Mechanisms Driving Gender Differences in Asthma
Tóm tắt
Từ khóa
Tài liệu tham khảo
Prevention of asthma. Global initiative for asthma (GINA). http://www.ginasthma.org/ . 2014.
Centers for Disease Control and Prevention, Vital Signs, May 2011.2013.
•• Wu W, Bleecker E, Moore W, Busse WW, Castro M, Chung KF, et al. Unsupervised phenotyping of severe asthma research program participants using expanded lung data. J Allergy Clin Immunol. 2014;133(5):1280–8. This study was critical in identifying different phenotypes of asthma and determining that women had increased prevalence in the more severe phenotypes of asthma
Kynyk JA, Mastronarde JG, McCallister JW. Asthma, the sex difference. Curr Opin Pulm Med. 2011;17(1):6–11.
Moorman JE, Zahran H, Truman BI, Molla MT. Current asthma prevalence—United States, 2006–2008. MMWR Surveill Summ. 2011;60(Suppl):84–6.
Chen Y, Stewart P, Johansen H, McRae L, Taylor G. Sex difference in hospitalization due to asthma in relation to age. J Clin Epidemiol. 2003;56(2):180–7.
Hyndman SJ, Williams DR, Merrill SL, Lipscombe JM, Palmer CR. Rates of admission to hospital for asthma. BMJ. 1994;308(6944):1596–600.
Skobeloff EM, Spivey WH, St Clair SS, Schoffstall JM. The influence of age and sex on asthma admissions. JAMA. 1992;268(24):3437–40.
Troisi RJ, Speizer FE, Willett WC, Trichopoulos D, Rosner B. Menopause, postmenopausal estrogen preparations, and the risk of adult-onset asthma. A prospective cohort study. Am J Respir Crit Care Med. 1995;152(4 Pt 1):1183–8.
Borish L, Chipps B, Deniz Y, Gujrathi S, Zheng B, Dolan CM, et al. Total serum IgE levels in a large cohort of patients with severe or difficult-to-treat asthma. Ann Allergy Asthma Immunol. 2005;95(3):247–53.
Genuneit J. Sex-specific development of asthma differs between farm and nonfarm children: a cohort study. Am J Respir Crit Care Med. 2014;190(5):588–90.
Pagtakhan RD, Bjelland JC, Landau LI, Loughlin G, Kaltenborn W, Seeley G, et al. Sex differences in growth patterns of the airways and lung parenchyma in children. J Appl Physiol Respir Environ Exerc Physiol. 1984;56(5):1204–10.
Vink NM, Postma DS, Schouten JP, Rosmalen JG, Boezen HM. Gender differences in asthma development and remission during transition through puberty: the tracking adolescents’ individual lives survey (trails) study. J Allergy Clin Immunol. 2010;126(3):498–504.
• Fu L, Freishtat RJ, Gordish-Dressman H, Teach SJ, Resca L, Hoffman EP, et al. Natural progression of childhood asthma symptoms and strong influence of sex and puberty. Ann Am Thorac Soc. 2014;11(6):939–44. This study showed that asthma symptoms increased as Tanner stages of puberty increased in girls
Castro-Rodriguez JA. A new childhood asthma phenotype: obese with early menarche. Paediatr Respir Rev. 2016;18:85–9.
Juniper EF, Kline PA, Roberts RS, Hargreave FE, Daniel EE. Airway responsiveness to methacholine during the natural menstrual cycle and the effect of oral contraceptives. Am Rev Respir Dis. 1987;135(5):1039–42.
Pauli BD, Reid RL, Munt PW, Wigle RD, Forkert L. Influence of the menstrual cycle on airway function in asthmatic and normal subjects. Am Rev Respir Dis. 1989;140(2):358–62.
Shames RS, Heilbron DC, Janson SL, Kishiyama JL, Au DS, Adelman DC. Clinical differences among women with and without self-reported perimenstrual asthma. Ann Allergy Asthma Immunol. 1998;81(1):65–72.
Brenner BE, Holmes TM, Mazal B, Camargo Jr CA. Relation between phase of the menstrual cycle and asthma presentations in the emergency department. Thorax. 2005;60(10):806–9.
Chandler MH, Schuldheisz S, Phillips BA, Muse KN. Premenstrual asthma: the effect of estrogen on symptoms, pulmonary function, and beta 2-receptors. Pharmacotherapy. 1997;17(2):224–34.
Rao CK, Moore CG, Bleecker E, Busse WW, Calhoun W, Castro M, et al. Characteristics of perimenstrual asthma and its relation to asthma severity and control: data from the severe asthma research program. Chest. 2013;143(4):984–92.
Dweik RA, Boggs PB, Erzurum SC, Irvin CG, Leigh MW, Lundberg JO, et al. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (feno) for clinical applications. Am J Respir Crit Care Med. 2011;184(5):602–15.
Oguzulgen IK, Turktas H, Erbas D. Airway inflammation in premenstrual asthma. J Asthma. 2002;39(6):517–22.
Zimmerman JL, Woodruff PG, Clark S, Camargo CA. Relation between phase of menstrual cycle and emergency department visits for acute asthma. Am J Respir Crit Care Med. 2000;162(2 Pt 1):512–5.
Macsali F, Real FG, Omenaas ER, Bjorge L, Janson C, Franklin K, et al. Oral contraception, body mass index, and asthma: a cross-sectional Nordic-Baltic population survey. J Allergy Clin Immunol. 2009;123(2):391–7.
Jenkins MA, Dharmage SC, Flander LB, Douglass JA, Ugoni AM, Carlin JB, et al. Parity and decreased use of oral contraceptives as predictors of asthma in young women. Clin Exp Allergy. 2006;36(5):609–13.
Erkocoglu M, Kaya A, Azkur D, Ozyer S, Ozcan C, Besli M, et al. The effect of oral contraceptives on current wheezing in young women. Allergol Immunopathol (Madr). 2013;41(3):169–75.
Salam MT, Wenten M, Gilliland FD. Endogenous and exogenous sex steroid hormones and asthma and wheeze in young women. J Allergy Clin Immunol. 2006;117(5):1001–7.
• Dratva J, Schindler C, Curjuric I, Stolz D, Macsali F, Gomez FR, et al. Perimenstrual increase in bronchial hyperreactivity in premenopausal women: results from the population-based SAPALDIA 2 cohort. J Allergy Clin Immunol. 2010;125(4):823–9. This study conducted methacholine challenges on the day of menstruation for over 500 women taking or not taking oral contractives to determine cyclic variations in bronchial hyperractivity. Authors determine systematic variation in BHR during the menstrual cycle and that oral contraceptives had a protective effect
Murphy VE, Gibson PG. Premenstrual asthma: prevalence, cycle-to-cycle variability and relationship to oral contraceptive use and menstrual symptoms. J Asthma. 2008;45(8):696–704.
Schatz M, Harden K, Forsythe A, Chilingar L, Hoffman C, Sperling W, et al. The course of asthma during pregnancy, post partum, and with successive pregnancies: a prospective analysis. J Allergy Clin Immunol. 1988;81(3):509–17.
Stenius-Aarniala B, Piirila P, Teramo K. Asthma and pregnancy: a prospective study of 198 pregnancies. Thorax. 1988;43(1):12–8.
Schatz M. Interrelationships between asthma and pregnancy: a literature review. J Allergy Clin Immunol. 1999;103(2 Pt 2):S330–6.
National Heart L, Blood I, National Asthma E, Prevention Program A, Pregnancy WG. Naepp expert panel report: managing asthma during pregnancy: recommendations for pharmacologic treatment—2004 update. J Allergy Clin Immunol. 2005;115(1):34–46.
GINA—Global strategy for asthma management and prevention. 2014.
Murphy VE, Clifton VL, Gibson PG. Asthma exacerbations during pregnancy: incidence and association with adverse pregnancy outcomes. Thorax. 2006;61(2):169–76.
Lim A, Stewart K, Konig K, George J. Systematic review of the safety of regular preventive asthma medications during pregnancy. Ann Pharmacother. 2011;45(7–8):931–45.
Gomez Real F, Svanes C, Bjornsson EH, Franklin KA, Gislason D, Gislason T, et al. Hormone replacement therapy, body mass index and asthma in perimenopausal women: a cross sectional survey. Thorax. 2006;61(1):34–40.
Real FG, Svanes C, Omenaas ER, Anto JM, Plana E, Jarvis D, et al. Lung function, respiratory symptoms, and the menopausal transition. J Allergy Clin Immunol. 2008;121(1):72–80. e3
Balzano G, Fuschillo S, De Angelis E, Gaudiosi C, Mancini A, Caputi M. Persistent airway inflammation and high exacerbation rate in asthma that starts at menopause. Monaldi Arch Chest Dis. 2007;67(3):135–41.
Triebner K, Johannessen A, Puggini L, Benediktsdottir B, Bertelsen RJ, Bifulco E, et al. Menopause as a predictor of new-onset asthma: a longitudinal northern european population study. J Allergy Clin Immunol. 2016;137(1):50–7. e6
Triebner K, Matulonga B, Johannessen A, Suske S, Benediktsdottir B, Demoly P, et al. Menopause is associated with accelerated lung function decline. Am J Respir Crit Care Med 2016.
Trejo Bittar HE, Yousem SA, Wenzel SE. Pathobiology of severe asthma. Annual Review of Pathology: Mechanisms of Disease. 2015;10:511–45.
Manni ML, Trudeau JB, Scheller EV, Mandalapu S, Elloso MM, Kolls JK, et al. The complex relationship between inflammation and lung function in severe asthma. Mucosal Immunol. 2014;7(5):1186–98.
Fajt ML, Wenzel SE. Asthma phenotypes and the use of biologic medications in asthma and allergic disease: the next steps toward personalized care. J Allergy Clin Immunol. 2015;135(2):299–310.
Fahy JV. Eosinophilic and neutrophilic inflammation in asthma: insights from clinical studies. Proc Am Thorac Soc. 2009;6(3):256–9.
Ray A, Raundhal M, Oriss TB, Ray P, Wenzel SE. Current concepts of severe asthma. J Clin Invest. 2016;126(7):2394–403.
Hayashi T, Adachi Y, Hasegawa K, Morimoto M. Less sensitivity for late airway inflammation in males than females in BALB/c mice. ScandJImmunol. 2003;57(6):562–7.
Takeda M, Tanabe M, Ito W, Ueki S, Konnno Y, Chihara M, et al. Gender difference in allergic airway remodelling and immunoglobulin production in mouse model of asthma. Respirology. 2013;18(5):797–806.
• Blacquiere MJ, Hylkema MN, Postma DS, Geerlings M, Timens W, Melgert BN. Airway inflammation and remodeling in two mouse models of asthma: comparison of males and females. Int Arch Allergy Immunol. 2010;153(2):173–81. This study showed that female mice had increased OVA or HDM-induced airway associated with severe asthma and that airway remodeling is not associated with increased asthma severity in mice
•• Riffo-Vasquez Y, Ligeiro de Oliveira AP, Page CP, Spina D, Tavares-de-Lima W. Role of sex hormones in allergic inflammation in mice. ClinExpAllergy. 2007;37(3):459–70. This study showed that female sex hormones increase OVA-induced type 2 airway inflammation by increasing IL-5 and eosinophil numbers in the BAL fluid and airway hyperesponsiveness to methacholine challenges
• Carey MA, Card JW, Bradbury JA, Moorman MP, Haykal-Coates N, Gavett SH, et al. Spontaneous airway hyperresponsiveness in estrogen receptor-alpha-deficient mice. AmJRespirCrit Care Med. 2007;175(2):126–35. Showed that estrogen receptor alpha decreases airway hyperresponsinvess to methacholine challenge and regulates M2 muscarinic receptor expression
Yu CK, Liu YH, Chen CL. Dehydroepiandrosterone attenuates allergic airway inflammation in Dermatophagoides farinae-sensitized mice. J Microbiol Immunol Infect. 2002;35(3):199–202.
Bartemes KR, Iijima K, Kobayashi T, Kephart GM, McKenzie AN, Kita H. Il-33-responsive lineage- CD25+ CD44hi lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs. J Immunol. 2012;188(3):1503–13.
Angkasekwinai P, Park H, Wang YH, Wang YH, Chang SH, Corry DB, et al. Interleukin 25 promotes the initiation of proallergic type 2 responses. J Exp Med. 2007;204(7):1509–17.
Ballantyne SJ, Barlow JL, Jolin HE, Nath P, Williams AS, Chung KF, et al. Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma. J Allergy Clin Immunol. 2007;120(6):1324–31.
Barlow JL, Bellosi A, Hardman CS, Drynan LF, Wong SH, Cruickshank JP, et al. Innate IL-13-producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity. J Allergy Clin Immunol. 2012;129(1):191–8 e1-4.
Warren KJ, Sweeter JM, Pavlik JA, Nelson AJ, Devasure JM, Dickinson JD, et al. Sex differences in activation of lung-related type 2 innate lymphoid cells in experimental asthma. Annals of Allergy, Asthma & Immunology.
Borish L, Culp JA. Asthma: a syndrome composed of heterogeneous diseases. Ann Allergy Asthma Immunol. 2008;101(1):1–8.
Munoz-Cruz S, Mendoza-Rodriquez Y, et al. Gender-related effects of sex steroids on histamine release and FcεR1 expression in rat peritoneal mast cells. Journal of Immunol Res. 2015;2015:10.
Melgert BN, Oriss TB, Qi Z, Dixon-McCarthy B, Geerlings M, Hylkema MN, et al. Macrophages: regulators of sex differences in asthma? Am J Respir Cell Mol Biol. 2010;42(5):595–603.
Bengtsson AK, Ryan EJ, Giordano D, Magaletti DM, Clark EA. 17beta-estradiol (E2) modulates cytokine and chemokine expression in human monocyte-derived dendritic cells. Blood. 2004;104(5):1404–10.
Paharkova-Vatchkova V, Maldonado R, Kovats S. Estrogen preferentially promotes the differentiation of CD11c+ CD11b (intermediate) dendritic cells from bone marrow precursors. The J Immunol. 2004;172(3):1426.
Calippe B, Douin-Echinard V, Delpy L, Laffargue M, Lelu K, Krust A, et al. 17beta-estradiol promotes TLR4-triggered proinflammatory mediator production through direct estrogen receptor alpha signaling in macrophages in vivo. J Immunol. 2010;185(2):1169–76.
• Newcomb DC, Peebles Jr RS. Th17-mediated inflammation in asthma. Curr Opin Immunol. 2013;25(6):755–60. First study to show that women with severe asthma have increased numbers of IL-17+ memory Th17 cells compared to men with severe asthma and that transfer of OVA-specific Th17 cells from female mice increased airway neutrophils in OVA-challenge recipient mice compared to transfer of OVA-specific Th17 cells from male mice
Chakir J, Shannon J, Molet S, Fukakusa M, Elias J, Laviolette M, et al. Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on tgf-beta, IL-11, IL-17, and type I and type III collagen expression. J Allergy Clin Immunol. 2003;111(6):1293–8.
Newcomb DC, Boswell MG, Sherrill TP, Polosukhin VV, Boyd KL, Goleniewska K, et al. Il-17a induces signal transducers and activators of transcription-6-independent airway mucous cell metaplasia. Am J Respir Cell Mol Biol. 2013;48(6):711–6.
Newcomb DC, Boswell MG, Reiss S, Zhou W, Goleniewska K, Toki S, et al. IL-17a inhibits airway reactivity induced by respiratory syncytial virus infection during allergic airway inflammation. Thorax. 2013;68(8):717–23.
Newcomb DC, Cephus JY, Boswell MG, Fahrenholz JM, Langley EW, Feldman AS, et al. Estrogen and progesterone decrease let-7f microRNA expression and increase IL-23/IL-23 receptor signaling and IL-17a production in patients with severe asthma. J Allergy Clin Immunol. 2015;136(4):1025–34. e11
Ullah MA, Revez JA, Loh Z, Simpson J, Zhang V, Bain L, et al. Allergen-induced IL-6 trans-signaling activates γδ T cells to promote type 2 and type 17 airway inflammation. J Allergy Clin Immunol. 2015;136(4):1065–73.
Bloodworth MH, Newcomb DC, Dulek DE, Stier MT, Cephus JY, Zhang J, et al. STAT6 signaling attenuates interleukin-17-producing gammadelta T cells during acute Klebsiella pneumoniae infection. Infect Immun. 2016;84(5):1548–55.
Andersson A, Grahnemo L, Engdahl C, Stubelius A, Lagerquist MK, Carlsten H, et al. IL-17-producing γδt cells are regulated by estrogen during development of experimental arthritis. Clin Immunol. 2015;161(2):324–32.
Card JW, Carey MA, Bradbury JA, DeGraff LM, Morgan DL, Moorman MP, et al. Gender differences in murine airway responsiveness and lipopolysaccharide-induced inflammation. J Immunol. 2006;177(1):621–30.
Massaro D, Massaro GD. Estrogen receptor regulation of pulmonary alveolar dimensions: alveolar sexual dimorphism in mice. Am J Physiol Lung Cell Mol Physiol. 2006;290(5):L866.
Card JW, Voltz JW, Ferguson CD, Carey MA, DeGraff LM, Peddada SD, et al. Male sex hormones promote vagally mediated reflex airway responsiveness to cholinergic stimulation. Am J Physiol Lung Cell Mol Physiol. 2007;292(4):L908.
Helmi AM, El Ghazzawi IF, Mandour MA, Shehata MA. The effect of oestrogen on the nasal respiratory mucosa. An experimental histopathological and histochemical study. J Laryngol Otol. 1975;89(12):1229–41.
Tam A, Wadsworth S, Dorscheid D, Man SF, Sin DD. Estradiol increases mucus synthesis in bronchial epithelial cells. PLoS One. 2014;9(6):e100633.
Choi HJ, Chung YS, Kim HJ, Moon UY, Choi YH, Van Seuningen I, et al. Signal pathway of 17beta-estradiol-induced muc5b expression in human airway epithelial cells. Am J Respir Cell Mol Biol. 2009;40(2):168–78.
• Jain R, Ray JM, Pan JH, Brody SL. Sex hormone-dependent regulation of cilia beat frequency in airway epithelium. Am J Respir Cell Mol Biol. 2012;46(4):446–53. Progesterone decreased cilia beat frequency in human primary airway epithelial cells, but adminstration of estrogen in combination with progesterone rescued cilia beat frequency. This study showed that sex hormones affect cilia beat frequency and mucociliary clearance