Renin-angiotensin system at the heart of COVID-19 pandemic

Biochimie - Tập 174 - Trang 30-33 - 2020
Marco Alifano1,2, Pietro Alifano3, Patricia Forgez4, Antonio Iannelli5,6
1INSERM U1138 Team «Cancer, Immune Control, and Escape», Cordeliers Research Center, University of Paris, France
2Thoracic Surgery Department, Cochin Hospital, APHP Centre, University of Paris, France
3Chair of Microbiology, Department of Biological and Environmental Sciences and Technologies, Salento University, Lecce, Italy
4INSERM UMR-S 1124 T3S, Eq 5 Cellular Homeostasis, Cancer and Therapy, University of Paris, Campus Saint Germain, Paris, France
5Digestive Disease Department, Archet 2 Hospital, Nice University Hospital, University of Nice Côte d’Azur, Nice, France
6INSERM,U1065, Team 8 “Hepatic Complications of Obesity”, University Nice Côte d’Azur, France

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Tài liệu tham khảo

Fang, 2020, Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? Published March 11, Lancet Respir Med, 10.1016/S2213-2600(20)30116-8

Chan, 2020, Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan, Emerg. Microb. Infect., 9, 221, 10.1080/22221751.2020.1719902

Hoffmann, 2020, SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor, Cell, 10.1016/j.cell.2020.02.052

Tipnis, 2000, A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase, J. Biol. Chem., 275, 33238, 10.1074/jbc.M002615200

Zheng, 2020, COVID-19 and the cardiovascular system, Nat. Rev. Cardiol., 10.1038/s41569-020-0360-5

Hamming, 2004, Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis, J. Pathol., 203, 631, 10.1002/path.1570

Guan WJ, Ni ZY, Hu Y, et al. N Engl J Med February 28, 2020, DOI: 10.1056/NEJMoa2002032.

Zhang, 2018, Association of Angiotensin-Converting Enzyme 2 gene polymorphism and enzymatic activity with essential hypertension in different gender: a case-control study, Medicine (Baltim.), 97

Lu, 2012, ACE2 gene polymorphism and essential hypertension: an updated meta-analysis involving 11,051 subjects, Mol. Biol. Rep., 39, 6581, 10.1007/s11033-012-1487-1

Pinheiro, 2019, The combination of ACE I/D and ACE2 G8790A polymorphisms revels susceptibility to hypertension: a genetic association study in Brazilian patients, PloS One, 14, 10.1371/journal.pone.0221248

Huang, 2012, Polymorphisms of ACE2 are associated with blood pressure response to cold pressor test: the GenSalt study, Am. J. Hypertens., 25, 937, 10.1038/ajh.2012.61

Patel, 2016, Role of the ACE2/angiotensin 1-7 Axis of the renin-angiotensin system in heart failure, Circ. Res., 118, 1313, 10.1161/CIRCRESAHA.116.307708

Meulenbelt, 1992, Biochemical and histological alterations in rats after acute nitrogen dioxide intoxication, Hum. Exp. Toxicol., 11, 189, 10.1177/096032719201100307

Patel, 1990, Oxidant injury increases cell surface receptor binding of angiotensin II to pulmonary artery endothelial cells, J. Biochem. Toxicol., 5, 253, 10.1002/jbt.2570050408

Kuan, 2011, Identifying the regulatory element for human angiotensin-converting enzyme 2 (ACE2) expression in human cardiofibroblasts, Peptides, 32, 1832, 10.1016/j.peptides.2011.08.009

Yang, 2019, Association of long-term exposure to ambient air pollutants with risk factors for cardiovascular disease in China, JAMA Netw Open, 2, 10.1001/jamanetworkopen.2019.0318

Cui, 2003, Air pollution and case fatality of SARS in the People’s Republic of China: an ecologic study, Environ. Health, 2, 15, 10.1186/1476-069X-2-15

European Space Agency

Oakes, 2018, Nicotine and the renin-angiotensin system, Am. J. Physiol. Regul. Integr. Comp. Physiol., 315, R895, 10.1152/ajpregu.00099.2018

Lippi, 2020, Active smoking is not associated with severity of coronavirus disease 2019 (COVID-19), Eur J Intern Med, 10.1016/j.ejim.2020.03.014

Cole-Jeffrey, 2015, ACE2 and microbiota: emerging targets for cardiopulmonary disease therapy, J. Cardiovasc. Pharmacol., 66, 540, 10.1097/FJC.0000000000000307

Gheblawi, 2020, Angiotensin converting enzyme 2: SARS-CoV-2 receptor and regulator of the renin-angiotensin system, Circ. Res.

Mills, 2016, Global disparities of hypertension prevalence and control: a systematic analysis of population-based studies from 90 countries, Circulation, 134, 441, 10.1161/CIRCULATIONAHA.115.018912

Ferrario, 2005, Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2, Circulation, 111, 2605, 10.1161/CIRCULATIONAHA.104.510461

Gao, 2020, Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies, Biosci Trends, 14, 72, 10.5582/bst.2020.01047

Vincent, 2005, Chloroquine is a potent inhibitor of SARS coronavirus infection and spread, Virol. J., 2, 69, 10.1186/1743-422X-2-69