Could cathepsin-k be a driver of the myofibroblastic differentiation observed in dermatofibroma, atypical fibroxanthoma and pleomorphic dermal sarcoma?

Chen, 2013, Cathepsin-S mediated fibroblast trans-differentiation contributes to left ventricular remodelling after myocardial infarction, Cardiovasc. Res., 100, 84, 10.1093/cvr/cvt158 Elder, 2018 Goldblum, 2014 Harding-Jackson, 2015, Spindle cell atypical fibroxanthoma: myofibroblastic differentiation represents a diagnostic pitfall in this variant of AFX, Am. J. Dermatopathol., 37, 509, 10.1097/DAD.0000000000000313 Hinz, 2007, Formation and function of the myofibroblast during tissue repair, J. Invest. Dermatol., 127, 526, 10.1038/sj.jid.5700613 Hinz, 2007, The myofibroblast: one function, multiple origins, Am. J. Pathol., 170, 1807, 10.2353/ajpath.2007.070112 Longacre, 1993, Atypical fibroxanthoma. Multiple immunohistologic profiles, Am. J. Surg. Pathol., 17, 1199, 10.1097/00000478-199312000-00001 Micallef, 2012, The myofibroblast, multiple origins for major roles in normal and pathological tissue repair, Fibrogenesis Tissue Rep., 5, S5, 10.1186/1755-1536-5-S1-S5 Prieto, 1995, Immunohistochemistry of dermatofibromas and benign fibrous histiocytomas, J. Cutan. Pathol., 22, 336, 10.1111/j.1600-0560.1995.tb01416.x Sakamoto, 2002, Calponin and h-caldesmon expression in atypical fibroxanthoma and superficial leiomyosarcoma, Virchows Arch., 440, 404, 10.1007/s004280100521 Shephard, 2004, Myofibroblast differentiation is induced in keratinocyte-fibroblast co-cultures is antagonistically regulated by endogenous transforming growth factor-beta and interleukin-1, Am. J. Pathol., 164, 2055, 10.1016/S0002-9440(10)63764-9 Tomasek, 2002, Myofibroblasts and mechano-regulation of connective tissue remodelling, Nat. Rev. Mol. Cell Biol., 3, 349, 10.1038/nrm809