p300/CBP/p53 interaction and regulation of the p53 response

FEBS Journal - Tập 268 Số 10 - Trang 2773-2778 - 2001
Steven R. Grossman1
1Departments of Adult Oncology and Cancer Biology, Dana‐Farber Cancer Institute and Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA

Tóm tắt

Substantial evidence points to a critical role for the p300/CREB binding protein (CBP) coactivators in p53 responses to DNA damage. p300/CBP and the associated protein P/CAF bind to and acetylate p53 during the DNA damage response, and are needed for full p53 transactivation as well as downstream p53 effects of growth arrest and/or apoptosis. Beyond this simplistic model, p300/CBP appear to be complex integrators of signals that regulate p53, and biochemically, the multipartite p53/p300/CBP interaction is equally complex. Through physical interaction with p53, p300/CBP can both positively and negatively regulate p53 transactivation, as well as p53 protein turnover depending on cellular context and environmental stimuli, such as DNA damage.

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FEBS Journal

Tập 268 Số 10

2773-2778

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