PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells
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Allali-Hassani, 2009, A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with altered stability and activity, Biochem. J., 424, 15, 10.1042/BJ20090723
Anastasiou, 2011, Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses, Science, 334, 1278, 10.1126/science.1211485
Anastasiou, 2012, Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis, Nat. Chem. Biol., 8, 839, 10.1038/nchembio.1060
Ayala, 2010, Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice, Dis. Model. Mech., 3, 525, 10.1242/dmm.006239
Baumhoer, 2008, Glypican 3 expression in human nonneoplastic, preneoplastic, and neoplastic tissues: a tissue microarray analysis of 4,387 tissue samples, Am. J. Clin. Pathol., 129, 899, 10.1309/HCQWPWD50XHD2DW6
Cairns, 2011, Regulation of cancer cell metabolism, Nat. Rev. Cancer, 11, 85, 10.1038/nrc2981
Cerami, 2012, The cBiol. cancer genomics portal: an open platform for exploring multidimensional cancer genomics data, Cancer Discov., 2, 401, 10.1158/2159-8290.CD-12-0095
Chaneton, 2012, Rocking cell metabolism: revised functions of the key glycolytic regulator PKM2 in cancer, Trends Biochem. Sci., 37, 309, 10.1016/j.tibs.2012.04.003
Chaneton, 2012, Serine is a natural ligand and allosteric activator of pyruvate kinase M2, Nature, 491, 458, 10.1038/nature11540
Chen, 2012, Concentration-dependent control of pyruvate kinase M mutually exclusive splicing by hnRNP proteins, Nat. Struct. Mol. Biol., 19, 346, 10.1038/nsmb.2219
Christofk, 2008, The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth, Nature, 452, 230, 10.1038/nature06734
Christofk, 2008, Pyruvate kinase M2 is a phosphotyrosine-binding protein, Nature, 452, 181, 10.1038/nature06667
Clower, 2010, The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism, Proc. Natl. Acad. Sci. USA, 107, 1894, 10.1073/pnas.0914845107
Commisso, 2013, Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells, Nature, 497, 633, 10.1038/nature12138
Cortés-Cros, 2013, M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth, Proc. Natl. Acad. Sci. USA, 110, 489, 10.1073/pnas.1212780110
David, 2010, HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer, Nature, 463, 364, 10.1038/nature08697
Dombrauckas, 2005, Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis, Biochemistry, 44, 9417, 10.1021/bi0474923
Gao, 2012, Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase, Mol. Cell, 45, 598, 10.1016/j.molcel.2012.01.001
Goldberg, 2012, Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression, J. Exp. Med., 209, 217, 10.1084/jem.20111487
Hitosugi, 2009, Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth, Sci. Signal., 2, ra73, 10.1126/scisignal.2000431
Imamura, 1972, Multimolecular forms of pyruvate kinase from rat and other mammalian tissues. I. Electrophoretic studies, J. Biochem., 71, 1043, 10.1093/oxfordjournals.jbchem.a129852
Jain, 2012, Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation, Science, 336, 1040, 10.1126/science.1218595
Jurczak, 2012, Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice, J. Biol. Chem., 287, 2558, 10.1074/jbc.M111.316760
Keller, 2012, SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions, Science, 338, 1069, 10.1126/science.1224409
Liang, 2012, Whole-exome sequencing combined with functional genomics reveals novel candidate driver cancer genes in endometrial cancer, Genome Res., 22, 2120, 10.1101/gr.137596.112
Luo, 2011, Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1, Cell, 145, 732, 10.1016/j.cell.2011.03.054
Lv, 2011, Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth, Mol. Cell, 42, 719, 10.1016/j.molcel.2011.04.025
Maquat, 2004, Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics, Nat. Rev. Mol. Cell Biol., 5, 89, 10.1038/nrm1310
Mazurek, 2011, Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells, Int. J. Biochem. Cell Biol., 43, 969, 10.1016/j.biocel.2010.02.005
Noguchi, 1986, The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing, J. Biol. Chem., 261, 13807, 10.1016/S0021-9258(18)67091-7
Parnell, 2013, Pharmacologic activation of PKM2 slows lung tumor Xenograft growth, Mol. Cancer Ther., 12, 1453, 10.1158/1535-7163.MCT-13-0026
Salk, 2010, Mutational heterogeneity in human cancers: origin and consequences, Annu. Rev. Pathol., 5, 51, 10.1146/annurev-pathol-121808-102113
Schraml, 1999, Tissue microarrays for gene amplification surveys in many different tumor types, Clin. Cancer Res., 5, 1966
Sonveaux, 2008, Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice, J. Clin. Invest., 118, 3930
Vander Heiden, 2001, Growth factors can influence cell growth and survival through effects on glucose metabolism, Mol. Cell. Biol., 21, 5899, 10.1128/MCB.21.17.5899-5912.2001
Vander Heiden, 2009, Understanding the Warburg effect: the metabolic requirements of cell proliferation, Science, 324, 1029, 10.1126/science.1160809
Vander Heiden, 2010, Evidence for an alternative glycolytic pathway in rapidly proliferating cells, Science, 329, 1492, 10.1126/science.1188015
Varghese, 2010, Prolactin inhibits activity of pyruvate kinase M2 to stimulate cell proliferation, Mol. Endocrinol., 24, 2356, 10.1210/me.2010-0219
Vaupel, 1989, Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review, Cancer Res., 49, 6449
Wang, 2012, Exon-centric regulation of pyruvate kinase M alternative splicing via mutually exclusive exons, J. Mol. Cell Biol., 4, 79, 10.1093/jmcb/mjr030
Xu, 1999, Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation, Nat. Genet., 22, 37, 10.1038/8743
Yang, 2011, Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation, Nature, 480, 118, 10.1038/nature10598
Yang, 2012, PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis, Cell, 150, 685, 10.1016/j.cell.2012.07.018
Yang, 2012, ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect, Nat. Cell Biol., 14, 1295, 10.1038/ncb2629
Bardeesy, 2002, Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation, Nature, 419, 162, 10.1038/nature01045
Raymond, 2007, High-efficiency FLP and PhiC31 site-specific recombination in mammalian cells, PLoS ONE, 2, e162, 10.1371/journal.pone.0000162
Wang, 1994, SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis, Cell, 77, 53, 10.1016/0092-8674(94)90234-8