Rapsyn may function as a link between the acetylcholine receptor and the agrin-binding dystrophin-associated glycoprotein complex

Adams, 1993, Two forms of mouse syntrophin, a 58 kd dystrophin-associated protein, differ in primary structure and tissue distribution, Neuron, 11, 531, 10.1016/0896-6273(93)90157-M Ahn, 1995, Syntrophin binds to an alternatively spliced exon of dystrophin, J. Cell Biol., 128, 363, 10.1083/jcb.128.3.363 Ahn, 1994, Cloning of human basic At, a distinct 59-kDa dystrophin-associated protein encoded on chromosome 8q23-24, 91, 4446 Apel, 1995, Assembly of the postsynaptic apparatus, Curr. Opin. Neurobiol., 5, 62, 10.1016/0959-4388(95)80088-3 Barrantes, 1980, Peptide extraction by alkaline treatment is accompanied by rearrangement of the membrane-bound acetylcholine receptor from Torpedo marmorata, FEBS Lett., 112, 73, 10.1016/0014-5793(80)80131-1 Bevan, 1977, The distribution of α-bungarotoxin binding sites on mammalian muscle developing in vivo, J. Physiol., 267, 195, 10.1113/jphysiol.1977.sp011808 Bewick, 1992, Different distributions of dystrophin and related proteins at nerve-muscle junctions, NeuroReport, 3, 857, 10.1097/00001756-199210000-00009 Bloch, 1991, Cytoplasmic components of acetylcholine receptor clusters of cultured rat myotubes: the 58-kD protein, J. Cell Biol., 115, 435, 10.1083/jcb.115.2.435 Blount, 1988, Native folding of an acetylcholine receptor a subunit expressed in the absence of other receptor subunits, J. Biol. Chem., 263, 1072, 10.1016/S0021-9258(19)35462-6 Bowe, 1994, Identification and purification of an agrin receptor from Torpedo postsynaptic membranes: a heteromeric complex related to the dystroglycans, Neuron, 12, 1173, 10.1016/0896-6273(94)90324-7 Butler, 1992, Association of the Mr 58,000 postsynaptic protein of electric tissue with Torpedo dystrophin and the Mr 87,000 postsynaptic protein, J. Biol. Chem., 267, 6213, 10.1016/S0021-9258(18)42683-X Campanelli, 1994, A role for dystrophin-associated glycoproteins and utrophin in agrin-induced AChR clustering, Cell, 77, 663, 10.1016/0092-8674(94)90051-5 Carr, 1989, A novel 87,000 Mr protein associated with acetylcholine receptors in Torpedo electric organ and vertebrate skeletal muscle, J. Cell Biol., 109, 1753, 10.1083/jcb.109.4.1753 Cartaud, 1981, Consequences of alkaline treatment for the ultrastructure of the acetylcholine-receptor-rich membranes from Torpedo marmorata electric organ, J. Cell Biol., 90, 418, 10.1083/jcb.90.2.418 Chamberlain, 1988, Expression of the murine Duchenne muscular dystrophy gene in muscle and brain, Science, 239, 1416, 10.1126/science.3347839 Chen, 1987, High-efficiency transformation of mammalian cells by plasmid DNA, Mol. Cell. Biol., 7, 2745, 10.1128/MCB.7.8.2745 Elliot, 1980, Purification of Torpedo californica post-synaptic membranes and fractionation of their constituent proteins, Biochem. J., 185, 667, 10.1042/bj1850667 Ervasti, 1991, Membrane organization of the dystrophin-glycoprotein complex, Cell, 66, 1121, 10.1016/0092-8674(91)90035-W Ervasti, 1993, A role for the dystrophin-glycoprotein complex as a transmembrane linker between laminin and actin, J. Cell Biol., 122, 809, 10.1083/jcb.122.4.809 Ervasti, 1990, Deficiency of a glycoprotein component of the dystrophin complex in dystrophic muscle, Nature, 345, 315, 10.1038/345315a0 Fertuck, 1974, Localization of acetylcholine receptor by 125I-labeled α-bungarotoxin binding at mouse motor endplates, 71, 1376 Frail, 1988, Identification of the mouse muscle 43,000-dalton acetylcholine receptor-associated protein (RAPsyn) by cDNA cloning, J. Biol. Chem., 263, 15602, 10.1016/S0021-9258(19)37631-8 Froehner, 1991, The submembrane machinery for nicotinic acetylcholine receptor clustering, J. Cell Biol., 114, 1, 10.1083/jcb.114.1.1 Froehner, 1981, Immunofluorescence localization at the mammalian neuromuscular junction of the Mr 43,000 protein of Torpedo postsynaptic membrane, 78, 5230 Froehner, 1987, A postsynaptic Mr 58,000 (58K) protein concentrated at acetylcholine receptor-rich sites in Torpedo electroplaques and skeletal muscle, J. Cell Biol., 104, 1633, 10.1083/jcb.104.6.1633 Froehner, 1990, The postsynaptic 43K protein clusters muscle nicotinic acetylcholine receptors in Xenopus oocytes, Neuron, 5, 403, 10.1016/0896-6273(90)90079-U Gee, 1994, Dystroglycan-α, a dystrophin-associated glycoprotein, is a functional agrin receptor, Cell, 77, 675, 10.1016/0092-8674(94)90052-3 Hoffman, 1987, Conservation of the Duchenne muscular dystrophy gene in mice and humans, Science, 238, 347, 10.1126/science.3659917 Ibraghimov, 1992, Primary structure of dystrophin-associated glycoproteins linking dystrophin to the extracellular matrix, Nature, 355, 696, 10.1038/355696a0 Johnson, 1981, A simple method of reducing the fading of immunofluorescence during microscopy, J. Immunol. Meth., 43, 349, 10.1016/0022-1759(81)90183-6 Khurana, 1991, Immunolocalization and developmental expression of dystrophin related protein in skeletal muscle, Neuromusc. Dis., 1, 185, 10.1016/0960-8966(91)90023-L Kramarcy, 1994, Association of utrophin and multiple dystrophin short forms with the mammalian M(r) 58,000 dystrophin-associated protein (syntrophin), J. Biol. Chem., 269, 2870, 10.1016/S0021-9258(17)42023-0 Laemmli, 1970, Cleavage of structural proteins during the assembly of the head of bacteriophage T4, Nature, 227, 680, 10.1038/227680a0 LaRochelle, 1986, Determination of the tissue distributions and relative concentrations of the postsynaptic 43kDa protein and the acetylcholine receptor in Torpedo, J. Biol. Chem., 261, 5270, 10.1016/S0021-9258(19)57209-X Lev, 1987, Expression of the Duchenne muscular dystrophy gene in cultured muscle cells, J. Biol. Chem., 262, 15817, 10.1016/S0021-9258(18)47660-0 Lo, 1980, Rotational mobility of the membrane-bound acetylcholine receptor of Torpedo electric organ measured by phosphorescence depolarization, FEBS Lett., 111, 407, 10.1016/0014-5793(80)80838-6 Maimone, 1993, Interaction of the 43 kd postsynaptic protein with all subunits of the muscle nicotinic acetylcholine receptor, Neuron, 11, 53, 10.1016/0896-6273(93)90270-2 Matsumura, 1992, Association of dystrophin-related protein with dystrophin-associated proteins in mdx mouse muscle, Nature, 360, 588, 10.1038/360588a0 Matsumara, 1994, Dystrophin-glycoprotein complex: its role in the molecular pathogenesis of muscular dystrophies, Muscle Nerve, 17, 2, 10.1002/mus.880170103 Matsumura, 1993, Differential expression of dystrophin, utrophin and dystrophin-associated proteins in peripheral nerve, FEBS Lett., 334, 281, 10.1016/0014-5793(93)80695-Q McMahan, 1992, Agrin isoforms and their role in synaptogenesis, Curr. Opin. Cell Biol., 4, 869, 10.1016/0955-0674(92)90113-Q Moscovici, 1977, Continuous tissue culture cell lines derived from chemically induced tumors of Japanese quail, Cell, 11, 95, 10.1016/0092-8674(77)90320-8 Nastuk, 1993, Agrin and the molecular choreography of synapse formation, Trends Neurosci., 16, 72, 10.1016/0166-2236(93)90020-M Neubig, 1979, Acetylcholine and local anesthetic binding to Torpedo nicotinic postsynaptic membrane after removal of nonreceptor peptides, 76, 690 Nudel, 1988, Expression of the putative Duchenne muscular dystrophy gene in differentiated myogenic cell cultures and in the brain, Nature, 331, 635, 10.1038/331635a0 Ohlendieck, 1991, Dystrophin-related protein is localized to neuromuscular junctions of adult skeletal muscle, Neuron, 7, 499, 10.1016/0896-6273(91)90301-F Ohlendieck, 1991, Dystrophin-glycoprotein complex is highly enriched in isolated skeletal muscle sarcolemma, J. Cell Biol., 112, 135, 10.1083/jcb.112.1.135 Peters, 1994, Beta-2-syntrophin — localization at the neuromuscular junction in skeletal muscle, NeuroReport, 5, 1577, 10.1097/00001756-199408150-00009 Phillips, 1992, Recombinant neuromuscular synapses, BioEssays, 14, 671, 10.1002/bies.950141005 Phillips, 1991, ACh receptor-rich membrane domains organized in fibroblasts by recombinant 43-kilodalton protein, Science, 251, 568, 10.1126/science.1703661 Phillips, 1991, Mutagenesis of the 43-kD postsynaptic protein defines domains involved in plasma membrane targeting and AChR clustering, J. Cell Biol., 115, 1713, 10.1083/jcb.115.6.1713 Phillips, 1993, Clustering and immobilization of acetylcholine receptors by the 43-kD protein: a possible role for dystrophin-related protein, J. Cell Biol., 123, 729, 10.1083/jcb.123.3.729 Pumplin, 1993, The membrane skeleton, Trends Cell Biol., 3, 113, 10.1016/0962-8924(93)90173-X Roberds, 1993, Primary structure and muscle-specific expression of the 50-kDa dystrophin-associated glycoprotein (adhalin), J. Biol. Chem., 268, 23739, 10.1016/S0021-9258(20)80440-2 Rousselet, 1982, The rotational diffusion of the acetylcholine receptor in Torpedo marmorata membane fragments studied with a spin-labelled α-toxin: importance of the 43,000 protein(s), EMBO J., 1, 439, 10.1002/j.1460-2075.1982.tb01188.x Sealock, 1984, Ultrastructural localization of the Mr 43,000 protein and the acetylcholine receptor in Torpedo postsynaptic membranes using monoclonal antibodies, J. Cell Biol., 98, 2239, 10.1083/jcb.98.6.2239 Sugiyama, 1994, Dystroglycan binds nerve and muscle agrin, Neuron, 13, 103, 10.1016/0896-6273(94)90462-6 Suzuki, 1994, Molecular organization at the glycoprotein-complexbinding site of dystrophin. Three dystrophin-associated proteins bind directly to the carboxy-terminal portion of dystrophin, Eur. J. Biochem., 220, 283, 10.1111/j.1432-1033.1994.tb18624.x Suzuki, 1995, Mammalian α1 and β1-syntrophin bind to the alternative splice-prone region of the dystrophin COOH terminus, J. Cell Biol., 128, 373, 10.1083/jcb.128.3.373 Tzartos, 1981, Mapping of surface structures of electrophorus acetylcholine receptors using monoclonal antibodies, J. Biol. Chem., 256, 8635, 10.1016/S0021-9258(19)68891-5 Wagner, 1993, The 87K postsynaptic membrane protein from Torpedo is a protein-tyrosine kinase substrate homologous to dystrophin, Neuron, 10, 511, 10.1016/0896-6273(93)90338-R Yamamoto, 1994, Expression of dystrophin-associated protein 35DAG (A4) and 50DAG (A2) is confined to striated muscles, J. Biochem., 115, 162, 10.1093/oxfordjournals.jbchem.a124294 Yang, 1994, Heterogeneity of the 59-kDa dystrophinassociated protein revealed by cDNA cloning and expression, J. Biol. Chem., 269, 6040, 10.1016/S0021-9258(17)37566-X Yang, 1995, Identification of α-syntrophin binding to syntrophin triplet, dystrophin and utrophin, J. Biol. Chem., 270, 4975, 10.1074/jbc.270.10.4975 Yoshida, 1990, Glycoprotein complex anchoring dystrophin to sarcolemma, J. Biochem., 108, 748, 10.1093/oxfordjournals.jbchem.a123276 Yoshida, 1994, Dissociation of the complex of dystrophin and its associated proteins into several unique groups by n-octyl β-d-glucoside, Eur. J. Biochem., 222, 1055, 10.1111/j.1432-1033.1994.tb18958.x Yu, 1994, The role of the cytoplasmic domains of individual subunits of the acetylcholine receptor in 43 kDa proteininduced clustering in COS cells, J. Neurosci., 14, 785, 10.1523/JNEUROSCI.14-02-00785.1994