Akude, 2011, Diminished superoxide generation is associated with respiratory chain dysfunction and changes in the mitochondrial proteome of sensory neurons from diabetic rats, Diabetes, 60, 288, 10.2337/db10-0818
Anderson, 2009, Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans, J Clin Invest, 119, 573, 10.1172/JCI37048
Azzu, 2008, High membrane potential promotes alkenal-induced mitochondrial uncoupling and influences adenine nucleotide translocase conformation, Biochem J, 413, 323, 10.1042/BJ20080321
Balaban, 2005, Mitochondria, oxidants, and aging, Cell, 120, 483, 10.1016/j.cell.2005.02.001
Belfort, 2005, Dose-response effect of elevated plasma free fatty acid on insulin signaling, Diabetes, 54, 1640, 10.2337/diabetes.54.6.1640
Benton, 2008, Modest PGC-1alpha overexpression in muscle in vivo is sufficient to increase insulin sensitivity and palmitate oxidation in subsarcolemmal, not intermyofibrillar, mitochondria, J Biol Chem, 283, 4228, 10.1074/jbc.M704332200
Benton, 2010, Increased levels of peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PGC-1alpha) improve lipid utilisation, insulin signalling and glucose transport in skeletal muscle of lean and insulin-resistant obese Zucker rats, Diabetologia, 53, 2008, 10.1007/s00125-010-1773-1
Bergman, 1981, Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose, J Clin Invest, 68, 1456, 10.1172/JCI110398
Bergmann, 1989, Noninvasive quantitation of myocardial blood flow in human subjects with oxygen-15-labeled water and positron emission tomography, J Am Coll Cardiol, 14, 639, 10.1016/0735-1097(89)90105-8
Bertoni, 2008, Suboptimal control of glycemia, blood pressure, and LDL cholesterol in overweight adults with diabetes: the Look AHEAD Study, J Diabetes Complications, 22, 1, 10.1016/j.jdiacomp.2006.10.003
Boden, 1991, Effects of fat on insulin-stimulated carbohydrate metabolism in normal men, J Clin Invest, 88, 960, 10.1172/JCI115399
Borradaile, 2005, Lipotoxicity in the heart, Curr Hypertens Rep, 7, 412, 10.1007/s11906-005-0035-y
Boudina, 2006, Mitochondrial uncoupling: a key contributor to reduced cardiac efficiency in diabetes, Physiology (Bethesda), 21, 250, 10.1152/physiol.00008.2006
Boudina, 2005, Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity, Circulation, 112, 2686, 10.1161/CIRCULATIONAHA.105.554360
Boudina, 2007, Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins, Diabetes, 56, 2457, 10.2337/db07-0481
Boule, 2001, Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta-analysis of controlled clinical trials, JAMA, 286, 1218, 10.1001/jama.286.10.1218
Boussageon, 2011, Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: meta-analysis of randomised controlled trials, BMJ, 343, d4169, 10.1136/bmj.d4169
Brand, 2005, Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3, Cell Metab, 2, 85, 10.1016/j.cmet.2005.06.002
Brehm, 2006, Increased lipid availability impairs insulin-stimulated ATP synthesis in human skeletal muscle, Diabetes, 55, 136, 10.2337/diabetes.55.01.06.db05-1286
Brookes, 2004, Calcium, ATP, and ROS: a mitochondrial love-hate triangle, Am J Physiol Cell Physiol, 287, C817, 10.1152/ajpcell.00139.2004
Brownlee, 2001, Biochemistry and molecular cell biology of diabetic complications, Nature, 414, 813, 10.1038/414813a
Bugger, 2010, Mitochondria in the diabetic heart, Cardiovasc Res, 88, 229, 10.1093/cvr/cvq239
Bugger, 2009, Tissue-specific remodeling of the mitochondrial proteome in type 1 diabetic akita mice, Diabetes, 58, 1986, 10.2337/db09-0259
Cai, 2005, Inhibition of superoxide generation and associated nitrosative damage is involved in metallothionein prevention of diabetic cardiomyopathy, Diabetes, 54, 1829, 10.2337/diabetes.54.6.1829
Camello-Almaraz, 2006, Mitochondrial reactive oxygen species and Ca2+ signaling, Am J Physiol Cell Physiol, 291, C1082, 10.1152/ajpcell.00217.2006
Cameron, 2001, Vascular factors and metabolic interactions in the pathogenesis of diabetic neuropathy, Diabetologia, 44, 1973, 10.1007/s001250100001
Campanucci, 2010, Diabetes depresses synaptic transmission in sympathetic ganglia by inactivating nAChRs through a conserved intracellular cysteine residue, Neuron, 66, 827, 10.1016/j.neuron.2010.06.010
Canto, 2009, PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure, Curr Opin Lipidol, 20, 98, 10.1097/MOL.0b013e328328d0a4
Casanova-Molla, 2012, Mitochondrial loss indicates early axonal damage in small fiber neuropathies, J Peripher Nerv Syst, 17, 147, 10.1111/j.1529-8027.2012.00396.x
Choi, 2008, Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism, Proc Natl Acad Sci U S A, 105, 19926, 10.1073/pnas.0810339105
Choi, 2011, Intrinsic bioenergetic properties and stress sensitivity of dopaminergic synaptosomes, J Neurosci, 31, 4524, 10.1523/JNEUROSCI.5817-10.2011
Chow, 2010, Skeletal muscle insulin resistance: the interplay of local lipid excess and mitochondrial dysfunction, Metabolism, 59, 70, 10.1016/j.metabol.2009.07.009
Chowdhury, 2010, Mitochondrial respiratory chain dysfunction in dorsal root ganglia of streptozotocin-induced diabetic rats and its correction by insulin treatment, Diabetes, 59, 1082, 10.2337/db09-1299
Coatesworth, 2006, Spatially organised mitochondrial calcium uptake through a novel pathway in chick neurones, Cell Calcium, 39, 217, 10.1016/j.ceca.2005.10.012
Crowther, 2003, Altered energetic properties in skeletal muscle of men with well-controlled insulin-dependent (type 1) diabetes, Am J Physiol Endocrinol Metab, 284, E655, 10.1152/ajpendo.00343.2002
David, 2000, Stimulation-evoked increases in cytosolic [Ca(2+)] in mouse motor nerve terminals are limited by mitochondrial uptake and are temperature-dependent, J Neurosci, 20, 7290, 10.1523/JNEUROSCI.20-19-07290.2000
David, 1998, Evidence that mitochondria buffer physiological Ca2+ loads in lizard motor nerve terminals, J Physiol, 509, 59, 10.1111/j.1469-7793.1998.059bo.x
DCCT/EDIC, 2000, Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy. The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group, N Engl J Med, 342, 381, 10.1056/NEJM200002103420603
Devereux, 2000, Impact of diabetes on cardiac structure and function: the strong heart study, Circulation, 101, 2271, 10.1161/01.CIR.101.19.2271
Diamant, 2003, Diastolic dysfunction is associated with altered myocardial metabolism in asymptomatic normotensive patients with well-controlled type 2 diabetes mellitus, J Am Coll Cardiol, 42, 328, 10.1016/S0735-1097(03)00625-9
Duncan, 2007, Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-alpha/PGC-1alpha gene regulatory pathway, Circulation, 115, 909, 10.1161/CIRCULATIONAHA.106.662296
Duncan, 2010, Rescue of cardiomyopathy in peroxisome proliferator-activated receptor-alpha transgenic mice by deletion of lipoprotein lipase identifies sources of cardiac lipids and peroxisome proliferator-activated receptor-alpha activators, Circulation, 121, 426, 10.1161/CIRCULATIONAHA.109.888735
Ebenezer, 2007, Denervation of skin in neuropathies: the sequence of axonal and Schwann cell changes in skin biopsies, Brain, 130, 2703, 10.1093/brain/awm199
el Midaoui, 1996, Effect of physical training on mitochondrial function in skeletal muscle of normal and diabetic rats, Metabolism, 45, 810, 10.1016/S0026-0495(96)90151-1
Erion, 2010, Diacylglycerol-mediated insulin resistance, Nat Med, 16, 400, 10.1038/nm0410-400
Feige, 2007, Transcriptional coregulators in the control of energy homeostasis, Trends Cell Biol, 17, 292, 10.1016/j.tcb.2007.04.001
Fein, 1985, Diabetic cardiomyopathy, Prog Cardiovasc Dis, 27, 255, 10.1016/0033-0620(85)90009-X
Fernyhough, 2002, Neurofilaments in diabetic neuropathy, Int Rev Neurobiol, 50, 115, 10.1016/S0074-7742(02)50075-1
Finck, 2002, The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus, J Clin Invest, 109, 121, 10.1172/JCI0214080
Finck, 2003, A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content, Proc Natl Acad Sci U S A, 100, 1226, 10.1073/pnas.0336724100
Gerstein, 2005, The relationship between dysglycaemia and cardiovascular and renal risk in diabetic and non-diabetic participants in the HOPE study: a prospective epidemiological analysis, Diabetologia, 48, 1749, 10.1007/s00125-005-1858-4
Gollnick, 1972, Enzyme activity and fiber composition in skeletal muscle of untrained and trained men, J Appl Physiol, 33, 312, 10.1152/jappl.1972.33.3.312
Goodyear, 1998, Exercise, glucose transport, and insulin sensitivity, Annu Rev Med, 49, 235, 10.1146/annurev.med.49.1.235
Gumy, 2008, Hyperglycaemia inhibits Schwann cell proliferation and migration and restricts regeneration of axons and Schwann cells from adult murine DRG, Mol Cell Neurosci, 37, 298, 10.1016/j.mcn.2007.10.004
Gunter, 2000, Mitochondrial calcium transport: mechanisms and functions, Cell Calcium, 28, 285, 10.1054/ceca.2000.0168
Gunter, 2004, Calcium and mitochondria, FEBS Lett, 567, 96, 10.1016/j.febslet.2004.03.071
Hall, 1995, Voltage-dependent calcium currents are enhanced in dorsal root ganglion neurones from the Bio Bred/Worchester diabetic rat, J Physiol, 486, 313, 10.1113/jphysiol.1995.sp020814
Hall, 2001, Impaired inhibitory G-protein function contributes to increased calcium currents in rats with diabetic neuropathy, J Neurophysiol, 86, 760, 10.1152/jn.2001.86.2.760
Hammer, 2008, Progressive caloric restriction induces dose-dependent changes in myocardial triglyceride content and diastolic function in healthy men, J Clin Endocrinol Metab, 93, 497, 10.1210/jc.2007-2015
Hammer, 2008, Prolonged caloric restriction in obese patients with type 2 diabetes mellitus decreases myocardial triglyceride content and improves myocardial function, J Am Coll Cardiol, 52, 1006, 10.1016/j.jacc.2008.04.068
Harmer, 2008, Sprint training increases muscle oxidative metabolism during high-intensity exercise in patients with type 1 diabetes, Diabetes Care, 31, 2097, 10.2337/dc08-0329
He, 2001, Skeletal muscle lipid content and oxidative enzyme activity in relation to muscle fiber type in type 2 diabetes and obesity, Diabetes, 50, 817, 10.2337/diabetes.50.4.817
Hemmingsen, 2011, Intensive glycaemic control for patients with type 2 diabetes: systematic review with meta-analysis and trial sequential analysis of randomised clinical trials, BMJ, 343, d6898, 10.1136/bmj.d6898
Henriksson, 1992, Effects of physical training on the metabolism of skeletal muscle, Diabetes Care, 15, 1701, 10.2337/diacare.15.11.1701
Henry, 1996, Glucose control and insulin resistance in non-insulin-dependent diabetes mellitus, Ann Intern Med, 124, 97, 10.7326/0003-4819-124-1_Part_2-199601011-00019
Herrero, 2006, Increased myocardial fatty acid metabolism in patients with type 1 diabetes mellitus, J Am Coll Cardiol, 47, 598, 10.1016/j.jacc.2005.09.030
Hey-Mogensen, 2010, Effect of physical training on mitochondrial respiration and reactive oxygen species release in skeletal muscle in patients with obesity and type 2 diabetes, Diabetologia, 53, 1976, 10.1007/s00125-010-1813-x
Ho, 2006, Aldose reductase-deficient mice are protected from delayed motor nerve conduction velocity, increased c-Jun NH2-terminal kinase activation, depletion of reduced glutathione, increased superoxide accumulation, and DNA damage, Diabetes, 55, 1946, 10.2337/db05-1497
Holloszy, 2009, Skeletal muscle “mitochondrial deficiency” does not mediate insulin resistance, Am J Clin Nutr, 89, 463S, 10.3945/ajcn.2008.26717C
Holloszy, 1976, Biochemical adaptations to endurance exercise in muscle, Annu Rev Physiol, 38, 273, 10.1146/annurev.ph.38.030176.001421
How, 2006, Increased myocardial oxygen consumption reduces cardiac efficiency in diabetic mice, Diabetes, 55, 466, 10.2337/diabetes.55.02.06.db05-1164
Huang, 2002, Diabetes-induced alterations in calcium homeostasis in sensory neurones of streptozotocin-diabetic rats are restricted to lumbar ganglia and are prevented by neurotrophin-3, Diabetologia, 45, 560, 10.1007/s00125-002-0785-x
Huang, 2003, Insulin prevents depolarization of the mitochondrial inner membrane in sensory neurons of type 1 diabetic rats in the presence of sustained hyperglycemia, Diabetes, 52, 2129, 10.2337/diabetes.52.8.2129
Huang, 2005, Neurotrophin-3 prevents mitochondrial dysfunction in sensory neurons of streptozotocin-diabetic rats, Exp Neurol, 194, 279, 10.1016/j.expneurol.2005.03.001
Huss, 2005, Mitochondrial energy metabolism in heart failure: a question of balance, J Clin Invest, 115, 547, 10.1172/JCI24405
Ibsen, 1961, The Crabtree effect: a review, Cancer Res, 21, 829
Iozzo, 2009, Contribution of glucose tolerance and gender to cardiac adiposity, J Clin Endocrinol Metab, 94, 4472, 10.1210/jc.2009-0436
Ismail-Beigi, 2010, Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial, Lancet, 376, 419, 10.1016/S0140-6736(10)60576-4
Itani, 2002, Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha, Diabetes, 51, 2005, 10.2337/diabetes.51.7.2005
Jiang, 2006, Novel sites of aldose reductase immunolocalization in normal and streptozotocin-diabetic rats, J Peripher Nerv Syst, 11, 274, 10.1111/j.1529-8027.2006.00099.x
Kalichman, 1998, Reactive, degenerative, and proliferative Schwann cell responses in experimental galactose and human diabetic neuropathy, Acta Neuropathol, 95, 47, 10.1007/s004010050764
Kamiya, 2005, Apoptotic stress is counterbalanced by survival elements preventing programmed cell death of dorsal root ganglions in subacute type 1 diabetic BB/Wor rats, Diabetes, 54, 3288, 10.2337/diabetes.54.11.3288
Kamiya, 2006, Degeneration of the Golgi and neuronal loss in dorsal root ganglia in diabetic BioBreeding/Worcester rats, Diabetologia, 49, 2763, 10.1007/s00125-006-0379-0
Karamitsos, 2008, Impact of autonomic neuropathy on left ventricular function in normotensive type 1 diabetic patients: a tissue Doppler echocardiographic study, Diabetes Care, 31, 325, 10.2337/dc07-1634
Kelley, 2002, Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes, Diabetes, 51, 2944, 10.2337/diabetes.51.10.2944
Kelly, 1994, Inherited cardiomyopathies, N Engl J Med, 330, 913, 10.1056/NEJM199403313301308
Kennedy, 1996, Quantitation of epidermal nerves in diabetic neuropathy, Neurology, 47, 1042, 10.1212/WNL.47.4.1042
Kirichok, 2004, The mitochondrial calcium uniporter is a highly selective ion channel, Nature, 427, 360, 10.1038/nature02246
Kluding, 2012, The effect of exercise on neuropathic symptoms, nerve function, and cutaneous innervation in people with diabetic peripheral neuropathy, J Diabetes Complications, 26, 424, 10.1016/j.jdiacomp.2012.05.007
Knowler, 2002, Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin, N Engl J Med, 346, 393, 10.1056/NEJMoa012512
Knuuti, 2001, Myocardial fatty acid oxidation in patients with impaired glucose tolerance, Diabetologia, 44, 184, 10.1007/s001250051597
Kostyuk, 1995, Calcium signal prolongation in sensory neurones of mice with experimental diabetes, Neuroreport, 6, 1010, 10.1097/00001756-199505090-00015
Kostyuk, 1999, Role of mitochondrial dysfunction in calcium signalling alterations in dorsal root ganglion neurons of mice with experimentally-induced diabetes, Neuroscience, 90, 535, 10.1016/S0306-4522(98)00471-0
Kostyuk, 2001, Diabetes-induced changes in calcium homeostasis and the effects of calcium channel blockers in rat and mice nociceptive neurons, Diabetologia, 44, 1302, 10.1007/s001250100642
Koves, 2008, Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance, Cell Metab, 7, 45, 10.1016/j.cmet.2007.10.013
Krssak, 1999, Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study, Diabetologia, 42, 113, 10.1007/s001250051123
Kruglikov, 2004, Diabetes-induced abnormalities in ER calcium mobilization in primary and secondary nociceptive neurons, Pflugers Arch, 448, 395, 10.1007/s00424-004-1263-8
Lanza, 2009, Muscle mitochondrial changes with aging and exercise, Am J Clin Nutr, 89, 467S, 10.3945/ajcn.2008.26717D
Lauria, 2003, Axonal swellings predict the degeneration of epidermal nerve fibers in painful neuropathies, Neurology, 61, 631, 10.1212/01.WNL.0000070781.92512.A4
Lee, 2001, Liporegulation in diet-induced obesity. The antisteatotic role of hyperleptinemia, J Biol Chem, 276, 5629, 10.1074/jbc.M008553200
Lehman, 2008, The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis, Am J Physiol Heart Circ Physiol, 295, H185, 10.1152/ajpheart.00081.2008
Lipscombe, 2007, Trends in diabetes prevalence, incidence, and mortality in Ontario, Canada 1995–2005: a population-based study, Lancet, 369, 750, 10.1016/S0140-6736(07)60361-4
Liu, 2001, The impact of diabetes on left ventricular filling pattern in normotensive and hypertensive adults: the Strong Heart Study, J Am Coll Cardiol, 37, 1943, 10.1016/S0735-1097(01)01230-X
Lopaschuk, 1983, The effect of alloxan- and streptozotocin-induced diabetes on calcium transport in rat cardiac sarcoplasmic reticulum. The possible involvement of long chain acylcarnitines, Can J Physiol Pharmacol, 61, 439, 10.1139/y83-068
Lopaschuk, 2010, Myocardial fatty acid metabolism in health and disease, Physiol Rev, 90, 207, 10.1152/physrev.00015.2009
Lowell, 2005, Mitochondrial dysfunction and type 2 diabetes, Science, 307, 384, 10.1126/science.1104343
Malik, 2005, Sural nerve pathology in diabetic patients with minimal but progressive neuropathy, Diabetologia, 48, 578, 10.1007/s00125-004-1663-5
Martin, 1992, Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study, Lancet, 340, 925, 10.1016/0140-6736(92)92814-V
Mazzone, 2008, Cardiovascular disease risk in type 2 diabetes mellitus: insights from mechanistic studies, Lancet, 371, 1800, 10.1016/S0140-6736(08)60768-0
McCormack, 1990, Role of calcium ions in regulation of mammalian intramitochondrial metabolism, Physiol Rev, 70, 391, 10.1152/physrev.1990.70.2.391
McGarry, 2002, Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes, Diabetes, 51, 7, 10.2337/diabetes.51.1.7
McGavock, 2004, Cardiovascular adaptations to exercise training in postmenopausal women with type 2 diabetes mellitus, Cardiovasc Diabetol, 3, 3, 10.1186/1475-2840-3-3
McGavock, 2004, The role of exercise in the treatment of cardiovascular disease associated with type 2 diabetes mellitus, Sports Med, 34, 27, 10.2165/00007256-200434010-00004
McGavock, 2004, Low cardiorespiratory fitness is associated with elevated C-reactive protein levels in women with type 2 diabetes, Diabetes Care, 27, 320, 10.2337/diacare.27.2.320
McGavock, 2006, Adiposity of the heart, revisited, Ann Intern Med, 144, 517, 10.7326/0003-4819-144-7-200604040-00011
McGavock, 2007, Cardiac steatosis in diabetes mellitus: a 1H-magnetic resonance spectroscopy study, Circulation, 116, 1170, 10.1161/CIRCULATIONAHA.106.645614
Meex, 2010, Restoration of muscle mitochondrial function and metabolic flexibility in type 2 diabetes by exercise training is paralleled by increased myocellular fat storage and improved insulin sensitivity, Diabetes, 59, 572, 10.2337/db09-1322
Mitchell, 1971, Maximal oxygen uptake, N Engl J Med, 284, 1018, 10.1056/NEJM197105062841809
Miura, 2003, Overexpression of peroxisome proliferator-activated receptor gamma coactivator-1alpha down-regulates GLUT4 mRNA in skeletal muscles, J Biol Chem, 278, 31385, 10.1074/jbc.M304312200
Miura, 2006, Overexpression of peroxisome proliferator-activated receptor gamma co-activator-1alpha leads to muscle atrophy with depletion of ATP, Am J Pathol, 169, 1129, 10.2353/ajpath.2006.060034
Mizisin, 2004, Ciliary neurotrophic factor improves nerve conduction and ameliorates regeneration deficits in diabetic rats, Diabetes, 53, 1807, 10.2337/diabetes.53.7.1807
Mizisin, 2007, Comparable myelinated nerve pathology in feline and human diabetes mellitus, Acta Neuropathol, 113, 431, 10.1007/s00401-006-0163-8
Mookerjee, 2010, Mitochondrial uncoupling and lifespan, Mech Ageing Dev, 131, 463, 10.1016/j.mad.2010.03.010
Mootha, 2003, PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes, Nat Genet, 34, 267, 10.1038/ng1180
Muoio, 2012, Lipid-induced mitochondrial stress and insulin action in muscle, Cell Metab, 15, 595, 10.1016/j.cmet.2012.04.010
Muoio, 2008, Mechanisms of disease: molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes, Nat Rev Mol Cell Biol, 9, 193, 10.1038/nrm2327
Musi, 2001, AMP-activated protein kinase (AMPK) is activated in muscle of subjects with type 2 diabetes during exercise, Diabetes, 50, 921, 10.2337/diabetes.50.5.921
Narayan, 2003, Lifetime risk for diabetes mellitus in the United States, JAMA, 290, 1884, 10.1001/jama.290.14.1884
Nathan, 2005, Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes, N Engl J Med, 353, 2643, 10.1056/NEJMoa052187
Neschen, 2005, Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice, Cell Metab, 2, 55, 10.1016/j.cmet.2005.06.006
Nicholls, 2004, Mitochondrial dysfunction and glutamate excitotoxicity studied in primary neuronal cultures, Curr Mol Med, 4, 149, 10.2174/1566524043479239
Nicholls, 2005, Mitochondria and calcium signaling, Cell Calcium, 38, 311, 10.1016/j.ceca.2005.06.011
Nicholls, 2006, Simultaneous monitoring of ionophore- and inhibitor-mediated plasma and mitochondrial membrane potential changes in cultured neurons, J Biol Chem, 281, 14864, 10.1074/jbc.M510916200
Nicholls, 2000, Mitochondria and neuronal survival, Physiol Rev, 80, 315, 10.1152/physrev.2000.80.1.315
Nielsen, 2010, Increased subsarcolemmal lipids in type 2 diabetes: effect of training on localization of lipids, mitochondria, and glycogen in sedentary human skeletal muscle, Am J Physiol Endocrinol Metab, 298, E706, 10.1152/ajpendo.00692.2009
Nishikawa, 2000, The missing link: a single unifying mechanism for diabetic complications, Kidney Int, 58, S26, 10.1046/j.1523-1755.2000.07705.x
Nishikawa, 2000, Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage, Nature, 404, 787, 10.1038/35008121
Nja, 1978, The effects of nerve growth factor and its antiserum on synapses in the superior cervical ganglion of the guinea-pig, J Physiol, 277, 53, 10.1113/jphysiol.1978.sp012260
Obrosova, 2002, How does glucose generate oxidative stress in peripheral nerve?, Int Rev Neurobiol, 50, 3, 10.1016/S0074-7742(02)50071-4
Obrosova, 2002, An aldose reductase inhibitor reverses early diabetes-induced changes in peripheral nerve function, metabolism, and antioxidative defense, FASEB J, 16, 123, 10.1096/fj.01-0603fje
Obrosova, 2005, Aldose reductase inhibition counteracts oxidative-nitrosative stress and poly(ADP-ribose) polymerase activation in tissue sites for diabetes complications, Diabetes, 54, 234, 10.2337/diabetes.54.1.234
Pagel-Langenickel, 2010, The role of mitochondria in the pathophysiology of skeletal muscle insulin resistance, Endocr Rev, 31, 25, 10.1210/er.2009-0003
Patti, 2010, The role of mitochondria in the pathogenesis of type 2 diabetes, Endocr Rev, 31, 364, 10.1210/er.2009-0027
Patti, 2003, Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1, Proc Natl Acad Sci U S A, 100, 8466, 10.1073/pnas.1032913100
Perez-Campo, 1998, The rate of free radical production as a determinant of the rate of aging: evidence from the comparative approach, J Comp Physiol B, 168, 149, 10.1007/s003600050131
Perseghin, 1996, Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects, N Engl J Med, 335, 1357, 10.1056/NEJM199610313351804
Perseghin, 2007, Abnormal left ventricular energy metabolism in obese men with preserved systolic and diastolic functions is associated with insulin resistance, Diabetes Care, 30, 1520, 10.2337/dc06-2429
Petersen, 2003, Mitochondrial dysfunction in the elderly: possible role in insulin resistance, Science, 300, 1140, 10.1126/science.1082889
Petersen, 2004, Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes, N Engl J Med, 350, 664, 10.1056/NEJMoa031314
Poirier, 2001, Diastolic dysfunction in normotensive men with well-controlled type 2 diabetes: importance of maneuvers in echocardiographic screening for preclinical diabetic cardiomyopathy, Diabetes Care, 24, 5, 10.2337/diacare.24.1.5
Poirier, 2003, Preclinical diabetic cardiomyopathy: relation of left ventricular diastolic dysfunction to cardiac autonomic neuropathy in men with uncomplicated well-controlled type 2 diabetes, Metabolism, 52, 1056, 10.1016/S0026-0495(03)00091-X
Polydefkis, 2004, The time course of epidermal nerve fibre regeneration: studies in normal controls and in people with diabetes, with and without neuropathy, Brain, 127, 1606, 10.1093/brain/awh175
Praet, 2006, 31P MR spectroscopy and in vitro markers of oxidative capacity in type 2 diabetes patients, MAGMA, 19, 321, 10.1007/s10334-006-0060-0
Puigserver, 1998, A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis, Cell, 92, 829, 10.1016/S0092-8674(00)81410-5
Purves, 2001, A role for mitogen-activated protein kinases in the etiology of diabetic neuropathy, FASEB J, 15, 2508, 10.1096/fj.01-0253hyp
Quattrini, 2007, Surrogate markers of small fiber damage in human diabetic neuropathy, Diabetes, 56, 2148, 10.2337/db07-0285
Ribisl, 2007, Exercise capacity and cardiovascular/metabolic characteristics of overweight and obese individuals with type 2 diabetes: the Look AHEAD clinical trial, Diabetes Care, 30, 2679, 10.2337/dc06-2487
Rijzewijk, 2008, Myocardial steatosis is an independent predictor of diastolic dysfunction in type 2 diabetes mellitus, J Am Coll Cardiol, 52, 1793, 10.1016/j.jacc.2008.07.062
Rijzewijk, 2009, Altered myocardial substrate metabolism and decreased diastolic function in nonischemic human diabetic cardiomyopathy: studies with cardiac positron emission tomography and magnetic resonance imaging, J Am Coll Cardiol, 54, 1524, 10.1016/j.jacc.2009.04.074
Roden, 1996, Mechanism of free fatty acid-induced insulin resistance in humans, J Clin Invest, 97, 2859, 10.1172/JCI118742
Rodgers, 2008, Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways, FEBS Lett, 582, 46, 10.1016/j.febslet.2007.11.034
Roy Chowdhury, 2012, Impaired adenosine monophosphate-activated protein kinase signalling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and peripheral neuropathy in diabetes, Brain, 135, 1751, 10.1093/brain/aws097
Russell, 2002, High glucose-induced oxidative stress and mitochondrial dysfunction in neurons, FASEB J, 16, 1738, 10.1096/fj.01-1027com
Saleh, 2013, Ciliary neurotrophic factor activates NF-kappaB to enhance mitochondrial bioenergetics and prevent neuropathy in sensory neurons of streptozotocin-induced diabetic rodents, Neuropharmacology, 65, 65, 10.1016/j.neuropharm.2012.09.015
Samuel, 2012, Mechanisms for insulin resistance: common threads and missing links, Cell, 148, 852, 10.1016/j.cell.2012.02.017
Sandri, 2006, PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription, Proc Natl Acad Sci U S A, 103, 16260, 10.1073/pnas.0607795103
Savage, 2006, Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2, J Clin Invest, 116, 817, 10.1172/JCI27300
Scheuermann-Freestone, 2003, Abnormal cardiac and skeletal muscle energy metabolism in patients with type 2 diabetes, Circulation, 107, 3040, 10.1161/01.CIR.0000072789.89096.10
Schmidt, 1997, Axonal cytoskeletal pathology in aged and diabetic human sympathetic autonomic ganglia, Brain Res, 769, 375, 10.1016/S0006-8993(97)00806-8
Schmidt, 1997, Dystrophic axonal swellings develop as a function of age and diabetes in human dorsal root ganglia, J Neuropathol Exp Neurol, 56, 1028, 10.1097/00005072-199709000-00008
Schmidt, 2003, Non-obese diabetic mice rapidly develop dramatic sympathetic neuritic dystrophy: a new experimental model of diabetic autonomic neuropathy, Am J Pathol, 163, 2077, 10.1016/S0002-9440(10)63565-1
Schmidt, 2008, Synaptic ultrastructural alterations anticipate the development of neuroaxonal dystrophy in sympathetic ganglia of aged and diabetic mice, J Neuropathol Exp Neurol, 67, 1166, 10.1097/NEN.0b013e318190d6db
Schmidt, 2009, Neuritic dystrophy and neuronopathy in Akita (Ins2(Akita)) diabetic mouse sympathetic ganglia, Exp Neurol, 216, 207, 10.1016/j.expneurol.2008.11.019
Schrauwen, 2004, Oxidative capacity, lipotoxicity, and mitochondrial damage in type 2 diabetes, Diabetes, 53, 1412, 10.2337/diabetes.53.6.1412
Shepherd, 1999, Glucose transporters and insulin action – implications for insulin resistance and diabetes mellitus, N Engl J Med, 341, 248, 10.1056/NEJM199907223410406
Short, 2003, Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity, Diabetes, 52, 1888, 10.2337/diabetes.52.8.1888
Shulman, 2004, Unraveling the cellular mechanism of insulin resistance in humans: new insights from magnetic resonance spectroscopy, Physiology (Bethesda), 19, 183, 10.1152/physiol.00007.2004
Sidenius, 1980, Reduced perikaryal volume of lower motor and primary sensory neurons in early experimental diabetes, Diabetes, 29, 182, 10.2337/diab.29.3.182
Sigal, 2007, Effects of aerobic training, resistance training, or both on glycemic control in type 2 diabetes: a randomized trial, Ann Intern Med, 147, 357, 10.7326/0003-4819-147-6-200709180-00005
Sima, 2004, Diabetic neuropathy in type 1 and type 2 diabetes and the effects of C-peptide, J Neurol Sci, 220, 133, 10.1016/j.jns.2004.03.014
Simoneau, 1997, Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM, J Appl Physiol, 83, 166, 10.1152/jappl.1997.83.1.166
Simoneau, 1995, Skeletal muscle glycolytic and oxidative enzyme capacities are determinants of insulin sensitivity and muscle composition in obese women, FASEB J, 9, 273, 10.1096/fasebj.9.2.7781930
Simoneau, 1999, Markers of capacity to utilize fatty acids in human skeletal muscle: relation to insulin resistance and obesity and effects of weight loss, FASEB J, 13, 2051, 10.1096/fasebj.13.14.2051
Sinha, 2002, Assessment of skeletal muscle triglyceride content by (1)H nuclear magnetic resonance spectroscopy in lean and obese adolescents: relationships to insulin sensitivity, total body fat, and central adiposity, Diabetes, 51, 1022, 10.2337/diabetes.51.4.1022
Smith, 2006, Lifestyle intervention for pre-diabetic neuropathy, Diabetes Care, 29, 1294, 10.2337/dc06-0224
Soyal, 2006, PGC-1alpha: a potent transcriptional cofactor involved in the pathogenesis of type 2 diabetes, Diabetologia, 49, 1477, 10.1007/s00125-006-0268-6
Srinivasan, 2000, Diabetic peripheral neuropathy: evidence for apoptosis and associated mitochondrial dysfunction, Diabetes, 49, 1932, 10.2337/diabetes.49.11.1932
Struthers, 2002, Screening for and treating left-ventricular abnormalities in diabetes mellitus: a new way of reducing cardiac deaths, Lancet, 359, 1430, 10.1016/S0140-6736(02)08358-7
Stumvoll, 2005, Type 2 diabetes: principles of pathogenesis and therapy, Lancet, 365, 1333, 10.1016/S0140-6736(05)61032-X
Suarez, 2004, In vivo adenoviral transfer of sorcin reverses cardiac contractile abnormalities of diabetic cardiomyopathy, Am J Physiol Heart Circ Physiol, 286, H68, 10.1152/ajpheart.00245.2003
Suarez, 2008, Alterations in mitochondrial function and cytosolic calcium induced by hyperglycemia are restored by mitochondrial transcription factor A in cardiomyocytes, Am J Physiol Cell Physiol, 295, C1561, 10.1152/ajpcell.00076.2008
Sung, 2009, Fasting blood glucose and the risk of stroke and myocardial infarction, Circulation, 119, 812, 10.1161/CIRCULATIONAHA.108.776989
Szczepaniak, 2003, Myocardial triglycerides and systolic function in humans: in vivo evaluation by localized proton spectroscopy and cardiac imaging, Magn Reson Med, 49, 417, 10.1002/mrm.10372
Szendroedi, 2008, Mitochondrial fitness and insulin sensitivity in humans, Diabetologia, 51, 2155, 10.1007/s00125-008-1153-2
Szendroedi, 2007, Muscle mitochondrial ATP synthesis and glucose transport/phosphorylation in type 2 diabetes, PLoS Med, 4, e154, 10.1371/journal.pmed.0040154
Taegtmeyer, 2002, Adaptation and maladaptation of the heart in diabetes. Part I: general concepts, Circulation, 105, 1727, 10.1161/01.CIR.0000012466.50373.E8
Territo, 2001, Calcium activation of heart mitochondrial oxidative phosphorylation: rapid kinetics of mVO2, NADH, AND light scattering, J Biol Chem, 276, 2586, 10.1074/jbc.M002923200
Thyfault, 2007, Contraction of insulin-resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism, Am J Physiol Cell Physiol, 292, C729, 10.1152/ajpcell.00311.2006
Toledo, 2007, Effects of physical activity and weight loss on skeletal muscle mitochondria and relationship with glucose control in type 2 diabetes, Diabetes, 56, 2142, 10.2337/db07-0141
Trost, 2002, Overexpression of the sarcoplasmic reticulum Ca(2+)-ATPase improves myocardial contractility in diabetic cardiomyopathy, Diabetes, 51, 1166, 10.2337/diabetes.51.4.1166
Tuomilehto, 2001, Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance, N Engl J Med, 344, 1343, 10.1056/NEJM200105033441801
Turner, 2007, Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents, Diabetes, 56, 2085, 10.2337/db07-0093
UKPDS, 1998, Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group, Lancet, 352, 837, 10.1016/S0140-6736(98)07019-6
UKPDS, 1998, Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group, Lancet, 352, 854, 10.1016/S0140-6736(98)07037-8
Urban, 2012, Modulating molecular chaperones improves sensory fiber recovery and mitochondrial function in diabetic peripheral neuropathy, Exp Neurol, 235, 388, 10.1016/j.expneurol.2012.03.005
van der Meer, 2007, Short-term caloric restriction induces accumulation of myocardial triglycerides and decreases left ventricular diastolic function in healthy subjects, Diabetes, 56, 2849, 10.2337/db07-0768
van der Meer, 2009, Pioglitazone improves cardiac function and alters myocardial substrate metabolism without affecting cardiac triglyceride accumulation and high-energy phosphate metabolism in patients with well-controlled type 2 diabetes mellitus, Circulation, 119, 2069, 10.1161/CIRCULATIONAHA.108.803916
Vincent, 2004, Oxidative stress in the pathogenesis of diabetic neuropathy, Endocr Rev, 25, 612, 10.1210/er.2003-0019
Vincent, 2004, Uncoupling proteins prevent glucose-induced neuronal oxidative stress and programmed cell death, Diabetes, 53, 726, 10.2337/diabetes.53.3.726
Vinik, 2003, Diabetic autonomic neuropathy, Diabetes Care, 26, 1553, 10.2337/diacare.26.5.1553
Voitenko, 1999, Changes in calcium signalling in dorsal horn neurons in rats with streptozotocin-induced diabetes, Neuroscience, 94, 887, 10.1016/S0306-4522(99)00330-9
Voitenko, 2000, Effect of streptozotocin-induced diabetes on the activity of calcium channels in rat dorsal horn neurons, Neuroscience, 95, 519, 10.1016/S0306-4522(99)00453-4
Wang, 2005, Impact of altered substrate utilization on cardiac function in isolated hearts from Zucker diabetic fatty rats, Am J Physiol Heart Circ Physiol, 288, H2102, 10.1152/ajpheart.00935.2004
Wang, 2009, Myocardial overexpression of adenine nucleotide translocase 1 ameliorates diabetic cardiomyopathy in mice, Exp Physiol, 94, 220, 10.1113/expphysiol.2008.044800
Wei, 2000, Low cardiorespiratory fitness and physical inactivity as predictors of mortality in men with type 2 diabetes, Ann Intern Med, 132, 605, 10.7326/0003-4819-132-8-200004180-00002
Weis, 1994, Rat heart expresses two forms of mitochondrial carnitine palmitoyltransferase I. The minor component is identical to the liver enzyme, J Biol Chem, 269, 18712, 10.1016/S0021-9258(17)32222-6
Wilson, 2000, Meta-analysis of the age-associated decline in maximal aerobic capacity in men: relation to training status, Am J Physiol Heart Circ Physiol, 278, H829, 10.1152/ajpheart.2000.278.3.H829
Wisloff, 2005, Cardiovascular risk factors emerge after artificial selection for low aerobic capacity, Science, 307, 418, 10.1126/science.1108177
Wittmeier, 2012, Hepatic steatosis and low cardiorespiratory fitness in youth with type 2 diabetes, Obesity (Silver Spring), 20, 1034, 10.1038/oby.2011.379
Yagihashi, 1997, Pathogenetic mechanisms of diabetic neuropathy: lessons from animal models, J Peripher Nerv Syst, 2, 113
Yan, 2006, Cross-talk between calcium and reactive oxygen species signaling, Acta Pharmacol Sin, 27, 821, 10.1111/j.1745-7254.2006.00390.x
Young, 2002, Adaptation and maladaptation of the heart in diabetes. Part II: potential mechanisms, Circulation, 105, 1861, 10.1161/01.CIR.0000012467.61045.87
Young, 2002, Impaired long-chain fatty acid oxidation and contractile dysfunction in the obese Zucker rat heart, Diabetes, 51, 2587, 10.2337/diabetes.51.8.2587
Yu, 2008, Hyperglycemia and downregulation of caveolin-1 enhance neuregulin-induced demyelination, Glia, 56, 877, 10.1002/glia.20662
Zhang, 2012, C-terminal heat shock protein 90 inhibitor decreases hyperglycemia-induced oxidative stress and improves mitochondrial bioenergetics in sensory neurons, J Proteome Res, 11, 2581, 10.1021/pr300056m
Zherebitskaya, 2009, Development of selective axonopathy in adult sensory neurons isolated from diabetic rats: role of glucose-induced oxidative stress, Diabetes, 58, 1356, 10.2337/db09-0034
Zherebitskaya, 2012, Sensory neurons derived from diabetic rats have diminished internal Ca2+ stores linked to impaired re-uptake by the endoplasmic reticulum, ASN Neuro, 4, e00072, 10.1042/AN20110038
Zhou, 2000, Lipotoxic heart disease in obese rats: implications for human obesity, Proc Natl Acad Sci U S A, 97, 1784, 10.1073/pnas.97.4.1784
Zib, 2007, Effect of pioglitazone therapy on myocardial and hepatic steatosis in insulin-treated patients with type 2 diabetes, J Investig Med, 55, 230, 10.2310/6650.2007.00003