, 74, 42, 10.1159/000101050

Esposti, 2010, Autophagy is induced by ischemic preconditioning in human livers formerly treated by chemotherapy to limit necrosis, Autophagy, 6, 172, 10.4161/auto.6.1.10699

Heizmann, 2008, Ischemic preconditioning improves postoperative outcome after liver resections: a randomized controlled study, Eur J Med Res, 13, 79

Schiesser, 2009, Intermittent ischemia but not ischemic preconditioning is effective in restoring bile flow after ischemia reperfusion injury in the livers of aged rats, J Surg Res, 152, 61, 10.1016/j.jss.2008.01.007

Wang, 2010, Remote ischemic preconditioning by hindlimb occlusion prevents liver ischemic/reperfusion injury: the role of High Mobility Group-Box 1, Ann Surg, 251, 292, 10.1097/SLA.0b013e3181bfda8c

Schlegel, 2013, Protective mechanisms of end-ischemic cold machine perfusion in DCD liver grafts, J Hepatol, 58, 278, 10.1016/j.jhep.2012.10.004

Vairetti, 2009, Subnormothermic machine perfusion protects steatotic livers against preservation injury: a potential for donor pool increase?, Liver Transpl, 15, 20, 10.1002/lt.21581

Hessheimer, 2011, Decompression of the portal bed and twice-baseline portal inflow are necessary for the functional recovery of a “small-for-size” graft, Ann Surg, 253, 1201, 10.1097/SLA.0b013e3181ffb2d7