IL-10 promotes neuronal survival following spinal cord injury

Abraham, 2004, The effects of endogenous interleukin-10 on gray matter damage and the development of pain behaviors following excitotoxic spinal cord injury in the mouse, Neuroscience, 124, 945, 10.1016/j.neuroscience.2004.01.004 Bachis, 2001, Interleukin-10 prevents glutamate-mediated cerebellar granule cell death by blocking caspase-3-like activity, J. Neurosci., 21, 3104, 10.1523/JNEUROSCI.21-09-03104.2001 Basso, 1995, A sensitive and reliable locomotor rating scale for open field testing in rats, J. Neurotrauma, 12, 1, 10.1089/neu.1995.12.1 Bethea, 1999, Systemically administered interleukin-10 reduces tumor necrosis factor-alpha production and significantly improves functional recovery following traumatic spinal cord injury in rats, J. Neurotrauma, 16, 851, 10.1089/neu.1999.16.851 Boyd, 2003, Interleukin-10 receptor signaling through STAT-3 regulates the apoptosis of retinal ganglion cells in response to stress, Invest. Ophthalmol. Vis. Sci., 44, 5206, 10.1167/iovs.03-0534 Brewer, 1999, Neuroprotective effects of interleukin-10 following excitotoxic spinal cord injury, Exp. Neurol., 159, 484, 10.1006/exnr.1999.7173 Citron, 2000, Rapid upregulation of caspase-3 in rat spinal cord after injury: mRNA, protein, and cellular localization correlates with apoptotic cell death, Exp. Neurol., 166, 213, 10.1006/exnr.2000.7523 Davies, 2007, Clinical correlates of elevated serum concentrations of cytokines and autoantibodies in patients with spinal cord injury, Arch. Phys. Med. Rehabil., 88, 1384, 10.1016/j.apmr.2007.08.004 Dietrich, 1999, Postischemic hypothermia and IL-10 treatment provide long-lasting neuroprotection of CA1 hippocampus following transient global ischemia in rats, Exp. Neurol., 158, 444, 10.1006/exnr.1999.7115 Dong, 2003, Enhanced oligodendrocyte survival after spinal cord injury in Bax-deficient mice and mice with delayed Wallerian degeneration, J. Neurosci., 23, 8682, 10.1523/JNEUROSCI.23-25-08682.2003 Grilli, 2000, Interleukin-10 modulates neuronal threshold of vulnerability to ischaemic damage, Eur. J. Neurosci., 12, 2265, 10.1046/j.1460-9568.2000.00090.x Howard, 1992, Biological properties of interleukin 10, J. Clin. Immunol., 12, 239, 10.1007/BF00918147 Jackson, 2005, Enhanced functional recovery from spinal cord injury following intrathecal or intramuscular administration of poliovirus replicons encoding IL-10, Virology, 336, 173, 10.1016/j.virol.2005.03.025 King, 2006, omega-3 Fatty acids improve recovery, whereas omega-6 fatty acids worsen outcome, after spinal cord injury in the adult rat, J. Neurosci., 26, 4672, 10.1523/JNEUROSCI.5539-05.2006 Mitchell, 2009, A CSF biomarker panel for identification of patients with amyotrophic lateral sclerosis, Neurology, 72, 14, 10.1212/01.wnl.0000333251.36681.a5 Moore, 2001, Interleukin-10 and the interleukin-10 receptor, Annu. Rev. Immunol., 19, 683, 10.1146/annurev.immunol.19.1.683 Plunkett, 2001, Effects of interleukin-10 (IL-10) on pain behavior and gene expression following excitotoxic spinal cord injury in the rat, Exp. Neurol., 168, 144, 10.1006/exnr.2000.7604 Sloane, 2009, Anti-inflammatory cytokine gene therapy decreases sensory and motor dysfunction in experimental multiple sclerosis: MOG–EAE behavioral and anatomical symptom treatment with cytokine gene therapy, Brain Behav. Immun., 23, 92, 10.1016/j.bbi.2008.09.004 Springer, 1999, Activation of the caspase-3 apoptotic cascade in traumatic spinal cord injury, Nat. Med., 5, 943, 10.1038/11387 Takami, 2002, Methylprednisolone and interleukin-10 reduce gray matter damage in the contused Fischer rat thoracic spinal cord but do not improve functional outcome, J. Neurotrauma, 19, 653, 10.1089/089771502753754118 Zhou, 2008, HSV-mediated transfer of interleukin-10 reduces inflammatory pain through modulation of membrane tumor necrosis factor alpha in spinal cord microglia, Gene. Ther., 15, 183, 10.1038/sj.gt.3303054 Zhou, 2009, Interleukin-10 provides direct trophic support to neurons, J. Neurochem., 110, 1617, 10.1111/j.1471-4159.2009.06263.x