Do mutant woodchuck hepatitis viruses play a role in hepatocellular carcinogenesis?

Botchan, 1980, Integration and excision of SV40 DNA from the chromosome of a transformed cell, Cell, 20, 143, 10.1016/0092-8674(80)90242-1 Bullock, 1985, Association of cross-over points with topoisomerase I cleavage sites: a model for non-homologous recombination, Science, 230, 954, 10.1126/science.2997924 Bullock, 1984, DNA sequence studies of simian virus 40 chromosomal excision and integration in rat cells, J. Biol. Med., 174, 55 Clayton, 1981, Cloning and characterization of the integrated viral DNA from 3 lines of SV40-transformed mouse cells, Cell, 25, 547, 10.1016/0092-8674(81)90073-8 DiNardo, 1984, DNA topoisomerase II mutant of Saccharomyces cerevisiae, Topoisomerase II is required for segregation of daughter molecules at the termination of replication, 81, 2616 Goto, 1985, Cloning of yeast TOP I, the gene encoding DNA topoisomerase I, and construction of mutants defective in both DNA topoisomerase I and topoisomerase II, 82, 7178 Hino, 1989, Features of two hepatitis B virus (HBV) integrations suggest mechanisms of HBV integration, J. Virol., 63, 2638, 10.1128/JVI.63.6.2638-2643.1989 Kew, 1993, Heterogeneity of the woodchuck hepatitis virus genome in a chronically infecte woodchuck, Virus Res., 27, 229, 10.1016/0168-1702(93)90035-L Konopka, 1988, Compilation of DNA strand exchange sites for non-homologous recombination in somatic cells, Nucl. Acids Res., 16, 1739, 10.1093/nar/16.5.1739 Matsubara, 1990, Integration of hepatitis B virus DNA and its implication for hepatocarcinogenesis, Mol. Biol. Med., 7, 243 Ogata, 1990, A comparison of the molecular structure of integrated hepatitis B virus genome in hepatocellular carcinoma cells and hepatocytes derived from the same patient, Hepatology, 11, 1017, 10.1002/hep.1840110617 Ogston, 1982, Cloning and structural analysis of integrated woodchuck hepatitis virus sequences from hepatocellular carcinoma of woodchucks, Cell, 29, 385, 10.1016/0092-8674(82)90155-6 Sambrook, 1980, Analysis of the sites of integration of viral DNA sequences in rat cells transformed by adenovirus 2 or SV40, Cold Spring Harbor Symp. Quant. Biol., 44, 569, 10.1101/SQB.1980.044.01.059 Shuman, 1992, DNA strand transfer reactions catalysed by vaccinia topoisomerase I, J. Biol. Chem., 6, 8620, 10.1016/S0021-9258(18)42488-X Wang, 1991, Topoisomerase-I-mediated integration of hepadnavirus DNA in vitro, J. Virol., 65, 2381, 10.1128/JVI.65.5.2381-2392.1991 Wang, 1985, DNA topoisomerase, Ann. Rev. Biochem., 54, 665, 10.1146/annurev.bi.54.070185.003313