The immunomodulatory properties of mesenchymal stem cells and their use for immunotherapy

Zuk, 2002, Human adipose tissue is a source of multipotent stem cells, Mol Biol Cell, 13, 4279, 10.1091/mbc.E02-02-0105 Toma, 2001, Isolation of multipotent adult stem cells from the dermis of mammalian skin, Nat Cell Biol, 3, 778, 10.1038/ncb0901-778 Hoogduijn, 2007, Human heart, spleen, and perirenal fat-derived mesenchymal stem cells have immunomodulatory capacities, Stem Cells Dev, 16, 597, 10.1089/scd.2006.0110 Le Blanc, 2003, HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells, Exp Hematol, 31, 890, 10.1016/S0301-472X(03)00110-3 Pittenger, 1999, Multilineage potential of adult human mesenchymal stem cells, Science, 284, 143, 10.1126/science.284.5411.143 Phinney, 2007, Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair–current views, Stem Cells, 25, 2896, 10.1634/stemcells.2007-0637 Di Nicola, 2002, Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli, Blood, 99, 3838, 10.1182/blood.V99.10.3838 Krampera, 2003, Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide, Blood, 101, 3722, 10.1182/blood-2002-07-2104 Comoli, 2008, Human mesenchymal stem cells inhibit antibody production induced in vitro by allostimulation, Nephrol Dial Transplant, 23, 1196, 10.1093/ndt/gfm740 Nauta, 2006, Mesenchymal stem cells inhibit generation and function of both CD34+-derived and monocyte-derived dendritic cells, J Immunol, 177, 2080, 10.4049/jimmunol.177.4.2080 Gonzalez-Rey, 2009, Human adult stem cells derived from adipose tissue protect against experimental colitis and sepsis, Gut, 58, 929, 10.1136/gut.2008.168534 Parekkadan, 2008, Bone Marrow-Derived Mesenchymal Stem Cells Ameliorate Autoimmune Enteropathy Independent of Regulatory T Cells, Stem Cells, 26, 1913, 10.1634/stemcells.2007-0790 Popp, 2008, Mesenchymal stem cells can induce long-term acceptance of solid organ allografts in synergy with low-dose mycophenolate, Transpl Immunol, 20, 60 Bartholomew, 2002, Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo, Exp Hematol, 30, 42, 10.1016/S0301-472X(01)00769-X Benvenuto, 2007, Human mesenchymal stem cells promote survival of T cells in a quiescent state, Stem Cells, 25, 1753, 10.1634/stemcells.2007-0068 Crop M, Baan CC, Korevaar SS, IJzermans JN, Weimar W, Hoogduijn MJ. Human adipose tissue-derived mesenchymal stem cells induce explosive T-cell proliferation. Stem Cells Dev 2010, in press. Sato, 2007, Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells, Blood, 109, 228, 10.1182/blood-2006-02-002246 Nasef, 2007, Immunosuppressive effects of mesenchymal stem cells: involvement of HLA-G, Transplantation, 84, 231, 10.1097/01.tp.0000267918.07906.08 Meisel, 2004, Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2, 3-dioxygenase-mediated tryptophan degradation, Blood, 103, 4619, 10.1182/blood-2003-11-3909 Krampera, 2006, Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells, Stem Cells, 24, 386, 10.1634/stemcells.2005-0008 Francois, 2009, Mesenchymal stromal cells cross-present soluble exogenous antigens as part of their antigen-presenting cell properties, Blood, 114, 2632, 10.1182/blood-2009-02-207795 Chan, 2008, MHC expression kinetics and immunogenicity of mesenchymal stromal cells after short-term IFN-gamma challenge, Exp Hematol, 36, 1545, 10.1016/j.exphem.2008.06.008 Albini, 1991, Tumor cell invasion inhibited by TIMP-2, J Natl Cancer Inst, 83, 775, 10.1093/jnci/83.11.775 Suva, 2008, In vitro activated human T lymphocytes very efficiently attach to allogenic multipotent mesenchymal stromal cells and transmigrate under them, J Cell Physiol, 214, 588, 10.1002/jcp.21244 Quaedackers, 2009, (2009) Cell contact interaction between adipose-derived stromal cells and allo-activated T lymphocytes, Eur J Immunol, 39, 3436, 10.1002/eji.200939584 Patel, 2010, Mesenchymal stem cells protect breast cancer cells through regulatory T cells: role of mesenchymal stem cell-derived TGF-beta, J Immunol, 184, 5885, 10.4049/jimmunol.0903143 Puissant, 2005, Immunomodulatory effect of human adipose tissue-derived adult stem cells: comparison with bone marrow mesenchymal stem cells, Br J Haematol, 129, 118, 10.1111/j.1365-2141.2005.05409.x English, 2007, IFN-gamma and TNF-alpha differentially regulate immunomodulation by murine mesenchymal stem cells, Immunol Lett, 110, 91, 10.1016/j.imlet.2007.04.001 Aggarwal, 2005, Human mesenchymal stem cells modulate allogeneic immune cell responses, Blood, 105, 1815, 10.1182/blood-2004-04-1559 Hoogduijn, 2009, Donor-derived mesenchymal stem cells remain present and functional in the transplanted human heart, Am J Transplant, 9, 222, 10.1111/j.1600-6143.2008.02450.x Masoodi, 2006, Lipidomic analysis of twenty-seven prostanoids and isoprostanes by liquid chromatography/electrospray tandem mass spectrometry, Rapid Commun Mass Spectrom, 20, 3023, 10.1002/rcm.2697 Yao, 2009, Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansion, Nat Med, 15, 633, 10.1038/nm.1968 Renner, 2009, Mesenchymal stem cells require a sufficient, ongoing immune response to exert their immunosuppressive function, Transplant Proc, 41, 2607, 10.1016/j.transproceed.2009.06.119 Nauta, 2006, Donor-derived mesenchymal stem cells are immunogenic in an allogeneic host and stimulate donor graft rejection in a nonmyeloablative setting, Blood, 108, 2114, 10.1182/blood-2005-11-011650 Sbano, 2008, Use of donor bone marrow mesenchymal stem cells for treatment of skin allograft rejection in a preclinical rat model, Arch Dermatol Res, 300, 115, 10.1007/s00403-007-0827-9 Hoogduijn, 2008, Susceptibility of human mesenchymal stem cells to tacrolimus, mycophenolic acid, and rapamycin, Transplantation, 86, 1283, 10.1097/TP.0b013e31818aa536 Buron, 2009, Human mesenchymal stem cells and immunosuppressive drug interactions in allogeneic responses: an in vitro study using human cells, Transplant Proc, 41, 3347, 10.1016/j.transproceed.2009.08.030 Ge, 2009, Infusion of mesenchymal stem cells and rapamycin synergize to attenuate alloimmune responses and promote cardiac allograft tolerance, Am J Transplant, 9, 1760, 10.1111/j.1600-6143.2009.02721.x Yanez, 2006, Adipose tissue-derived mesenchymal stem cells have in vivo immunosuppressive properties applicable for the control of the graft-versus-host disease, Stem Cells, 24, 2582, 10.1634/stemcells.2006-0228 Sudres, 2006, Bone marrow mesenchymal stem cells suppress lymphocyte proliferation in vitro but fail to prevent graft-versus-host disease in mice, J Immunol, 176, 7761, 10.4049/jimmunol.176.12.7761 Polchert, 2008, IFN-gamma activation of mesenchymal stem cells for treatment and prevention of graft versus host disease, Eur J Immunol, 38, 1745, 10.1002/eji.200738129 Casiraghi, 2008, Pretransplant infusion of mesenchymal stem cells prolongs the survival of a semiallogeneic heart transplant through the generation of regulatory T cells, J Immunol, 181, 3933, 10.4049/jimmunol.181.6.3933 Ren, 2009, Species variation in the mechanisms of mesenchymal stem cell-mediated immunosuppression, Stem Cells, 27, 1954, 10.1002/stem.118 Le Blanc, 2008, Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study, Lancet, 371, 1579, 10.1016/S0140-6736(08)60690-X Garcia-Olmo, 2005, A phase I clinical trial of the treatment of Crohn's fistula by adipose mesenchymal stem cell transplantation, Dis Colon Rectum, 48, 1416, 10.1007/s10350-005-0052-6 Dryden, 2009, Overview of stem cell therapy for Crohn's disease, Expert Opin Biol 441 Ther, 9, 841, 10.1517/14712590902956615 Dahlke, 2009, Toward MSC in solid organ transplantation: 2008 position paper of the MISOT study group, Transplantation, 88, 614, 10.1097/TP.0b013e3181b4425a Popp, 2009, Mesenchymal stem cells as immunomodulators after liver transplantation, Liver Transpl, 15, 1192, 10.1002/lt.21862