Resveratrol and liver: A systematic review

Brown, 2009, Alcohol Clin Exp Res, The biological responses to resveratrol and other polyphenols from alcoholic beverages, 1513

Luther, 2011, Invest New Drugs, Chemopreventive doses of resveratrol do not produce cardiotoxicity in a rodent model of hepatocellular carcinoma, 380

Wang, 2012, Bioorg Med Chem Lett, A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells, 2114

Baur, 2006, Nat Rev Drug Discov, Therapeutic potential of resveratrol: The in vivo evidence, 493

Shankar, 2007, Front Biosci, Chemoprevention by resveratrol: Molecular mechanisms and therapeutic potential, 4839

Saiko, 2008, Mutat Res, Resveratrol and its analogs: Defense against cancer, coronary disease and neurodegenerative maladies or just a fad?, 68

Shakibaei, 2009, Mol Nutr Food Res, Resveratrol addiction: To die or not to die, 115

Baur, 2006, Nature, Resveratrol improves health and survival of mice on a high-calorie diet, 337

Muriel, 2008, J Appl Toxicol, Beneficial drugs for liver diseases, 93

Kawada, 1998, Hepatology, Effect of antioxidants, resveratrol, quercetin, and N-acetylcysteine, on the functions of cultured rat hepatic stellate cells and Kupffer cells, 1265

Bechmann, 2009, Hepatol Res, Resveratrol amplifies profibrogenic effects of free fatty acids on human hepatic stellate cells, 601

Schmatz, 2012, Biochimie, Effects of resveratrol on biomarkers of oxidative stress and on the activity of delta aminolevulinic acid dehydratase in liver and kidney of streptozotocin-induced diabetic rats, 374

Godichaud, 2000, Hepatology, Deactivation of cultured human liver myofibroblasts by trans-resveratrol, a grapevine-derived polyphenol, 922

Godichaud, 2006, Int J Biochem Cell Biol, The grape-derived polyphenol resveratrol differentially affects epidermal and platelet-derived growth factor signaling in human liver myofibroblasts, 629

Shang, 2008, Acta Pharmacol Sin, Resveratrol improves non-alcoholic fatty liver disease by activating AMP-activated protein kinase, 698

Nah, 2005, Chonnam Med J, Resveratrol protects HepG2 and chang liver cells from oxidative stress, 243

Souza, 2008, Mol Cell Biochem, Resveratrol inhibits cell growth by inducing cell cycle arrest in activated hepatic stellate cells, 1

Rubiolo, 2008, Eur J Pharmacol, Resveratrol protects primary rat hepatocytes against oxidative stress damage: Activation of the Nrf2 transcription factor and augmented activities of antioxidant enzymes, 66

Rubiolo, 2008, Biomed Pharmacother, Resveratrol protects primary rat hepatocytes against necrosis induced by reactive oxygen species, 606

Wang, 2012, Int J Environ Res Public Health, Resveratrol inhibited hydroquinone-induced cytotoxicity in mouse primary hepatocytes, 3354

Gnoni, 2009, Eur J Clin Invest, Resveratrol inhibits fatty acid and triacylglycerol synthesis in rat hepatocytes, 211

Cerný, 2009, Nitric Oxide, Effects of resveratrol pretreatment on tert-butylhydroperoxide induced hepatocyte toxicity in immobilized perifused hepatocytes: Involvement of inducible nitric oxide synthase and hemoxygenase-1, 1

Chen, 2009, Int J Mol Sci, Inhibition of citrinin-induced apoptotic biochemical signaling in human hepatoma G2 cells by resveratrol, 3338

Notas, 2006, Biochim Biophys Acta, Resveratrol exerts its antiproliferative effect on HepG2 hepatocellular carcinoma cells, by inducing cell cycle arrest, and NOS activation, 1657

Parekh, 2011, Exp Toxicol Pathol, Downregulation of cyclin D1 is associated with decreased levels of p38 MAP kinases, Akt/PKB and Pak1 during chemopreventive effects of resveratrol in liver cancer cells, 167

Choi, 2009, Cancer Genomics Proteomics, Resveratrol induces apoptosis in human SK-HEP-1 hepatic cancer cells, 263

Gallis, 2012, Pharmacol Res, Resveratrol plus ethanol counteract the ethanol-induced impairment of energy metabolism: 31P NMR study of ATP and sn-glycerol-3-phosphate on isolated and perfused rat liver, 387

Wu, 2006, Pharmacol Res, Apoptosis of lymphocytes in allograft in a rat liver transplantation model induced by resveratrol, 19

Wu, 2006, Transplant Proc, The suppressive effect of resveratrol on protein kinase C theta in peripheral blood T lymphocytes in a rat liver transplantation model, 3052

Wu, 2005, Transplant Proc, Immunosuppression by combined use of cyclosporine and resveratrol in a rat liver transplantation model, 2354

Wu, 2005, World J Gastroenterol, Resveratrol prolongs allograft survival after liver transplantation in rats, 4745

Wu, 2004, World J Gastroenterol, Effect of resveratrol and in combination with 5-FU on murine liver cancer, 3048

Yu, 2003, World J Gastroenterol, Effect of resveratrol on cell cycle proteins in murine transplantable liver cancer, 2341

Bishayee, 2010, Cancer Prev Res (Phila), Resveratrol suppresses oxidative stress and inflammatory response in diethylnitrosamine-initiated rat hepatocarcinogenesis, 753

Bishayee, 2010, Pharm Res, Suppression of the inflammatory cascade is implicated in resveratrol chemoprevention of experimental hepatocarcinogenesis, 1080

Mbimba, 2012, Curr Pharm Biotechnol, Alteration of hepatic proinflammatory cytokines is involved in the resveratrol-mediated chemoprevention of chemically-induced hepatocarcinogenesis, 229

Salado, 2011, J Transl Med, Resveratrol prevents inflammation-dependent hepatic melanoma metastasis by inhibiting the secretion and effects of interleukin-18, 59

Burgess, 2011, Arch Surg, Improving glucose metabolism with resveratrol in a swine model of metabolic syndrome through alteration of signaling pathways in the liver and skeletal muscle, 556

Gedik, 2008, World J Gastroenterol, Resveratrol attenuates oxidative stress and histological alterations induced by liver ischemia/reperfusion in rats, 7101

Hassan-Khabbar, 2008, Liver Transpl, Postischemic treatment by trans-resveratrol in rat liver ischemia-reperfusion: A possible strategy in liver surgery, 451

Plin, 2005, Eur J Pharmacol, Resveratrol protects against cold ischemia-warm reoxygenation-induced damages to mitochondria and cells in rat liver, 162

Rivera, 2008, J Appl Toxicol, Resveratrol and trimethylated resveratrol protect from acute liver damage induced by CCl4 in the rat, 147

Fan, 2009, Environ Toxicol Pharmacol, Resveratrol ameliorates carbon tetrachloride-induced acute liver injury in mice, 350

Lodovici, 2011, Pharmacology, Protective effect of resveratrol against oxidation stress induced by 2-nitropropane in rat liver, 127

Tunali-Akbay, 2010, J Pharm Pharm Sci, Resveratrol protects against methotrexate-induced hepatic injury in rats, 303

Roy, 2011, Oxid Med Cell Longev, Resveratrol regulates antioxidant status, inhibits cytokine expression and restricts apoptosis in carbon tetrachloride induced rat hepatic injury, 703676

Vitaglione, 2009, J Gastroenterol Hepatol, Dietary trans-resveratrol bioavailability and effect on CCl4-induced liver lipid peroxidation, 618

El-Agamy, 2010, Arch Toxicol, Comparative effects of curcumin and resveratrol on aflatoxin B(1)-induced liver injury in rats, 389

Hamadi, 2012, J Biochem Mol Toxicol, Ameliorative effects of resveratrol on liver injury in streptozotocin-induced diabetic rats, 384

Chan, 2011, Mol Nutr Food Res, The protective role of natural phytoalexin resveratrol on inflammation, fibrosis and regeneration in cholestatic liver injury, 1841

Velioglu-Ogünç, 2009, Free Radic Res, Resveratrol protects against irradiation-induced hepatic and ileal damage via its anti-oxidative activity, 1060

Yu, 2008, Shock, Resveratrol attenuates hepatic injury after trauma-hemorrhage via estrogen receptor-related pathway, 324

Bujanda, 2006, BMC Gastroenterol, Effect of resveratrol on alcohol-induced mortality and liver lesions in mice, 35

Kasdallah-Grissa, 2007, Life Sci, Resveratrol, a red wine polyphenol, attenuates ethanol-induced oxidative stress in rat liver, 1033

Jinghui, 2010, Pharmacol Clin Chin Mater Med, Effects of resveratrol on serum TNF-α, IL-6, ICAM-1 in alcohol-induced hepatic injury in rats, 006

Schirmer, 2012, Mol Biol Rep, Modulatory effect of resveratrol on SIRT1, SIRT3, SIRT4, PGC1a and NAMPT gene expression profiles in wild-type adult zebrafish liver, 3281

Chang, 2012, Chin J Physiol, Effect of resveratrol on oxidative and inflammatory stress in liver and spleen of streptozotocin-induced type 1 diabetic rats, 192

Sebai, 2010, Ecotoxicol Environ Saf, Resveratrol, a red wine polyphenol, attenuates lipopolysaccharide-induced oxidative stress in rat liver, 1078

Rocha, 2009, Food Chem Toxicol, Resveratrol toxicity: Effects on risk factors for atherosclerosis and hepatic oxidative stress in standard and high-fat diets, 1362

Bagul, 2012, Pharmacol Res, Attenuation of insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats, 260

Palsamy, 2010, Chem Biol Interact, Resveratrol attenuates hyperglycemia-mediated oxidative stress, proinflammatory cytokines and protects hepatocytes ultrastructure in streptozotocin-nicotinamide-induced experimental diabetic rats, 200

Upadhyay, 2008, Eur J Pharmacol, Resveratrol modulates pyrogallol-induced changes in hepatic toxicity markers, xenobiotic metabolizing enzymes and oxidative stress, 146

Farghali, 2009, Nitric Oxide, Resveratrol attenuates lipopolysaccharide-induced hepatitis in D-galactosamine sensitized rats: Role of nitric oxide synthase 2 and heme oxygenase-1, 216

Kirimlioglu, 2008, Transplant Proc, Effect of resveratrol on oxidative stress enzymes in rats subjected to 70% partial hepatectomy, 293

Sengottuvelan, 2006, Int J Pharmacal, Resveratrol, a phytoalexin enhances hepatic antioxidant defense in 1,2-dimethylhydrazine-induced colon carcinogenesis, 335

Sahin, 2012, J Anim Physiol Anim Nutr (Berl), Resveratrol protects quail hepatocytes against heat stress: Modulation of the Nrf2 transcription factor and heat shock proteins, 66

Xin, 2013, Food Chem Toxicol, Alleviative effects of resveratrol on nonalcoholic fatty liver disease are associated with up regulation of hepatic low density lipoprotein receptor and scavenger receptor class B type I gene expressions in rats, 12

Kopeæ, 2013, J Funct Foods, Effect of long term administration of resveratrol on lipid concentration in selected organs and liver′s histology in rats fed high fructose diet, 299

Poulsen, 2012, Nutr Res, Resveratrol up-regulates hepatic uncoupling protein 2 and prevents development of nonalcoholic fatty liver disease in rats fed a high-fat diet, 701

Alberdi, 2013, Nutrition, Hepatic lipid metabolic pathways modified by resveratrol in rats fed an obesogenic diet, 562

Cho, 2012, Br J Nutr, Differential effects of low-dose resveratrol on adiposity and hepatic steatosis in diet-induced obese mice, 2166

Bujanda, 2008, BMC Gastroenterol, Resveratrol inhibits nonalcoholic fatty liver disease in rats, 40

Ajmo, 2008, Am J Physiol Gastrointest Liver Physiol, Resveratrol alleviates alcoholic fatty liver in mice, G833

Shiozaki, 2011, Histochem Cell Biol, Closer association of mitochondria with lipid droplets in hepatocytes and activation of Kupffer cells in resveratrol-treated senescence-accelerated mice, 475

Zhu, 2008, Asian Australas J Anim Sci, Effect of resveratrol on serum and liver lipid profile and antioxidant activity in hyperlipidemia rats, 890

Chen, 2012, Lipids Health Dis, Dietary resveratrol increases the expression of hepatic 7a-hydroxylase and ameliorates hypercholesterolemia in high-fat fed C57BL/6J mice, 56

Miura, 2003, Life Sci, Hypolipidemic action of dietary resveratrol, a phytoalexin in grapes and red wine, in hepatoma-bearing rats, 1393

Di, 2013, J Hepatol, Resveratrol improves intrahepatic endothelial dysfunction and reduces hepatic fibrosis and portal pressure in cirrhotic rats, 904

Hong, 2010, Arch Pharm Res, The protective effect of resveratrol on dimethylnitrosamine-induced liver fibrosis in rats, 601

Lee, 2010, Arch Pharm Res, Resveratrol inhibits dimethylnitrosamine-induced hepatic fibrosis in rats, 925

Lv, 2005, Chin New Drugs J, Effects of resveratrol on chronic liver fibrosis in rats, 855

Hassan-Khabbar, 2010, Biochimie, Protective effect of post-ischemic treatment with trans-resveratrol on cytokine production and neutrophil recruitment by rat liver, 405

Kirimlioglu, 2008, Transplant Proc, Effect of resveratrol and melatonin on oxidative stress enzymes, regeneration, and hepatocyte ultrastructure in rats subjected to 70% partial hepatectomy, 285