Inhibitory effects of ursolic acid on hepatic polyol pathway and glucose production in streptozotocin-induced diabetic mice

Metabolism - 2010
Sun-Mi Jang1, Myung-Joo Kim2, Myung-Sook Choi3, Eun-Young Kwon3, Mi-Kyung Lee4
1Department of Nutrition Education, Graduate School of Education, Sunchon National University, Suncheon 540-742, Republic of Korea
2Department of Food Science and Nutrition, Daegu Polytechnic College, Daegu 706-022, Republic of Korea
3Department of Food Science and Nutrition, Kyungpook National University, Daegu 702-701, Republic of Korea
4Department of Food and Nutrition, Sunchon National University, Suncheon 540-742, Republic of Korea

Tóm tắt

Từ khóa


Tài liệu tham khảo

Pedersen, 1991, Reduction of glomerular hyperfiltration in normoalbuminuric IDDM patients by 6 mo of aldose reductase inhibition, Diabetes, 40, 527, 10.2337/diabetes.40.5.527 Lee, 1999, Contributions of polyol pathway to oxidative stress in diabetic cataract, FASEB J, 13, 23, 10.1096/fasebj.13.1.23 Srivastava, 2005, Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options, Endocr Rev, 26, 380, 10.1210/er.2004-0028 Bhatnagar, 1992, Aldose reductase: congenial and injurious profiles of an enigmatic enzyme, Biochem Med Metab Biol, 48, 91, 10.1016/0885-4505(92)90055-4 Pfeifer, 1997, Aldose reductase inhibitors: the end of an era or the need for different trial designs?, Diabetes, 46, S82, 10.2337/diab.46.2.S82 Kawanishi, 2003, Aldose reductase inhibitors from the nature, Curr Med Chem, 10, 1353, 10.2174/0929867033457304 Halder, 2003, Lens aldose reductase inhibiting potential of some indigenous plants, J Ethnopharmacol, 86, 113, 10.1016/S0378-8741(03)00052-7 Ovesná, 2004, Pentacyclic triterpenoic acids: new chemoprotective compounds, Neoplasma, 51, 327 Banno, 2004, Triterpene acids from the leaves of Perilla frutescens and their anti-inflammatory and antitumor-promoting effects, Biosci Biotechnol Biochem, 68, 85, 10.1271/bbb.68.85 Saraswat, 1996, Protective action of ursolic acid against chemical induced hepatotoxicity in rats, Indian J Pharmacol, 28, 232 Rodriguez, 2003, Oleanolic acid promotes healing of acetic acid-induced chronic gastric lesions in rats, Pharmacol Res, 48, 291, 10.1016/S1043-6618(03)00155-5 Somova, 2003, Cardiovascular, antihyperlipidemic and antioxidant effects of oleanolic and ursolic acids in experimental hypertension, Phytomedicine, 10, 115, 10.1078/094471103321659807 Raphael, 2003, Effect of naturally occurring triterpenoids glycyrrhizic acid, ursolic acid, oleanolic acid and nomilin on the immune system, Phytomedicine, 10, 483, 10.1078/094471103322331421 Lee, 2001, Ursolic acid-induced changes in tumor growth, O2 consumption, and tumor interstitial fluid pressure, Anticancer Res, 21, 2827 Liu, 1995, Pharmacology of oleanolic acid and ursolic acid, J Ethnopharmacol, 49, 57, 10.1016/0378-8741(95)90032-2 Lee, 1994, Induction of differentiation in the cultured F9 teratocarcinoma stem cells by triterpene acids, J Cancer Res Clin Oncol, 120, 513, 10.1007/BF01221027 Pozzilli, 2007, A new expression of diabetes: double diabetes, Trends Endocrinol Metab, 18, 52, 10.1016/j.tem.2006.12.003 Green, 2001, Trends in the incidence of childhood-onset diabetes in Europe 1989-1998, Diabetologia, 44, B3, 10.1007/PL00002950 Jang, 2009, Ursolic acid enhances the cellular immune system and pancreatic β-cell function in streptozotocin-induced diabetic mice fed a high-fat diet, Int Pharmacol, 9, 113 American Institute of Nutrition, 1977, Report of the American Institute of Nutrition ad hoc committee on standards for nutritional studies, J Nutr, 107, 1340, 10.1093/jn/107.7.1340 American Institute of Nutrition, 1980, Report of ad hoc committee on standards for nutritional studies, J Nutr, 110, 1717 Hulcher, 1973, Simplified spectrophotometric assay for microsomal 3-hydroxy-3-methylglutaryl CoA reductase by measurement of coenzyme A, J Lipid Res, 14, 625, 10.1016/S0022-2275(20)36843-7 Bradford, 1976, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Anal Biochem, 72, 248, 10.1016/0003-2697(76)90527-3 Nishimura, 1991, Purification and characterization of the recombinant human aldose reductase expressed in baculovirus system, Biochim Biophys Acta, 1078, 171, 10.1016/0167-4838(91)99006-E Ulrich, 1974, vol. 2, 567 Davidson, 1987, Factors underlying significant underestimations of glucokinase activity in crude liver extract: physiological implications of higher cellular activity, Arch Biochem Biophys, 253, 156, 10.1016/0003-9861(87)90648-5 Newgard, 1983, Studies on the mechanism by which exogenous glucose is converted into liver glycogen in the rat, J Biol Chem, 258, 8046, 10.1016/S0021-9258(20)82025-0 Alegre, 1988, Determination of glucose-6-phosphatase activity using the glucose dehydrogenase-coupled reaction, Anal Biochem, 173, 185, 10.1016/0003-2697(88)90176-5 Bentle, 1976, Interaction of anions and divalent metal ions with phosphoenolpyruvate carboxykinase, J Biol Chem, 251, 2916, 10.1016/S0021-9258(17)33478-6 Seifter, 1950, The estimation of glycogen with the anthrone reagent, Arch Biochem, 25, 191 Folch, 1957, Simple method for isolation and purification of total lipids from animal tissues, J Biol Chem, 226, 497, 10.1016/S0021-9258(18)64849-5 Nepokroeff, 1975, Fatty acid synthase from rat liver, Methods Enzymol, 35, 37, 10.1016/0076-6879(75)35136-7 Lazarow, 1981, Assay of peroxisomal β-oxidation of fatty acids, Method Enzymol, 72, 315, 10.1016/S0076-6879(81)72021-4 Bieber, 1972, Rapid spectrophotometric assay for carnitine palmitoyltransferase, Anal Biochem, 50, 509, 10.1016/0003-2697(72)90061-9 Saladin, 1995, Transient increase in obese gene expression after food intake or insulin administration, Nature, 377, 527, 10.1038/377527a0 Mizuno, 1996, Obese gene expression: reduction by fasting and stimulation by insulin and glucose in lean mice, and persistent elevation in acquired (diet-induced) and genetic (yellow agouti) obesity, Proc Natl Acad Sci USA, 93, 3434, 10.1073/pnas.93.8.3434 Kiess, 1998, Serum leptin levels in children and adolescents with insulin-dependent diabetes mellitus in relation to metabolic control and body mass index, Eur J Endocrinol, 138, 501, 10.1530/eje.0.1380501 Jung, 2007, Insulin-mimetic and insulin-sensitizing activities of a pentacyclic triterpenoid insulin receptor activator, Biochem J, 403, 243, 10.1042/BJ20061123 Agius, 1996, Evidence for a role of glucose induced translocation of glucokinase in the control of hepatic glycogen synthesis, J Biol Chem, 271, 30479, 10.1074/jbc.271.48.30479 Meglasson, 1986, Pancreatic islet glucose metabolism and regulation of insulin secretion, Diabetes Metab Res Rev, 2, 163, 10.1002/dmr.5610020301 Morral, 2002, Adenovirus-mediated expression of glucokinase in the liver as an adjuvant treatment for type 1 diabetes, Hum Gene Ther, 13, 1561, 10.1089/10430340260201653 Tomlinson, 1993, Aldose reductase inhibitors and the complications of diabetes mellitus, Diabet Med, 10, 214, 10.1111/j.1464-5491.1993.tb00049.x Maekawa, 2002, Gene expression of enzymes comprising the polyol pathway in various rat tissues determined by the competitive RT-PCR method, Japan J Pharmacol, 88, 123, 10.1254/jjp.88.123 Estonius, 1993, Distribution of alcohol and sorbitol dehydrogenases. Assessment of mRNA species in mammalian tissues, Eur J Biochem, 215, 497, 10.1111/j.1432-1033.1993.tb18059.x Lee, 1995, Cloning, sequencing, and determination of the site of expression of mouse sorbitol dehydrogenase cDNA, Eur J Biochem, 230, 1059, 10.1111/j.1432-1033.1995.tb20656.x Cumbie, 2007, Current concepts in targeted therapies for the pathophysiology of diabetic microvascular complications, Vasc Health Risk Manag, 3, 823 Chung, 2003, Contribution of polyol pathway to diabetes-induced oxidative stress, J Am Soc Nephrol, 14, S233, 10.1097/01.ASN.0000077408.15865.06 Hoshi, 1996, Glycation and inactivation of sorbitol dehydrogenase in normal and diabetic rats, Biochem J, 318, 119, 10.1042/bj3180119 Latha, 2004, Effect of an aqueous extract of Scoparia dulcis on blood glucose, plasma insulin and some polyol pathway enzymes in experimental rat diabetes, Braz J Med Biol Res, 37, 577, 10.1590/S0100-879X2004000400015 Bar-On, 1976, Serum lipoproteins and apolipoproteins in rats with streptozotocin-induced diabeties, J Clin Invest, 57, 714, 10.1172/JCI108329 Bar-On, 1984, Removal defect of very-low-density lipoproteins from diabetic rats, Biochim Biophys Acta, 793, 115, 10.1016/0005-2760(84)90059-6 Mamo, 1992, Hypertriglyceridemia is exacerbated by slow lipolysis of triacylglycerol-rich lipoproteins in fed but not fasted streptozotocin diabetic rats, Biochim Biophys Acta, 1128, 132, 10.1016/0005-2760(92)90298-A Yoshino, 1993, Hypertriglyceridemia in nephrotic rats is due to a clearance defect of plasma triglyceride: overproduction of triglyceride-rich lipoprotein is not an obligatory factor, J Lipid Res, 34, 875, 10.1016/S0022-2275(20)39674-7 Sparks, 1992, Impaired hepatic apolipoprotein B and E translation in streptozotocin diabetic rats, J Clin Invest, 89, 1418, 10.1172/JCI115731 Sharma, 2003, Hypoglycaemic and hypolipidemic effect of ethanolic extract of seeds of Eugenia jambolana in alloxan-induced diabetic rabbits, J Ethnopharmacol, 85, 202, 10.1016/S0378-8741(02)00366-5 Jayaprakasam, 2006, Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins and ursolic acid in Cornelian cherry (Cornus mas), J Agric Food Chem, 54, 243, 10.1021/jf0520342 Ozcelikay, 1996, Improvement of glucose and lipid metabolism in diabetic rats treated with molybdate, Am J Physiol, 270, E344 Paulauskis, 1989, Hormonal regulation of mouse fatty acid synthase gene transcription in liver, J Biol Chem, 264, 574, 10.1016/S0021-9258(17)31298-X