Vitamin D supplementation and body weight status: a systematic review and meta‐analysis of randomized controlled trials

Obesity Reviews - Tập 15 Số 6 - Trang 528-537 - 2014
Kaveri Pathak1, Mário J. Soares1, Emily Calton1, Yun Zhao2, Jonathan Hallett3
1Department of Nutrition, Dietetics & Food Science, School of Public Health, Faculty of Health Sciences, Curtin University, Perth, Western Australia, Australia
2Department of Epidemiology & Biostatistics, School of Public Health, Faculty of Health Sciences, Curtin University, Perth, Western Australia, Australia
3Department of Health Promotion & Sexology, School of Public Health, Faculty of Health Sciences, Curtin University, Perth, Western Australia, Australia

Tóm tắt

SummaryVitamin D is anticipated to have many extra‐skeletal health benefits. We questioned whether supplementation with the vitamin influenced body weight and composition. A systematic review and meta‐analysis was conducted on high‐quality, randomized controlled trials (RCTs) that had supplemented vitamin D without imposing any caloric restriction. Eighteen trials reporting either body weight, body mass index (BMI), fat mass (FM), percentage fat mass (%FM) or lean body mass (LBM) met our criteria. Twelve studies provided the required data for the meta‐analysis. Vitamin D supplementation did not influence the standardized mean difference (SMD) for body weight, FM, %FM or LBM. A small but non‐significant decrease in BMI (SMD = −0.097, 95% confidence interval: [−0.210, 0.016], P = 0.092) was observed. Meta‐regression confirmed that neither the absolute vitamin D status achieved nor its change from baseline influenced the SMD of any obesity measure. However, increasing age of the subjects predicted a shift in the SMD for FM towards the placebo treatment, whereas a greater percentage of women in these studies favoured a decrease in FM following vitamin D. Vitamin D supplementation did not decrease measures of adiposity in the absence of caloric restriction. A potential confounding by age and gender was encountered.

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Obesity Reviews

Tập 15 Số 6

528-537

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