Effect of mid-dose efavirenz concentrations and CYP2B6 genotype on viral suppression in patients on first-line antiretroviral therapy

International Journal of Antimicrobial Agents - Tập 47 - Trang 466-472 - 2016
Catherine Orrell1, Andrzej Bienczak2, Karen Cohen2, David Bangsberg3,4,5, Robin Wood1, Gary Maartens2, Paolo Denti2
1Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine and Department of Medicine, University of Cape Town, Cape Town, South Africa
2Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa
3Harvard Medical School, Boston, MA, USA
4Massachusetts General Hospital Center for Global Health, Boston, MA, USA
5Ragon Institute of Massachusetts General Hospital, Boston, MA, USA

Tài liệu tham khảo

Back, 2002, Therapeutic drug monitoring in HIV infection: current status and future directions, AIDS, 16, S5, 10.1097/00002030-200203001-00002 Liu, 2010, Therapeutic drug monitoring in highly active antiretroviral therapy, Expert Opin Drug Saf, 9, 743, 10.1517/14740331003767395 Kredo, 2009, Therapeutic drug monitoring of antiretrovirals for people with HIV, Cochrane Database Syst Rev, 10.1002/14651858.CD007268.pub2 Lee, 2014, Sleep quality in efavirenz-treated Chinese HIV patients—comparing between GT and GG genotype of CYP2B6-516 G/T polymorphisms, Int J STD AIDS, 25, 193, 10.1177/0956462413498581 Gutiérrez, 2005, Prediction of neuropsychiatric adverse events associated with long-term efavirenz therapy, using plasma drug level monitoring, Clin Infect Dis, 41, 1648, 10.1086/497835 Dickinson, 2015, Pharmacokinetic and pharmacodynamic comparison of once-daily efavirenz (400 mg vs. 600 mg) in treatment-naïve HIV-infected patients: results of the ENCORE1 study, Clin Pharmacol Ther, 98, 406, 10.1002/cpt.156 Sinxadi, 2015, Pharmacogenetics of plasma efavirenz exposure in HIV-infected adults and children in South Africa, Br J Clin Pharmacol, 80, 146, 10.1111/bcp.12590 Holzinger, 2012, Genome-wide association study of plasma efavirenz pharmacokinetics in AIDS Clinical Trials Group protocols implicates several CYP2B6 variants, Pharmacogenet Genomics, 22, 858, 10.1097/FPC.0b013e32835a450b Stahle, 2004, Efavirenz plasma concentrations in HIV-infected patients: inter- and intraindividual variability and clinical effects, Ther Drug Monit, 26, 267, 10.1097/00007691-200406000-00008 Lehmann, 2015, Genome-wide association study of virologic response with efavirenz-containing or abacavir-containing regimens in AIDS Clinical Trials Group protocols, Pharmacogenet Genomics, 25, 51, 10.1097/FPC.0000000000000106 Marzolini, 2001, Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patients, AIDS, 15, 71, 10.1097/00002030-200101050-00011 Leth, 2006, Pharmacokinetic parameters of nevirapine and efavirenz in relation to antiretroviral efficacy, AIDS Res Hum Retroviruses, 22, 232, 10.1089/aid.2006.22.232 Orrell, 2011, Virological breakthrough: a risk factor for loss to followup in a large community-based cohort on antiretroviral therapy, AIDS Res Treat, 2011, 469127 Orrell, 2007, Conservation of first-line antiretroviral treatment regimen where therapeutic options are limited, Antivir Ther, 12, 83, 10.1177/135965350701200106 Orrell, 2015, A randomised controlled trial of real-time electronic adherence monitoring with text message dosing reminders in people starting first-line antiretroviral therapy, J Acquir Immune Defic Syndr, 70, 495, 10.1097/QAI.0000000000000770 Dooley, 2015, Pharmacokinetics of efavirenz and treatment of HIV-1 among pregnant women with and without tuberculosis coinfection, J Infect Dis, 211, 197, 10.1093/infdis/jiu429 McIlleron, 2013, Effects of rifampin-based antituberculosis therapy on plasma efavirenz concentrations in children vary by CYP2B6 genotype, AIDS, 27, 1933, 10.1097/QAD.0b013e328360dbb4 R Development Core Team, 2015 Therneau Therneau, 2000 Andersen, 1982, Cox's regression model for counting processes: a large sample study, Ann Stat, 10, 1100, 10.1214/aos/1176345976 Klein, 2003 Bienczak, 2015 Cohen, 2009, Effect of rifampicin-based antitubercular therapy and the cytochrome P450 2B6 516G>T polymorphism on efavirenz concentrations in adults in South Africa, Antivir Ther, 14, 687, 10.1177/135965350901400502 Haas, 2004, Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study, AIDS, 18, 2391