Atlas of nonribosomal peptide and polyketide biosynthetic pathways reveals common occurrence of nonmodular enzymes

Proceedings of the National Academy of Sciences of the United States of America - Tập 111 Số 25 - Trang 9259-9264 - 2014
Hao Wang1, David P. Fewer1, Liisa Holm2, Leo Rouhiainen3, Kaarina Sivonen3
1Division of Microbiology and Biotechnology, Department of Food and Environmental Sciences and.
2Institute of Biotechnology and Department of Biosciences, Viikki Biocenter, University of Helsinki, FIN-00014, Helsinki, Finland.
3aDivision of Microbiology and Biotechnology, Department of Food and Environmental Sciences and

Tóm tắt

Significance This study demonstrates the widespread distribution of nonribosomal peptide synthetase and modular polyketide synthase biosynthetic pathways across the three domains of life, by cataloging a total of 3,339 gene clusters from 2,699 genomes. Our analysis suggests that noncanonical nonmodular biosynthetic enzymes are common in bacteria. Proteobacteria , Actinobacteria , Firmicutes , and Cyanobacteria in bacteria and Ascomycota in fungi contained higher number of these gene clusters and are likely to produce a wide variety of nonribosomal peptide and polyketide types of natural products. The data generated here provide a basis for the exploration of nonribosomal peptide and polyketide biosynthetic capacity and present a compelling wealth of new information for natural product discovery.

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Proceedings of the National Academy of Sciences of the United States of America

Tập 111 Số 25

9259-9264

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