Aspirin and blood pressure: Effects when used alone or in combination with antihypertensive drugs

Mancia, 2013, 2013 ESH/ESC Guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC), J Hypertens, 31, 1281, 10.1097/01.hjh.0000431740.32696.cc Polonia, 2014, Prevalence, awareness, treatment and control of hypertension and salt intake in Portugal: changes over a decade. The PHYSA study, J Hypertens, 32, 1211, 10.1097/HJH.0000000000000162 James, 2014, 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8), JAMA, 311, 507, 10.1001/jama.2013.284427 Hansson, 1998, Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial, Lancet, 351, 1755, 10.1016/S0140-6736(98)04311-6 Berger, 2006, Aspirin for the primary prevention of cardiovascular events in women and men: a sex-specific meta-analysis of randomized controlled trials, JAMA, 295, 306, 10.1001/jama.295.3.306 Baigent, 2009, Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials, Lancet, 373, 1849, 10.1016/S0140-6736(09)60503-1 Beygui, 2010, Benefits of low-dose aspirin in patients with hypertension, Hot Top Cardiol, 19, 17 Piepoli, 2016, Eur Heart J, 37, 2315, 10.1093/eurheartj/ehw106 Sziegoleit, 1982, Influence of acetylsalicylic acid on acute circulatory effects of the beta-blocking agents pindolol and propranolol in humans, Int J Clin Pharmacol Ther Toxicol, 20, 423 Guazzi, 1998, Antihypertensive efficacy of angiotensin converting enzyme inhibition and aspirin counteraction, Clin Pharmacol Ther, 63, 79, 10.1016/S0009-9236(98)90123-0 Tuttle, 1985, Inhibition by metoprolol of the antihypertensive effect of aspirin in young rats, J Pharmacol Exp Ther, 234, 166 Sziegoleit, 1984, Influence of indometacin and acetylsalicylic acid on the therapeutic effectiveness of talinolol in patients with essential hypertension, Biomed Biochim Acta, 43, S463 Avanzini, 2000, Effects of low-dose aspirin on clinic and ambulatory blood pressure in treated hypertensive patients. Collaborative Group of the Primary Prevention Project (PPP)–Hypertension study, Am J Hypertens, 13, 611, 10.1016/S0895-7061(00)00231-4 Nawarskas, 1999, Effect of aspirin on blood pressure in hypertensive patients taking enalapril or losartan, Am J Hypertens, 12, 784, 10.1016/S0895-7061(99)00037-0 Fossum, 2005, The effect of losartan versus atenolol on cardiovascular morbidity and mortality in patients with hypertension taking aspirin: the Losartan Intervention for Endpoint Reduction in hypertension (LIFE) study, J Am Coll Cardiol, 46, 770, 10.1016/j.jacc.2005.05.060 Lindenfeld, 2001, Aspirin impairs reverse myocardial remodeling in patients with heart failure treated with beta-blockers, J Am Coll Cardiol, 38, 1950, 10.1016/S0735-1097(01)01641-2 Nguyen, 1997, Interaction between enalapril and aspirin on mortality after acute myocardial infarction: subgroup analysis of the Cooperative New Scandinavian Enalapril Survival Study II (CONSENSUS II), Am J Cardiol, 79, 115, 10.1016/S0002-9149(96)00696-0 Patrono, 2005, Low-dose aspirin for the prevention of atherothrombosis, N Engl J Med, 353, 2373, 10.1056/NEJMra052717 Bautista, 2010, Antihypertensive effects of aspirin: what is the evidence?, Curr Hypertens Rep, 12, 282, 10.1007/s11906-010-0115-5 Paez Espinosa, 2012, Aspirin: pharmacology and clinical applications, Thrombosis, 2012, 173124, 10.1155/2012/173124 Hao, 2008, Physiological regulation of prostaglandins in the kidney, Annu Rev Physiol, 70, 357, 10.1146/annurev.physiol.70.113006.100614 Leinonen, 2011, Low-dose acetylsalicylic acid and blood pressure control in drug-treated hypertensive patients, Eur J Cardiovasc Prev Rehabil, 18, 136, 10.1097/HJR.0b013e32833ace3a Walsh, 1989, Low-dose aspirin: treatment for the imbalance of increased thromboxane and decreased prostacyclin in preeclampsia, Am J Perinatol, 6, 124, 10.1055/s-2007-999562 Rodriguez, 2000, Renal changes induced by a cyclooxygenase-2 inhibitor during normal and low sodium intake, Hypertension, 36, 276, 10.1161/01.HYP.36.2.276 Serhan, 2014, Pro-resolving lipid mediators are leads for resolution physiology, Nature, 510, 92, 10.1038/nature13479 Reina-Couto, 2016, Resolving inflammation in heart failure: novel protective lipid mediators, Curr Drug Targets, 17, 1206, 10.2174/1389450117666160101121135 Claria, 1995, Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions, Proc Natl Acad Sci U S A, 92, 9475, 10.1073/pnas.92.21.9475 Serhan, 2005, Lipoxins and aspirin-triggered 15-epi-lipoxins are the first lipid mediators of endogenous anti-inflammation and resolution, Prostaglandins Leukot Essent Fatty Acids, 73, 141, 10.1016/j.plefa.2005.05.002 Chiang, 2004, Aspirin triggers antiinflammatory 15-epi-lipoxin A4 and inhibits thromboxane in a randomized human trial, Proc Natl Acad Sci U S A, 101, 15178, 10.1073/pnas.0405445101 von der Weid, 2004, Aspirin-triggered, cyclooxygenase-2-dependent lipoxin synthesis modulates vascular tone, Circulation, 110, 1320, 10.1161/01.CIR.0000140985.89766.CB Reina-Couto, 2014, Impaired resolution of inflammation in human chronic heart failure, Eur J Clin Investig, 44, 527, 10.1111/eci.12265 Demetz, 2014, The arachidonic acid metabolome serves as a conserved regulator of cholesterol metabolism, Cell Metab, 20, 787, 10.1016/j.cmet.2014.09.004 Sha, 2015, Lipoxin A4 promotes ABCA1 expression and cholesterol efflux through the LXRα signaling pathway in THP-1 macrophage-derived foam cells, Int J Clin Exp Pathol, 8, 6708 Dhalla, 2000, Role of oxidative stress in cardiovascular diseases, J Hypertens, 18, 655, 10.1097/00004872-200018060-00002 Siti, 2015, The role of oxidative stress, antioxidants and vascular inflammation in cardiovascular disease (a review), Vasc Pharmacol, 71, 40, 10.1016/j.vph.2015.03.005 Paravicini, 2008, NADPH oxidases, reactive oxygen species, and hypertension: clinical implications and therapeutic possibilities, Diabetes Care, 31, S170, 10.2337/dc08-s247 Sousa, 2008, Role of superoxide and hydrogen peroxide in hypertension induced by an antagonist of adenosine receptors, Eur J Pharmacol, 588, 267, 10.1016/j.ejphar.2008.04.044 Sousa, 2012, Lipid peroxidation and antioxidants in arterial hypertension, 345 Sousa, 2012, Role of H2O2 in hypertension, renin-angiotensin system activation and renal medullary disfunction caused by angiotensin II, Br J Pharmacol, 166, 2386, 10.1111/j.1476-5381.2012.01957.x Vaziri, 2008, Causal link between oxidative stress, inflammation, and hypertension, Iran J Kidney Dis, 2, 1 Wu, 2002, Antioxidative properties of acetylsalicylic acid on vascular tissues from normotensive and spontaneously hypertensive rats, Circulation, 105, 387, 10.1161/hc0302.102609 Wu, 2004, Prevention of angiotensin II-induced hypertension, cardiovascular hypertrophy and oxidative stress by acetylsalicylic acid in rats, J Hypertens, 22, 793, 10.1097/00004872-200404000-00023 Wang, 2012, Aspirin suppresses cardiac fibroblast proliferation and collagen formation through downregulation of angiotensin type 1 receptor transcription, Toxicol Appl Pharmacol, 259, 346, 10.1016/j.taap.2012.01.013 Nascimento-Silva, 2007, Aspirin-triggered lipoxin A4 blocks reactive oxygen species generation in endothelial cells: a novel antioxidative mechanism, Thromb Haemost, 97, 88, 10.1160/TH06-06-0315 Nascimento-Silva, 2005, Novel lipid mediator aspirin-triggered lipoxin A4 induces heme oxygenase-1 in endothelial cells, Am J Physiol Cell Physiol, 289, C557, 10.1152/ajpcell.00045.2005 Carlo, 2013, 15-Epi-lipoxin A4 inhibits human neutrophil superoxide anion generation by regulating polyisoprenyl diphosphate phosphatase 1, FASEB J, 27, 2733, 10.1096/fj.12-223982 Jozsef, 2002, Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit peroxynitrite formation. NF-kappa B and AP-1 activation, and IL-8 gene expression in human leukocytes, Proc Natl Acad Sci U S A, 99, 13266, 10.1073/pnas.202296999 Ying, 2009, Salicylates dilate blood vessels through inhibiting PYK2-mediated RhoA/Rho-kinase activation, Cardiovasc Res, 83, 155, 10.1093/cvr/cvp084 Wang, 2001, Salicylate inhibits phosphorylation of the nonreceptor tyrosine kinases, proline-rich tyrosine kinase 2 and c-Src, Hypertension, 37, 148, 10.1161/01.HYP.37.1.148 Avraham, 2000, RAFTK/Pyk2-mediated cellular signalling, Cell Signal, 12, 123, 10.1016/S0898-6568(99)00076-5 Husain, 1998, Aspirin improves endothelial dysfunction in atherosclerosis, Circulation, 97, 716, 10.1161/01.CIR.97.8.716 Noon, 1998, Impairment of forearm vasodilatation to acetylcholine in hypercholesterolemia is reversed by aspirin, Cardiovasc Res, 38, 480, 10.1016/S0008-6363(98)00013-3 Monobe, 2001, Effects of low-dose aspirin on endothelial function in hypertensive patients, Clin Cardiol, 24, 705, 10.1002/clc.4960241104 Taubert, 2004, Aspirin induces nitric oxide release from vascular endothelium: a novel mechanism of action, Br J Pharmacol, 143, 159, 10.1038/sj.bjp.0705907 Dusting, 1983, Differences in arachidonic acid metabolism and effects of aspirin between one- and two-kidney Goldblatt hypertensive rats, Clin Exp Pharmacol Physiol, 10, 355, 10.1111/j.1440-1681.1983.tb00212.x Tuttle, 1988, Age and the antihypertensive effect of aspirin in rats, Br J Pharmacol, 94, 755, 10.1111/j.1476-5381.1988.tb11585.x Schirner, 1993, Different effects of aspirin on blood pressure of spontaneously hypertensive rats (SHR) with high and spontaneously low levels of blood pressure, Br J Pharmacol, 109, 900, 10.1111/j.1476-5381.1993.tb13704.x El Midaoui, 2002, Prevention of hypertension, hyperglycemia and vascular oxidative stress by aspirin treatment in chronically glucose-fed rats, J Hypertens, 20, 1407, 10.1097/00004872-200207000-00028 Rahmani, 1998, Effect of aspirin on the contractility of aortic smooth muscle and the course of blood pressure development in male spontaneously hypertensive rats, Artery, 23, 37 Rahmani, 1998, Vascular smooth muscle, endothelial regulation and effects of aspirin in hypertension, Front Biosci, 3, e23, 10.2741/A365 Knight, 2005, Effect of COX inhibitors and NO on renal hemodynamics following ischemia-reperfusion injury in normotensive and hypertensive rats, Am J Physiol Renal Physiol, 289, F1072, 10.1152/ajprenal.00430.2004 Sousa, 2013, Interaction of low-dose acetylsalicylic acid with losartan: effect on systolic blood pressure, renal function, oxidative stress and lipoxins synthesis in spontaneous hypertension [abstract], J Hypertens, 31 Vertiz-Hernandez, 2015, Parecoxib increases blood pressure through inhibition of cyclooxygenase-2 messenger RNA in an experimental model, Rev Investig Clin, 67, 250 Sousa, 2014, Low-dose aspirin improves renal function and antihypertensive efficacy in hypertensive rats treated with losartan [abstract], J Nephrol Ther, 4, 4 DiNicolantonio, 1981, Failure of aspirin to modify the hypotensive action of captopril in spontaneously hypertensive rats, Clin Exp Pharmacol Physiol, 8, 345, 10.1111/j.1440-1681.1981.tb00738.x Quilley, 1987, Aspirin enhances the antihypertensive effect of captopril in spontaneously hypertensive rats, Hypertension, 10, 294, 10.1161/01.HYP.10.3.294 Dubey, 2003, Potential adverse interaction between aspirin and lisinopril in hypertensive rats, Hum Exp Toxicol, 22, 143, 10.1191/0960327103ht331oa Boger, 1996, Effect of captopril on prostacyclin and nitric oxide formation in healthy human subjects: interaction with low dose acetylsalicylic acid, Br J Clin Pharmacol, 42, 721, 10.1046/j.1365-2125.1996.00480.x Hermida, 1994, Time-dependent effects of ASA administration on blood pressure in healthy subjects, Chronobiologia, 21, 201 Hermida, 1997, Influence of aspirin usage on blood pressure: dose and administration-time dependencies, Chronobiol Int, 14, 619, 10.3109/07420529709001452 Hermida, 2003, Administration time-dependent effects of aspirin on blood pressure in untreated hypertensive patients, Hypertension, 41, 1259, 10.1161/01.HYP.0000072335.73748.0D Hermida, 2005, Aspirin administered at bedtime, but not on awakening, has an effect on ambulatory blood pressure in hypertensive patients, J Am Coll Cardiol, 46, 975, 10.1016/j.jacc.2004.08.071 Hermida, 2005, Differing administration time-dependent effects of aspirin on blood pressure in dipper and non-dipper hypertensives, Hypertension, 46, 1060, 10.1161/01.HYP.0000172623.36098.4e Ayala, 2010, Sex differences in the administration-time-dependent effects of low-dose aspirin on ambulatory blood pressure in hypertensive subjects, Chronobiol Int, 27, 345, 10.3109/07420521003624662 Magagna, 1994, Hemodynamic and humoral effects of low-dose aspirin in treated and untreated essential hypertensive patients, Blood Press, 3, 236, 10.3109/08037059409102263 Snoep, 2009, Time-dependent effects of low-dose aspirin on plasma renin activity, aldosterone, cortisol, and catecholamines, Hypertension, 54, 1136, 10.1161/HYPERTENSIONAHA.109.134825 Hermida, 1997, Time-dependent effects of low-dose aspirin administration on blood pressure in pregnant women, Hypertension, 30, 589, 10.1161/01.HYP.30.3.589 Hermida, 1999, Administration time-dependent effects of aspirin in women at differing risk for preeclampsia, Hypertension, 34, 1016, 10.1161/01.HYP.34.4.1016 Hermida, 2003, Administration time-dependent influence of aspirin on blood pressure in pregnant women, Hypertension, 41, 651, 10.1161/01.HYP.0000047876.63997.EE Hermida, 2009, Ambulatory blood pressure control with bedtime aspirin administration in subjects with prehypertension, Am J Hypertens, 22, 896, 10.1038/ajh.2009.83 Smith, 1993, Effect of low-dose aspirin on thromboxane production and the antihypertensive effect of captopril, J Am Soc Nephrol, 4, 1133, 10.1681/ASN.V451133 Polonia, 1995, Influence of non-steroidal anti-inflammatory drugs on renal function and 24h ambulatory blood pressure-reducing effects of enalapril and nifedipine gastrointestinal therapeutic system in hypertensive patients, J Hypertens, 13, 925, 10.1097/00004872-199508000-00014 Fisman, 2002, Clinical evidence of dose-dependent interaction between aspirin and angiotensin-converting enzyme inhibitors, J Hum Hypertens, 16, 379, 10.1038/sj.jhh.1001406 Prikryl, 2005, Chronobiologically explored effects of Telmisartan, Clin Exp Hypertens, 27, 119, 10.1081/CEH-48733 Zanchetti, 2002, Benefit and harm of low-dose aspirin in well-treated hypertensives at different baseline cardiovascular risk, J Hypertens, 20, 2301, 10.1097/00004872-200211000-00031 Dimitrov, 2012, Is there a BP benefit of changing the time of aspirin administration in treated hypertensive patients?, Eur J Prev Cardiol, 19, 706, 10.1177/1741826711418165 Bonten, 2015, Time-dependent effects of aspirin on blood pressure and morning platelet reactivity: a randomized crossover trial, Hypertension, 65, 743, 10.1161/HYPERTENSIONAHA.114.04980