Cul3-KLHL20 Ubiquitin Ligase Governs the Turnover of ULK1 and VPS34 Complexes to Control Autophagy Termination

Alemu, 2012, ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs, J. Biol. Chem., 287, 39275, 10.1074/jbc.M112.378109

Antonioli, 2014, AMBRA1 interplay with cullin E3 ubiquitin ligases regulates autophagy dynamics, Dev. Cell, 31, 734, 10.1016/j.devcel.2014.11.013

Choi, 2013, Autophagy in human health and disease, N. Engl. J. Med., 368, 651, 10.1056/NEJMra1205406

Di Bartolomeo, 2010, The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy, J. Cell Biol., 191, 155, 10.1083/jcb.201002100

Dorsey, 2009, Mapping the phosphorylation sites of Ulk1, J. Proteome Res., 8, 5253, 10.1021/pr900583m

Fan, 2011, Autophagosome targeting and membrane curvature sensing by Barkor/Atg14(L), Proc. Natl. Acad. Sci. USA, 108, 7769, 10.1073/pnas.1016472108

Feng, 2014, The machinery of macroautophagy, Cell Res., 24, 24, 10.1038/cr.2013.168

Füllgrabe, 2013, The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy, Nature, 500, 468, 10.1038/nature12313

Ganley, 2009, ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy, J. Biol. Chem., 284, 12297, 10.1074/jbc.M900573200

Hosokawa, 2009, Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy, Mol. Biol. Cell, 20, 1981, 10.1091/mbc.E08-12-1248

Itakura, 2010, Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins, Autophagy, 6, 764, 10.4161/auto.6.6.12709

Itakura, 2008, Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG, Mol. Biol. Cell, 19, 5360, 10.1091/mbc.E08-01-0080

Jiang, 2014, Autophagy and human diseases, Cell Res., 24, 69, 10.1038/cr.2013.161

Joo, 2011, Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy, Mol. Cell, 43, 572, 10.1016/j.molcel.2011.06.018

Jung, 2009, ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery, Mol. Biol. Cell, 20, 1992, 10.1091/mbc.E08-12-1249

Kim, 2011, AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1, Nat. Cell Biol., 13, 132, 10.1038/ncb2152

Kraft, 2012, Binding of the Atg1/ULK1 kinase to the ubiquitin-like protein Atg8 regulates autophagy, EMBO J., 31, 3691, 10.1038/emboj.2012.225

Kroemer, 2010, Autophagy and the integrated stress response, Mol. Cell, 40, 280, 10.1016/j.molcel.2010.09.023

Lee, 2010, The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses, EMBO J., 29, 1748, 10.1038/emboj.2010.62

Levine, 2008, Autophagy in the pathogenesis of disease, Cell, 132, 27, 10.1016/j.cell.2007.12.018

Liang, 2010, Negative regulation of autophagy, Cell Death Differ., 17, 1807, 10.1038/cdd.2010.115

Liu, 2015, Autosis and autophagic cell death: the dark side of autophagy, Cell Death Differ., 22, 367, 10.1038/cdd.2014.143

Liu, 2011, Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13, Cell, 147, 223, 10.1016/j.cell.2011.08.037

Matsunaga, 2010, Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L, J. Cell Biol., 190, 511, 10.1083/jcb.200911141

Mizushima, 2010, The role of the Atg1/ULK1 complex in autophagy regulation, Curr. Opin. Cell Biol., 22, 132, 10.1016/j.ceb.2009.12.004

Mizushima, 2011, Autophagy in protein and organelle turnover, Cold Spring Harb. Symp. Quant. Biol., 76, 397, 10.1101/sqb.2011.76.011023

Mizushima, 2010, Autophagy in mammalian development and differentiation, Nat. Cell Biol., 12, 823, 10.1038/ncb0910-823

Nakatogawa, 2009, Dynamics and diversity in autophagy mechanisms: lessons from yeast, Nat. Rev. Mol. Cell Biol., 10, 458, 10.1038/nrm2708

Nakatogawa, 2012, The autophagy-related protein kinase Atg1 interacts with the ubiquitin-like protein Atg8 via the Atg8 family interacting motif to facilitate autophagosome formation, J. Biol. Chem., 287, 28503, 10.1074/jbc.C112.387514

Nazio, 2013, mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6, Nat. Cell Biol., 15, 406, 10.1038/ncb2708

Neel, 2013, Skeletal muscle autophagy: a new metabolic regulator, Trends Endocrinol. Metab., 24, 635, 10.1016/j.tem.2013.09.004

O Farrell, 2013, Phosphoinositide 3-kinases as accelerators and brakes of autophagy, FEBS J., 280, 6322, 10.1111/febs.12486

Platta, 2012, Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1, Biochem. J., 441, 399, 10.1042/BJ20111424

Proikas-Cezanne, 2015, WIPI proteins: essential PtdIns3P effectors at the nascent autophagosome, J. Cell Sci., 128, 207, 10.1242/jcs.146258

Russell, 2013, ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase, Nat. Cell Biol., 15, 741, 10.1038/ncb2757

Sala, 2014, Autophagy-regulating TP53INP2 mediates muscle wasting and is repressed in diabetes, J. Clin. Invest., 124, 1914, 10.1172/JCI72327

Sandri, 2013, Misregulation of autophagy and protein degradation systems in myopathies and muscular dystrophies, J. Cell Sci., 126, 5325, 10.1242/jcs.114041

Schink, 2013, Phosphatidylinositol 3-phosphate, a lipid that regulates membrane dynamics, protein sorting and cell signalling, BioEssays, 35, 900, 10.1002/bies.201300064

Schwander, 2003, Beta1 integrins regulate myoblast fusion and sarcomere assembly, Dev. Cell, 4, 673, 10.1016/S1534-5807(03)00118-7

Shi, 2010, TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy, Sci. Signal., 3, ra42, 10.1126/scisignal.2000751

Sun, 2008, Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase, Proc. Natl. Acad. Sci. USA, 105, 19211, 10.1073/pnas.0810452105

Suttangkakul, 2011, The ATG1/ATG13 protein kinase complex is both a regulator and a target of autophagic recycling in Arabidopsis, Plant Cell, 23, 3761, 10.1105/tpc.111.090993

Thoresen, 2010, A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic, Exp. Cell Res., 316, 3368, 10.1016/j.yexcr.2010.07.008

Wirth, 2013, Autophagosome formation--the role of ULK1 and Beclin1-PI3KC3 complexes in setting the stage, Semin. Cancer Biol., 23, 301, 10.1016/j.semcancer.2013.05.007

Wong, 2013, The ULK1 complex: sensing nutrient signals for autophagy activation, Autophagy, 9, 124, 10.4161/auto.23323

Xia, 2013, WASH inhibits autophagy through suppression of Beclin 1 ubiquitination, EMBO J., 32, 2685, 10.1038/emboj.2013.189

Xiao, 2015, FBXL20-mediated Vps34 ubiquitination as a p53 controlled checkpoint in regulating autophagy and receptor degradation, Genes Dev., 29, 184, 10.1101/gad.252528.114

Xu, 2014, Regulation of autophagy by E3 ubiquitin ligase RNF216 through BECN1 ubiquitination, Autophagy, 10, 2239, 10.4161/15548627.2014.981792

Yang, 2010, Mammalian autophagy: core molecular machinery and signaling regulation, Curr. Opin. Cell Biol., 22, 124, 10.1016/j.ceb.2009.11.014

Yu, 2010, Termination of autophagy and reformation of lysosomes regulated by mTOR, Nature, 465, 942, 10.1038/nature09076

Zhang, 2015, G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L, eLife, 4, e06734, 10.7554/eLife.06734