Hypothalamic Orexin Stimulates Feeding-Associated Glucose Utilization in Skeletal Muscle via Sympathetic Nervous System

Cell Metabolism - Tập 10 - Trang 466-480 - 2009
Tetsuya Shiuchi1,2, Mohammad Shahidul Haque3, Shiki Okamoto1,2, Tsuyoshi Inoue2,4, Haruaki Kageyama5, Suni Lee1, Chitoku Toda1,2, Atsushi Suzuki1, Eric S. Bachman6, Young-Bum Kim7, Takashi Sakurai8, Masashi Yanagisawa9, Seiji Shioda5, Keiji Imoto2,4, Yasuhiko Minokoshi1,2
1Division of Endocrinology and Metabolism, Department of Developmental Physiology, National Institute for Physiological Sciences, Okazaki, Aichi 444-8585, Japan
2Department of Physiological Sciences, The Graduate University for Advanced Studies (Sokendai), Hayama, Kanagawa 240-0193, Japan
3Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, Bangladesh
4Division of Neural Signaling, Department of Information Physiology, National Institute for Physiological Sciences, Okazaki, Aichi 444-8787, Japan
5Department of Anatomy, Showa University School of Medicine, Tokyo 142-8555, Japan
6Oncology-Pharmacology, Merck Research Laboratories, Boston, MA 02115, USA
7Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA
8Department of Molecular Neuroscience and Integrative Physiology, Graduate School of Medical Science Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8640, Japan
9Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA

Tài liệu tham khảo

Akiyama, 2004, Reduced food anticipatory activity in genetically orexin (hypocretin) neuron-ablated mice, Eur. J. Neurosci., 20, 3054, 10.1111/j.1460-9568.2004.03749.x Asensio, 2005, The lack of beta-adrenoceptors results in enhanced insulin sensitivity in mice exhibiting increased adiposity and glucose intolerance, Diabetes, 54, 3490, 10.2337/diabetes.54.12.3490 Astrup, 1990, Effects of nutrient intake on sympathoadrenal activity and thermogenic mechanisms, J. Neurosci. Methods, 34, 187, 10.1016/0165-0270(90)90057-M Bachman, 2002, βAR signaling required for diet-induced thermogenesis and obesity resistance, Science, 297, 843, 10.1126/science.1073160 Brennan, 1993, Quantitative analysis of the human α-skeletal muscle actin gene in transgenic mice, J. Biol. Chem., 268, 719, 10.1016/S0021-9258(18)54211-3 Chemelli, 1999, Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation, Cell, 98, 437, 10.1016/S0092-8674(00)81973-X Chiu, 2008, Direct administration of insulin into skeletal muscle reveals that the transport of insulin across the capillary endothelium limits the time course of insulin to activate glucose disposal, Diabetes, 57, 828, 10.2337/db07-1444 Clerk, 2006, Obesity blunts insulin-mediated microvascular recruitment in human forearm muscle, Diabetes, 55, 1436, 10.2337/db05-1373 de Lecea, 2006, Addiction and arousal: alternative roles of hypothalamic peptides, J. Neurosci., 26, 10372, 10.1523/JNEUROSCI.3118-06.2006 de Lecea, 1998, The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity, Proc. Natl. Acad. Sci. USA, 95, 322, 10.1073/pnas.95.1.322 Diamond, 1985, Palatability and postprandial thermogenesis in dogs, Am. J. Physiol., 248, E75 Diano, 2003, Fasting activates the nonhuman primate hypocretin (orexin) system and its postsynaptic targets, Endocrinology, 144, 3774, 10.1210/en.2003-0274 Dube, 1999, Food intake elicited by central administration of orexins/hypocretins: identification of hypothalamic sites of action, Brain Res., 842, 473, 10.1016/S0006-8993(99)01824-7 Dulloo, 1988, Sympathetic nervous system responses to cold exposure and diet in rat skeletal muscle, Am. J. Physiol., 255, E180 Flier, 2004, Obesity wars: Molecular progress confronts an expanding epidemic, Cell, 116, 337, 10.1016/S0092-8674(03)01081-X Fujimoto, 2007, Dmbx1 is essential in agouti-related protein action, Proc. Natl. Acad. Sci. USA, 104, 15514, 10.1073/pnas.0707328104 Funato, 2009, Enhanced orexin receptor-2 signaling prevents diet-induced obesity and improves leptin sensitivity, Cell Metab., 9, 64, 10.1016/j.cmet.2008.10.010 Furudono, 2006, Involvement of specific orexigenic neuropeptides in sweetener-induced overconsumption in rats, Behav. Brain Res., 175, 241, 10.1016/j.bbr.2006.08.031 Guimarães, 2001, Vascular adrenoceptors: an update, Pharmacol. Rev., 53, 319 Haque, 1999, Role of the sympathetic nervous system and insulin in enhancing glucose uptake in peripheral tissues after intrahypothalamic injection of leptin in rats, Diabetes, 48, 1706, 10.2337/diabetes.48.9.1706 Hara, 2001, Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity, Neuron, 30, 345, 10.1016/S0896-6273(01)00293-8 Harris, 2005, A role for lateral hypothalamic orexin neurons in reward seeking, Nature, 437, 556, 10.1038/nature04071 Horvath, 1999, Synaptic interaction between hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus: a novel circuit implicated in metabolic and endocrine regulations, J. Neurosci., 19, 1072, 10.1523/JNEUROSCI.19-03-01072.1999 Kahn, 2000, Obesity and insulin resistance, J. Clin. Invest., 106, 473, 10.1172/JCI10842 Kamohara, 1997, Acute stimulation of glucose metabolism in mice by leptin treatment, Nature, 389, 374, 10.1038/38717 Kotz, 2006, Integration of feeding and spontaneous physical activity: role of orexin, Physiol. Behav., 88, 294, 10.1016/j.physbeh.2006.05.031 LeBlanc, 1984, Reduced postprandial heat production with gavage as compared with meal feeding in human subjects, Am. J. Physiol., 246, E95 LeBlanc, 1985, Role of palatability on meal-induced thermogenesis in human subjects, Am. J. Physiol., 248, E333 LeBlanc, 2000, Nutritional implications of cephalic phase thermogenic responses, Appetite, 34, 214, 10.1006/appe.1999.0283 Lundberg, 1986, Co-release of neuropeptide Y and catecholamines upon adrenal activation in the cat, Acta Physiol. Scand., 126, 231, 10.1111/j.1748-1716.1986.tb07810.x Marcus, 2001, Differential expression of orexin receptors 1 and 2 in the rat brain, J. Comp. Neurol., 435, 6, 10.1002/cne.1190 Mieda, 2004, Orexin neurons function in an efferent pathway of a food-entrainable circadian oscillator in eliciting food-anticipatory activity and wakefulness, J. Neurosci., 24, 10493, 10.1523/JNEUROSCI.3171-04.2004 Minokoshi, 1999, Microinjection of leptin into the ventromedial hypothalamus increases glucose uptake in peripheral tissues in rats, Diabetes, 48, 287, 10.2337/diabetes.48.2.287 Minokoshi, 2002, Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase, Nature, 415, 339, 10.1038/415339a Nevzorova, 2006, Multiple signalling pathways involved in β2-adrenoceptor-mediated glucose uptake in rat skeletal muscle cells, Br. J. Pharmacol., 147, 446, 10.1038/sj.bjp.0706626 Niwa, 1991, Efficient selection for high-expression transfectants with a novel eukaryotic vector, Gene, 108, 193, 10.1016/0378-1119(91)90434-D Parker, 2002, Steroidogenic factor 1: an essential mediator of endocrine development, Recent Prog. Horm. Res., 57, 19, 10.1210/rp.57.1.19 Rothwell, 1978, A paradox in the control of energy intake in the rat, Nature, 273, 146, 10.1038/273146a0 Saito, 1989, Accelerated norepinephrine turnover in peripheral tissues after ventromedial hypothalamic stimulation in rats, Brain Res., 481, 298, 10.1016/0006-8993(89)90806-8 Saito, 1989, Metabolic and sympathetic nerve activities of brown adipose tissue in tube-fed rats, Am. J. Physiol., 257, E374 Sakurai, 2007, The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness, Nat. Rev. Neurosci., 8, 171, 10.1038/nrn2092 Sakurai, 1998, Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior, Cell, 92, 573, 10.1016/S0092-8674(00)80949-6 Satoh, 1999, Sympathetic activation of leptin via the ventromedial hypothalamus: leptin-induced increase in catecholamine secretion, Diabetes, 48, 1787, 10.2337/diabetes.48.9.1787 Schuld, 2000, Increased body-mass index in patients with narcolepsy, Lancet, 355, 1274, 10.1016/S0140-6736(05)74704-8 Schwartz, 2000, Central nervous system control of food intake, Nature, 404, 661, 10.1038/35007534 Shima, 2005, Ventromedial hypothalamic nucleus-specific enhancer of Ad4BP/SF-1 gene, Mol. Endocrinol., 19, 2812, 10.1210/me.2004-0431 Shirasaka, 1999, Sympathetic and cardiovascular actions of orexins in conscious rats, Am. J. Physiol., 277, R1780 Smart, 2001, SB-334867-A: the first selective orexin-1 receptor antagonist, Br. J. Pharmacol., 132, 1179, 10.1038/sj.bjp.0703953 Sowers, 2004, Insulin resistance and hypertension, Am. J. Physiol. Heart Circ. Physiol., 286, H1597, 10.1152/ajpheart.00026.2004 Sudo, 1991, Ventromedial hypothalamic stimulation enhances peripheral glucose uptake in anesthetized rats, Am. J. Physiol., 261, E298 Tsuneki, 2008, Age-related insulin resistance in hypothalamus and peripheral tissues of orexin knockout mice, Diabetologia, 51, 657, 10.1007/s00125-008-0929-8 Welle, 1980, Increased plasma norepinephrine concentrations and metabolic rates following glucose ingestion in man, Metabolism, 29, 806, 10.1016/0026-0495(80)90118-3 Yamanaka, 2003, Hypothalamic orexin neurons regulate arousal according to energy balance in mice, Neuron, 38, 701, 10.1016/S0896-6273(03)00331-3 Young, 1977, Stimulation of the sympathetic nervous system during sucrose feeding, Nature, 269, 615, 10.1038/269615a0