Effects of empagliflozin in women and men with acute myocardial infarction: An analysis from the EMMY trial

Caren Sourij1, Faisal Aziz2, Norbert J. Tripolt2, Jolanta Siller-Matula3, Peter N. Pferschy2, Ewald Kolesnik1, Markus Wallner1, Ceren Eyileten4, Marek Postula4, Abderrahim Oulhaj5, Harald Sourij2, Dirk von Lewinski1
1Division of Cardiology, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria
2Trials Unit for Interdisciplinary Metabolic Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria
3Department of Cardiology, Medical University of Vienna, Währinger Gürtel 18-20 1090 Vienna, Austria
4Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Center for Preclinical Research and Technology CEPT, 61 Zwirki i Wigury Street, 02-091 Warsaw, Poland
5Department of Epidemiology and Population Health, College of Medicine and Health Sciences, Khalifa University of Science and Technology, Abu Dhabi, UAE P O Box 127788, United Arab Emirates

Tài liệu tham khảo

Mozaffarian, 2015, Heart disease and stroke statistics--2015 update: a report from the American Heart Association, Circulation, 131, e29 Mehta, 2016, Acute Myocardial Infarction in Women: A Scientific Statement From the American Heart Association, Circulation, 133, 916, 10.1161/CIR.0000000000000351 Akhter, 2009, Gender differences among patients with acute coronary syndromes undergoing percutaneous coronary intervention in the American College of Cardiology-National Cardiovascular Data Registry (ACC-NCDR), Am Heart J, 157, 141, 10.1016/j.ahj.2008.08.012 Lansky, 2009, Impact of gender and antithrombin strategy on early and late clinical outcomes in patients with non-ST-elevation acute coronary syndromes (from the ACUITY trial), Am J Cardiol, 103, 1196, 10.1016/j.amjcard.2009.01.030 Barrett-Connor, 1991, Why is diabetes mellitus a stronger risk factor for fatal ischemic heart disease in women than in men? The Rancho Bernardo Study, JAMA, 265, 627, 10.1001/jama.1991.03460050081025 Kawamoto, 2016, Acute Coronary Syndromes: Differences in Men and Women, Curr Atherosclerosis Rep, 18, 73, 10.1007/s11883-016-0629-7 Mosca, 2011, Sex/gender differences in cardiovascular disease prevention: what a difference a decade makes, Circulation, 124, 2145, 10.1161/CIRCULATIONAHA.110.968792 Blomkalns, 2005, J Am Coll Cardiol, 45, 832, 10.1016/j.jacc.2004.11.055 Koopman, 2013, Persisting gender differences and attenuating age differences in cardiovascular drug use for prevention and treatment of coronary heart disease, 1998-2010, Eur Heart J, 34, 3198, 10.1093/eurheartj/eht368 Packer, 2022, Critical Reanalysis of the Mechanisms Underlying the Cardiorenal Benefits of SGLT2 Inhibitors and Reaffirmation of the Nutrient Deprivation Signaling/Autophagy Hypothesis, Circulation, 146, 1383, 10.1161/CIRCULATIONAHA.122.061732 Santos-Gallego, 2019, Empagliflozin Ameliorates Adverse Left Ventricular Remodeling in Nondiabetic Heart Failure by Enhancing Myocardial Energetics, J Am Coll Cardiol, 73, 1931, 10.1016/j.jacc.2019.01.056 Santos-Gallego, 2021, Randomized Trial of Empagliflozin in Nondiabetic Patients With Heart Failure and Reduced Ejection Fraction, J Am Coll Cardiol, 77, 243, 10.1016/j.jacc.2020.11.008 Requena-Ibanez, 2022, Empagliflozin improves quality of life in nondiabetic HFrEF patients. Sub-analysis of the EMPATROPISM trial, Diabetes Metabol Syndr, 16, 102417, 10.1016/j.dsx.2022.102417 McMurray, 2019, Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction, N Engl J Med, 381, 1995, 10.1056/NEJMoa1911303 Packer, 2020, Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure, N Engl J Med, 383, 1413, 10.1056/NEJMoa2022190 Anker, 2021, Empagliflozin in Heart Failure with a Preserved Ejection Fraction, N Engl J Med, 385, 1451, 10.1056/NEJMoa2107038 Butler, 2022, Effects of Empagliflozin in Women and Men With Heart Failure and Preserved Ejection Fraction, Circulation, 146, 1046, 10.1161/CIRCULATIONAHA.122.059755 Solomon, 2022, Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction, N Engl J Med, 387, 1089, 10.1056/NEJMoa2206286 Wang, 2022, Sex Differences in Characteristics, Outcomes and Treatment Response with Dapagliflozin across the Range of Ejection Fraction in Patients with Heart Failure: Insights from DAPA-HF and DELIVER, Circulation, 147, 624, 10.1161/CIRCULATIONAHA.122.062832 von Lewinski, 2022, Empagliflozin in acute myocardial infarction: the EMMY trial, Eur Heart J, 43, 4421, 10.1093/eurheartj/ehac494 Tripolt, 2020, Impact of EMpagliflozin on cardiac function and biomarkers of heart failure in patients with acute MYocardial infarction-The EMMY trial, Am Heart J, 221, 39, 10.1016/j.ahj.2019.12.004 Myhre, 2022, Sex and Race Differences in N-Terminal Pro-B-type Natriuretic Peptide Concentration and Absolute Risk of Heart Failure in the Community, JAMA Cardiol, 7, 623, 10.1001/jamacardio.2022.0680 Lam, 2011, Influence of sex and hormone status on circulating natriuretic peptides, J Am Coll Cardiol, 58, 618, 10.1016/j.jacc.2011.03.042 Gardin, 1995, Sex, age, and disease affect echocardiographic left ventricular mass and systolic function in the free-living elderly. The Cardiovascular Health Study, Circulation, 91, 1739, 10.1161/01.CIR.91.6.1739 Vergaro, 2021, NT-proBNP for Risk Prediction in Heart Failure: Identification of Optimal Cutoffs Across Body Mass Index Categories, JACC Heart Fail, 9, 653, 10.1016/j.jchf.2021.05.014 O’Donoghue, 2021, The efficacy and safety of dapagliflozin in women and men with type 2 diabetes mellitus, Diabetologia, 64, 1226, 10.1007/s00125-021-05399-2 Zinman, 2018, Empagliflozin in women with type 2 diabetes and cardiovascular disease - an analysis of EMPA-REG OUTCOME(R), Diabetologia, 61, 1522, 10.1007/s00125-018-4630-2 Daitch, 2022, Underrepresentation of women in randomized controlled trials: a systematic review and meta-analysis, Trials, 23, 1038, 10.1186/s13063-022-07004-2 Dadashova, 2016, Gender differences of response to various options of drug therapy in patients with chronic heart failure after suffered myocardial infarction, Kazan Medical Journal, 97, 17, 10.17750/KMJ2016-17 Lee, 2019, Sex-Specific Thresholds of High-Sensitivity Troponin in Patients With Suspected Acute Coronary Syndrome, J Am Coll Cardiol, 74, 2032, 10.1016/j.jacc.2019.07.082 Jin, 2020, Women’s Participation in Cardiovascular Clinical Trials From 2010 to 2017, Circulation, 141, 540, 10.1161/CIRCULATIONAHA.119.043594 Ding, 2007, Sex differences in perceived risks, distrust, and willingness to participate in clinical trials: a randomized study of cardiovascular prevention trials, Arch Intern Med, 167, 905, 10.1001/archinte.167.9.905 Peterson, 2004, Willingness to participate in cardiac trials, Am J Geriatr Cardiol, 13, 11, 10.1111/j.1076-7460.2004.01709.x