Expression of TRAF6 and pro-inflammatory cytokines through activation of TLR2, TLR4, NOD1, and NOD2 in human periodontal ligament fibroblasts

Janeway, 2002, Innate immune recognition, Annu Rev Immunol, 20, 197, 10.1146/annurev.immunol.20.083001.084359 Aderem, 2000, Toll-like receptors in the induction of the innate immune response, Nature, 406, 782, 10.1038/35021228 Akira, 2001, Toll-like receptors: critical proteins linking innate and acquired immunity, Nat Immunol, 2, 675, 10.1038/90609 Inohara, 2003, NODs: intracellular proteins involved in inflammation and apoptosis, Nat Rev Immunol, 3, 371, 10.1038/nri1086 Takeuchi, 1999, Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components, Immunity, 11, 443, 10.1016/S1074-7613(00)80119-3 Chamaillard, 2003, An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid, Nat Immunol, 4, 702, 10.1038/ni945 Girardin, 2003, Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection, J Biol Chem, 278, 8869, 10.1074/jbc.C200651200 Yamaji, 1995, Inflammatory cytokine gene expression in human periodontal ligament fibroblasts stimulated with bacterial lipopolysaccharides, Infect Immun, 63, 3576, 10.1128/IAI.63.9.3576-3581.1995 Hatakeyama, 2003, Contrasting responses of human gingival and periodontal ligament fibroblasts to bacterial cell-surface components through the CD14/Toll-like receptor system, Oral Microbiol Immunol, 18, 14, 10.1034/j.1399-302X.2003.180103.x Sun, 2008, Toll-like receptor 4 signaling plays a role in triggering periodontal infection, FEMS Immunol Med Microbiol, 52, 362, 10.1111/j.1574-695X.2008.00386.x Uehara, 2007, Functional TLRs and NODs in human gingival fibroblasts, J Dent Res, 86, 249, 10.1177/154405910708600310 Hirao, 2009, Roles of TLR2, TLR4, NOD2, and NOD1 in pulp fibroblasts, J Dent Res, 88, 762, 10.1177/0022034509341779 Wang, 2010, TRAF-mediated regulation of immune and inflammatory responses, Sci China Life Sci, 53, 159, 10.1007/s11427-010-0050-3 Hirata, 2006, MyD88 and TNF receptor-associated factor 6 are critical signal transducers in Helicobacter pylori-infected human epithelial cells, J Immunol, 176, 3796, 10.4049/jimmunol.176.6.3796 Lomaga, 1999, TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling, Gene Dev, 13, 1015, 10.1101/gad.13.8.1015 Yang, 2009, Immunolocalization of tumor necrosis factor receptor-associated factor 6 in rat periapical lesions, J Endod, 35, 834, 10.1016/j.joen.2009.03.011 Medzhitov, 1998, MyD88 is an adaptor protein in the Toll/IL-1 receptor family signaling pathways, Mol Cell, 2, 253, 10.1016/S1097-2765(00)80136-7 Yang, 1999, Signaling events induced by lipopolysaccharide-activated toll-like receptor 2, J Immunol, 163, 639, 10.4049/jimmunol.163.2.639 Márton, 2000, Protective and destructive immune reactions in apical periodontitis, Oral Microbiol Immunol, 15, 139, 10.1034/j.1399-302x.2000.150301.x Akira, 2004, Toll-like receptor signalling, Nat Rev Immunol, 4, 499, 10.1038/nri1391 Martinon, 2005, NLRs join TLRs as innate sensors of pathogens, Trends Immunol, 26, 447, 10.1016/j.it.2005.06.004 Uehara, 2008, Synergism between TLRs and NOD1/2 in oral epithelial cells, J Dent Res, 87, 682, 10.1177/154405910808700709 Wang, 2006, Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling, Nat Immunol, 7, 139, 10.1038/ni1294 Hosokawa, 2010, Proinflammatory effects of muramyldipeptide on human gingival fibroblasts, J Periodontal Res, 45, 193, 10.1111/j.1600-0765.2009.01217.x Liu, 2010, TRAF6 knockdown promotes survival and inhibits inflammatory response to lipopolysaccharides in rat primary renal proximal tubule cells, Acta Physiol, 199, 339 Barkhordar, 1992, Detection of interleukin-1 beta in human periapical lesions, Oral Surg Oral Med Oral Pathol, 73, 334, 10.1016/0030-4220(92)90131-9 de Sá, 2003, Immunolocalization of interleukin 4, interleukin 6, and lymphotoxin in dental granuloma, Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 96, 356, 10.1016/S1079-2104(03)00067-2 Marton, 2000, Differential in situ distribution of interleukin-8, macrophage chemoattractant protein-1 and Rantes in human chronic periapical granuloma, Oral Microbiol Immunol, 15, 63, 10.1034/j.1399-302x.2000.150111.x Ataoğlu, 2002, Interleukin-1β and tumour necrosis factor-levels in periapical exudates, Int Endod J, 35, 181, 10.1046/j.1365-2591.2002.00467.x Nair, 2004, Pathogenesis of apical periodontitis and the causes of endodontic failures, Crit Rev Oral Biol Med, 15, 348, 10.1177/154411130401500604