Linking Rap to cell adhesion

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Katagiri, 2003, RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1, Nat Immunol, 4, 741, 10.1038/ni950

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Boettner, 2003, The AF-6 homolog canoe acts as a Rap1 effector during dorsal closure of the Drosophila embryo, Genetics, 165, 159, 10.1093/genetics/165.1.159

Su, 2003, AF-6 controls integrin-mediated cell adhesion by regulating Rap1 activation through the specific recruitment of Rap1GTP and SPA-1, J Biol Chem, 278, 15232, 10.1074/jbc.M211888200

Boettner, 2000, The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profiling, Proc Natl Acad Sci USA, 97, 9064, 10.1073/pnas.97.16.9064

Katagiri, 2004, Crucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell trafficking, Nat Immunol, 5, 1045, 10.1038/ni1111

Lafuente, 2004, RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion, Dev Cell, 7, 585, 10.1016/j.devcel.2004.07.021

Krugmann, 2002, Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices, Mol Cell, 9, 95, 10.1016/S1097-2765(02)00434-3

Krugmann, 2004, ARAP3 is a PI3K- and rap-regulated GAP for RhoA, Curr Biol, 14, 1380, 10.1016/j.cub.2004.07.058

Arthur, 2004, Rap1 promotes cell spreading by localizing Rac guanine nucleotide exchange factors, J Cell Biol, 167, 111, 10.1083/jcb.200404068

Maillet, 2003, Crosstalk between Rap1 and Rac regulates secretion of sAPPα, Nat Cell Biol, 5, 633, 10.1038/ncb1007

Kang, 2001, A GDP/GTP exchange factor involved in linking a spatial landmark to cell polarity, Science, 292, 1376, 10.1126/science.1060360

Park, 2002, Localization of the Rsr1/Bud1 GTPase involved in selection of a proper growth site in yeast, J Biol Chem, 277, 26721, 10.1074/jbc.C200245200

Fukuyama, 2005, Involvement of the c-Src–Crk–C3G–Rap1 signaling in the nectin-induced activation of Cdc42 and formation of adherens junctions, J Biol Chem, 280, 815, 10.1074/jbc.M411099200

Liao, 2001, RA-GEF-1, a guanine nucleotide exchange factor for Rap1, is activated by translocation induced by association with Rap1*GTP and enhances Rap1-dependent B-Raf activation, J Biol Chem, 276, 28478, 10.1074/jbc.M101737200

Christian, 2003, Activation of the Rap GTPases in B lymphocytes modulates B cell antigen receptor-induced activation of Akt but has no effect on MAPK activation, J Biol Chem, 278, 41756, 10.1074/jbc.M303180200

Stoletov, 2004, Bmx is a downstream Rap1 effector in VEGF-induced endothelial cell activation, Biochem Biophys Res Commun, 320, 70, 10.1016/j.bbrc.2004.05.134

Zawistowski, 2002, KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis, Hum Mol Genet, 11, 389, 10.1093/hmg/11.4.389

Taira, 2004, The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeleton, J Biol Chem, 279, 15711, 10.1074/jbc.M406370200

Schmidt, 2001, A new phospholipase-C–calcium signalling pathway mediated by cyclic AMP and a Rap GTPase, Nat Cell Biol, 3, 1020, 10.1038/ncb1101-1020

Schwamborn, 2004, The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity, Nat Neurosci, 7, 923, 10.1038/nn1295