Pathways to a robust immune response in the elderly

Proust, 2000, Immunity and aging, 68

Lewthwaite, 2002, Group G streptococcal bacteremia: an opportunistic infection associated with immune senescence, Scand J Infect Dis, 34, 83, 10.1080/00365540110077209

Fein, 1999, Pneumonia in the elderly: overview of diagnostic and therapeutic approaches, Clin Infect Dis, 28, 726, 10.1086/515218

Berger, 1981, Decrease of the lymphoproliferative response to varicella-zoster virus antigen in the aged, Infect Immun, 32, 24, 10.1128/IAI.32.1.24-27.1981

Zhang, 1994, Cytokine production in varicella zoster virus-stimulated limiting dilution lymphocyte cultures, Clin Exp Immunol, 98, 128, 10.1111/j.1365-2249.1994.tb06618.x

Scott, 1994, Seroepidemiologic evidence of Epstein-Barr virus reactivation in a veterans' nursing home, Serodiagnosis and Immunotherapy of Infectious Diseases, 6, 87, 10.1016/0888-0786(94)90052-3

Nagami, 1983, Tuberculosis in the geriatric patient, J Am Geriatr Soc, 31, 356, 10.1111/j.1532-5415.1983.tb05747.x

Falsey, 2000, Epidemiology of infectious disease, 55

La Croix, 1989, Prospective study of pneumonia hospitalization and mortality of US older people: the role of chronic conditions, health behaviors and nutritional status, Public Health Rep, 104, 350

Ackermann, 1996, Bacteremic urinary tract infection in older people, J Am Geriatr Soc, 44, 927, 10.1111/j.1532-5415.1996.tb01862.x

Chattopadhyay, 1983, Septocemia and its unacceptably high mortality in the elderly, J Infect, 7, 134, 10.1016/S0163-4453(83)90548-0

Gorse, 1984, Bacterial meningitis in the elderly, Arch Intern Med, 144, 1603, 10.1001/archinte.1984.00350200107016

Barker, 1980, Impact of epidemic type A influenza in a defined adult population, Am J Epidemiol, 112, 798, 10.1093/oxfordjournals.aje.a113052

Sprenger, 1993, Impact of influenza on mortality in relation to age and underlying disease, Int J Epidemiol, 22, 334, 10.1093/ije/22.2.334

Yoshikawa, 1997, Perspective: Aging and infectious diseases: past, present, and future, J Infect Dis, 176, 1053, 10.1086/516547

Looney, 2002, Effect of aging on cytokine production in response to respiratory syncitial virus infection, J Infect Dis, 185, 682, 10.1086/339008

MacGee, 1993, Causes of death in a hospitalized geriatric population: an autopsy study of 3000 patients, Virchows Arch, 423, 343, 10.1007/BF01607146

Klima, 1997, Causes of death in geriatric patients: a cross-cultural study, J Gerontol A Biol Sci Med Sci, 52, M247, 10.1093/gerona/52A.4.M247

Bordin, 1999, Causes of death and clinical diagnostic errors in extreme aged hospitalized people: a retrospective clinical-necropsy survey, J Gerontol A Biol Sci Med Sci, 54, M554, 10.1093/gerona/54.11.M554

Horiuchi, 1997, Age patterns of the life table aging rate for major causes of death in Japan, 1951–1990, J Gerontol A Biol Sci Med Sci, 52, B67, 10.1093/gerona/52A.1.B67

Dworsky, 1983, Immune responses of healthy humans 83–104 years of age, J Natl Cancer Inst, 71, 265

Schatz, 1998, Aging and the immune response to tetanus toxoid: diminished frequency and level of cellular immune reactivity to antigenic stimulation, Clin Diagn Lab Immunol, 5, 894, 10.1128/CDLI.5.6.894-896.1998

Remarque, 1999, Influenza vaccination in elderly people, Exp Gerontol, 34, 445, 10.1016/S0531-5565(99)00007-8

Murasko, 2002, Role of humoral and cell mediated-immunity in protection from influenza disease after immunization of healthy elderly, Exp Gerontol, 37, 427, 10.1016/S0531-5565(01)00210-8

Ruben, 1978, Antitoxin responses in the elderly to tetanus-diphtheria in the (Td) immunizations, Am J Epidemiol, 108, 145, 10.1093/oxfordjournals.aje.a112598

Armitage, 1993, Transient normalization of lymphocyte blastogenic and specific antibody responses following boosting of healthy elderly subjects with tetanus toxoid, J Gerontol, 48, M19, 10.1093/geronj/48.1.M19

Steger, 1996, Vaccination against tetanus in the elderly: do recommended vaccination strategies give sufficient protection?, Lancet, 348, 762, 10.1016/S0140-6736(05)65680-2

McElhaney, 1995, Vaccine-related determinants of the interleukin-2 response to influenza vaccination in healthy young and elderly adults, Vaccine, 13, 6, 10.1016/0264-410X(95)80003-V

Provinciali, 2000, Efficacy of cancer gene therapy in aging: adenocarcinoma cells engineered to release IL-2 are rejected but do not induce tumor specific immune memory in old mice, Gene Ther, 7, 624, 10.1038/sj.gt.3301131

Remarque, 1996, Functional disability and antibody response to influenza vaccine in elderly patients in a Dutch nursing home, BMJ, 312, 1015, 10.1136/bmj.312.7037.1015

De Greef, 1992, Influence of aging on antibody formation in vivo after immunisation with the primary T-cell dependent antigen helix-pomatia haemocyanin, Mech Ageing Dev, 66, 15, 10.1016/0047-6374(92)90070-T

Lesourd, 1995, Protein undernutrition as the major cause of decreased immune function in the elderly: clinical and functional implications, Nutr Rev, 53, S86, 10.1111/j.1753-4887.1995.tb01523.x

Kreft, 2000, The impaired immune response to diphtheria vaccination in elderly chronic hemodialysis patients is related to zinc deficiency, Biogerontology, 1, 61, 10.1023/A:1010077622172

Potter, 1999, Serological responses to influenza vaccination and nutritional and functional status of patients in geriatric medical long-term care, Age Aging, 28, 141, 10.1093/ageing/28.2.141

Pawelec, 2002, T cells and aging, Front Biosci, 7, D1056, 10.2741/A831

Roberts-Thomson, 1974, Aging, immune response and mortality, Lancet, 2, 368, 10.1016/S0140-6736(74)91755-3

Murasko, 1988, Association of lack of mitogen induced lymphocyte proliferation with increased mortality in the elderly, Aging: Immunology and Infectious Disease, 1, 1

Wayne, 1990, Cell-mediated immunity as a predictor of morbidity and mortality in subjects over 60, J Gerontol, 45, 45, 10.1093/geronj/45.2.M45

Ligthart, 1984, Admission criteria for immunogerontological studies in man: the SENIEUR protocol, Mech Ageing Dev, 28, 47, 10.1016/0047-6374(84)90152-0

Bernstein, 1998, Effect of age on cytokine production in humans, Age, 21, 137, 10.1007/s11357-998-0024-6

Pawelec, 2001, Altered T cell signalling in aging, Mech Ageing Dev, 122, 1613, 10.1016/S0047-6374(01)00290-1

Wikby, 1994, Age-related changes in immune parameters in a very old population of Swedish people: a longitudinal study, Exp Gerontol, 29, 531, 10.1016/0531-5565(94)90036-1

Ferguson, 1995, Immune parameters in a longitudinal study of a very old population of Swedish people: a comparison between survivors and nonsurvivors, J Gerontol A Biol Sci Med Sci, 50, B378, 10.1093/gerona/50A.6.B378

Wikby, 1998, Changes in CD8 and CD4 lymphocyte subsets, T cell proliferation responses and non-survival in the very old: the Swedish longitudinal OCTO-immune study, Mech Ageing Dev, 102, 187, 10.1016/S0047-6374(97)00151-6

Olsson, 2000, Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study, Mech Ageing Dev, 121, 187, 10.1016/S0047-6374(00)00210-4

Pawelec, 2001, The SENIEUR protocol after 16 years, Mech Ageing Dev, 122, 132, 10.1016/S0047-6374(00)00240-2

Looney, 1999, Role of cytomegalovirus in the T cell changes seen in elderly individuals, Clin Immunol, 90, 213, 10.1006/clim.1998.4638

Wikby, 2002, Expansion of peripheral blood CD8 T lymphocyte subpopulations and an association with cytomegalovirus positivity in the elderly: the Swedish NONA-immune study, Exp Gerontol, 37, 445, 10.1016/S0531-5565(01)00212-1

Appay, 2002, Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections, Nat Med, 8, 379, 10.1038/nm0402-379

Lombardi, 1994, Anergic T cells as suppressor cells in vitro, Science, 264, 1587, 10.1126/science.8202711

Spaulding, 1999, Resistance to apoptosis in human CD8+T cells that reach replicative senescence after multiple rounds of antigen-specific proliferation, Exp Gerontol, 34, 633, 10.1016/S0531-5565(99)00033-9

Globerson, 2000, Aging of lymphocytes and lymphocytes in the aged, Immunol Today, 21, 515, 10.1016/S0167-5699(00)01714-X

Posnett, 1999, Differentiation of human CD8 T cells: implications for in vivo persistence of CD8+ CD28− cytotoxic effector clones, Int Immunol, 11, 229, 10.1093/intimm/11.2.229

Spaulding, 1997, The accumulation of non-replicative, non-functional, senescent T cells with age is avoided in calorically restricted mice by an enhancement of T cell apoptosis, Mech Ageing Dev, 93, 25, 10.1016/S0047-6374(96)01808-8

Grayson, 2000, Cutting edge: Increased expression of Bcl-2 in antigen-specific memory CD8(+) T cells, J Immunol, 164, 3950, 10.4049/jimmunol.164.8.3950

Zhou, 1995, Prevention of age-related T cell apoptosis defect in CD2-fas-transgenic mice, J Exp Med, 182, 129, 10.1084/jem.182.1.129

Hsu, 2001, Activated CD8+ T cells from aged mice exhibit decreased activation-induced cell death, Mech Ageing Dev, 122, 1663, 10.1016/S0047-6374(01)00279-2

Zhang, 2002, Aging leads to disturbed homeostasis of memory phenotype CD8+ cells, J Exp Med, 195, 283, 10.1084/jem.20011267

Ku, 2000, Control of homeostasis of CD8(+) memory T cells by opposing cytokines, Science, 288, 675, 10.1126/science.288.5466.675

Provinciali, 1994, Adjuvant effect of low-dose interleukin-2 on antibody response to influenza virus vaccination in healthy elderly subjects, Mech Ageing Dev, 77, 75, 10.1016/0047-6374(94)90016-7

Franceschi, 2000, Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space, Vaccine, 18, 1717, 10.1016/S0264-410X(99)00513-7

Effros, 1997, Replicative senescence of T lymphocytes: does the Hayflick Limit lead to immune exhaustion?, Immunol Today, 18, 450, 10.1016/S0167-5699(97)01079-7

Adibzadeh, 1995, Long-term culture of monoclonal human T lymphocytes: models for immunosenescence?, Mech Ageing Dev, 83, 171, 10.1016/0047-6374(95)01625-A

Pawelec, 1997, Human T cell clones as a model for immunosenescence, Immunol Rev, 160, 31, 10.1111/j.1600-065X.1997.tb01025.x

Pawelec, 2000, Longevity in vitro of human CD4+ T helper cell clones derived from young donors and elderly donors, or from progenitor cells: age-associated differences in cell surface molecule expression and cytokine secretion, Biogerontology, 1, 247, 10.1023/A:1010086229931

Pawelec, 2002, Human CD4+ T cell clone longevity in tissue culture: lack of influence of donor age or cell origin, Exp Gerontol, 37, 265, 10.1016/S0531-5565(01)00192-9

Globerson, 1999, Hematopoietic stem cells and aging, Exp Gerontol, 34, 137, 10.1016/S0531-5565(98)00069-2

Guba, 1997, Peripheral stem cell mobilization and engraftment in patients over age 60, Bone Marrow Transplant, 20, 1, 10.1038/sj.bmt.1700833

Effros, 2002, Hematopoietic stem cells and replicative senescence, Exp Gerontol, 37, 191, 10.1016/S0531-5565(01)00183-8

Jamieson, 1999, Generation of functional thymocytes in the human adult, Immunity, 10, 569, 10.1016/S1074-7613(00)80056-4

Aspinall, 2000, Thymic atrophy in the mouse is a soluble problem of the thymic environment, Vaccine, 18, 1629, 10.1016/S0264-410X(99)00498-3

Hooijberg, 2000, Immortalization of human CD8(+) T cell clones by ectopic expression of telomerase reverse transcriptase, J Immunol, 165, 4239, 10.4049/jimmunol.165.8.4239

Adolfsson, 2001, Vitamin E-enhanced IL-2 production in old mice: naı̈ve but not memory T cells show increased cell division cycling and IL-2-producing capacity, J Immunol, 167, 3809, 10.4049/jimmunol.167.7.3809

Couziech, 2002, Modulation of human lymphocyte proliferative responses with aging, Exp Gerontol, 37, 369, 10.1016/S0531-5565(01)00204-2

Orentreich, 1992, Long-term longitudinal measurements of plasma dehydroepiandrosterone sulfate in normal men, J Clin Endocrinol Metab, 75, 1002, 10.1210/jc.75.4.1002

Petersen, 2000, The possible association of decreased total cholesterol and severity of disease in elderly hospitalized patients, Clin Chim Acta, 290, 213, 10.1016/S0009-8981(99)00185-0

Weverling-Rijnsburger, 1997, Total cholesterol and risk of mortality in the oldest old, Lancet, 350, 1119, 10.1016/S0140-6736(97)04430-9

Lio, 2002, Gender-specifc association between -1082 IL-10 promoter polymorphism and longevity, Genes Immun, 3, 30, 10.1038/sj.gene.6363827

Schoenfeld, 2001