Ligand-Dependent Exponential Amplification of Self-Replicating RNA Enzymes

Burgstaller, 1994, Isolation of RNA aptamers for biological cofactors by in vitro selection, Angewandte Chemie, 33, 1084, 10.1002/anie.199410841 Engvall, 1971, Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G, Immunochemistry, 8, 871, 10.1016/0019-2791(71)90454-X Ferré-D’Amaré, 1996, Use of cis- and trans-ribozymes to remove 5′ and 3′ heterogeneities from milligrams of in vitro transcribed RNA, Nucleic Acids Research, 24, 977, 10.1093/nar/24.5.977 Ferretti, 2013, Kinetic properties of an RNA enzyme that undergoes self-sustained exponential amplification, Biochemistry, 52, 1227, 10.1021/bi301646n Forster, 1990, External guide sequence for an RNA enzyme, Science, 249, 783, 10.1126/science.1697102 Jenison, 1994, High-resolution molecular discrimination by RNA, Science, 263, 1425, 10.1126/science.7510417 Kim, 2004, Cross-catalytic replication of an RNA ligase ribozyme, Chemistry & Biology, 11, 1505, 10.1016/j.chembiol.2004.08.021 Klussmann, 1996, Mirror-image RNA that binds D-adenosine, Nature Biotechnology, 14, 1112, 10.1038/nbt0996-1112 Kumar, 2005, Terminal phosphate labeled nucleotides: Synthesis, applications, and linker effect on incorporation by DNA polymerases, Nucleosides, Nucleotides & Nucleic Acids, 24, 401, 10.1081/NCN-200059823 Lam, 2009, Autocatalytic aptazymes enable ligand-dependent exponential amplification of RNA, Nature Biotechnology, 27, 288, 10.1038/nbt.1528 Lam, 2011, An isothermal system that couples ligand-dependent catalysis to ligand-independent exponential amplification, Journal of the American Chemical Society, 133, 3191, 10.1021/ja111136d Leva, 2002, GnRH binding RNA and DNA Spiegelmers, Chemistry & Biology, 9, 351, 10.1016/S1074-5521(02)00111-4 Lincoln, 2009, Self-sustained replication of an RNA enzyme, Science, 323, 1229, 10.1126/science.1167856 Ludwig, 1989, Rapid and efficient synthesis of nucleoside 5′-O-(1-thiotriphosphates), 5′-triphosphates and 2′,3′-cyclophosphorothioates using 2-chloro-4H-1,3,2-benzodioxaphosphorin-4-one, The Journal of Organic Chemistry, 54, 631, 10.1021/jo00264a024 Olea, 2012, Ligand-dependent exponential amplification of a self-replicating L-RNA enzyme, Journal of the American Chemical Society, 134, 8050, 10.1021/ja302197x Paul, 2002, A self-replicating ligase ribozyme, Proceedings of the National Academy of Sciences of the United States of America, 99, 12733, 10.1073/pnas.202471099 Robertson, 2014, Highly efficient self-replicating RNA enzymes, Chemistry & Biology, 21, 238, 10.1016/j.chembiol.2013.12.004 Rogers, 2001, The effect of cytidine on the structure and function of an RNA ligase ribozyme, RNA, 7, 395, 10.1017/S135583820100228X Ronaghi, 1996, Real-time DNA sequencing using detection of pyrophosphate release, Analytical Biochemistry, 242, 84, 10.1006/abio.1996.0432 Rychlik, 1995, Selection of primers for polymerase chain-reaction, Molecular Biotechnology, 3, 129, 10.1007/BF02789108 Soukup, 1999, Engineering precision RNA molecular switches, Proceedings of the National Academy of Sciences of the United States of America, 96, 3584, 10.1073/pnas.96.7.3584 Tang, 1997, Rational design of allosteric ribozymes, Chemistry & Biology, 4, 453, 10.1016/S1074-5521(97)90197-6 Tyagi, 1996, Molecular beacons: Probes that fluoresce upon hybridization, Nature Biotechnology, 14, 303, 10.1038/nbt0396-303 Wang, 1989, Quantitation of mRNA by the polymerase chain reaction, Proceedings of the National Academy of Sciences of the United States of America, 86, 9717, 10.1073/pnas.86.24.9717 Winkler, 2004, Control of gene expression by a natural metabolite-responsive ribozyme, Nature, 428, 281, 10.1038/nature02362