Activin C Antagonizes Activin A in Vitro and Overexpression Leads to Pathologies in Vivo

The American Journal of Pathology - Tập 174 - Trang 184-195 - 2009
Elspeth Gold1, Niti Jetly2, Moira K. O'Bryan3, Sarah Meachem4, Deepa Srinivasan1, Supreeti Behuria2, L. Gabriel Sanchez-Partida3, Teresa Woodruff2, Shelley Hedwards1, Hong Wang1, Helen McDougall1, Victoria Casey1, Birunthi Niranjan1, Shane Patella1, Gail Risbridger1
1Centre for Urological Research, Monash University, Clayton, Australia
2Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois
3Monash Institute of Medical Research, and the Australian Research Council Centre of Excellence in Biotechnology and Development, Monash University, Clayton, Australia
4Prince Henry’s Institute, Clayton, Australia

Tài liệu tham khảo

Smith, 1990, Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A, Nature, 345, 729, 10.1038/345729a0 Green, 1992, Responses of embryonic Xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm, Cell, 71, 731, 10.1016/0092-8674(92)90550-V Cancilla, 2001, Regulation of prostate branching morphogenesis by activin A and follistatin, Dev Biol, 237, 145, 10.1006/dbio.2001.0364 Clotman, 2005, Control of liver cell fate decision by a gradient of TGF beta signaling modulated by Onecut transcription factors, Genes Dev, 19, 1849, 10.1101/gad.340305 de Kretser, 2001, Inhibins, activins and follistatin: actions on the testis, Mol Cell Endocrinol, 180, 87, 10.1016/S0303-7207(01)00502-0 Schwall, 1993, Activin induces cell death in hepatocytes in vivo and in vitro, Hepatology, 18, 347 Yasuda, 1993, Activin A: an autocrine inhibitor of initiation of DNA synthesis in rat hepatocytes, J Clin Invest, 92, 1491, 10.1172/JCI116727 Phillips, 2000, Regulation of activin's access to the cell: why is mother nature such a control freak?, Bioessays, 22, 689, 10.1002/1521-1878(200008)22:8<689::AID-BIES2>3.0.CO;2-5 Massagué, 2000, Controlling TGF-beta signaling, Genes Dev, 14, 627, 10.1101/gad.14.6.627 Burger, 1992, Inhibin, Reprod Med Rev, 1, 1, 10.1017/S0962279900000417 de Winter, 1996, Follistatins neutralize activin bioactivity by inhibition of activin binding to its type II receptors, Mol Cell Endocrinol, 116, 105, 10.1016/0303-7207(95)03705-5 Lau, 2000, Activin betaC and betaE genes are not essential for mouse liver growth, differentiation, and regeneration, Mol Cell Biol, 20, 6127, 10.1128/MCB.20.16.6127-6137.2000 Loveland, 1996, Expression of activin beta C subunit mRNA in reproductive tissues, J Mol Endocrinol, 17, 61, 10.1677/jme.0.0170061 Gold, 2004, Cell-specific expression of betaC-activin in the rat reproductive tract, adrenal and liver, Mol Cell Endocrinol, 222, 61, 10.1016/j.mce.2004.05.007 Mellor, 2000, Localization of activin betaA, betaB and betaC subunits in human prostate and evidence for formation of new activin heterodimers of betaC subunit, J Clin Endocrinol Metab, 85, 4851, 10.1210/jc.85.12.4851 Mellor, 2003, Activin betaC-subunit heterodimers provide a new mechanism of regulating activin levels in the prostate, Endocrinology, 144, 4410, 10.1210/en.2003-0225 McPherson, 1999, Expression of activin A and follistatin core proteins by human prostate tumor cell lines, Endocrinology, 140, 5303, 10.1210/en.140.11.5303 Suszko, 2003, Regulation of the rat follicle-stimulating hormone beta-subunit promoter by activin, Mol Endocrinol, 17, 318, 10.1210/me.2002-0081 Burdette, 2007, Activin and estrogen crosstalk regulates transcription in human breast cancer cells, Endocr Relat Cancer, 14, 679, 10.1677/ERC-07-0054 Buzzard, 2004, Changes in circulating and testicular levels of inhibin A and B and activin A during postnatal development in the rat, Endocrinology, 145, 3532, 10.1210/en.2003-1036 O'Connor, 1999, Serum activin A and follistatin concentrations during human pregnancy: a cross-sectional and longitudinal study, Hum Reprod, 14, 827, 10.1093/humrep/14.3.827 Wreford, 1994, Gonadotropin-suppressing activity of human recombinant inhibin in the male rat is age dependent, Biol Reprod, 50, 1066, 10.1095/biolreprod50.5.1066 Gold, 2005, BetaA- and betaC-activin, follistatin, activin receptor mRNA and betaC-activin peptide expression during rat liver regeneration, J Mol Endocrinol, 34, 505, 10.1677/jme.1.01657 Cotton, 2006, FGFR-1 [corrected] signaling is involved in spermiogenesis and sperm capacitation, J Cell Sci, 119, 75, 10.1242/jcs.02704 Meachem, 1996, Neonatal exposure of rats to recombinant follicle stimulating hormone increases adult Sertoli and spermatogenic cell numbers, Biol Reprod, 54, 36, 10.1095/biolreprod54.1.36 Wreford, 1995, Theory and practice of stereological techniques applied to the estimation of cell number and nuclear volume in the testis, Microsc Res Tech, 32, 423, 10.1002/jemt.1070320505 Barakat, 2008, Inhibin, activin, follistatin and follicle stimulating hormone serum levels and testicular production are highly modulated during the first spermatogenic wave in mice, Reproduction, 136, 345, 10.1530/REP-08-0140 Cho, 2001, Reproductive deficiencies in transgenic mice expressing the rat inhibin alpha-subunit gene, Endocrinology, 142, 4994, 10.1210/en.142.11.4994 McMullen, 2001, Gonadal pathologies in transgenic mice expressing the rat inhibin alpha-subunit, Endocrinology, 142, 5005, 10.1210/en.142.11.5005 Guo, 1998, Overexpression of mouse follistatin causes reproductive defects in transgenic mice, Mol Endocrinol, 12, 96, 10.1210/me.12.1.96 Brown, 2000, Insertion of Inhbb into the Inhba locus rescues the Inhba-null phenotype and reveals new activin functions, Nat Genet, 25, 453, 10.1038/78161 Cipriano, 2000, Follistatin is a modulator of gonadal tumor progression and the activin-induced wasting syndrome in inhibin-deficient mice, Endocrinology, 141, 2319, 10.1210/en.141.7.2319 Patella, 2001, Characterization of serum activin-A and follistatin and their relation to virological and histological determinants in chronic viral hepatitis, J Hepatol, 34, 576, 10.1016/S0168-8278(00)00029-5 Patella, 2006, Follistatin attenuates early liver fibrosis: effects on hepatic stellate cell activation and hepatocyte apoptosis, Am J Physiol, 290, G137 Esquela, 1997, Transient down-regulation of inhibin-betaC expression following partial hepatectomy, Biochem Biophys Res Commun, 235, 553, 10.1006/bbrc.1997.6850 Zhang, 1997, Reciprocal expression of mRNA for inhibin betaC and betaA subunits in hepatocytes, Endocr J, 44, 759, 10.1507/endocrj.44.759 Chabicovsky, 2003, Overexpression of activin beta(C) or activin beta(E) in the mouse liver inhibits regenerative deoxyribonucleic acid synthesis of hepatic cells, Endocrinology, 144, 3497, 10.1210/en.2003-0388 Vejda, 2003, Expression of activins C and E induces apoptosis in human and rat hepatoma cells, Carcinogenesis, 24, 1801, 10.1093/carcin/bgg154 Wada, 2004, Assessment of the function of the betaC-subunit of activin in cultured hepatocytes, Am J Physiol, 287, E247 Wada, 2005, Adenovirus-mediated overexpression of the activin betaC subunit accelerates liver regeneration in partially hepatectomized rats, J Hepatol, 43, 823, 10.1016/j.jhep.2005.04.013 Kron, 1998, Expression of human activin C protein in insect larvae infected with a recombinant baculovirus, J Virol Methods, 72, 9, 10.1016/S0166-0934(97)00215-2 Chang, 2001, Studying TGF-beta superfamily signaling by knockouts and knockins, Mol Cell Endocrinol, 180, 39, 10.1016/S0303-7207(01)00513-5 Hsiao, 2000, Characterization of growth-differentiation factor 15, a transforming growth factor beta superfamily member induced following liver injury, Mol Cell Biol, 20, 3742, 10.1128/MCB.20.10.3742-3751.2000 Johnen, 2007, Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1, Nat Med, 13, 1333, 10.1038/nm1677