The mammary gland as a bioreactor: Production of foreign proteins in milk

Protein Expression and Purification - Tập 1 - Trang 3-8 - 1990
Lothar Hennighausen1
1Laboratory of Biochemistry and Metabolism, National Institutes of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Building 10, Room 9N113, Bethesda, Maryland 20892, USA

Tài liệu tham khảo

Di Scipio, 1978, Activation of human factor IX (Christmas factor), J. Clin. Invest, 61, 1528, 10.1172/JCI109073 Yu-Lee, 1986, Evolution of the casein multigene family: Conserved sequences in the 5′ flanking and exon regions, Nucleic Acids Res, 14, 1883, 10.1093/nar/14.4.1883 Devinoy, 1988, Recent data on the structure of rabbit milk protein genes and on the mechanism of the hormonal control of their expression, Reprod. Nutr. Dev, 28, 1145, 10.1051/rnd:19880711 Gorodetsky, 1988, Isolation and characterization of the Bos taurus β-casein gene, Gene, 66, 87, 10.1016/0378-1119(88)90227-2 Yoshimura, 1989, Isolation and structural analysis of the mouse β-casein gene, Gene, 78, 267, 10.1016/0378-1119(89)90229-1 Jones, 1985, The rat casein multigene family, J. Biol. Chem, 260, 7042, 10.1016/S0021-9258(18)88885-8 Vilotte, 1987, Biochemie, 69, 609, 10.1016/0300-9084(87)90180-5 Laird, 1988, Structure and expression of the guinea-pig α-lactalbumin gene, Biochem. J, 254, 85, 10.1042/bj2540085 Hall, 1987, Organization and sequence of the human α-lactalbumin gene, Biochem. J, 242, 735, 10.1042/bj2420735 Qasba, 1984, Similarity of the nucleotide sequences of rat α-lactalbumin and chicken lysozyme genes, Nature (London), 308, 377, 10.1038/308377a0 Ali, 1988, Characterization of the gene encoding ovine β-lactoglobulin, J. Mol. Biol, 199, 415, 10.1016/0022-2836(88)90614-6 Campbell, 1984, Comparison of the whey acidic protein genes of the rat and mouse, Nucleic Acids Res, 12, 8685, 10.1093/nar/12.22.8685 Pittius, 1988, A milk protein gene promoter directs the expression of human tissue plasminogen activator cDNA to the mammary gland in transgenic mice, 85, 5874 Lee, 1988, Tissue-specific expression of the rat β-casein gene in transgenic mice, Nucleic Acids Res, 16, 1027, 10.1093/nar/16.3.1027 Simons, 1987, Alteration of the quality of milk by expression of sheep β-lactoglobulin in transgenic mice, Nature (London), 328, 530, 10.1038/328530a0 Lee, 1989, Differential regulation of rat β-casein-chloramphenicol acetyltransferase fusion gene expression in transgenic mice, Mol. Cell. Biol, 9, 560, 10.1128/MCB.9.2.560 Gordon, 1987, Production of human tissue plasminogen activator in transgenic mouse milk, Bio/Technology, 5, 1183, 10.1038/nbt1187-1183 Shu-Hua, 1989, Functional human CD4 protein produced in milk of transgenic mice, Mol. Biol. Med, 6, 255 Clark, 1989, Expression of human anti-hemophilic factor IX in the milk of transgenic sheep, Bio/Technology, 7, 487, 10.1038/nbt0589-487 Bühler, 1990, Rabbit β-casein promoter directs secretion of human interleukin-2 into the milk of transgenic rabbits, Bio/Technology, 8, 140, 10.1038/nbt0290-140 Kaufman, 1988, J. Biol. Chem, 263, 6352, 10.1016/S0021-9258(18)68793-9 Palmiter, 1986, Germ line transformation of mice, Annu. Rev. Genet, 20, 465, 10.1146/annurev.ge.20.120186.002341 Jänisch, 1988, Transgenic animals, Science, 240, 1468, 10.1126/science.3287623 Wall, 1990, Transgenic farm animals: Current state of the art, AgBiotech News Inf Andres, 1987, Ha-ras oncogene expression directed by a milk protein gene promoter: Tissue specificity, hormonal regulation, and tumor induction in transgenic mice, 84, 1299 Schoenenberger, 1988, Targeted c-myc gene expression in mammary glands of transgenic mice induces mammary tumors with constitutive milk protein gene transcription, EMBO J, 7, 69, 10.1002/j.1460-2075.1988.tb02797.x Reddy, V. P., Wei, C. M., Robl, J. M., Vitale, J., and Duby, R. T., submitted for publication. Grosveld, 1987, Position-independent, high level expression of the human β-globin gene in transgenic mice, Cell, 51, 975, 10.1016/0092-8674(87)90584-8 Meade, 1990, Bovine αs1-casein gene sequences direct high level expression of active human urokinase in mouse milk, Bio/Technology, 8, 443, 10.1038/nbt0590-443 Brinster, 1988, Introns increase transcriptional efficiency in transgenic mice, 85, 836 Tomasetto, 1989, Breast cancer protein PS2 synthesis in mammary gland of transgenic mice into milk, Mol. Endocrinol, 3, 1579, 10.1210/mend-3-10-1579 Günzburg, W. H., Salmons, B., Zimmermann, B., Müller, M., Erfie, V., and Brem, G., submitted for publication. William Velander, personal communication. Vilotte, 1989, Efficient tissue-specific expression of bovine α-lactalbumin in transgenic mice, Eur. J. Biochem, 186, 43, 10.1111/j.1432-1033.1989.tb15175.x Maschio, A., Brickell, P. M., Kioussis, D., Mellor, A. L., Katz, D., and Craig, R. K., submitted for publication. Burdon, T., Wall, R., and Hennighausen, L., manuscript in preparation. Bayna, 1990, Tissue-specific, high level expression of the rat whey acidic protein gene in transgenic mice, Nucleic Acids Res, 18, 2977, 10.1093/nar/18.10.2977 Pittius, 1988, Comparison of the regulation of the whey acidic protein gene to a hybrid gene containing the whey acidic protein gene promoter in transgenic mice, Mol. Endocrinol, 2, 1027, 10.1210/mend-2-11-1027 Archibald, 1990, High-level expression of biologically active human α1-antitrypsin in the milk of transgenic mice, 87, 5178