Failure of neuronal ion exchange, not potentiated excitation, causes excitotoxicity after inhibition of oxidative phosphorylation

Benveniste, 1984, Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis, J. Neurochem., 43, 1369, 10.1111/j.1471-4159.1984.tb05396.x Chen, 1992, Protein kinase C reduces Mg2+ block of NMDA-receptor channels as a mechanism of modulation, Nature, 356, 521, 10.1038/356521a0 Choi, 1987, Glutamate neurotoxicity in cortical cell culture, J. Neurosci., 7, 357, 10.1523/JNEUROSCI.07-02-00357.1987 Coles, 1979, Inactivation of succinate dehydrogenase by 3-nitropropionate, J. biol. Chem., 254, 5161, 10.1016/S0021-9258(18)50574-3 Dingledine, 1980, The in vitro brain slice as a useful neurophysiological preparation for intracellular recording, J. Neurosci. Meth., 2, 323, 10.1016/0165-0270(80)90002-3 Erecinska, 1990, Relationships between the neuronal sodium/potassium pump and energy metabolism. Effects of K+, Na+, and adenosine triphosphate in isolated brain synaptosomes, J. gen. Physiol., 95, 591, 10.1085/jgp.95.4.591 Fujiwara, 1987, Effects of hypoxia on hippocampal neurons in vitro, J. Physiol. (Lond), 384, 131, 10.1113/jphysiol.1987.sp016447 Garthwaite, 1985, Cellular uptake disguises action ofl-glutamate on N-methyl-d-aspartate receptors, Br. J. Pharmac., 85, 297, 10.1111/j.1476-5381.1985.tb08860.x Hansen, 1985, Effects of anoxia on distribution in the brain, Physiol. Rev., 65, 101, 10.1152/physrev.1985.65.1.101 Henneberry, 1989, Neurotoxicity at the N-methyl-d-aspartate receptor in energy compromised neurons. An hypothesis for cell death in aging and disease, Ann. N.Y. Acad. Sci., 568, 225, 10.1111/j.1749-6632.1989.tb12512.x Hori, 1988, Excitatory amino acid receptors in piriform cortex do not show receptor desensitization, Brain Res., 457, 350, 10.1016/0006-8993(88)90705-6 Hori, 1991, Appearance of NMDA receptors triggered by anoxia independent of voltage in vivo and in vitro, Expl Neurol., 112, 304, 10.1016/0014-4886(91)90131-U Kelso, 1992, Protein kinase C-mediated enhancement of NMDA currents by metabotropic glutamate receptors in Xenopus oocytes, J. Physiol. (Lond), 449, 705, 10.1113/jphysiol.1992.sp019110 Koh, 1990, Non-NMDA receptor mediated neurotoxicity in cortical culture, J. Neurosci., 10, 693, 10.1523/JNEUROSCI.10-02-00693.1990 Kuwahara, 1992, Characterization ofd-aspartic acid uptake by rat hippocampal slices and effect of ischemic conditions, J. Neurochem., 59, 616, 10.1111/j.1471-4159.1992.tb09414.x Ludolph, 1992, 3-nitropropionic acid decreases cellular energy levels and causes neuronal degeneration in cortical explants, Neurodegeneration, 1, 155 MacDonald, 1989, Regulation of N-methyl-d-aspartate receptors revealed by intracellular dialysis of murine neurons in culture, J. Physiol. (Lond), 414, 17, 10.1113/jphysiol.1989.sp017674 Matsuda, 1992, Glucose and oxygen deprivation induces a Ca2+-mediated decrease in (Na+ + K+)-ATPase activity in rat brain slices, Brain Res., 576, 263, 10.1016/0006-8993(92)90689-7 Mayer, 1987, The physiology of excitatory amino acids in the vertebrate central nervous system, Prog. Neurobiol., 28, 197, 10.1016/0301-0082(87)90011-6 Nagafuji, 1992, Neurochemical correlates of selective neuronal loss following cerebral ischemia: role of decreased Na+, K+-ATPase activity, Brain Res., 571, 265, 10.1016/0006-8993(92)90664-U Olney, 1969, Brain lesions, obesity and other disturbances in mice treated with monosodium glutamate, Science, 164, 719, 10.1126/science.164.3880.719 Ozawa, 1990, Suppression by extracellular K+ of N-methyl-d-aspartate responses in cultured rat hippocampal neurons, J. Neurophysiol., 64, 1361, 10.1152/jn.1990.64.5.1361 Raffin, 1992, Glycolysis, oxidative metabolism, and brain potassium ion clearance, J. cerebr. Blood Flow Metab., 12, 34, 10.1038/jcbfm.1992.5 Riepe, 1992, Inhibition of energy metabolism by 3-nitropropionic acid activates ATP-sensitive potassium channels, Brain Res., 586, 61, 10.1016/0006-8993(92)91371-K Rothman, 1986, Glutamate and the pathophysiology of hypoxic-ischemic brain damage, Ann. Neurol., 19, 105, 10.1002/ana.410190202 Siesjö, 1989, Calcium fluxes, calcium antagonists, and calcium related pathology in brainischemia, hypoglycemia, and spreading depression: a unifying hypothesis, J. cerebr. Blood Flow Metab., 9, 127, 10.1038/jcbfm.1989.20 Simon, 1984, Blockade of N-methyl-d-aspartate receptors may protect against ischemic damage in the brain, Science, 226, 850, 10.1126/science.6093256 Teichberg, 1991, Glial glutamate receptors: likely actors in brain signaling, Fedn. Am. Soc. exp. Biol., 5, 3086 Thompson, 1986, Activation of the electrohenic sodium pump in hippocampal CA1 neurons following glutamate-induced depolarization, J. Neurophysiol., 56, 507, 10.1152/jn.1986.56.2.507 Turski, 1991, Protection of substantia nigra from MPP+ neurotoxicity by NMDA antagonists, Nature, 349, 414, 10.1038/349414a0 von Blankefeld, 1991, Glutamate and GABA receptors in vertebrate glial cells, Molec. Neurobiol., 5, 31, 10.1007/BF02935611 Vycklicky, 1990, The effect of external pH changes on responses to excitatory amino acids in mouse hippocampal neurones, J. Physiol. (Lond), 430, 497, 10.1113/jphysiol.1990.sp018304 Yoneda, 1991, Inhibitory modulation by sodium ions of the N-methyl-d-aspartate recognition site in brain synaptic membranes, J. Neurochem., 57, 2036, 10.1111/j.1471-4159.1991.tb06419.x