Human Bone Marrow Stromal Cells Hamper Specific Interactions of CD4 and CD8 T Lymphocytes with Antigen-Presenting Cells

Dorshkind, 1990, Regulation of hemopoiesis by bone marrow stromal cells and their products, Annu Rev Immunol, 8, 111, 10.1146/annurev.iy.08.040190.000551 Trentin, 1970, Influence of Hematopoietic Organ Stroma (Hematopoietic Inductive Microenvironments) on Stem Cell Differentiation Dejbakhsh-Jones, 1995, Extrathymic maturation of alpha beta T cells from hemopoietic stem cells, J Immunol, 155, 3338, 10.4049/jimmunol.155.7.3338 Li, 2000, Evidence for migration of donor bone marrow stromal cells into recipient thymus after bone marrow transplantation plus bone grafts: a role of stromal cells in positive selection, Exp Hematol, 28, 950, 10.1016/S0301-472X(00)00483-5 Suniara, 2000, An essential role for thymic mesenchyme in early T cell development, J Exp Med, 191, 1051, 10.1084/jem.191.6.1051 Pittenger, 1999, Multilineage potential of adult human mesenchymal stem cells, Science, 284, 143, 10.1126/science.284.5411.143 Di Nicola, 2002, Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli, Blood, 99, 3838, 10.1182/blood.V99.10.3838 Krampera, 2003, Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide, Blood, 101, 3722, 10.1182/blood-2002-07-2104 Le Blanc, 2003, Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex, Scand J Immunol, 57, 11, 10.1046/j.1365-3083.2003.01176.x Corcione, 2006, Human mesenchymal stem cells modulate B-cell functions, Blood, 107, 367, 10.1182/blood-2005-07-2657 Bartholomew, 2002, Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo, Exp Hematol, 30, 42, 10.1016/S0301-472X(01)00769-X Li Pira, 2004, Identification of new Th peptides from the cytomegalovirus protein pp65 to design a peptide library for generation of CD4 T cell lines for cellular immunoreconstitution, Int Immunol, 16, 635, 10.1093/intimm/dxh065 Li Pira, 2004, Recognition of CMV pp65 protein antigen by human CD4 T-cell lines induced with an immunodominant peptide pool, Hum Immunol, 65, 537, 10.1016/j.humimm.2004.02.010 Li Pira, 2005, Generation of cytomegalovirus (CMV)-specific CD4 T cell lines devoid of alloreactivity, by use of a mixture of CMV-phosphoprotein 65 peptides for reconstitution of the T helper repertoire, J Infect Dis, 191, 215, 10.1086/427040 Martin, 1997, Fibroblast growth factor-2 supports ex vivo expansion and maintenance of osteogenic precursors from human bone marrow, Endocrinology, 138, 4456, 10.1210/en.138.10.4456 Johnstone, 1998, In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells, Exp Cell Res, 238, 265, 10.1006/excr.1997.3858 Muraglia, 2003, Formation of a chondro-osseous rudiment in micromass cultures of human bone-marrow stromal cells, J Cell Sci, 116, 2949, 10.1242/jcs.00527 Ryan, 1992, Tumor necrosis factor-induced endothelial tissue factor is associated with subendothelial matrix vesicles but is not expressed on the apical surface, Blood, 80, 966, 10.1182/blood.V80.4.966.966 Mulder, 1994, Tumor necrosis factor alpha-induced endothelial tissue factor is located on the cell surface rather than in the subendothelial matrix, Blood, 84, 1559, 10.1182/blood.V84.5.1559.1559 Koc, 2000, Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy, J Clin Oncol, 18, 307, 10.1200/JCO.2000.18.2.307 Koc, 2001, Mesenchymal stem cells: heading into the clinic, Bone Marrow Transplant, 27, 235, 10.1038/sj.bmt.1702791 Devine, 2003, Clinical application of hematopoietic progenitor cell expansion: current status and future prospects, Bone Marrow Transplant, 31, 241, 10.1038/sj.bmt.1703813 Maitra, 2004, Human mesenchymal stem cells support unrelated donor hematopoietic stem cells and suppress T-cell activation, Bone Marrow Transplant, 33, 597, 10.1038/sj.bmt.1704400 Djouad, 2003, Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals, Blood, 102, 3837, 10.1182/blood-2003-04-1193 Meisel, 2004, Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation, Blood, 103, 4619, 10.1182/blood-2003-11-3909 Sarkosh, 2003, Immune cell proliferation is suppressed by the interferon gamma induced indoleamine 2,3-doxygenase expression of fibroblasts populated in collagen gel (FPCG), J Cell Biochem, 90, 206, 10.1002/jcb.10593 Mellor, 2004, IDO expression by dendritic cells: tolerance and tryptophan catabolism, Nature Rev Immunol, 4, 762, 10.1038/nri1457 Frank, 2004, Immunomodulatory functions of mesenchymal stem cells, Lancet, 363, 1411, 10.1016/S0140-6736(04)16134-5 Beyth, 2005, Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness, Blood, 105, 2214, 10.1182/blood-2004-07-2921 Schofield, 1999, Expression of proteoglycan core proteins in human bone marrow stroma, Biochem J, 343, 663, 10.1042/0264-6021:3430663 Drzeniek, 1997, Proteoglycan synthesis in haematopoietic cells: isolation and characterization of heparan sulphate proteoglycans expressed by the bone-marrow stromal cell line MS-5, Biochem J, 327, 473, 10.1042/bj3270473 Roberts, 1988, Heparan sulphate bound growth factors: a mechanism for stromal cell mediated haemopoiesis, Nature, 332, 376, 10.1038/332376a0 Lebbink, 2006, Collagens are functional, high affinity ligands for the inhibitory immune receptor LAIR-1, J Exp Med, 203, 1419, 10.1084/jem.20052554 Majumdar, 2003, Characterization and functionality of cell surface molecules on human mesenchymal stem cells, J Biomed Sci, 10, 228, 10.1007/BF02256058 Tse, 2003, Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation, Transplantation, 75, 389, 10.1097/01.TP.0000045055.63901.A9 Maccario, 2005, Interaction of human mesenchymal stem cells with cells involved in alloantigen-specific immune response favors the differentiation of CD4+ T-cell subsets expressing a regulatory/suppressive phenotype, Haematologica, 90, 516 Le Blanc, 2004, Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells, Lancet, 363, 1439, 10.1016/S0140-6736(04)16104-7