SoNar, a Highly Responsive NAD+/NADH Sensor, Allows High-Throughput Metabolic Screening of Anti-tumor Agents

Cell Metabolism - Tập 21 - Trang 777-789 - 2015
Yuzheng Zhao1,2,3,4, Qingxun Hu1, Feixiong Cheng4, Ni Su1,2,4, Aoxue Wang1,2,4, Yejun Zou1,2,4, Hanyang Hu1, Xianjun Chen1,2,4, Hai-Meng Zhou5, Xinzhi Huang6, Kai Yang6, Qian Zhu1,2, Xue Wang1, Jing Yi6, Linyong Zhu7, Xuhong Qian8, Lixin Chen9, Yun Tang4, Joseph Loscalzo10, Yi Yang1,2,3,4
1Synthetic Biology and Biotechnology Laboratory, State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing Technology, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, China
2Optogenetics & Molecular Imaging Interdisciplinary Research Center, CAS Center for Excellence in Brain Science, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, China
3Collaborative Innovation Center of Genetics and Development, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, China
4Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, China
5Zhejiang Provincial Key Laboratory of Applied Enzymology, Yangtze Delta Region Institute of Tsinghua University, Jiaxing 314006, China
6Department of Biochemistry and Molecular Cell Biology, Key Laboratory of the Education Ministry for Cell Differentiation and Apoptosis, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, 280 S. Chongqing Road, Shanghai 200025, China
7Key Laboratory for Advanced Materials, Institute of Fine Chemicals, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, China
8Shanghai Key Laboratory of Chemical Biology, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, China
9Shanghai Laboratory Animal Center, Chinese Academy of Sciences, Shanghai 201615, China
10Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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