Combining single patient (N-of-1) trials to estimate population treatment effects and to evaluate individual patient responses to treatment

Cochrane, 1972 Barlow, 1984 Guyatt, 1986, Determining optimal therapy—Randomized trials in individual patients, N Engl J Med, 314, 889, 10.1056/NEJM198604033141406 Louis, 1984, Crossover and self-controlled designs in clinical research, N Engl J Med, 310, 24, 10.1056/NEJM198401053100106 Senn, 1993 Edgington, 1984, Statistics and the single case analysis, Prog Behavior Modification, 16, 83, 10.1016/B978-0-12-535616-9.50008-0 Guyatt, 1990, The n-of-1 randomized controlled trial: Clinical usefulness: Our three-year experience, Ann Intern Med, 112, 293, 10.7326/0003-4819-112-4-293 Larson, 1993, Randomized clinical trials in single patients during a 2-year period, JAMA, 270, 2708, 10.1001/jama.1993.03510220064035 March, 1994, n Of 1 trials comparing a non-steroidal anti-inflammatory drug with paracetamol in osteoarthritis, Br Med J, 309, 1041, 10.1136/bmj.309.6961.1041 Kleveland, 1985, The effect of cimetidine in non-ulcer dyspepsia: Experience with a multi-crossover model, Scand J Gastroenterol, 20, 19, 10.3109/00365528509089627 Jaeschke, 1991, Clinical usefulness of amitriptyline in fibromyalgia: The results of 23 N-of-1 randomized controlled trials, J Rheumatol, 18, 447 Larson, 1990, N-of-1 clinical trials: A technique for improving medical therapeutics, West J Med, 152, 52 Guyatt, 1990, N of 1 randomized trials for investigating new drugs, Controlled Clin Trials, 11, 88, 10.1016/0197-2456(90)90003-K Guyatt, 1988, A clinician's guide for conducting randomized trials in individual patients, Can Med Assoc J, 139, 497 Edgington, 1984, Statistics and single case analysis, Prog Behav Modif, 16, 83, 10.1016/B978-0-12-535616-9.50008-0 Spiegelhalter, 1988, Statistical issues in studies of individual response, Scand J Gastroenterol, 23, 40, 10.3109/00365528809099158 DuMouchel, 1995 Jaeschke, 1989, Measurement of health status: Ascertaining the minimally clinically important difference, Controlled Clinical Trials, 10, 407, 10.1016/0197-2456(89)90005-6 Juniper, 1994, Determining a minimal important change in disease specific quality of life questionnaire, J Clin Epidemiol, 47, 81, 10.1016/0895-4356(94)90036-1 Juniper, 1996, Measuring quality of life in children with Asthma, Qual Life Res, 5, 35, 10.1007/BF00435967 DuMouchel, 1990, Bayesian metaanalysis, 509 DuMouchel, 1992, Hierarchical Models for Combining Information and for Meta-Analyses Goldenberg, 1986, A randomized, controlled trial of amitriptyline and naproxen in the treatment of patients with fibromyalgia, Arthritis Rheum, 29, 1371, 10.1002/art.1780291110 Carette, 1994, Comparison of amitriptyline, cyclobenzaprine, and placebo in the treatment of fibromyalgia. A randomized, double-blinded clinical trial, Arthritis Rheum, 37, 32, 10.1002/art.1780370106 D'Agostino, 1995, Measuring effectiveness: What to expect without a randomized control group, Med Care, 33, AS95 Irwig, 1995, Ethics of N-of-1 trials, Lancet, 345, 469, 10.1016/S0140-6736(95)90578-2 Greenfield, 1988, Patient's participation in medical care: Effects on blood sugar control and quality of life in diabetes, J Gen Intern Med, 3, 448, 10.1007/BF02595921 Mahon, 1996, Randomised study of n of 1 trials versus standard practice, Br Med J, 312, 1069, 10.1136/bmj.312.7038.1069