Pain-Induced Negative Affect Is Mediated via Recruitment of The Nucleus Accumbens Kappa Opioid System
Nicolas Massaly1, Bryan A. Copits1, Adrianne R. Wilson-Poe1, Lucia Hipólito2, Tamara Markovic1, Hye Jean Yoon1, Shiwei Liu3, Marie C. Walicki1,4,5, Dionnet L. Bhatti1, Sunil Sirohi6, Amanda Klaas7, Brendan M. Walker6, Rachael Neve8, Catherine M. Cahill3, Kooresh I. Shoghi7,9, Robert W. Gereau1,9, Jordan G. McCall1,4,5, Ream Al-Hasani1,4,5, Michael R. Bruchas1,9, Jose A. Morón1,9
1Department of Anesthesiology, Washington University Pain Center, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA
2Department of Pharmacy and Pharmaceutical Technology and Parasitology, University of Valencia, Valencia 46100, Spain
3Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA 90095 USA
4Department of Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, St. Louis, MO 63110, USA
5Center for Clinical Pharmacology, St. Louis College of Pharmacy and Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA
6Department of Psychology, Washington State University, Pullman, WA 99164-4820, USA
7Department of Radiology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA
8Department of Brain and Cognitive Science, Viral Gene Transfer Core, MIT, Cambridge, MA 02139-4307, USA
9