Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways

Anderson, 1990, Binding of SH2 domains of PLC-γ1, GAP and src to activated growth factor receptors, Science, 250, 979, 10.1126/science.2173144 Bottaro, 1991, Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product, Science, 251, 802, 10.1126/science.1846706 Boyle, 1991, Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin layer cellulose plates, Meth. Enzymol., 201, 110, 10.1016/0076-6879(91)01013-R Cantley, 1991, Oncogenes and signal transduction, Cell, 64, 281, 10.1016/0092-8674(91)90639-G Cohen, 1990, Tyrosine-phosphorylation is a signal for the trafficking of pp85, an 85-kDa phosphorylated polypeptide associated with phosphatidylinositol kinase activity, 87, 4458 Coughlin, 1989, Role of phosphatidylinositol kinase in PDGF receptor signal transduction, Science, 243, 1191, 10.1126/science.2466336 Ebina, 1985, The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signaling, Cell, 40, 747, 10.1016/0092-8674(85)90334-4 Ek, 1982, Charaterization of a tyrosine specific kinase activity in human fibroblast membranes stimulated by platelet-derived growth factor, J. Biol. Chem., 257, 10486, 10.1016/S0021-9258(18)34044-4 Ellis, 1990, Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases, Nature, 343, 377, 10.1038/343377a0 Escobedo, 1988, A PDGF receptor domain essential for mitogenesis but not for many other responses to PDGF, Nature, 335, 85, 10.1038/335085a0 Escobedo, 1988, Platelet-derived growth factor receptors expressed by cDNA couple to a diverse group of cellular responses associated with cell proliferation, J. Biol. Chem., 262, 1482, 10.1016/S0021-9258(19)57328-8 Escobedo, 1991, A phosphatidylinositol-3 kinase binds to platelet-derived growth factor receptors through a specific receptor sequence containing phosphotyrosine, Mol. Cell. Biol., 11, 1125, 10.1128/MCB.11.2.1125 Escobedo, 1991, cDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of Pl3-kinase to the PDGF β-receptor, Cell, 65, 75, 10.1016/0092-8674(91)90409-R Huang, 1990, The hematopoietic growth factor KL is encoded at the SI locus and is the ligand of the c-kit receptor, the gene product of the W locus, Cell, 63, 225, 10.1016/0092-8674(90)90303-V Kaplan, 1987, Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity, Cell, 50, 1021, 10.1016/0092-8674(87)90168-1 Kaplan, 1990, PDGF β-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signalling complex, Cell, 61, 125, 10.1016/0092-8674(90)90220-9 Kazlauskas, 1989, Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins, Cell, 58, 1121, 10.1016/0092-8674(89)90510-2 Kazlauskas, 1990, Phosphorylation of the PDGF receptor β subunit creates a tight binding site for phosphatidylinositol 3 kinase, EMBO J., 9, 3279, 10.1002/j.1460-2075.1990.tb07527.x Kazlauskas, 1990, Binding of GAP to activated PDGF receptors, Science, 247, 1578, 10.1126/science.2157284 Kumjian, 1989, Platelet-derived growth factor (PDGF) binding promotes the physical association of PDGF receptor with phospholipase-C, 86, 8232 Martin, 1990, Primary structure and functional expression of rat and human stem cell factor DNAs, Cell, 63, 203, 10.1016/0092-8674(90)90301-T Martin, 1992, GAP domains responsible for ras p21-dependent inhibition of the muscarinic atrial K+ channel currents, Science, 255, 192, 10.1126/science.1553544 Matsuda, 1990, Binding of the oncoprotein, P47gag-crk, to a broad range of phosphotyrosine-containing proteins, Science, 248, 1537, 10.1126/science.1694307 Matsui, 1989, Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes, Science, 243, 800, 10.1126/science.2536956 Mayer, 1990, Association of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase activity, 87, 2638 Mayer, 1991, The noncatalytic src homology region 2 segment of abl tyrosine kinase binds to tyrosine-phosphorylated cellular proteins with high affinity, 88, 627 Meisenhelder, 1989, Phospholipase C-γ is a substrate for the PDGF and the EGF receptor protein-tyrosine kinases in vivo and in vitro, Cell, 57, 1109, 10.1016/0092-8674(89)90048-2 Mohammadi, 1991, A tyrosine-phosphorylated carboxy-terminal peptide of the FGF receptor is a site for the SH2 domain of phospholipase C-γ1, Mol. Cell. Biol., 11, 5068, 10.1128/MCB.11.10.5068 Molloy, 1989, PDGF induction of tyrosine phosphorylation of the GTPase activating protein, Nature, 342, 711, 10.1038/342711a0 Morrison, 1989, Direct activation of the serine/threonine kinase activity of Raf-1 through tyrosine phosphorylation by the PDGF β-receptor, Cell, 58, 649, 10.1016/0092-8674(89)90100-1 Morrison, 1990, Platelet-derived growth factor (PDGF)-dependent association of phospholipase C-γ with the PDGF receptor signaling complex, Mol. Cell. Biol., 10, 2359, 10.1128/MCB.10.5.2359 Nishimura, 1982, Platelet-derived growth factor stimulates tyrosine specific protein kinase activity in Swiss mouse 3T3 membranes, 79, 4303 Pawson, 1988, Non-catalytic domains of the cytoplasmic proteintyrosine kinases: regulatory elements in signal transduction, Oncogene, 3, 491 Reedijk, 1990, Interactions of phosphotidylinositol kinase, GTPase-activating protein (GAP), and GAP-associated proteins with the colony-stimulating factor 1 receptor, Mol. Cell. Biol., 10, 5601, 10.1128/MCB.10.11.5601 Sadowski, 1986, A non-catalytic domain conserved among cytoplasmic tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps, Mol. Cell. Biol., 6, 4396, 10.1128/MCB.6.12.4396 Severinsson, 1990, Deletion of the kinase insert of the B-type PDGF receptor affects receptor kinase activity and signal transduction, Mol. Cell. Biol., 10, 801, 10.1128/MCB.10.2.801 Sherr, 1985, The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1, Cell, 41, 665, 10.1016/S0092-8674(85)80047-7 Summers, 1987 Sun, 1991, Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein, Nature, 352, 73, 10.1038/352073a0 Turck, 1992, Identification of phosphotyrosine residues in peptides by high performance liquid chromatography online derivative chromatography, Peptide Research Ullrich, 1986, Insulin-like growth factor 1 receptor suggests structural determinants that define functional specificity, EMBO J., 5, 2503, 10.1002/j.1460-2075.1986.tb04528.x Varticovski, 1989, The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol-3 kinase, Nature, 342, 699, 10.1038/342699a0 Wahl, 1989, Platelet-derived growth factor induces rapid and sustained tyrosine phosphorylation of phospholipase C-γ in quiescent Balbc3T3 cells, Mol. Cell. Biol., 9, 2934, 10.1128/MCB.9.7.2934 Yarden, 1986, Structure of the receptor for platelet-derived growth factor helps to define a family of closely related growth factor receptors, Nature, 325, 226, 10.1038/323226a0 Yu, 1991, Tyrosine mutations within the α platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction, Mol. Cell. Biol., 11, 3780, 10.1128/MCB.11.7.3780 Zoller, 1982, Oligonucleotide-directed mutagenesis using M13-derived vectors: an efficient and general procedure for the production of point mutations in any fragment of DNA, Nucl. Acids Res., 10, 6487, 10.1093/nar/10.20.6487